LeishMANIAdb
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LysM domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LysM domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q609_LEIMA
TriTrypDb:
LmjF.31.2520 , LMJLV39_310034800 , LMJSD75_310034900
Length:
847

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 4
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

Q4Q609
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q609

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 174 178 PF00656 0.545
CLV_C14_Caspase3-7 645 649 PF00656 0.484
CLV_NRD_NRD_1 6 8 PF00675 0.666
CLV_NRD_NRD_1 756 758 PF00675 0.484
CLV_NRD_NRD_1 759 761 PF00675 0.504
CLV_NRD_NRD_1 791 793 PF00675 0.561
CLV_NRD_NRD_1 811 813 PF00675 0.568
CLV_NRD_NRD_1 816 818 PF00675 0.547
CLV_NRD_NRD_1 844 846 PF00675 0.444
CLV_PCSK_FUR_1 757 761 PF00082 0.523
CLV_PCSK_KEX2_1 121 123 PF00082 0.750
CLV_PCSK_KEX2_1 6 8 PF00082 0.666
CLV_PCSK_KEX2_1 756 758 PF00082 0.486
CLV_PCSK_KEX2_1 759 761 PF00082 0.501
CLV_PCSK_KEX2_1 793 795 PF00082 0.571
CLV_PCSK_KEX2_1 811 813 PF00082 0.576
CLV_PCSK_KEX2_1 816 818 PF00082 0.577
CLV_PCSK_KEX2_1 844 846 PF00082 0.444
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.635
CLV_PCSK_PC1ET2_1 793 795 PF00082 0.551
CLV_PCSK_PC7_1 812 818 PF00082 0.577
CLV_PCSK_SKI1_1 437 441 PF00082 0.693
CLV_PCSK_SKI1_1 7 11 PF00082 0.658
CLV_PCSK_SKI1_1 76 80 PF00082 0.652
CLV_PCSK_SKI1_1 811 815 PF00082 0.551
DEG_APCC_DBOX_1 41 49 PF00400 0.412
DEG_APCC_DBOX_1 6 14 PF00400 0.455
DEG_COP1_1 766 776 PF00400 0.692
DEG_SCF_FBW7_1 387 394 PF00400 0.415
DEG_SPOP_SBC_1 245 249 PF00917 0.463
DEG_SPOP_SBC_1 334 338 PF00917 0.566
DOC_CDC14_PxL_1 209 217 PF14671 0.468
DOC_CKS1_1 269 274 PF01111 0.504
DOC_CKS1_1 353 358 PF01111 0.442
DOC_CKS1_1 388 393 PF01111 0.457
DOC_MAPK_FxFP_2 77 80 PF00069 0.440
DOC_MAPK_gen_1 756 767 PF00069 0.711
DOC_MAPK_MEF2A_6 345 353 PF00069 0.477
DOC_MAPK_MEF2A_6 543 550 PF00069 0.460
DOC_MAPK_MEF2A_6 798 805 PF00069 0.719
DOC_MAPK_RevD_3 743 757 PF00069 0.446
DOC_MAPK_RevD_3 803 817 PF00069 0.772
DOC_PP2B_LxvP_1 722 725 PF13499 0.528
DOC_PP4_FxxP_1 106 109 PF00568 0.390
DOC_PP4_FxxP_1 353 356 PF00568 0.455
DOC_PP4_FxxP_1 388 391 PF00568 0.409
DOC_PP4_FxxP_1 740 743 PF00568 0.342
DOC_PP4_FxxP_1 77 80 PF00568 0.498
DOC_PP4_FxxP_1 836 839 PF00568 0.630
DOC_USP7_MATH_1 179 183 PF00917 0.645
DOC_USP7_MATH_1 189 193 PF00917 0.472
DOC_USP7_MATH_1 217 221 PF00917 0.468
DOC_USP7_MATH_1 245 249 PF00917 0.500
DOC_USP7_MATH_1 334 338 PF00917 0.554
DOC_USP7_MATH_1 356 360 PF00917 0.386
DOC_USP7_MATH_1 391 395 PF00917 0.538
DOC_USP7_MATH_1 400 404 PF00917 0.309
DOC_USP7_MATH_1 431 435 PF00917 0.459
DOC_USP7_MATH_1 477 481 PF00917 0.418
DOC_USP7_MATH_1 552 556 PF00917 0.500
DOC_USP7_MATH_1 653 657 PF00917 0.482
DOC_USP7_MATH_1 85 89 PF00917 0.529
DOC_WW_Pin1_4 105 110 PF00397 0.441
DOC_WW_Pin1_4 160 165 PF00397 0.503
DOC_WW_Pin1_4 185 190 PF00397 0.568
DOC_WW_Pin1_4 268 273 PF00397 0.437
DOC_WW_Pin1_4 352 357 PF00397 0.425
DOC_WW_Pin1_4 387 392 PF00397 0.446
DOC_WW_Pin1_4 481 486 PF00397 0.484
DOC_WW_Pin1_4 59 64 PF00397 0.464
DOC_WW_Pin1_4 703 708 PF00397 0.519
LIG_14-3-3_CanoR_1 122 128 PF00244 0.460
LIG_14-3-3_CanoR_1 240 245 PF00244 0.437
LIG_14-3-3_CanoR_1 246 251 PF00244 0.475
LIG_14-3-3_CanoR_1 328 334 PF00244 0.466
LIG_14-3-3_CanoR_1 553 561 PF00244 0.467
LIG_14-3-3_CanoR_1 664 669 PF00244 0.441
LIG_14-3-3_CanoR_1 777 786 PF00244 0.698
LIG_14-3-3_CanoR_1 84 94 PF00244 0.528
LIG_Actin_WH2_2 423 439 PF00022 0.348
LIG_APCC_ABBA_1 374 379 PF00400 0.460
LIG_APCC_ABBA_1 489 494 PF00400 0.450
LIG_BIR_III_4 494 498 PF00653 0.346
LIG_BIR_III_4 633 637 PF00653 0.503
LIG_BRCT_BRCA1_1 434 438 PF00533 0.378
LIG_BRCT_BRCA1_1 685 689 PF00533 0.493
LIG_BRCT_BRCA1_1 87 91 PF00533 0.387
LIG_BRCT_BRCA1_2 434 440 PF00533 0.367
LIG_deltaCOP1_diTrp_1 146 152 PF00928 0.450
LIG_eIF4E_1 481 487 PF01652 0.498
LIG_EVH1_1 836 840 PF00568 0.628
LIG_FHA_1 224 230 PF00498 0.388
LIG_FHA_1 245 251 PF00498 0.516
LIG_FHA_1 255 261 PF00498 0.431
LIG_FHA_1 353 359 PF00498 0.443
LIG_FHA_1 424 430 PF00498 0.450
LIG_FHA_1 465 471 PF00498 0.409
LIG_FHA_2 172 178 PF00498 0.516
LIG_FHA_2 203 209 PF00498 0.471
LIG_FHA_2 301 307 PF00498 0.466
LIG_FHA_2 404 410 PF00498 0.534
LIG_FHA_2 589 595 PF00498 0.466
LIG_FHA_2 66 72 PF00498 0.481
LIG_FHA_2 779 785 PF00498 0.695
LIG_HCF-1_HBM_1 370 373 PF13415 0.397
LIG_LIR_Apic_2 103 109 PF02991 0.385
LIG_LIR_Apic_2 151 156 PF02991 0.404
LIG_LIR_Apic_2 350 356 PF02991 0.443
LIG_LIR_Gen_1 201 212 PF02991 0.474
LIG_LIR_Gen_1 354 365 PF02991 0.451
LIG_LIR_Gen_1 731 740 PF02991 0.370
LIG_LIR_Nem_3 146 150 PF02991 0.420
LIG_LIR_Nem_3 201 207 PF02991 0.422
LIG_LIR_Nem_3 208 212 PF02991 0.356
LIG_LIR_Nem_3 370 376 PF02991 0.423
LIG_LIR_Nem_3 51 56 PF02991 0.377
LIG_LIR_Nem_3 716 720 PF02991 0.522
LIG_LIR_Nem_3 731 735 PF02991 0.319
LIG_LIR_Nem_3 775 779 PF02991 0.782
LIG_LYPXL_yS_3 517 520 PF13949 0.479
LIG_PCNA_PIPBox_1 807 816 PF02747 0.686
LIG_PCNA_yPIPBox_3 806 814 PF02747 0.683
LIG_Pex14_2 283 287 PF04695 0.408
LIG_Pex14_2 353 357 PF04695 0.505
LIG_PTB_Apo_2 194 201 PF02174 0.494
LIG_SH2_CRK 124 128 PF00017 0.486
LIG_SH2_CRK 153 157 PF00017 0.483
LIG_SH2_CRK 209 213 PF00017 0.481
LIG_SH2_CRK 241 245 PF00017 0.460
LIG_SH2_CRK 56 60 PF00017 0.458
LIG_SH2_CRK 717 721 PF00017 0.493
LIG_SH2_GRB2like 232 235 PF00017 0.489
LIG_SH2_NCK_1 153 157 PF00017 0.483
LIG_SH2_NCK_1 492 496 PF00017 0.401
LIG_SH2_SRC 232 235 PF00017 0.489
LIG_SH2_SRC 492 495 PF00017 0.366
LIG_SH2_STAP1 261 265 PF00017 0.540
LIG_SH2_STAP1 347 351 PF00017 0.390
LIG_SH2_STAP1 365 369 PF00017 0.406
LIG_SH2_STAP1 425 429 PF00017 0.368
LIG_SH2_STAT5 100 103 PF00017 0.424
LIG_SH2_STAT5 204 207 PF00017 0.466
LIG_SH2_STAT5 209 212 PF00017 0.422
LIG_SH2_STAT5 367 370 PF00017 0.496
LIG_SH2_STAT5 373 376 PF00017 0.362
LIG_SH2_STAT5 425 428 PF00017 0.443
LIG_SH2_STAT5 700 703 PF00017 0.488
LIG_SH3_3 266 272 PF00018 0.506
LIG_SH3_3 532 538 PF00018 0.404
LIG_SH3_3 581 587 PF00018 0.451
LIG_SH3_3 758 764 PF00018 0.764
LIG_SH3_3 834 840 PF00018 0.632
LIG_SUMO_SIM_anti_2 134 142 PF11976 0.473
LIG_SUMO_SIM_anti_2 165 171 PF11976 0.389
LIG_SUMO_SIM_anti_2 426 431 PF11976 0.421
LIG_SUMO_SIM_anti_2 43 49 PF11976 0.378
LIG_SUMO_SIM_anti_2 731 737 PF11976 0.412
LIG_SUMO_SIM_anti_2 747 753 PF11976 0.285
LIG_SUMO_SIM_par_1 428 435 PF11976 0.459
LIG_SUMO_SIM_par_1 497 502 PF11976 0.388
LIG_TYR_ITIM 207 212 PF00017 0.466
LIG_TYR_ITIM 715 720 PF00017 0.714
LIG_UBA3_1 800 806 PF00899 0.698
LIG_WRC_WIRS_1 149 154 PF05994 0.576
LIG_WW_1 724 727 PF00397 0.642
LIG_WW_3 624 628 PF00397 0.603
MOD_CK1_1 160 166 PF00069 0.631
MOD_CK1_1 168 174 PF00069 0.524
MOD_CK1_1 191 197 PF00069 0.669
MOD_CK1_1 220 226 PF00069 0.567
MOD_CK1_1 28 34 PF00069 0.657
MOD_CK1_1 297 303 PF00069 0.610
MOD_CK1_1 311 317 PF00069 0.468
MOD_CK1_1 359 365 PF00069 0.496
MOD_CK1_1 403 409 PF00069 0.461
MOD_CK1_1 480 486 PF00069 0.572
MOD_CK1_1 568 574 PF00069 0.530
MOD_CK1_1 620 626 PF00069 0.727
MOD_CK1_1 703 709 PF00069 0.692
MOD_CK2_1 202 208 PF00069 0.599
MOD_CK2_1 588 594 PF00069 0.475
MOD_CK2_1 778 784 PF00069 0.613
MOD_CMANNOS 11 14 PF00535 0.527
MOD_Cter_Amidation 842 845 PF01082 0.536
MOD_GlcNHglycan 159 162 PF01048 0.614
MOD_GlcNHglycan 181 184 PF01048 0.837
MOD_GlcNHglycan 197 200 PF01048 0.680
MOD_GlcNHglycan 219 222 PF01048 0.674
MOD_GlcNHglycan 23 26 PF01048 0.617
MOD_GlcNHglycan 313 316 PF01048 0.568
MOD_GlcNHglycan 322 325 PF01048 0.557
MOD_GlcNHglycan 543 546 PF01048 0.529
MOD_GlcNHglycan 566 571 PF01048 0.606
MOD_GlcNHglycan 601 604 PF01048 0.485
MOD_GlcNHglycan 620 623 PF01048 0.667
MOD_GlcNHglycan 650 653 PF01048 0.500
MOD_GlcNHglycan 693 696 PF01048 0.627
MOD_GlcNHglycan 822 825 PF01048 0.692
MOD_GlcNHglycan 87 90 PF01048 0.638
MOD_GSK3_1 131 138 PF00069 0.665
MOD_GSK3_1 185 192 PF00069 0.829
MOD_GSK3_1 21 28 PF00069 0.638
MOD_GSK3_1 240 247 PF00069 0.591
MOD_GSK3_1 264 271 PF00069 0.578
MOD_GSK3_1 316 323 PF00069 0.490
MOD_GSK3_1 329 336 PF00069 0.554
MOD_GSK3_1 352 359 PF00069 0.559
MOD_GSK3_1 36 43 PF00069 0.524
MOD_GSK3_1 387 394 PF00069 0.547
MOD_GSK3_1 403 410 PF00069 0.480
MOD_GSK3_1 477 484 PF00069 0.544
MOD_GSK3_1 55 62 PF00069 0.467
MOD_GSK3_1 63 70 PF00069 0.515
MOD_GSK3_1 698 705 PF00069 0.609
MOD_GSK3_1 80 87 PF00069 0.397
MOD_GSK3_1 95 102 PF00069 0.456
MOD_N-GLC_1 135 140 PF02516 0.678
MOD_N-GLC_1 233 238 PF02516 0.493
MOD_N-GLC_1 33 38 PF02516 0.454
MOD_N-GLC_1 363 368 PF02516 0.555
MOD_N-GLC_1 423 428 PF02516 0.488
MOD_N-GLC_1 599 604 PF02516 0.474
MOD_N-GLC_1 617 622 PF02516 0.695
MOD_N-GLC_1 63 68 PF02516 0.546
MOD_NEK2_1 114 119 PF00069 0.599
MOD_NEK2_1 157 162 PF00069 0.630
MOD_NEK2_1 20 25 PF00069 0.653
MOD_NEK2_1 215 220 PF00069 0.641
MOD_NEK2_1 259 264 PF00069 0.560
MOD_NEK2_1 415 420 PF00069 0.647
MOD_NEK2_1 432 437 PF00069 0.392
MOD_NEK2_1 541 546 PF00069 0.485
MOD_NEK2_1 768 773 PF00069 0.811
MOD_NEK2_2 148 153 PF00069 0.475
MOD_NEK2_2 261 266 PF00069 0.669
MOD_NEK2_2 442 447 PF00069 0.410
MOD_NEK2_2 552 557 PF00069 0.606
MOD_OFUCOSY 398 404 PF10250 0.588
MOD_OFUCOSY 565 572 PF10250 0.596
MOD_OFUCOSY 683 688 PF10250 0.639
MOD_PIKK_1 162 168 PF00454 0.571
MOD_PIKK_1 220 226 PF00454 0.638
MOD_PIKK_1 389 395 PF00454 0.490
MOD_PIKK_1 40 46 PF00454 0.549
MOD_PIKK_1 403 409 PF00454 0.525
MOD_PIKK_1 63 69 PF00454 0.541
MOD_PIKK_1 708 714 PF00454 0.676
MOD_PKA_2 195 201 PF00069 0.761
MOD_PKA_2 245 251 PF00069 0.496
MOD_PKA_2 28 34 PF00069 0.518
MOD_PKA_2 552 558 PF00069 0.439
MOD_Plk_1 135 141 PF00069 0.719
MOD_Plk_1 294 300 PF00069 0.615
MOD_Plk_1 33 39 PF00069 0.614
MOD_Plk_1 347 353 PF00069 0.547
MOD_Plk_1 363 369 PF00069 0.464
MOD_Plk_1 423 429 PF00069 0.456
MOD_Plk_1 432 438 PF00069 0.458
MOD_Plk_1 499 505 PF00069 0.568
MOD_Plk_1 530 536 PF00069 0.582
MOD_Plk_1 684 690 PF00069 0.631
MOD_Plk_1 70 76 PF00069 0.542
MOD_Plk_4 135 141 PF00069 0.664
MOD_Plk_4 165 171 PF00069 0.589
MOD_Plk_4 233 239 PF00069 0.470
MOD_Plk_4 28 34 PF00069 0.617
MOD_Plk_4 391 397 PF00069 0.581
MOD_Plk_4 425 431 PF00069 0.488
MOD_Plk_4 531 537 PF00069 0.473
MOD_Plk_4 70 76 PF00069 0.546
MOD_ProDKin_1 105 111 PF00069 0.544
MOD_ProDKin_1 160 166 PF00069 0.623
MOD_ProDKin_1 185 191 PF00069 0.713
MOD_ProDKin_1 268 274 PF00069 0.539
MOD_ProDKin_1 352 358 PF00069 0.507
MOD_ProDKin_1 387 393 PF00069 0.556
MOD_ProDKin_1 481 487 PF00069 0.584
MOD_ProDKin_1 59 65 PF00069 0.567
MOD_ProDKin_1 703 709 PF00069 0.648
TRG_ENDOCYTIC_2 124 127 PF00928 0.553
TRG_ENDOCYTIC_2 204 207 PF00928 0.462
TRG_ENDOCYTIC_2 209 212 PF00928 0.435
TRG_ENDOCYTIC_2 241 244 PF00928 0.488
TRG_ENDOCYTIC_2 373 376 PF00928 0.479
TRG_ENDOCYTIC_2 416 419 PF00928 0.602
TRG_ENDOCYTIC_2 517 520 PF00928 0.619
TRG_ENDOCYTIC_2 56 59 PF00928 0.613
TRG_ENDOCYTIC_2 717 720 PF00928 0.706
TRG_ENDOCYTIC_2 727 730 PF00928 0.618
TRG_ER_diArg_1 5 7 PF00400 0.578
TRG_ER_diArg_1 755 757 PF00400 0.561
TRG_ER_diArg_1 759 761 PF00400 0.592
TRG_ER_diArg_1 792 795 PF00400 0.757
TRG_ER_diArg_1 810 812 PF00400 0.702
TRG_NLS_MonoExtC_3 791 797 PF00514 0.694
TRG_Pf-PMV_PEXEL_1 447 451 PF00026 0.512
TRG_Pf-PMV_PEXEL_1 777 782 PF00026 0.750

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JPQ5 Bodo saltans 27% 100%
A0A1X0NFL6 Trypanosomatidae 32% 100%
A0A3Q8IFR8 Leishmania donovani 78% 100%
A0A3S7X4W3 Leishmania donovani 78% 100%
A4HJP2 Leishmania braziliensis 63% 100%
A4I711 Leishmania infantum 78% 100%
A4I759 Leishmania infantum 78% 100%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9B252 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9B253 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
Q4Q607 Leishmania major 99% 100%
Q4Q608 Leishmania major 99% 100%
V5BQ27 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS