WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q624_LEIMA

TriTrypDb:

LmjF.31.2370 , LMJLV39_310033200 , LMJSD75_310033200

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q624

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q624

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.482
CLV_MEL_PAP_1	354	360	PF00089	0.449
CLV_NRD_NRD_1	145	147	PF00675	0.404
CLV_NRD_NRD_1	197	199	PF00675	0.585
CLV_NRD_NRD_1	316	318	PF00675	0.557
CLV_NRD_NRD_1	53	55	PF00675	0.553
CLV_PCSK_KEX2_1	157	159	PF00082	0.510
CLV_PCSK_KEX2_1	39	41	PF00082	0.490
CLV_PCSK_KEX2_1	53	55	PF00082	0.664
CLV_PCSK_KEX2_1	67	69	PF00082	0.657
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.502
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.479
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.689
CLV_PCSK_SKI1_1	127	131	PF00082	0.380
CLV_PCSK_SKI1_1	181	185	PF00082	0.322
CLV_PCSK_SKI1_1	298	302	PF00082	0.454
CLV_PCSK_SKI1_1	39	43	PF00082	0.442
DEG_APCC_DBOX_1	495	503	PF00400	0.369
DEG_Nend_UBRbox_1	1	4	PF02207	0.439
DEG_ODPH_VHL_1	218	229	PF01847	0.357
DEG_SCF_SKP2-CKS1_1	409	416	PF00560	0.414
DOC_AGCK_PIF_1	355	360	PF00069	0.452
DOC_CKS1_1	443	448	PF01111	0.448
DOC_CYCLIN_RxL_1	36	43	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.527
DOC_MAPK_gen_1	146	154	PF00069	0.366
DOC_MAPK_MEF2A_6	264	271	PF00069	0.447
DOC_MAPK_MEF2A_6	337	345	PF00069	0.473
DOC_MIT_MIM_1	206	215	PF04212	0.422
DOC_PP1_RVXF_1	349	356	PF00149	0.405
DOC_PP4_FxxP_1	344	347	PF00568	0.256
DOC_USP7_MATH_1	104	108	PF00917	0.564
DOC_USP7_MATH_1	111	115	PF00917	0.677
DOC_USP7_MATH_1	125	129	PF00917	0.503
DOC_USP7_MATH_1	230	234	PF00917	0.516
DOC_USP7_MATH_1	27	31	PF00917	0.428
DOC_USP7_MATH_1	311	315	PF00917	0.592
DOC_USP7_MATH_1	370	374	PF00917	0.395
DOC_USP7_MATH_1	97	101	PF00917	0.597
DOC_USP7_UBL2_3	149	153	PF12436	0.462
DOC_USP7_UBL2_3	298	302	PF12436	0.482
DOC_USP7_UBL2_3	63	67	PF12436	0.655
DOC_WW_Pin1_4	343	348	PF00397	0.372
DOC_WW_Pin1_4	410	415	PF00397	0.567
DOC_WW_Pin1_4	442	447	PF00397	0.394
DOC_WW_Pin1_4	88	93	PF00397	0.683
LIG_14-3-3_CanoR_1	162	167	PF00244	0.467
LIG_14-3-3_CanoR_1	357	361	PF00244	0.435
LIG_14-3-3_CanoR_1	40	45	PF00244	0.506
LIG_14-3-3_CanoR_1	490	497	PF00244	0.535
LIG_14-3-3_CanoR_1	70	75	PF00244	0.612
LIG_Actin_WH2_2	444	462	PF00022	0.513
LIG_BRCT_BRCA1_1	472	476	PF00533	0.378
LIG_CtBP_PxDLS_1	417	421	PF00389	0.425
LIG_FHA_1	114	120	PF00498	0.672
LIG_FHA_1	223	229	PF00498	0.527
LIG_FHA_1	256	262	PF00498	0.425
LIG_FHA_1	348	354	PF00498	0.381
LIG_FHA_1	419	425	PF00498	0.480
LIG_FHA_2	258	264	PF00498	0.413
LIG_FHA_2	280	286	PF00498	0.385
LIG_FHA_2	428	434	PF00498	0.484
LIG_FHA_2	490	496	PF00498	0.403
LIG_FHA_2	510	516	PF00498	0.342
LIG_LIR_Apic_2	373	379	PF02991	0.444
LIG_LIR_Apic_2	515	520	PF02991	0.347
LIG_LIR_Gen_1	148	156	PF02991	0.503
LIG_LIR_Gen_1	30	37	PF02991	0.424
LIG_LIR_Gen_1	356	365	PF02991	0.368
LIG_LIR_LC3C_4	128	133	PF02991	0.314
LIG_LIR_Nem_3	148	154	PF02991	0.504
LIG_LIR_Nem_3	30	35	PF02991	0.423
LIG_LIR_Nem_3	356	361	PF02991	0.356
LIG_PDZ_Class_2	516	521	PF00595	0.372
LIG_Pex14_2	150	154	PF04695	0.359
LIG_PTAP_UEV_1	91	96	PF05743	0.524
LIG_RPA_C_Fungi	485	497	PF08784	0.371
LIG_SH2_CRK	376	380	PF00017	0.362
LIG_SH2_GRB2like	376	379	PF00017	0.341
LIG_SH2_NCK_1	376	380	PF00017	0.394
LIG_SH2_SRC	376	379	PF00017	0.560
LIG_SH2_STAP1	363	367	PF00017	0.443
LIG_SH2_STAT5	151	154	PF00017	0.508
LIG_SH2_STAT5	501	504	PF00017	0.376
LIG_SH3_1	376	382	PF00018	0.463
LIG_SH3_3	30	36	PF00018	0.427
LIG_SH3_3	364	370	PF00018	0.463
LIG_SH3_3	376	382	PF00018	0.429
LIG_SH3_3	411	417	PF00018	0.519
LIG_SH3_3	422	428	PF00018	0.388
LIG_SH3_3	89	95	PF00018	0.787
LIG_SUMO_SIM_anti_2	128	135	PF11976	0.381
LIG_SUMO_SIM_par_1	128	135	PF11976	0.311
LIG_SUMO_SIM_par_1	256	263	PF11976	0.475
LIG_SUMO_SIM_par_1	285	293	PF11976	0.375
LIG_TRAF2_1	336	339	PF00917	0.612
MOD_CDK_SPxK_1	410	416	PF00069	0.415
MOD_CDK_SPxK_1	442	448	PF00069	0.444
MOD_CK1_1	222	228	PF00069	0.382
MOD_CK1_1	254	260	PF00069	0.417
MOD_CK1_1	275	281	PF00069	0.497
MOD_CK1_1	316	322	PF00069	0.706
MOD_CK1_1	356	362	PF00069	0.462
MOD_CK1_1	477	483	PF00069	0.400
MOD_CK1_1	79	85	PF00069	0.807
MOD_CK1_1	87	93	PF00069	0.682
MOD_CK1_1	96	102	PF00069	0.638
MOD_CK2_1	257	263	PF00069	0.408
MOD_CK2_1	279	285	PF00069	0.472
MOD_CK2_1	332	338	PF00069	0.649
MOD_CK2_1	389	395	PF00069	0.527
MOD_CK2_1	427	433	PF00069	0.448
MOD_CK2_1	509	515	PF00069	0.488
MOD_CK2_1	70	76	PF00069	0.650
MOD_CK2_1	80	86	PF00069	0.591
MOD_GlcNHglycan	113	116	PF01048	0.706
MOD_GlcNHglycan	127	130	PF01048	0.350
MOD_GlcNHglycan	175	178	PF01048	0.360
MOD_GlcNHglycan	334	337	PF01048	0.643
MOD_GlcNHglycan	479	483	PF01048	0.414
MOD_GlcNHglycan	503	506	PF01048	0.368
MOD_GlcNHglycan	82	85	PF01048	0.677
MOD_GlcNHglycan	92	95	PF01048	0.746
MOD_GSK3_1	109	116	PF00069	0.609
MOD_GSK3_1	162	169	PF00069	0.368
MOD_GSK3_1	251	258	PF00069	0.402
MOD_GSK3_1	275	282	PF00069	0.460
MOD_GSK3_1	328	335	PF00069	0.634
MOD_GSK3_1	343	350	PF00069	0.333
MOD_GSK3_1	427	434	PF00069	0.420
MOD_GSK3_1	45	52	PF00069	0.689
MOD_GSK3_1	470	477	PF00069	0.422
MOD_GSK3_1	76	83	PF00069	0.712
MOD_GSK3_1	84	91	PF00069	0.601
MOD_GSK3_1	93	100	PF00069	0.613
MOD_N-GLC_1	418	423	PF02516	0.619
MOD_NEK2_1	131	136	PF00069	0.465
MOD_NEK2_1	173	178	PF00069	0.395
MOD_NEK2_1	183	188	PF00069	0.363
MOD_NEK2_1	279	284	PF00069	0.311
MOD_NEK2_1	418	423	PF00069	0.586
MOD_NEK2_2	27	32	PF00069	0.407
MOD_NEK2_2	370	375	PF00069	0.405
MOD_PIKK_1	230	236	PF00454	0.371
MOD_PK_1	162	168	PF00069	0.408
MOD_PK_1	251	257	PF00069	0.374
MOD_PK_1	70	76	PF00069	0.638
MOD_PKA_2	191	197	PF00069	0.586
MOD_PKA_2	316	322	PF00069	0.728
MOD_PKA_2	328	334	PF00069	0.663
MOD_PKA_2	356	362	PF00069	0.448
MOD_PKA_2	489	495	PF00069	0.395
MOD_PKA_2	509	515	PF00069	0.336
MOD_PKA_2	80	86	PF00069	0.774
MOD_PKB_1	249	257	PF00069	0.367
MOD_PKB_1	68	76	PF00069	0.692
MOD_Plk_1	222	228	PF00069	0.469
MOD_Plk_1	251	257	PF00069	0.352
MOD_Plk_1	363	369	PF00069	0.334
MOD_Plk_1	55	61	PF00069	0.753
MOD_Plk_4	27	33	PF00069	0.479
MOD_Plk_4	328	334	PF00069	0.566
MOD_Plk_4	363	369	PF00069	0.478
MOD_Plk_4	471	477	PF00069	0.365
MOD_Plk_4	61	67	PF00069	0.466
MOD_ProDKin_1	343	349	PF00069	0.366
MOD_ProDKin_1	410	416	PF00069	0.572
MOD_ProDKin_1	442	448	PF00069	0.396
MOD_ProDKin_1	88	94	PF00069	0.681
TRG_DiLeu_BaEn_1	223	228	PF01217	0.390
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.430
TRG_ENDOCYTIC_2	151	154	PF00928	0.508
TRG_ER_diArg_1	248	251	PF00400	0.329
TRG_NLS_Bipartite_1	53	71	PF00514	0.796
TRG_NLS_MonoExtC_3	197	202	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P1	Leptomonas seymouri	64%	100%
A0A0S4JK75	Bodo saltans	33%	100%
A0A1X0NFD4	Trypanosomatidae	38%	100%
A0A3Q8ICP9	Leishmania donovani	90%	100%
A0A3R7KS12	Trypanosoma rangeli	47%	100%
A4HJM1	Leishmania braziliensis	79%	100%
A4I743	Leishmania infantum	90%	100%
C9ZME4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
C9ZWN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	92%
E9B237	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B2M4	Trypanosoma cruzi	45%	100%