DUF447 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q619_LEIMA

TriTrypDb:

LmjF.31.2420 , LMJLV39_310033700 , LMJSD75_310033700

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q619

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q619

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.442
CLV_NRD_NRD_1	140	142	PF00675	0.417
CLV_NRD_NRD_1	198	200	PF00675	0.491
CLV_NRD_NRD_1	24	26	PF00675	0.475
CLV_PCSK_KEX2_1	140	142	PF00082	0.352
CLV_PCSK_KEX2_1	198	200	PF00082	0.566
CLV_PCSK_KEX2_1	24	26	PF00082	0.475
CLV_PCSK_SKI1_1	224	228	PF00082	0.355
CLV_PCSK_SKI1_1	25	29	PF00082	0.474
CLV_PCSK_SKI1_1	86	90	PF00082	0.382
DOC_USP7_MATH_1	124	128	PF00917	0.513
DOC_USP7_MATH_1	183	187	PF00917	0.719
DOC_USP7_MATH_1	209	213	PF00917	0.533
DOC_WW_Pin1_4	243	248	PF00397	0.407
DOC_WW_Pin1_4	55	60	PF00397	0.637
DOC_WW_Pin1_4	7	12	PF00397	0.506
LIG_14-3-3_CanoR_1	12	18	PF00244	0.470
LIG_14-3-3_CanoR_1	140	144	PF00244	0.464
LIG_14-3-3_CanoR_1	182	190	PF00244	0.630
LIG_14-3-3_CanoR_1	224	229	PF00244	0.422
LIG_14-3-3_CanoR_1	24	28	PF00244	0.476
LIG_BRCT_BRCA1_1	152	156	PF00533	0.438
LIG_CaMK_CASK_1	219	224	PF00069	0.402
LIG_deltaCOP1_diTrp_1	120	125	PF00928	0.472
LIG_FHA_1	140	146	PF00498	0.362
LIG_FHA_1	83	89	PF00498	0.407
LIG_FHA_2	225	231	PF00498	0.447
LIG_FHA_2	42	48	PF00498	0.612
LIG_LIR_Gen_1	211	220	PF02991	0.423
LIG_LIR_Nem_3	120	125	PF02991	0.543
LIG_LIR_Nem_3	16	21	PF02991	0.468
LIG_LIR_Nem_3	211	216	PF02991	0.447
LIG_LIR_Nem_3	52	57	PF02991	0.605
LIG_MYND_1	38	42	PF01753	0.613
LIG_NBox_RRM_1	238	248	PF00076	0.441
LIG_Pex14_2	156	160	PF04695	0.613
LIG_Pex14_2	17	21	PF04695	0.472
LIG_Pex14_2	78	82	PF04695	0.392
LIG_PTAP_UEV_1	58	63	PF05743	0.473
LIG_REV1ctd_RIR_1	154	163	PF16727	0.525
LIG_SH2_CRK	252	256	PF00017	0.484
LIG_SH2_CRK	4	8	PF00017	0.495
LIG_SH2_STAT5	133	136	PF00017	0.420
LIG_SH2_STAT5	144	147	PF00017	0.322
LIG_SH2_STAT5	98	101	PF00017	0.412
LIG_SH3_3	203	209	PF00018	0.500
LIG_SH3_3	32	38	PF00018	0.499
LIG_SH3_3	56	62	PF00018	0.605
LIG_SUMO_SIM_par_1	85	92	PF11976	0.393
MOD_CDK_SPK_2	7	12	PF00069	0.478
MOD_CDK_SPxxK_3	243	250	PF00069	0.406
MOD_CK1_1	155	161	PF00069	0.555
MOD_CK2_1	183	189	PF00069	0.536
MOD_CK2_1	41	47	PF00069	0.615
MOD_Cter_Amidation	196	199	PF01082	0.510
MOD_GlcNHglycan	183	186	PF01048	0.735
MOD_GlcNHglycan	59	62	PF01048	0.473
MOD_GSK3_1	161	168	PF00069	0.604
MOD_GSK3_1	181	188	PF00069	0.753
MOD_GSK3_1	198	205	PF00069	0.617
MOD_GSK3_1	78	85	PF00069	0.479
MOD_LATS_1	84	90	PF00433	0.434
MOD_NEK2_1	78	83	PF00069	0.627
MOD_NEK2_1	97	102	PF00069	0.334
MOD_NEK2_2	139	144	PF00069	0.329
MOD_PK_1	115	121	PF00069	0.414
MOD_PKA_1	198	204	PF00069	0.458
MOD_PKA_2	139	145	PF00069	0.386
MOD_PKA_2	161	167	PF00069	0.572
MOD_PKA_2	181	187	PF00069	0.536
MOD_PKA_2	198	204	PF00069	0.528
MOD_PKA_2	23	29	PF00069	0.476
MOD_Plk_1	202	208	PF00069	0.536
MOD_Plk_1	78	84	PF00069	0.478
MOD_Plk_4	13	19	PF00069	0.467
MOD_Plk_4	152	158	PF00069	0.554
MOD_Plk_4	202	208	PF00069	0.507
MOD_Plk_4	209	215	PF00069	0.425
MOD_Plk_4	36	42	PF00069	0.509
MOD_ProDKin_1	243	249	PF00069	0.402
MOD_ProDKin_1	55	61	PF00069	0.630
MOD_ProDKin_1	7	13	PF00069	0.505
MOD_SUMO_for_1	151	154	PF00179	0.368
TRG_ENDOCYTIC_2	213	216	PF00928	0.555
TRG_ENDOCYTIC_2	252	255	PF00928	0.574
TRG_ENDOCYTIC_2	4	7	PF00928	0.499
TRG_NES_CRM1_1	219	230	PF08389	0.317
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W0	Leptomonas seymouri	32%	100%
A0A0N1ILD5	Leptomonas seymouri	38%	93%
A0A3S7X4T4	Leishmania donovani	87%	100%
A4HJM6	Leishmania braziliensis	48%	100%
A4I748	Leishmania infantum	87%	100%
E9B242	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q618	Leishmania major	27%	76%