Putative lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lipase

Gene product:

lipase, putative

Species:

Leishmania major

UniProt:

Q4Q615_LEIMA

TriTrypDb:

LmjF.31.2460 , LMJLV39_310034100 , LMJSD75_310034100

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 9
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q615

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q615

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	16
GO:0008152	metabolic process	1	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004806	triglyceride lipase activity	5	7
GO:0016298	lipase activity	4	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0052689	carboxylic ester hydrolase activity	4	8
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0052739	phosphatidylserine 1-acylhydrolase activity	5	1
GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.195
CLV_NRD_NRD_1	249	251	PF00675	0.535
CLV_PCSK_KEX2_1	108	110	PF00082	0.397
CLV_PCSK_KEX2_1	251	253	PF00082	0.533
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.397
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.535
CLV_PCSK_SKI1_1	269	273	PF00082	0.435
DEG_APCC_DBOX_1	169	177	PF00400	0.297
DOC_CDC14_PxL_1	1	9	PF14671	0.511
DOC_CKS1_1	274	279	PF01111	0.201
DOC_MAPK_gen_1	108	114	PF00069	0.271
DOC_MAPK_HePTP_8	210	222	PF00069	0.205
DOC_MAPK_MEF2A_6	213	222	PF00069	0.205
DOC_PP1_RVXF_1	4	11	PF00149	0.405
DOC_PP1_RVXF_1	51	58	PF00149	0.248
DOC_PP4_FxxP_1	230	233	PF00568	0.221
DOC_USP7_MATH_1	152	156	PF00917	0.354
DOC_USP7_MATH_1	301	305	PF00917	0.290
DOC_WW_Pin1_4	214	219	PF00397	0.236
DOC_WW_Pin1_4	273	278	PF00397	0.302
DOC_WW_Pin1_4	78	83	PF00397	0.292
LIG_14-3-3_CanoR_1	130	135	PF00244	0.164
LIG_14-3-3_CanoR_1	250	255	PF00244	0.266
LIG_14-3-3_CanoR_1	269	274	PF00244	0.342
LIG_Actin_WH2_2	14	32	PF00022	0.165
LIG_deltaCOP1_diTrp_1	50	57	PF00928	0.225
LIG_eIF4E_1	171	177	PF01652	0.302
LIG_EVH1_2	267	271	PF00568	0.247
LIG_FHA_1	173	179	PF00498	0.333
LIG_FHA_1	9	15	PF00498	0.332
LIG_FHA_1	93	99	PF00498	0.401
LIG_FHA_2	227	233	PF00498	0.314
LIG_FHA_2	274	280	PF00498	0.260
LIG_FHA_2	282	288	PF00498	0.350
LIG_FHA_2	295	301	PF00498	0.239
LIG_FHA_2	321	327	PF00498	0.364
LIG_GBD_Chelix_1	13	21	PF00786	0.239
LIG_LIR_Apic_2	132	137	PF02991	0.244
LIG_LIR_Apic_2	229	233	PF02991	0.238
LIG_LIR_Apic_2	337	341	PF02991	0.268
LIG_LIR_Gen_1	117	124	PF02991	0.298
LIG_LIR_Gen_1	197	206	PF02991	0.216
LIG_LIR_Gen_1	343	353	PF02991	0.401
LIG_LIR_Gen_1	81	90	PF02991	0.346
LIG_LIR_Nem_3	117	121	PF02991	0.311
LIG_LIR_Nem_3	197	201	PF02991	0.292
LIG_LIR_Nem_3	343	348	PF02991	0.291
LIG_LIR_Nem_3	49	55	PF02991	0.281
LIG_LIR_Nem_3	81	87	PF02991	0.360
LIG_NRBOX	16	22	PF00104	0.313
LIG_PTB_Apo_2	123	130	PF02174	0.238
LIG_PTB_Apo_2	234	241	PF02174	0.229
LIG_PTB_Apo_2	353	360	PF02174	0.269
LIG_SH2_CRK	118	122	PF00017	0.349
LIG_SH2_CRK	153	157	PF00017	0.330
LIG_SH2_CRK	345	349	PF00017	0.303
LIG_SH2_GRB2like	90	93	PF00017	0.335
LIG_SH2_NCK_1	118	122	PF00017	0.205
LIG_SH2_NCK_1	338	342	PF00017	0.267
LIG_SH2_NCK_1	345	349	PF00017	0.235
LIG_SH2_STAP1	174	178	PF00017	0.290
LIG_SH2_STAP1	336	340	PF00017	0.297
LIG_SH2_STAT5	174	177	PF00017	0.349
LIG_SH2_STAT5	228	231	PF00017	0.238
LIG_SH2_STAT5	239	242	PF00017	0.240
LIG_SH2_STAT5	24	27	PF00017	0.610
LIG_SH2_STAT5	273	276	PF00017	0.316
LIG_SH2_STAT5	318	321	PF00017	0.259
LIG_SH2_STAT5	62	65	PF00017	0.248
LIG_SH3_2	264	269	PF14604	0.302
LIG_SH3_3	261	267	PF00018	0.229
LIG_SH3_3	271	277	PF00018	0.279
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.237
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.207
LIG_SUMO_SIM_par_1	16	22	PF11976	0.286
LIG_SUMO_SIM_par_1	223	229	PF11976	0.330
LIG_SUMO_SIM_par_1	346	351	PF11976	0.375
LIG_TRAF2_1	276	279	PF00917	0.197
LIG_TRAF2_1	328	331	PF00917	0.336
LIG_TRFH_1	338	342	PF08558	0.377
LIG_TYR_ITIM	316	321	PF00017	0.277
LIG_TYR_ITIM	98	103	PF00017	0.279
LIG_WRC_WIRS_1	227	232	PF05994	0.238
LIG_WW_3	266	270	PF00397	0.302
MOD_CK1_1	214	220	PF00069	0.316
MOD_CK1_1	241	247	PF00069	0.265
MOD_CK2_1	226	232	PF00069	0.314
MOD_CK2_1	273	279	PF00069	0.270
MOD_CK2_1	281	287	PF00069	0.382
MOD_CK2_1	320	326	PF00069	0.340
MOD_GlcNHglycan	100	103	PF01048	0.517
MOD_GlcNHglycan	213	216	PF01048	0.424
MOD_GlcNHglycan	42	45	PF01048	0.581
MOD_GSK3_1	172	179	PF00069	0.333
MOD_GSK3_1	24	31	PF00069	0.684
MOD_GSK3_1	246	253	PF00069	0.251
MOD_GSK3_1	269	276	PF00069	0.404
MOD_GSK3_1	303	310	PF00069	0.333
MOD_GSK3_1	40	47	PF00069	0.295
MOD_N-GLC_1	241	246	PF02516	0.514
MOD_N-GLC_1	357	362	PF02516	0.669
MOD_N-GLC_1	78	83	PF02516	0.515
MOD_N-GLC_1	91	96	PF02516	0.448
MOD_N-GLC_2	141	143	PF02516	0.495
MOD_NEK2_1	114	119	PF00069	0.271
MOD_NEK2_1	129	134	PF00069	0.259
MOD_NEK2_1	176	181	PF00069	0.296
MOD_NEK2_1	254	259	PF00069	0.253
MOD_NEK2_1	55	60	PF00069	0.311
MOD_NEK2_2	152	157	PF00069	0.277
MOD_NEK2_2	172	177	PF00069	0.314
MOD_PKA_1	250	256	PF00069	0.191
MOD_PKA_2	114	120	PF00069	0.229
MOD_PKA_2	129	135	PF00069	0.229
MOD_PKA_2	254	260	PF00069	0.230
MOD_Plk_1	241	247	PF00069	0.205
MOD_Plk_1	34	40	PF00069	0.472
MOD_Plk_2-3	226	232	PF00069	0.294
MOD_Plk_4	172	178	PF00069	0.348
MOD_Plk_4	19	25	PF00069	0.366
MOD_Plk_4	243	249	PF00069	0.260
MOD_Plk_4	303	309	PF00069	0.292
MOD_Plk_4	34	40	PF00069	0.515
MOD_Plk_4	9	15	PF00069	0.346
MOD_ProDKin_1	214	220	PF00069	0.236
MOD_ProDKin_1	273	279	PF00069	0.300
MOD_ProDKin_1	78	84	PF00069	0.286
MOD_SUMO_rev_2	101	110	PF00179	0.293
TRG_ENDOCYTIC_2	100	103	PF00928	0.323
TRG_ENDOCYTIC_2	118	121	PF00928	0.314
TRG_ENDOCYTIC_2	153	156	PF00928	0.264
TRG_ENDOCYTIC_2	174	177	PF00928	0.337
TRG_ENDOCYTIC_2	318	321	PF00928	0.269
TRG_ENDOCYTIC_2	345	348	PF00928	0.391
TRG_ENDOCYTIC_2	62	65	PF00928	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	56%	100%
A0A0S4IJE8	Bodo saltans	33%	100%
A0A0S4J5D7	Bodo saltans	39%	100%
A0A0S4JTA1	Bodo saltans	36%	100%
A0A1X0NZH3	Trypanosomatidae	40%	86%
A0A1X0P001	Trypanosomatidae	37%	100%
A0A3Q8IFI3	Leishmania donovani	86%	99%
A0A3Q8IG97	Leishmania donovani	31%	100%
A0A422NPJ5	Trypanosoma rangeli	38%	73%
A4HJN0	Leishmania braziliensis	59%	98%
A4HLK7	Leishmania braziliensis	35%	100%
A4I6H7	Leishmania infantum	31%	100%
A4I752	Leishmania infantum	86%	99%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	99%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
O42815	Aspergillus tubingensis	30%	100%
O59952	Thermomyces lanuginosus	30%	100%
P19515	Rhizomucor miehei	34%	100%
P61871	Rhizopus niveus	29%	93%
P61872	Rhizopus oryzae	29%	93%
Q4Q6I0	Leishmania major	32%	100%
Q5VKJ7	Ricinus communis	27%	69%
Q9BHD5	Leishmania major	38%	100%
Q9P979	Aspergillus awamori	31%	100%
Q9XTR8	Caenorhabditis elegans	28%	100%
V5B761	Trypanosoma cruzi	41%	100%