LeishMANIAdb
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DDE-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DDE-1 domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
Q4Q618_LEIMA
TriTrypDb:
LmjF.31.2430 * , LMJLV39_310033800 * , LMJSD75_310033800 *
Length:
345

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q618
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q618

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 338 342 PF00656 0.460
CLV_NRD_NRD_1 136 138 PF00675 0.464
CLV_NRD_NRD_1 164 166 PF00675 0.495
CLV_NRD_NRD_1 310 312 PF00675 0.508
CLV_PCSK_KEX2_1 261 263 PF00082 0.623
CLV_PCSK_KEX2_1 310 312 PF00082 0.508
CLV_PCSK_KEX2_1 326 328 PF00082 0.309
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.551
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.376
CLV_PCSK_SKI1_1 150 154 PF00082 0.595
CLV_PCSK_SKI1_1 203 207 PF00082 0.437
CLV_PCSK_SKI1_1 256 260 PF00082 0.600
CLV_PCSK_SKI1_1 311 315 PF00082 0.477
CLV_PCSK_SKI1_1 337 341 PF00082 0.525
CLV_PCSK_SKI1_1 60 64 PF00082 0.487
DEG_APCC_DBOX_1 277 285 PF00400 0.357
DEG_APCC_DBOX_1 7 15 PF00400 0.480
DOC_MAPK_gen_1 201 208 PF00069 0.446
DOC_MAPK_MEF2A_6 201 208 PF00069 0.446
DOC_MAPK_NFAT4_5 201 209 PF00069 0.447
DOC_PP2B_LxvP_1 14 17 PF13499 0.473
DOC_PP2B_LxvP_1 63 66 PF13499 0.472
DOC_PP2B_PxIxI_1 131 137 PF00149 0.488
DOC_USP7_MATH_1 192 196 PF00917 0.411
DOC_USP7_MATH_1 247 251 PF00917 0.661
DOC_USP7_MATH_1 270 274 PF00917 0.721
DOC_WW_Pin1_4 12 17 PF00397 0.474
DOC_WW_Pin1_4 186 191 PF00397 0.454
DOC_WW_Pin1_4 94 99 PF00397 0.495
LIG_14-3-3_CanoR_1 144 154 PF00244 0.504
LIG_14-3-3_CanoR_1 278 284 PF00244 0.424
LIG_BIR_III_2 128 132 PF00653 0.482
LIG_DCNL_PONY_1 1 4 PF03556 0.468
LIG_FHA_1 147 153 PF00498 0.610
LIG_FHA_1 158 164 PF00498 0.428
LIG_FHA_1 280 286 PF00498 0.461
LIG_FHA_1 30 36 PF00498 0.426
LIG_FHA_2 207 213 PF00498 0.462
LIG_FHA_2 286 292 PF00498 0.565
LIG_FHA_2 336 342 PF00498 0.555
LIG_LIR_Gen_1 194 205 PF02991 0.475
LIG_LIR_Nem_3 171 177 PF02991 0.546
LIG_LIR_Nem_3 183 188 PF02991 0.461
LIG_LIR_Nem_3 194 200 PF02991 0.460
LIG_MYND_1 12 16 PF01753 0.476
LIG_PTB_Apo_2 260 267 PF02174 0.578
LIG_SH2_CRK 174 178 PF00017 0.476
LIG_SH2_CRK 197 201 PF00017 0.432
LIG_SH2_STAP1 293 297 PF00017 0.432
LIG_SH3_3 47 53 PF00018 0.485
LIG_SH3_3 59 65 PF00018 0.476
LIG_SH3_3 77 83 PF00018 0.483
LIG_SH3_3 95 101 PF00018 0.525
LIG_SH3_4 117 124 PF00018 0.660
LIG_SUMO_SIM_anti_2 294 299 PF11976 0.396
LIG_SUMO_SIM_par_1 148 155 PF11976 0.598
LIG_SUMO_SIM_par_1 2 7 PF11976 0.471
LIG_TYR_ITIM 172 177 PF00017 0.498
LIG_UBA3_1 298 304 PF00899 0.461
LIG_WRC_WIRS_1 222 227 PF05994 0.457
MOD_CK1_1 164 170 PF00069 0.497
MOD_CK1_1 19 25 PF00069 0.485
MOD_CK1_1 196 202 PF00069 0.405
MOD_CK1_1 221 227 PF00069 0.553
MOD_CK1_1 273 279 PF00069 0.566
MOD_CK1_1 289 295 PF00069 0.306
MOD_CK1_1 67 73 PF00069 0.463
MOD_CK2_1 206 212 PF00069 0.454
MOD_CK2_1 285 291 PF00069 0.449
MOD_CK2_1 337 343 PF00069 0.491
MOD_GlcNHglycan 234 237 PF01048 0.619
MOD_GlcNHglycan 245 248 PF01048 0.645
MOD_GlcNHglycan 272 275 PF01048 0.602
MOD_GlcNHglycan 39 42 PF01048 0.442
MOD_GSK3_1 12 19 PF00069 0.476
MOD_GSK3_1 146 153 PF00069 0.584
MOD_GSK3_1 157 164 PF00069 0.402
MOD_GSK3_1 192 199 PF00069 0.348
MOD_GSK3_1 213 220 PF00069 0.586
MOD_GSK3_1 221 228 PF00069 0.571
MOD_GSK3_1 243 250 PF00069 0.580
MOD_GSK3_1 25 32 PF00069 0.442
MOD_GSK3_1 273 280 PF00069 0.588
MOD_GSK3_1 285 292 PF00069 0.321
MOD_GSK3_1 337 344 PF00069 0.554
MOD_GSK3_1 64 71 PF00069 0.464
MOD_GSK3_1 85 92 PF00069 0.521
MOD_N-GLC_1 241 246 PF02516 0.497
MOD_NEK2_1 173 178 PF00069 0.535
MOD_NEK2_1 2 7 PF00069 0.471
MOD_NEK2_1 206 211 PF00069 0.446
MOD_NEK2_1 225 230 PF00069 0.371
MOD_NEK2_1 265 270 PF00069 0.589
MOD_NEK2_1 91 96 PF00069 0.526
MOD_PIKK_1 116 122 PF00454 0.607
MOD_PIKK_1 68 74 PF00454 0.468
MOD_PIKK_1 85 91 PF00454 0.509
MOD_PKA_2 145 151 PF00069 0.511
MOD_PKA_2 164 170 PF00069 0.374
MOD_PKA_2 277 283 PF00069 0.388
MOD_PKB_1 144 152 PF00069 0.513
MOD_PKB_1 8 16 PF00069 0.481
MOD_Plk_1 193 199 PF00069 0.363
MOD_Plk_1 211 217 PF00069 0.488
MOD_Plk_1 241 247 PF00069 0.589
MOD_Plk_1 276 282 PF00069 0.518
MOD_Plk_4 221 227 PF00069 0.592
MOD_Plk_4 234 240 PF00069 0.479
MOD_Plk_4 279 285 PF00069 0.401
MOD_ProDKin_1 12 18 PF00069 0.475
MOD_ProDKin_1 186 192 PF00069 0.452
MOD_ProDKin_1 94 100 PF00069 0.489
MOD_SUMO_for_1 303 306 PF00179 0.452
TRG_DiLeu_BaLyEn_6 229 234 PF01217 0.409
TRG_ENDOCYTIC_2 174 177 PF00928 0.482
TRG_ENDOCYTIC_2 197 200 PF00928 0.423
TRG_ER_diArg_1 144 147 PF00400 0.537
TRG_ER_diArg_1 8 11 PF00400 0.487
TRG_NLS_MonoExtC_3 164 169 PF00514 0.517
TRG_Pf-PMV_PEXEL_1 150 155 PF00026 0.595
TRG_Pf-PMV_PEXEL_1 175 180 PF00026 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H7Q5 Leishmania donovani 84% 100%
A4HJM7 Leishmania braziliensis 51% 100%
A4I749 Leishmania infantum 85% 100%
E9B243 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
Q4Q619 Leishmania major 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS