LeishMANIAdb
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LysM domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LysM domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q607_LEIMA
TriTrypDb:
LmjF.31.2540 , LMJLV39_310034800 * , LMJSD75_310034900 *
Length:
845

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 4
NetGPI no yes: 0, no: 15
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15
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Expansion

Sequence features

Q4Q607
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q607

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 194 198 PF00656 0.530
CLV_C14_Caspase3-7 665 669 PF00656 0.442
CLV_NRD_NRD_1 776 778 PF00675 0.466
CLV_NRD_NRD_1 779 781 PF00675 0.485
CLV_NRD_NRD_1 811 813 PF00675 0.545
CLV_NRD_NRD_1 831 833 PF00675 0.517
CLV_NRD_NRD_1 836 838 PF00675 0.499
CLV_PCSK_FUR_1 777 781 PF00082 0.507
CLV_PCSK_KEX2_1 141 143 PF00082 0.633
CLV_PCSK_KEX2_1 776 778 PF00082 0.469
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0S4JPQ5 Bodo saltans 27% 100%
A0A1X0NFL6 Trypanosomatidae 32% 100%
A0A3Q8IFR8 Leishmania donovani 78% 100%
A0A3S7X4W3 Leishmania donovani 79% 100%
A4HJP2 Leishmania braziliensis 63% 100%
A4I711 Leishmania infantum 78% 100%
A4I759 Leishmania infantum 79% 100%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9B252 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS