Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q625_LEIMA

TriTrypDb:

LmjF.31.2360 , LMJLV39_310033100 , LMJSD75_310033100

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q625

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q625

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	449	451	PF00675	0.595
CLV_PCSK_KEX2_1	33	35	PF00082	0.724
CLV_PCSK_KEX2_1	449	451	PF00082	0.595
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.724
DEG_APCC_DBOX_1	473	481	PF00400	0.640
DEG_ODPH_VHL_1	377	389	PF01847	0.743
DEG_SCF_FBW7_2	472	479	PF00400	0.634
DEG_SPOP_SBC_1	66	70	PF00917	0.823
DOC_CDC14_PxL_1	251	259	PF14671	0.771
DOC_CDC14_PxL_1	304	312	PF14671	0.723
DOC_CKS1_1	43	48	PF01111	0.694
DOC_CKS1_1	473	478	PF01111	0.641
DOC_MAPK_FxFP_2	516	519	PF00069	0.607
DOC_MAPK_MEF2A_6	44	52	PF00069	0.697
DOC_MAPK_RevD_3	19	34	PF00069	0.729
DOC_PP2B_LxvP_1	469	472	PF13499	0.599
DOC_PP2B_PxIxI_1	18	24	PF00149	0.586
DOC_PP4_FxxP_1	194	197	PF00568	0.836
DOC_PP4_FxxP_1	435	438	PF00568	0.551
DOC_PP4_FxxP_1	516	519	PF00568	0.607
DOC_SPAK_OSR1_1	359	363	PF12202	0.595
DOC_USP7_MATH_1	275	279	PF00917	0.637
DOC_USP7_MATH_1	319	323	PF00917	0.803
DOC_USP7_MATH_1	329	333	PF00917	0.693
DOC_USP7_MATH_1	66	70	PF00917	0.721
DOC_USP7_UBL2_3	419	423	PF12436	0.751
DOC_WW_Pin1_4	122	127	PF00397	0.725
DOC_WW_Pin1_4	137	142	PF00397	0.794
DOC_WW_Pin1_4	199	204	PF00397	0.792
DOC_WW_Pin1_4	234	239	PF00397	0.810
DOC_WW_Pin1_4	368	373	PF00397	0.758
DOC_WW_Pin1_4	402	407	PF00397	0.611
DOC_WW_Pin1_4	42	47	PF00397	0.690
DOC_WW_Pin1_4	472	477	PF00397	0.627
DOC_WW_Pin1_4	81	86	PF00397	0.725
DOC_WW_Pin1_4	98	103	PF00397	0.709
LIG_14-3-3_CanoR_1	159	164	PF00244	0.758
LIG_14-3-3_CanoR_1	165	171	PF00244	0.783
LIG_14-3-3_CanoR_1	265	274	PF00244	0.722
LIG_14-3-3_CanoR_1	400	407	PF00244	0.753
LIG_14-3-3_CanoR_1	417	425	PF00244	0.653
LIG_deltaCOP1_diTrp_1	454	463	PF00928	0.563
LIG_deltaCOP1_diTrp_1	499	508	PF00928	0.546
LIG_deltaCOP1_diTrp_1	54	63	PF00928	0.700
LIG_EVH1_1	436	440	PF00568	0.609
LIG_EVH1_1	469	473	PF00568	0.598
LIG_FHA_1	1	7	PF00498	0.698
LIG_FHA_1	126	132	PF00498	0.824
LIG_FHA_1	18	24	PF00498	0.521
LIG_FHA_1	238	244	PF00498	0.598
LIG_FHA_1	393	399	PF00498	0.641
LIG_FHA_1	45	51	PF00498	0.676
LIG_FHA_1	464	470	PF00498	0.600
LIG_FHA_2	178	184	PF00498	0.724
LIG_FHA_2	208	214	PF00498	0.659
LIG_FHA_2	313	319	PF00498	0.683
LIG_FHA_2	49	55	PF00498	0.697
LIG_FXI_DFP_1	515	519	PF00024	0.606
LIG_Integrin_RGD_1	26	28	PF01839	0.808
LIG_LIR_Apic_2	191	197	PF02991	0.831
LIG_LIR_Apic_2	60	66	PF02991	0.707
LIG_LIR_Gen_1	499	509	PF02991	0.542
LIG_LIR_Gen_1	526	537	PF02991	0.641
LIG_LIR_Nem_3	175	181	PF02991	0.642
LIG_LIR_Nem_3	454	459	PF02991	0.560
LIG_LIR_Nem_3	505	511	PF02991	0.529
LIG_LIR_Nem_3	526	532	PF02991	0.644
LIG_LYPXL_yS_3	307	310	PF13949	0.725
LIG_MYND_3	254	258	PF01753	0.766
LIG_NRBOX	424	430	PF00104	0.611
LIG_PCNA_yPIPBox_3	187	198	PF02747	0.710
LIG_Pex14_2	431	435	PF04695	0.621
LIG_Rb_pABgroove_1	510	518	PF01858	0.576
LIG_SH2_SRC	282	285	PF00017	0.762
LIG_SH2_STAP1	166	170	PF00017	0.748
LIG_SH2_STAP1	174	178	PF00017	0.641
LIG_SH2_STAP1	459	463	PF00017	0.573
LIG_SH2_STAT5	208	211	PF00017	0.773
LIG_SH2_STAT5	253	256	PF00017	0.675
LIG_SH2_STAT5	282	285	PF00017	0.656
LIG_SH2_STAT5	424	427	PF00017	0.613
LIG_SH2_STAT5	459	462	PF00017	0.443
LIG_SH3_1	346	352	PF00018	0.731
LIG_SH3_2	200	205	PF14604	0.627
LIG_SH3_2	438	443	PF14604	0.629
LIG_SH3_3	149	155	PF00018	0.690
LIG_SH3_3	194	200	PF00018	0.716
LIG_SH3_3	285	291	PF00018	0.795
LIG_SH3_3	346	352	PF00018	0.817
LIG_SH3_3	40	46	PF00018	0.688
LIG_SH3_3	434	440	PF00018	0.580
LIG_SH3_3	467	473	PF00018	0.611
LIG_SH3_CIN85_PxpxPR_1	438	443	PF14604	0.629
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.584
LIG_SUMO_SIM_par_1	19	25	PF11976	0.584
LIG_SUMO_SIM_par_1	47	54	PF11976	0.701
LIG_TRAF2_1	210	213	PF00917	0.749
LIG_TRAF2_1	314	317	PF00917	0.738
LIG_TYR_ITIM	206	211	PF00017	0.602
LIG_WW_3	440	444	PF00397	0.634
LIG_WW_3	471	475	PF00397	0.627
MOD_CDC14_SPxK_1	202	205	PF00782	0.746
MOD_CDK_SPxK_1	199	205	PF00069	0.742
MOD_CDK_SPxxK_3	81	88	PF00069	0.748
MOD_CK1_1	125	131	PF00069	0.785
MOD_CK1_1	237	243	PF00069	0.759
MOD_CK1_1	390	396	PF00069	0.748
MOD_CK1_1	399	405	PF00069	0.822
MOD_CK1_1	81	87	PF00069	0.734
MOD_CK2_1	177	183	PF00069	0.720
MOD_CK2_1	207	213	PF00069	0.665
MOD_CK2_1	275	281	PF00069	0.599
MOD_CK2_1	312	318	PF00069	0.714
MOD_CK2_1	48	54	PF00069	0.700
MOD_CK2_1	67	73	PF00069	0.724
MOD_GlcNHglycan	148	151	PF01048	0.607
MOD_GlcNHglycan	166	169	PF01048	0.619
MOD_GlcNHglycan	213	217	PF01048	0.681
MOD_GlcNHglycan	218	221	PF01048	0.709
MOD_GlcNHglycan	244	247	PF01048	0.755
MOD_GlcNHglycan	268	271	PF01048	0.640
MOD_GlcNHglycan	389	392	PF01048	0.713
MOD_GlcNHglycan	401	404	PF01048	0.828
MOD_GlcNHglycan	58	62	PF01048	0.798
MOD_GlcNHglycan	80	83	PF01048	0.730
MOD_GlcNHglycan	96	99	PF01048	0.706
MOD_GSK3_1	173	180	PF00069	0.795
MOD_GSK3_1	207	214	PF00069	0.748
MOD_GSK3_1	226	233	PF00069	0.611
MOD_GSK3_1	242	249	PF00069	0.668
MOD_GSK3_1	292	299	PF00069	0.681
MOD_GSK3_1	308	315	PF00069	0.777
MOD_GSK3_1	319	326	PF00069	0.737
MOD_GSK3_1	392	399	PF00069	0.785
MOD_GSK3_1	402	409	PF00069	0.620
MOD_GSK3_1	419	426	PF00069	0.637
MOD_GSK3_1	44	51	PF00069	0.798
MOD_GSK3_1	94	101	PF00069	0.706
MOD_N-GLC_1	308	313	PF02516	0.735
MOD_NEK2_1	1	6	PF00069	0.757
MOD_NEK2_1	297	302	PF00069	0.685
MOD_NEK2_1	387	392	PF00069	0.706
MOD_NEK2_1	48	53	PF00069	0.698
MOD_NEK2_2	166	171	PF00069	0.692
MOD_PIKK_1	159	165	PF00454	0.660
MOD_PIKK_1	188	194	PF00454	0.825
MOD_PIKK_1	297	303	PF00454	0.695
MOD_PKA_1	33	39	PF00069	0.712
MOD_PKA_2	164	170	PF00069	0.811
MOD_PKA_2	33	39	PF00069	0.618
MOD_PKA_2	399	405	PF00069	0.766
MOD_PKA_2	78	84	PF00069	0.733
MOD_Plk_1	188	194	PF00069	0.825
MOD_Plk_1	34	40	PF00069	0.703
MOD_Plk_2-3	312	318	PF00069	0.684
MOD_Plk_4	249	255	PF00069	0.759
MOD_Plk_4	275	281	PF00069	0.688
MOD_Plk_4	34	40	PF00069	0.717
MOD_Plk_4	44	50	PF00069	0.756
MOD_Plk_4	67	73	PF00069	0.728
MOD_ProDKin_1	122	128	PF00069	0.725
MOD_ProDKin_1	137	143	PF00069	0.795
MOD_ProDKin_1	199	205	PF00069	0.796
MOD_ProDKin_1	234	240	PF00069	0.807
MOD_ProDKin_1	368	374	PF00069	0.759
MOD_ProDKin_1	402	408	PF00069	0.610
MOD_ProDKin_1	42	48	PF00069	0.692
MOD_ProDKin_1	472	478	PF00069	0.632
MOD_ProDKin_1	81	87	PF00069	0.724
MOD_ProDKin_1	98	104	PF00069	0.709
MOD_SUMO_for_1	32	35	PF00179	0.722
MOD_SUMO_for_1	445	448	PF00179	0.623
MOD_SUMO_rev_2	420	425	PF00179	0.732
TRG_ENDOCYTIC_2	208	211	PF00928	0.833
TRG_ENDOCYTIC_2	307	310	PF00928	0.718
TRG_ER_diArg_1	195	198	PF00400	0.841
TRG_ER_diArg_1	449	452	PF00400	0.583
TRG_ER_diArg_1	484	487	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC95	Leptomonas seymouri	50%	91%
A0A3Q8IST7	Leishmania donovani	93%	100%
A4HJM0	Leishmania braziliensis	70%	100%
A4I742	Leishmania infantum	93%	100%
E9B236	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%