Uridine kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

uridine kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q614_LEIMA

TriTrypDb:

LmjF.31.2470 , LMJLV39_310034300 , LMJSD75_310034400

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q614

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q614

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0044237	cellular metabolic process	2	5
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006220	pyrimidine nucleotide metabolic process	5	2
GO:0006221	pyrimidine nucleotide biosynthetic process	6	2
GO:0006222	UMP biosynthetic process	8	2
GO:0006241	CTP biosynthetic process	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008655	pyrimidine-containing compound salvage	4	2
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009123	nucleoside monophosphate metabolic process	5	2
GO:0009124	nucleoside monophosphate biosynthetic process	6	2
GO:0009129	pyrimidine nucleoside monophosphate metabolic process	6	2
GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	7	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009142	nucleoside triphosphate biosynthetic process	6	2
GO:0009147	pyrimidine nucleoside triphosphate metabolic process	6	2
GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	7	2
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	2
GO:0009161	ribonucleoside monophosphate metabolic process	6	2
GO:0009165	nucleotide biosynthetic process	6	2
GO:0009173	pyrimidine ribonucleoside monophosphate metabolic process	7	2
GO:0009174	pyrimidine ribonucleoside monophosphate biosynthetic process	8	2
GO:0009199	ribonucleoside triphosphate metabolic process	6	2
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	2
GO:0009208	pyrimidine ribonucleoside triphosphate metabolic process	7	2
GO:0009209	pyrimidine ribonucleoside triphosphate biosynthetic process	8	2
GO:0009218	pyrimidine ribonucleotide metabolic process	6	2
GO:0009220	pyrimidine ribonucleotide biosynthetic process	7	2
GO:0009259	ribonucleotide metabolic process	5	2
GO:0009260	ribonucleotide biosynthetic process	6	2
GO:0010138	pyrimidine ribonucleotide salvage	6	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019693	ribose phosphate metabolic process	4	2
GO:0032262	pyrimidine nucleotide salvage	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043094	cellular metabolic compound salvage	3	2
GO:0043173	nucleotide salvage	4	2
GO:0044206	UMP salvage	7	2
GO:0044211	CTP salvage	7	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046036	CTP metabolic process	7	2
GO:0046049	UMP metabolic process	7	2
GO:0046390	ribose phosphate biosynthetic process	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072527	pyrimidine-containing compound metabolic process	4	2
GO:0072528	pyrimidine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004849	uridine kinase activity	7	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0017076	purine nucleotide binding	4	5
GO:0019205	nucleobase-containing compound kinase activity	5	5
GO:0019206	nucleoside kinase activity	6	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.504
CLV_NRD_NRD_1	216	218	PF00675	0.304
CLV_NRD_NRD_1	241	243	PF00675	0.224
CLV_NRD_NRD_1	285	287	PF00675	0.507
CLV_PCSK_KEX2_1	156	158	PF00082	0.224
CLV_PCSK_KEX2_1	216	218	PF00082	0.304
CLV_PCSK_KEX2_1	241	243	PF00082	0.224
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.224
CLV_PCSK_SKI1_1	220	224	PF00082	0.286
CLV_PCSK_SKI1_1	79	83	PF00082	0.581
DEG_APCC_DBOX_1	82	90	PF00400	0.557
DEG_Nend_UBRbox_1	1	4	PF02207	0.559
DEG_SCF_FBW7_1	33	40	PF00400	0.529
DOC_CKS1_1	206	211	PF01111	0.494
DOC_CKS1_1	34	39	PF01111	0.529
DOC_MAPK_gen_1	273	282	PF00069	0.415
DOC_MAPK_gen_1	77	86	PF00069	0.453
DOC_MAPK_MEF2A_6	77	86	PF00069	0.513
DOC_MAPK_NFAT4_5	79	87	PF00069	0.426
DOC_PP2B_LxvP_1	280	283	PF13499	0.449
DOC_USP7_MATH_1	106	110	PF00917	0.515
DOC_USP7_MATH_1	12	16	PF00917	0.505
DOC_USP7_MATH_1	37	41	PF00917	0.528
DOC_USP7_MATH_1	4	8	PF00917	0.545
DOC_WW_Pin1_4	175	180	PF00397	0.504
DOC_WW_Pin1_4	205	210	PF00397	0.494
DOC_WW_Pin1_4	33	38	PF00397	0.531
LIG_14-3-3_CanoR_1	145	152	PF00244	0.426
LIG_14-3-3_CanoR_1	170	176	PF00244	0.424
LIG_14-3-3_CanoR_1	225	230	PF00244	0.503
LIG_14-3-3_CanoR_1	273	283	PF00244	0.430
LIG_Actin_WH2_2	137	155	PF00022	0.504
LIG_APCC_ABBAyCdc20_2	108	114	PF00400	0.398
LIG_BRCT_BRCA1_1	108	112	PF00533	0.401
LIG_BRCT_BRCA1_1	294	298	PF00533	0.489
LIG_BRCT_BRCA1_1	63	67	PF00533	0.467
LIG_eIF4E_1	60	66	PF01652	0.477
LIG_FHA_1	178	184	PF00498	0.440
LIG_FHA_2	190	196	PF00498	0.604
LIG_FHA_2	206	212	PF00498	0.420
LIG_FHA_2	66	72	PF00498	0.488
LIG_LIR_Apic_2	131	137	PF02991	0.350
LIG_LIR_LC3C_4	31	34	PF02991	0.526
LIG_PCNA_yPIPBox_3	26	39	PF02747	0.518
LIG_PDZ_Class_2	299	304	PF00595	0.486
LIG_Rb_LxCxE_1	109	126	PF01857	0.396
LIG_SH2_CRK	163	167	PF00017	0.504
LIG_SH2_SRC	163	166	PF00017	0.504
LIG_SH2_STAP1	236	240	PF00017	0.504
LIG_SH2_STAT3	23	26	PF00017	0.470
LIG_SH2_STAT5	165	168	PF00017	0.504
LIG_SH3_3	155	161	PF00018	0.504
LIG_SH3_3	203	209	PF00018	0.494
LIG_SH3_3	31	37	PF00018	0.528
LIG_SH3_3	43	49	PF00018	0.477
LIG_SH3_5	130	134	PF00018	0.258
LIG_SH3_5	161	165	PF00018	0.504
LIG_SUMO_SIM_par_1	180	186	PF11976	0.500
MOD_CDK_SPxK_1	175	181	PF00069	0.258
MOD_CDK_SPxK_1	33	39	PF00069	0.531
MOD_CK1_1	15	21	PF00069	0.484
MOD_CK1_1	171	177	PF00069	0.272
MOD_CK1_1	5	11	PF00069	0.547
MOD_CK1_1	55	61	PF00069	0.497
MOD_CK2_1	189	195	PF00069	0.496
MOD_Cter_Amidation	154	157	PF01082	0.244
MOD_GlcNHglycan	10	13	PF01048	0.542
MOD_GlcNHglycan	108	111	PF01048	0.479
MOD_GlcNHglycan	170	173	PF01048	0.272
MOD_GlcNHglycan	256	260	PF01048	0.346
MOD_GlcNHglycan	264	267	PF01048	0.370
MOD_GlcNHglycan	294	297	PF01048	0.489
MOD_GlcNHglycan	39	42	PF01048	0.530
MOD_GSK3_1	128	135	PF00069	0.480
MOD_GSK3_1	171	178	PF00069	0.339
MOD_GSK3_1	28	35	PF00069	0.520
MOD_GSK3_1	4	11	PF00069	0.547
MOD_GSK3_1	52	59	PF00069	0.505
MOD_GSK3_1	61	68	PF00069	0.498
MOD_N-GLC_1	106	111	PF02516	0.452
MOD_NEK2_1	144	149	PF00069	0.356
MOD_NEK2_1	189	194	PF00069	0.496
MOD_NEK2_1	32	37	PF00069	0.528
MOD_NEK2_1	56	61	PF00069	0.467
MOD_NEK2_1	65	70	PF00069	0.452
MOD_NEK2_2	236	241	PF00069	0.356
MOD_PIKK_1	5	11	PF00454	0.547
MOD_PK_1	2	8	PF00069	0.549
MOD_PKA_2	144	150	PF00069	0.246
MOD_Plk_1	56	62	PF00069	0.474
MOD_Plk_4	61	67	PF00069	0.523
MOD_ProDKin_1	175	181	PF00069	0.356
MOD_ProDKin_1	205	211	PF00069	0.342
MOD_ProDKin_1	33	39	PF00069	0.531
TRG_ENDOCYTIC_2	163	166	PF00928	0.356
TRG_ENDOCYTIC_2	247	250	PF00928	0.429
TRG_ER_diArg_1	215	217	PF00400	0.342
TRG_ER_diArg_1	240	242	PF00400	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4U8	Leishmania donovani	79%	98%
A4HJN1	Leishmania braziliensis	60%	100%
A4HJN5	Leishmania braziliensis	60%	100%
Q9HA47	Homo sapiens	26%	100%