Zinc transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc transporter, putative

Species:

Leishmania major

UniProt:

Q4Q622_LEIMA

TriTrypDb:

LmjF.31.2390 , LMJLV39_310033400 , LMJSD75_310033400

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q622

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q622

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	2
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006829	zinc ion transport	8	2
GO:0009987	cellular process	1	2
GO:0030001	metal ion transport	6	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071577	zinc ion transmembrane transport	6	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098662	inorganic cation transmembrane transport	5	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005385	zinc ion transmembrane transporter activity	7	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0046915	transition metal ion transmembrane transporter activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.305
CLV_PCSK_KEX2_1	51	53	PF00082	0.303
CLV_PCSK_SKI1_1	345	349	PF00082	0.313
CLV_PCSK_SKI1_1	56	60	PF00082	0.255
DOC_ANK_TNKS_1	122	129	PF00023	0.432
DOC_CYCLIN_RxL_1	342	350	PF00134	0.300
DOC_MAPK_MEF2A_6	180	187	PF00069	0.374
DOC_USP7_MATH_1	162	166	PF00917	0.275
DOC_USP7_MATH_1	176	180	PF00917	0.273
DOC_USP7_MATH_1	330	334	PF00917	0.300
DOC_USP7_MATH_1	402	406	PF00917	0.560
DOC_WW_Pin1_4	356	361	PF00397	0.539
DOC_WW_Pin1_4	442	447	PF00397	0.657
LIG_14-3-3_CanoR_1	116	120	PF00244	0.476
LIG_AP2alpha_2	329	331	PF02296	0.379
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_BRCT_BRCA1_1	332	336	PF00533	0.256
LIG_FHA_1	139	145	PF00498	0.334
LIG_FHA_1	28	34	PF00498	0.680
LIG_FHA_1	342	348	PF00498	0.256
LIG_FHA_1	424	430	PF00498	0.484
LIG_FHA_1	7	13	PF00498	0.733
LIG_FHA_1	85	91	PF00498	0.346
LIG_FHA_2	32	38	PF00498	0.620
LIG_FHA_2	445	451	PF00498	0.623
LIG_LIR_Gen_1	135	145	PF02991	0.274
LIG_LIR_Gen_1	329	339	PF02991	0.317
LIG_LIR_Gen_1	390	401	PF02991	0.486
LIG_LIR_Nem_3	135	140	PF02991	0.271
LIG_LIR_Nem_3	141	145	PF02991	0.274
LIG_LIR_Nem_3	146	152	PF02991	0.232
LIG_LIR_Nem_3	230	234	PF02991	0.495
LIG_LIR_Nem_3	329	334	PF02991	0.331
LIG_LIR_Nem_3	362	368	PF02991	0.563
LIG_LIR_Nem_3	390	396	PF02991	0.495
LIG_NRBOX	347	353	PF00104	0.311
LIG_Pex14_2	302	306	PF04695	0.356
LIG_Pex14_2	65	69	PF04695	0.300
LIG_PTB_Apo_2	308	315	PF02174	0.273
LIG_PTB_Phospho_1	308	314	PF10480	0.273
LIG_RPA_C_Fungi	46	58	PF08784	0.434
LIG_SH2_PTP2	393	396	PF00017	0.426
LIG_SH2_SRC	320	323	PF00017	0.379
LIG_SH2_STAP1	152	156	PF00017	0.332
LIG_SH2_STAP1	320	324	PF00017	0.308
LIG_SH2_STAP1	99	103	PF00017	0.281
LIG_SH2_STAT5	201	204	PF00017	0.329
LIG_SH2_STAT5	308	311	PF00017	0.329
LIG_SH2_STAT5	393	396	PF00017	0.426
LIG_SUMO_SIM_anti_2	178	185	PF11976	0.334
LIG_SUMO_SIM_anti_2	350	359	PF11976	0.356
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.256
LIG_SUMO_SIM_par_1	129	135	PF11976	0.274
LIG_SUMO_SIM_par_1	376	383	PF11976	0.433
LIG_TYR_ITIM	363	368	PF00017	0.346
LIG_UBA3_1	338	345	PF00899	0.368
MOD_CK1_1	132	138	PF00069	0.258
MOD_CK2_1	215	221	PF00069	0.372
MOD_CK2_1	31	37	PF00069	0.549
MOD_GlcNHglycan	164	167	PF01048	0.419
MOD_GlcNHglycan	389	392	PF01048	0.436
MOD_GlcNHglycan	403	407	PF01048	0.383
MOD_GlcNHglycan	440	443	PF01048	0.584
MOD_GlcNHglycan	45	48	PF01048	0.504
MOD_GlcNHglycan	75	78	PF01048	0.401
MOD_GSK3_1	19	26	PF00069	0.604
MOD_GSK3_1	202	209	PF00069	0.300
MOD_GSK3_1	211	218	PF00069	0.306
MOD_GSK3_1	27	34	PF00069	0.536
MOD_GSK3_1	337	344	PF00069	0.294
MOD_GSK3_1	355	362	PF00069	0.226
MOD_GSK3_1	438	445	PF00069	0.558
MOD_GSK3_1	6	13	PF00069	0.747
MOD_GSK3_1	91	98	PF00069	0.365
MOD_N-GLC_1	341	346	PF02516	0.262
MOD_NEK2_1	202	207	PF00069	0.301
MOD_NEK2_1	211	216	PF00069	0.294
MOD_NEK2_1	341	346	PF00069	0.319
MOD_NEK2_1	355	360	PF00069	0.337
MOD_NEK2_2	27	32	PF00069	0.522
MOD_NEK2_2	320	325	PF00069	0.295
MOD_NEK2_2	377	382	PF00069	0.358
MOD_PKA_1	51	57	PF00069	0.425
MOD_PKA_2	115	121	PF00069	0.332
MOD_PKA_2	51	57	PF00069	0.421
MOD_PKA_2	6	12	PF00069	0.772
MOD_Plk_1	320	326	PF00069	0.305
MOD_Plk_1	37	43	PF00069	0.480
MOD_Plk_2-3	37	43	PF00069	0.480
MOD_Plk_4	126	132	PF00069	0.301
MOD_Plk_4	138	144	PF00069	0.283
MOD_Plk_4	195	201	PF00069	0.367
MOD_Plk_4	320	326	PF00069	0.260
MOD_Plk_4	330	336	PF00069	0.314
MOD_Plk_4	350	356	PF00069	0.374
MOD_ProDKin_1	356	362	PF00069	0.430
MOD_ProDKin_1	442	448	PF00069	0.588
MOD_SUMO_rev_2	53	59	PF00179	0.378
TRG_DiLeu_BaEn_1	55	60	PF01217	0.390
TRG_ENDOCYTIC_2	231	234	PF00928	0.246
TRG_ENDOCYTIC_2	365	368	PF00928	0.326
TRG_ENDOCYTIC_2	393	396	PF00928	0.338
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K4	Leptomonas seymouri	34%	99%
A0A3Q8IDA3	Leishmania donovani	23%	100%
A0A3Q8IGB8	Leishmania donovani	93%	100%
A4HFQ2	Leishmania braziliensis	24%	69%
A4HJM3	Leishmania braziliensis	81%	100%
A4I2S7	Leishmania infantum	23%	100%
A4I745	Leishmania infantum	94%	100%
A4IFD7	Bos taurus	26%	100%
C9ZME5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
C9ZWN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9B239	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O13918	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O14863	Homo sapiens	27%	100%
O35149	Mus musculus	28%	100%
O55174	Rattus norvegicus	28%	100%
P0CE46	Rattus norvegicus	29%	100%
P20107	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P32798	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P97441	Mus musculus	29%	100%
Q08E25	Bos taurus	29%	100%
Q2HJ10	Mus musculus	29%	100%
Q3UVU3	Mus musculus	25%	97%
Q4R6K2	Macaca fascicularis	24%	90%
Q54QU8	Dictyostelium discoideum	32%	84%
Q5BJM8	Rattus norvegicus	25%	100%
Q5I020	Xenopus laevis	29%	100%
Q5MNV6	Gallus gallus	27%	100%
Q5R617	Pongo abelii	29%	100%
Q5XHB4	Xenopus tropicalis	29%	100%
Q60738	Mus musculus	25%	91%
Q62720	Rattus norvegicus	24%	90%
Q688R1	Oryza sativa subsp. japonica	31%	100%
Q6QIX3	Rattus norvegicus	29%	100%
Q6XR72	Homo sapiens	24%	94%
Q8BGG0	Mus musculus	27%	100%
Q8H329	Oryza sativa subsp. japonica	26%	100%
Q8IWU4	Homo sapiens	27%	100%
Q8NEW0	Homo sapiens	26%	100%
Q99726	Homo sapiens	29%	100%
Q9JKN1	Mus musculus	25%	100%
Q9LXS1	Arabidopsis thaliana	30%	100%
Q9TTF3	Bos taurus	27%	100%
Q9Y6M5	Homo sapiens	24%	90%
Q9ZT63	Arabidopsis thaliana	31%	100%
V5AMB7	Trypanosoma cruzi	53%	97%
V5BV32	Trypanosoma cruzi	36%	100%