Rad60-SLD_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q617_LEIMA

TriTrypDb:

LmjF.31.2440 , LMJLV39_310033900 , LMJSD75_310033900

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q617

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q617

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.494
CLV_NRD_NRD_1	181	183	PF00675	0.425
CLV_NRD_NRD_1	37	39	PF00675	0.474
CLV_PCSK_KEX2_1	181	183	PF00082	0.445
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.445
CLV_PCSK_SKI1_1	183	187	PF00082	0.519
CLV_PCSK_SKI1_1	23	27	PF00082	0.433
DEG_COP1_1	100	110	PF00400	0.611
DOC_CYCLIN_RxL_1	180	188	PF00134	0.407
DOC_MAPK_gen_1	74	81	PF00069	0.450
DOC_MAPK_MEF2A_6	74	81	PF00069	0.450
DOC_MAPK_NFAT4_5	74	82	PF00069	0.451
DOC_PP1_RVXF_1	1	8	PF00149	0.405
DOC_USP7_MATH_1	214	218	PF00917	0.463
DOC_USP7_MATH_1	89	93	PF00917	0.477
LIG_14-3-3_CanoR_1	158	165	PF00244	0.325
LIG_14-3-3_CanoR_1	60	70	PF00244	0.479
LIG_APCC_ABBAyCdc20_2	182	188	PF00400	0.409
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_BRCT_BRCA1_1	66	70	PF00533	0.373
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.348
LIG_FHA_1	19	25	PF00498	0.435
LIG_FHA_1	31	37	PF00498	0.426
LIG_FHA_1	76	82	PF00498	0.348
LIG_FHA_1	96	102	PF00498	0.445
LIG_FHA_2	158	164	PF00498	0.452
LIG_FHA_2	27	33	PF00498	0.502
LIG_FHA_2	95	101	PF00498	0.523
LIG_GBD_Chelix_1	167	175	PF00786	0.339
LIG_LIR_Gen_1	67	77	PF02991	0.515
LIG_LIR_Nem_3	67	73	PF02991	0.482
LIG_Pex14_1	155	159	PF04695	0.378
LIG_SH2_STAP1	165	169	PF00017	0.428
LIG_SH3_3	105	111	PF00018	0.712
LIG_SH3_3	83	89	PF00018	0.389
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.448
LIG_SUMO_SIM_par_1	23	29	PF11976	0.435
LIG_SUMO_SIM_par_1	31	37	PF11976	0.454
LIG_TYR_ITIM	45	50	PF00017	0.504
MOD_CK1_1	109	115	PF00069	0.677
MOD_CK1_1	161	167	PF00069	0.443
MOD_CK1_1	64	70	PF00069	0.480
MOD_Cter_Amidation	179	182	PF01082	0.439
MOD_GlcNHglycan	145	148	PF01048	0.627
MOD_GlcNHglycan	216	219	PF01048	0.585
MOD_GlcNHglycan	65	69	PF01048	0.375
MOD_GSK3_1	106	113	PF00069	0.636
MOD_GSK3_1	157	164	PF00069	0.399
MOD_GSK3_1	203	210	PF00069	0.471
MOD_GSK3_1	26	33	PF00069	0.431
MOD_NEK2_1	116	121	PF00069	0.632
MOD_NEK2_1	151	156	PF00069	0.505
MOD_NEK2_2	75	80	PF00069	0.362
MOD_PIKK_1	130	136	PF00454	0.681
MOD_PIKK_1	18	24	PF00454	0.457
MOD_PK_1	106	112	PF00069	0.528
MOD_PK_1	158	164	PF00069	0.414
MOD_PKA_2	157	163	PF00069	0.396
MOD_PKA_2	175	181	PF00069	0.427
MOD_Plk_1	116	122	PF00069	0.682
MOD_Plk_4	151	157	PF00069	0.544
TRG_ENDOCYTIC_2	47	50	PF00928	0.438
TRG_ER_diArg_1	182	185	PF00400	0.412
TRG_NLS_MonoCore_2	180	185	PF00514	0.420
TRG_NLS_MonoExtN_4	181	186	PF00514	0.398
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I730	Leptomonas seymouri	28%	100%
A0A0N1I8Q6	Leptomonas seymouri	45%	96%
A0A0N1PCW5	Leptomonas seymouri	36%	100%
A0A3Q8IF19	Leishmania donovani	96%	100%
A0A3Q8IKA6	Leishmania donovani	23%	100%
A0A3S5H7Q5	Leishmania donovani	40%	93%
A4HJM7	Leishmania braziliensis	41%	90%
A4HJM8	Leishmania braziliensis	76%	99%
A4HJM9	Leishmania braziliensis	23%	100%
A4I749	Leishmania infantum	40%	94%
A4I750	Leishmania infantum	95%	100%
A4I751	Leishmania infantum	23%	100%
E9B243	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	94%
E9B244	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B245	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4Q616	Leishmania major	22%	100%