Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania major

UniProt:

Q4Q612_LEIMA

TriTrypDb:

LmjF.31.2490 , LMJLV39_310034500 , LMJSD75_310034600

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q612

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q612

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	21
GO:0008152	metabolic process	1	21
GO:0009987	cellular process	1	21
GO:0022900	electron transport chain	4	21
GO:0044237	cellular metabolic process	2	21
GO:0140647	P450-containing electron transport chain	5	21

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	21
GO:0009055	electron transfer activity	3	3
GO:0016491	oxidoreductase activity	2	3
GO:0051536	iron-sulfur cluster binding	3	21
GO:0051537	2 iron, 2 sulfur cluster binding	4	21
GO:0051540	metal cluster binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	138	142	PF00082	0.387
DEG_Nend_UBRbox_1	1	4	PF02207	0.618
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.427
DOC_PP2B_LxvP_1	14	17	PF13499	0.415
DOC_PP4_FxxP_1	51	54	PF00568	0.273
DOC_USP7_MATH_1	79	83	PF00917	0.253
DOC_USP7_UBL2_3	94	98	PF12436	0.397
DOC_WW_Pin1_4	123	128	PF00397	0.462
DOC_WW_Pin1_4	44	49	PF00397	0.340
LIG_14-3-3_CanoR_1	2	7	PF00244	0.500
LIG_DLG_GKlike_1	2	10	PF00625	0.382
LIG_FHA_1	114	120	PF00498	0.307
LIG_FHA_1	139	145	PF00498	0.518
LIG_FHA_1	24	30	PF00498	0.489
LIG_FHA_1	8	14	PF00498	0.597
LIG_FHA_1	81	87	PF00498	0.351
LIG_FHA_2	45	51	PF00498	0.304
LIG_LIR_Apic_2	50	54	PF02991	0.277
LIG_LIR_Nem_3	90	96	PF02991	0.297
LIG_SH2_CRK	31	35	PF00017	0.447
LIG_SH2_NCK_1	31	35	PF00017	0.534
LIG_SH2_STAP1	25	29	PF00017	0.361
LIG_SH2_STAT5	25	28	PF00017	0.512
LIG_SH2_STAT5	87	90	PF00017	0.254
LIG_SH3_3	131	137	PF00018	0.393
LIG_SH3_4	98	105	PF00018	0.159
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.298
LIG_TRAF2_1	100	103	PF00917	0.352
MOD_CK2_1	97	103	PF00069	0.295
MOD_GSK3_1	40	47	PF00069	0.352
MOD_N-GLC_1	138	143	PF02516	0.355
MOD_N-GLC_1	2	7	PF02516	0.391
MOD_NEK2_1	113	118	PF00069	0.383
MOD_NEK2_1	24	29	PF00069	0.489
MOD_NEK2_1	7	12	PF00069	0.562
MOD_OFUCOSY	78	84	PF10250	0.293
MOD_Plk_1	114	120	PF00069	0.319
MOD_Plk_1	2	8	PF00069	0.645
MOD_Plk_4	2	8	PF00069	0.483
MOD_Plk_4	55	61	PF00069	0.328
MOD_ProDKin_1	123	129	PF00069	0.457
MOD_ProDKin_1	44	50	PF00069	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	57%	100%
A0A0N0P799	Leptomonas seymouri	49%	88%
A0A0N1HYR7	Leptomonas seymouri	49%	99%
A0A0N1HZ74	Leptomonas seymouri	36%	83%
A0A0N1I5P4	Leptomonas seymouri	71%	100%
A0A0N1ILD8	Leptomonas seymouri	50%	85%
A0A0N1PE81	Leptomonas seymouri	51%	100%
A0A0S4J024	Bodo saltans	56%	94%
A0A3Q8IIS3	Leishmania donovani	92%	100%
A0A3R7MK78	Trypanosoma rangeli	50%	89%
A0A3R7NM96	Trypanosoma rangeli	43%	76%
A0A3S7X4S6	Leishmania donovani	45%	91%
A0A3S7X4U4	Leishmania donovani	45%	80%
A0A3S7X4W8	Leishmania donovani	52%	100%
A4HJN2	Leishmania braziliensis	43%	90%
A4HJN3	Leishmania braziliensis	77%	100%
A4HJN4	Leishmania braziliensis	58%	92%
A4HJN8	Leishmania braziliensis	57%	100%
A4HJN9	Leishmania braziliensis	46%	81%
A4I755	Leishmania infantum	45%	91%
A4I756	Leishmania infantum	92%	100%
A4I757	Leishmania infantum	52%	100%
A4I758	Leishmania infantum	44%	80%
D5IGG4	Sphingomonas sp.	39%	100%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	91%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	80%
P00257	Bos taurus	38%	78%
P00258	Sus scrofa	39%	78%
P00259	Pseudomonas putida	39%	100%
P10109	Homo sapiens	39%	79%
P13216	Gallus gallus	36%	100%
P24483	Rattus norvegicus	38%	77%
P29330	Ovis aries	40%	100%
P37098	Caulobacter vibrioides (strain ATCC 19089 / CB15)	35%	100%
P37193	Drosophila melanogaster	37%	84%
P46656	Mus musculus	37%	77%
P80306	Rhodobacter capsulatus	40%	100%
Q05B51	Bos taurus	41%	78%
Q08C57	Danio rerio	40%	74%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	84%
Q1RJ69	Rickettsia bellii (strain RML369-C)	43%	100%
Q4Q610	Leishmania major	43%	100%
Q4Q611	Leishmania major	53%	100%
Q4Q613	Leishmania major	45%	91%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	46%	100%
Q5FWQ0	Xenopus laevis	40%	75%
Q5S3I4	Stenotrophomonas maltophilia	36%	100%
Q6P4F2	Homo sapiens	40%	78%
Q8S904	Arabidopsis thaliana	37%	74%
Q8SZA8	Drosophila melanogaster	36%	95%
Q92J08	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	45%	100%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	45%	100%
Q9AKH1	Rickettsia rickettsii	46%	100%
Q9AKM6	Rickettsia montanensis	46%	100%
Q9M0V0	Arabidopsis thaliana	34%	74%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	45%	100%
X5CWH9	Rhizorhabdus wittichii (strain DC-6 / KACC 16600)	40%	100%