Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania major

UniProt:

Q4Q610_LEIMA

TriTrypDb:

LmjF.31.2510 , LMJLV39_310034700 , LMJSD75_310034800

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 25
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q610

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q610

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	29
GO:0008152	metabolic process	1	29
GO:0009987	cellular process	1	29
GO:0022900	electron transport chain	4	29
GO:0044237	cellular metabolic process	2	29
GO:0140647	P450-containing electron transport chain	5	29

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	29
GO:0009055	electron transfer activity	3	6
GO:0016491	oxidoreductase activity	2	6
GO:0051536	iron-sulfur cluster binding	3	29
GO:0051537	2 iron, 2 sulfur cluster binding	4	29
GO:0051540	metal cluster binding	2	29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.556
CLV_NRD_NRD_1	5	7	PF00675	0.525
CLV_PCSK_KEX2_1	177	179	PF00082	0.426
CLV_PCSK_KEX2_1	4	6	PF00082	0.516
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DOC_MAPK_gen_1	4	13	PF00069	0.434
DOC_MAPK_HePTP_8	3	15	PF00069	0.414
DOC_MAPK_MEF2A_6	6	15	PF00069	0.416
DOC_MAPK_MEF2A_6	85	94	PF00069	0.341
DOC_PP2B_LxvP_1	13	16	PF13499	0.412
DOC_PP2B_LxvP_1	39	42	PF13499	0.393
DOC_USP7_MATH_1	42	46	PF00917	0.680
DOC_WW_Pin1_4	21	26	PF00397	0.441
DOC_WW_Pin1_4	37	42	PF00397	0.480
DOC_WW_Pin1_4	51	56	PF00397	0.449
LIG_14-3-3_CanoR_1	145	152	PF00244	0.297
LIG_14-3-3_CanoR_1	5	11	PF00244	0.586
LIG_DLG_GKlike_1	6	13	PF00625	0.433
LIG_FHA_1	10	16	PF00498	0.446
LIG_FHA_1	104	110	PF00498	0.350
LIG_FHA_1	165	171	PF00498	0.554
LIG_FHA_1	87	93	PF00498	0.327
LIG_FHA_2	125	131	PF00498	0.315
LIG_FHA_2	66	72	PF00498	0.310
LIG_LIR_Gen_1	68	74	PF02991	0.303
LIG_Pex14_1	172	176	PF04695	0.522
LIG_SH2_STAP1	70	74	PF00017	0.306
LIG_SH3_3	8	14	PF00018	0.583
LIG_SH3_3	89	95	PF00018	0.328
MOD_CDK_SPxK_1	21	27	PF00069	0.425
MOD_CDK_SPxK_1	51	57	PF00069	0.506
MOD_CK1_1	138	144	PF00069	0.325
MOD_CK1_1	40	46	PF00069	0.524
MOD_CK1_1	49	55	PF00069	0.503
MOD_CK1_1	9	15	PF00069	0.476
MOD_CK2_1	124	130	PF00069	0.315
MOD_CK2_1	65	71	PF00069	0.255
MOD_DYRK1A_RPxSP_1	51	55	PF00069	0.413
MOD_GlcNHglycan	112	115	PF01048	0.269
MOD_GlcNHglycan	137	140	PF01048	0.174
MOD_GlcNHglycan	152	155	PF01048	0.398
MOD_GlcNHglycan	19	22	PF01048	0.489
MOD_GlcNHglycan	34	37	PF01048	0.432
MOD_GlcNHglycan	45	48	PF01048	0.638
MOD_GSK3_1	144	151	PF00069	0.324
MOD_GSK3_1	15	22	PF00069	0.628
MOD_GSK3_1	42	49	PF00069	0.602
MOD_GSK3_1	98	105	PF00069	0.360
MOD_N-GLC_1	98	103	PF02516	0.324
MOD_NEK2_1	19	24	PF00069	0.511
MOD_OFUCOSY	102	107	PF10250	0.353
MOD_PKA_2	144	150	PF00069	0.313
MOD_PKA_2	176	182	PF00069	0.419
MOD_PKB_1	4	12	PF00069	0.422
MOD_PKB_1	63	71	PF00069	0.229
MOD_Plk_1	141	147	PF00069	0.323
MOD_Plk_1	85	91	PF00069	0.214
MOD_Plk_4	6	12	PF00069	0.574
MOD_ProDKin_1	21	27	PF00069	0.441
MOD_ProDKin_1	37	43	PF00069	0.482
MOD_ProDKin_1	51	57	PF00069	0.438
TRG_DiLeu_BaEn_1	76	81	PF01217	0.365
TRG_ENDOCYTIC_2	70	73	PF00928	0.359
TRG_ER_diArg_1	176	178	PF00400	0.408
TRG_ER_diArg_1	3	6	PF00400	0.485
TRG_ER_diArg_1	60	63	PF00400	0.433
TRG_NES_CRM1_1	115	130	PF08389	0.189

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	41%	100%
A0A0N0P799	Leptomonas seymouri	33%	100%
A0A0N1HYR7	Leptomonas seymouri	38%	100%
A0A0N1HZ74	Leptomonas seymouri	30%	100%
A0A0N1ILD8	Leptomonas seymouri	58%	100%
A0A0N1PE81	Leptomonas seymouri	36%	100%
A0A1X0NSB1	Trypanosomatidae	37%	100%
A0A3Q8IIS3	Leishmania donovani	47%	100%
A0A3R7NM96	Trypanosoma rangeli	37%	95%
A0A3S7X4S6	Leishmania donovani	37%	100%
A0A3S7X4U4	Leishmania donovani	90%	100%
A0A3S7X4W8	Leishmania donovani	39%	100%
A4HEW1	Leishmania braziliensis	29%	97%
A4HJN2	Leishmania braziliensis	36%	100%
A4HJN3	Leishmania braziliensis	41%	100%
A4HJN4	Leishmania braziliensis	38%	100%
A4HJN8	Leishmania braziliensis	41%	100%
A4HJN9	Leishmania braziliensis	69%	100%
A4I755	Leishmania infantum	37%	100%
A4I756	Leishmania infantum	47%	100%
A4I757	Leishmania infantum	38%	100%
A4I758	Leishmania infantum	89%	100%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P00258	Sus scrofa	35%	98%
P13216	Gallus gallus	32%	100%
P46656	Mus musculus	33%	97%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4Q611	Leishmania major	39%	100%
Q4Q612	Leishmania major	43%	100%
Q4Q613	Leishmania major	38%	100%
Q4Q989	Leishmania major	39%	100%
Q6P4F2	Homo sapiens	32%	98%
Q8S904	Arabidopsis thaliana	34%	92%
Q9M0V0	Arabidopsis thaliana	29%	92%