Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q623_LEIMA

TriTrypDb:

LmjF.31.2380 , LMJLV39_310033300 , LMJSD75_310033300

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q623

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q623

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.673
CLV_C14_Caspase3-7	199	203	PF00656	0.554
CLV_C14_Caspase3-7	776	780	PF00656	0.642
CLV_NRD_NRD_1	167	169	PF00675	0.628
CLV_NRD_NRD_1	197	199	PF00675	0.647
CLV_NRD_NRD_1	319	321	PF00675	0.634
CLV_NRD_NRD_1	401	403	PF00675	0.700
CLV_NRD_NRD_1	473	475	PF00675	0.726
CLV_NRD_NRD_1	477	479	PF00675	0.686
CLV_NRD_NRD_1	481	483	PF00675	0.628
CLV_NRD_NRD_1	592	594	PF00675	0.687
CLV_NRD_NRD_1	617	619	PF00675	0.667
CLV_NRD_NRD_1	787	789	PF00675	0.699
CLV_PCSK_FUR_1	788	792	PF00082	0.694
CLV_PCSK_KEX2_1	197	199	PF00082	0.647
CLV_PCSK_KEX2_1	321	323	PF00082	0.641
CLV_PCSK_KEX2_1	378	380	PF00082	0.661
CLV_PCSK_KEX2_1	401	403	PF00082	0.697
CLV_PCSK_KEX2_1	477	479	PF00082	0.723
CLV_PCSK_KEX2_1	591	593	PF00082	0.692
CLV_PCSK_KEX2_1	617	619	PF00082	0.667
CLV_PCSK_KEX2_1	790	792	PF00082	0.688
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.641
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.661
CLV_PCSK_PC1ET2_1	790	792	PF00082	0.688
CLV_PCSK_PC7_1	587	593	PF00082	0.623
CLV_PCSK_SKI1_1	180	184	PF00082	0.560
CLV_PCSK_SKI1_1	449	453	PF00082	0.565
CLV_PCSK_SKI1_1	546	550	PF00082	0.581
CLV_PCSK_SKI1_1	587	591	PF00082	0.666
CLV_PCSK_SKI1_1	677	681	PF00082	0.670
CLV_PCSK_SKI1_1	775	779	PF00082	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SPOP_SBC_1	383	387	PF00917	0.635
DEG_SPOP_SBC_1	503	507	PF00917	0.665
DEG_SPOP_SBC_1	567	571	PF00917	0.600
DOC_CYCLIN_yCln2_LP_2	635	641	PF00134	0.551
DOC_PP2B_LxvP_1	204	207	PF13499	0.631
DOC_PP2B_LxvP_1	732	735	PF13499	0.634
DOC_PP4_FxxP_1	140	143	PF00568	0.609
DOC_PP4_FxxP_1	316	319	PF00568	0.555
DOC_USP7_MATH_1	106	110	PF00917	0.505
DOC_USP7_MATH_1	207	211	PF00917	0.631
DOC_USP7_MATH_1	21	25	PF00917	0.658
DOC_USP7_MATH_1	27	31	PF00917	0.639
DOC_USP7_MATH_1	286	290	PF00917	0.601
DOC_USP7_MATH_1	363	367	PF00917	0.647
DOC_USP7_MATH_1	369	373	PF00917	0.630
DOC_USP7_MATH_1	417	421	PF00917	0.706
DOC_USP7_MATH_1	511	515	PF00917	0.709
DOC_USP7_MATH_1	61	65	PF00917	0.605
DOC_USP7_MATH_1	622	626	PF00917	0.646
DOC_USP7_MATH_1	735	739	PF00917	0.645
DOC_USP7_MATH_1	78	82	PF00917	0.546
DOC_USP7_MATH_1	812	816	PF00917	0.671
DOC_USP7_UBL2_3	475	479	PF12436	0.722
DOC_WW_Pin1_4	172	177	PF00397	0.628
DOC_WW_Pin1_4	23	28	PF00397	0.610
DOC_WW_Pin1_4	315	320	PF00397	0.634
DOC_WW_Pin1_4	335	340	PF00397	0.505
DOC_WW_Pin1_4	351	356	PF00397	0.723
DOC_WW_Pin1_4	427	432	PF00397	0.600
DOC_WW_Pin1_4	507	512	PF00397	0.639
DOC_WW_Pin1_4	548	553	PF00397	0.613
DOC_WW_Pin1_4	574	579	PF00397	0.691
DOC_WW_Pin1_4	612	617	PF00397	0.702
DOC_WW_Pin1_4	657	662	PF00397	0.652
DOC_WW_Pin1_4	671	676	PF00397	0.538
DOC_WW_Pin1_4	717	722	PF00397	0.569
LIG_14-3-3_CanoR_1	116	120	PF00244	0.606
LIG_14-3-3_CanoR_1	150	155	PF00244	0.618
LIG_14-3-3_CanoR_1	197	201	PF00244	0.678
LIG_14-3-3_CanoR_1	238	248	PF00244	0.596
LIG_14-3-3_CanoR_1	255	262	PF00244	0.584
LIG_14-3-3_CanoR_1	271	280	PF00244	0.520
LIG_14-3-3_CanoR_1	394	400	PF00244	0.701
LIG_14-3-3_CanoR_1	401	411	PF00244	0.651
LIG_14-3-3_CanoR_1	415	420	PF00244	0.606
LIG_14-3-3_CanoR_1	522	530	PF00244	0.614
LIG_14-3-3_CanoR_1	565	574	PF00244	0.671
LIG_14-3-3_CanoR_1	624	630	PF00244	0.647
LIG_14-3-3_CanoR_1	765	770	PF00244	0.673
LIG_14-3-3_CanoR_1	775	784	PF00244	0.598
LIG_14-3-3_CanoR_1	87	96	PF00244	0.827
LIG_BRCT_BRCA1_1	392	396	PF00533	0.593
LIG_BRCT_BRCA1_1	62	66	PF00533	0.567
LIG_BRCT_BRCA1_1	667	671	PF00533	0.671
LIG_CSL_BTD_1	658	661	PF09270	0.680
LIG_EH_1	758	762	PF12763	0.597
LIG_FHA_1	12	18	PF00498	0.787
LIG_FHA_1	279	285	PF00498	0.638
LIG_FHA_1	292	298	PF00498	0.615
LIG_FHA_1	327	333	PF00498	0.587
LIG_FHA_1	359	365	PF00498	0.631
LIG_FHA_1	450	456	PF00498	0.568
LIG_FHA_1	571	577	PF00498	0.634
LIG_FHA_1	630	636	PF00498	0.588
LIG_FHA_2	290	296	PF00498	0.655
LIG_FHA_2	322	328	PF00498	0.660
LIG_FHA_2	34	40	PF00498	0.774
LIG_FHA_2	384	390	PF00498	0.646
LIG_FHA_2	535	541	PF00498	0.653
LIG_Integrin_RGD_1	230	232	PF01839	0.583
LIG_LIR_Apic_2	118	123	PF02991	0.599
LIG_LIR_Apic_2	314	319	PF02991	0.536
LIG_LIR_Gen_1	113	122	PF02991	0.552
LIG_LIR_Gen_1	393	404	PF02991	0.601
LIG_LIR_Gen_1	676	682	PF02991	0.647
LIG_LIR_Nem_3	113	117	PF02991	0.553
LIG_LIR_Nem_3	354	359	PF02991	0.618
LIG_LIR_Nem_3	393	399	PF02991	0.597
LIG_LIR_Nem_3	676	681	PF02991	0.647
LIG_NRP_CendR_1	813	816	PF00754	0.587
LIG_Pex14_2	344	348	PF04695	0.553
LIG_Pex14_2	62	66	PF04695	0.704
LIG_SH2_CRK	114	118	PF00017	0.627
LIG_SH2_CRK	120	124	PF00017	0.607
LIG_SH2_NCK_1	114	118	PF00017	0.581
LIG_SH2_SRC	103	106	PF00017	0.600
LIG_SH2_SRC	594	597	PF00017	0.633
LIG_SH2_STAT3	7	10	PF00017	0.519
LIG_SH2_STAT5	224	227	PF00017	0.808
LIG_SH2_STAT5	35	38	PF00017	0.707
LIG_SH2_STAT5	594	597	PF00017	0.677
LIG_SH2_STAT5	7	10	PF00017	0.519
LIG_SH3_2	613	618	PF14604	0.660
LIG_SH3_3	39	45	PF00018	0.535
LIG_SH3_3	428	434	PF00018	0.662
LIG_SH3_3	550	556	PF00018	0.650
LIG_SH3_3	610	616	PF00018	0.694
LIG_SH3_3	635	641	PF00018	0.651
LIG_SH3_3	647	653	PF00018	0.571
LIG_SH3_3	72	78	PF00018	0.533
LIG_SH3_4	475	482	PF00018	0.713
LIG_SUMO_SIM_par_1	360	366	PF11976	0.566
LIG_WW_1	578	581	PF00397	0.642
MOD_CDC14_SPxK_1	318	321	PF00782	0.625
MOD_CDC14_SPxK_1	615	618	PF00782	0.665
MOD_CDK_SPK_2	315	320	PF00069	0.632
MOD_CDK_SPK_2	427	432	PF00069	0.576
MOD_CDK_SPK_2	612	617	PF00069	0.658
MOD_CDK_SPK_2	717	722	PF00069	0.569
MOD_CDK_SPxK_1	315	321	PF00069	0.615
MOD_CDK_SPxK_1	612	618	PF00069	0.660
MOD_CDK_SPxK_1	671	677	PF00069	0.666
MOD_CDK_SPxxK_3	315	322	PF00069	0.642
MOD_CK1_1	115	121	PF00069	0.605
MOD_CK1_1	153	159	PF00069	0.664
MOD_CK1_1	178	184	PF00069	0.714
MOD_CK1_1	185	191	PF00069	0.631
MOD_CK1_1	193	199	PF00069	0.555
MOD_CK1_1	209	215	PF00069	0.525
MOD_CK1_1	218	224	PF00069	0.575
MOD_CK1_1	270	276	PF00069	0.600
MOD_CK1_1	289	295	PF00069	0.522
MOD_CK1_1	306	312	PF00069	0.583
MOD_CK1_1	333	339	PF00069	0.684
MOD_CK1_1	418	424	PF00069	0.700
MOD_CK1_1	442	448	PF00069	0.623
MOD_CK1_1	454	460	PF00069	0.644
MOD_CK1_1	487	493	PF00069	0.701
MOD_CK1_1	504	510	PF00069	0.556
MOD_CK1_1	514	520	PF00069	0.630
MOD_CK1_1	569	575	PF00069	0.700
MOD_CK1_1	577	583	PF00069	0.605
MOD_CK1_1	60	66	PF00069	0.586
MOD_CK1_1	623	629	PF00069	0.717
MOD_CK1_1	667	673	PF00069	0.665
MOD_CK1_1	720	726	PF00069	0.707
MOD_CK1_1	746	752	PF00069	0.679
MOD_CK1_1	770	776	PF00069	0.668
MOD_CK1_1	88	94	PF00069	0.679
MOD_CK1_1	9	15	PF00069	0.653
MOD_CK2_1	289	295	PF00069	0.655
MOD_CK2_1	383	389	PF00069	0.644
MOD_CK2_1	492	498	PF00069	0.569
MOD_CK2_1	536	542	PF00069	0.589
MOD_CK2_1	577	583	PF00069	0.684
MOD_CK2_1	712	718	PF00069	0.667
MOD_CK2_1	725	731	PF00069	0.617
MOD_CK2_1	750	756	PF00069	0.670
MOD_CK2_1	78	84	PF00069	0.686
MOD_DYRK1A_RPxSP_1	657	661	PF00069	0.554
MOD_GlcNHglycan	146	149	PF01048	0.666
MOD_GlcNHglycan	156	159	PF01048	0.638
MOD_GlcNHglycan	177	180	PF01048	0.765
MOD_GlcNHglycan	2	5	PF01048	0.611
MOD_GlcNHglycan	220	223	PF01048	0.623
MOD_GlcNHglycan	241	244	PF01048	0.628
MOD_GlcNHglycan	249	252	PF01048	0.632
MOD_GlcNHglycan	267	270	PF01048	0.522
MOD_GlcNHglycan	288	291	PF01048	0.636
MOD_GlcNHglycan	305	308	PF01048	0.690
MOD_GlcNHglycan	332	335	PF01048	0.761
MOD_GlcNHglycan	373	376	PF01048	0.663
MOD_GlcNHglycan	415	418	PF01048	0.652
MOD_GlcNHglycan	420	423	PF01048	0.623
MOD_GlcNHglycan	441	444	PF01048	0.621
MOD_GlcNHglycan	470	473	PF01048	0.706
MOD_GlcNHglycan	50	53	PF01048	0.655
MOD_GlcNHglycan	540	545	PF01048	0.649
MOD_GlcNHglycan	59	62	PF01048	0.666
MOD_GlcNHglycan	625	628	PF01048	0.664
MOD_GlcNHglycan	63	66	PF01048	0.671
MOD_GlcNHglycan	661	664	PF01048	0.682
MOD_GlcNHglycan	667	670	PF01048	0.613
MOD_GlcNHglycan	682	685	PF01048	0.615
MOD_GlcNHglycan	727	730	PF01048	0.711
MOD_GlcNHglycan	765	768	PF01048	0.642
MOD_GlcNHglycan	772	775	PF01048	0.630
MOD_GlcNHglycan	779	782	PF01048	0.580
MOD_GlcNHglycan	87	90	PF01048	0.640
MOD_GSK3_1	144	151	PF00069	0.727
MOD_GSK3_1	178	185	PF00069	0.670
MOD_GSK3_1	196	203	PF00069	0.521
MOD_GSK3_1	207	214	PF00069	0.569
MOD_GSK3_1	23	30	PF00069	0.542
MOD_GSK3_1	261	268	PF00069	0.675
MOD_GSK3_1	289	296	PF00069	0.682
MOD_GSK3_1	303	310	PF00069	0.525
MOD_GSK3_1	326	333	PF00069	0.660
MOD_GSK3_1	390	397	PF00069	0.656
MOD_GSK3_1	413	420	PF00069	0.695
MOD_GSK3_1	421	428	PF00069	0.645
MOD_GSK3_1	439	446	PF00069	0.569
MOD_GSK3_1	454	461	PF00069	0.613
MOD_GSK3_1	484	491	PF00069	0.702
MOD_GSK3_1	499	506	PF00069	0.572
MOD_GSK3_1	507	514	PF00069	0.652
MOD_GSK3_1	536	543	PF00069	0.632
MOD_GSK3_1	544	551	PF00069	0.611
MOD_GSK3_1	566	573	PF00069	0.694
MOD_GSK3_1	57	64	PF00069	0.627
MOD_GSK3_1	6	13	PF00069	0.753
MOD_GSK3_1	625	632	PF00069	0.653
MOD_GSK3_1	648	655	PF00069	0.680
MOD_GSK3_1	657	664	PF00069	0.602
MOD_GSK3_1	665	672	PF00069	0.515
MOD_GSK3_1	709	716	PF00069	0.640
MOD_GSK3_1	746	753	PF00069	0.677
MOD_GSK3_1	763	770	PF00069	0.513
MOD_GSK3_1	773	780	PF00069	0.590
MOD_GSK3_1	85	92	PF00069	0.681
MOD_N-GLC_1	484	489	PF02516	0.692
MOD_N-GLC_1	567	572	PF02516	0.637
MOD_N-GLC_1	602	607	PF02516	0.532
MOD_NEK2_1	154	159	PF00069	0.651
MOD_NEK2_1	200	205	PF00069	0.672
MOD_NEK2_1	211	216	PF00069	0.603
MOD_NEK2_1	22	27	PF00069	0.497
MOD_NEK2_1	225	230	PF00069	0.534
MOD_NEK2_1	256	261	PF00069	0.761
MOD_NEK2_1	278	283	PF00069	0.687
MOD_NEK2_1	303	308	PF00069	0.655
MOD_NEK2_1	451	456	PF00069	0.576
MOD_NEK2_1	48	53	PF00069	0.623
MOD_NEK2_1	57	62	PF00069	0.564
MOD_NEK2_1	700	705	PF00069	0.655
MOD_NEK2_1	743	748	PF00069	0.659
MOD_NEK2_1	8	13	PF00069	0.614
MOD_NEK2_2	767	772	PF00069	0.628
MOD_NEK2_2	78	83	PF00069	0.552
MOD_PIKK_1	261	267	PF00454	0.551
MOD_PIKK_1	278	284	PF00454	0.496
MOD_PIKK_1	308	314	PF00454	0.611
MOD_PIKK_1	6	12	PF00454	0.587
MOD_PIKK_1	629	635	PF00454	0.663
MOD_PIKK_1	687	693	PF00454	0.625
MOD_PK_1	415	421	PF00069	0.577
MOD_PK_1	432	438	PF00069	0.530
MOD_PK_1	488	494	PF00069	0.704
MOD_PKA_1	321	327	PF00069	0.639
MOD_PKA_1	449	455	PF00069	0.574
MOD_PKA_2	115	121	PF00069	0.605
MOD_PKA_2	196	202	PF00069	0.647
MOD_PKA_2	215	221	PF00069	0.523
MOD_PKA_2	254	260	PF00069	0.629
MOD_PKA_2	270	276	PF00069	0.523
MOD_PKA_2	321	327	PF00069	0.661
MOD_PKA_2	487	493	PF00069	0.701
MOD_PKA_2	514	520	PF00069	0.657
MOD_PKA_2	623	629	PF00069	0.651
MOD_PKB_1	392	400	PF00069	0.616
MOD_Plk_1	112	118	PF00069	0.521
MOD_Plk_1	185	191	PF00069	0.624
MOD_Plk_1	225	231	PF00069	0.758
MOD_Plk_1	750	756	PF00069	0.627
MOD_Plk_4	115	121	PF00069	0.647
MOD_Plk_4	27	33	PF00069	0.613
MOD_Plk_4	432	438	PF00069	0.664
MOD_ProDKin_1	172	178	PF00069	0.629
MOD_ProDKin_1	23	29	PF00069	0.611
MOD_ProDKin_1	315	321	PF00069	0.639
MOD_ProDKin_1	335	341	PF00069	0.506
MOD_ProDKin_1	351	357	PF00069	0.724
MOD_ProDKin_1	427	433	PF00069	0.601
MOD_ProDKin_1	507	513	PF00069	0.641
MOD_ProDKin_1	548	554	PF00069	0.612
MOD_ProDKin_1	574	580	PF00069	0.689
MOD_ProDKin_1	612	618	PF00069	0.704
MOD_ProDKin_1	657	663	PF00069	0.651
MOD_ProDKin_1	671	677	PF00069	0.536
MOD_ProDKin_1	717	723	PF00069	0.569
MOD_SUMO_rev_2	442	451	PF00179	0.684
TRG_ENDOCYTIC_2	114	117	PF00928	0.606
TRG_ER_diArg_1	319	322	PF00400	0.639
TRG_ER_diArg_1	401	403	PF00400	0.701
TRG_ER_diArg_1	476	478	PF00400	0.723
TRG_ER_diArg_1	590	593	PF00400	0.689
TRG_ER_diArg_1	616	618	PF00400	0.664
TRG_NLS_MonoCore_2	473	478	PF00514	0.724
TRG_NLS_MonoCore_2	787	792	PF00514	0.694
TRG_NLS_MonoExtC_3	473	478	PF00514	0.724
TRG_NLS_MonoExtC_3	788	794	PF00514	0.690
TRG_NLS_MonoExtN_4	319	324	PF00514	0.636
TRG_NLS_MonoExtN_4	788	793	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	775	779	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGI6	Leishmania donovani	85%	100%
A4HJM2	Leishmania braziliensis	58%	98%
A4I744	Leishmania infantum	84%	100%
E9B238	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%