Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q606_LEIMA

TriTrypDb:

LmjF.31.2550 , LMJLV39_310035000 , LMJSD75_310035000

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q606

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q606

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	470	474	PF00656	0.406
CLV_C14_Caspase3-7	50	54	PF00656	0.743
CLV_C14_Caspase3-7	58	62	PF00656	0.725
CLV_C14_Caspase3-7	673	677	PF00656	0.611
CLV_NRD_NRD_1	102	104	PF00675	0.604
CLV_NRD_NRD_1	262	264	PF00675	0.412
CLV_NRD_NRD_1	28	30	PF00675	0.411
CLV_NRD_NRD_1	446	448	PF00675	0.463
CLV_NRD_NRD_1	463	465	PF00675	0.436
CLV_NRD_NRD_1	489	491	PF00675	0.555
CLV_NRD_NRD_1	565	567	PF00675	0.625
CLV_PCSK_FUR_1	563	567	PF00082	0.653
CLV_PCSK_KEX2_1	102	104	PF00082	0.601
CLV_PCSK_KEX2_1	262	264	PF00082	0.412
CLV_PCSK_KEX2_1	28	30	PF00082	0.411
CLV_PCSK_KEX2_1	357	359	PF00082	0.514
CLV_PCSK_KEX2_1	446	448	PF00082	0.430
CLV_PCSK_KEX2_1	463	465	PF00082	0.436
CLV_PCSK_KEX2_1	489	491	PF00082	0.555
CLV_PCSK_KEX2_1	565	567	PF00082	0.630
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.514
CLV_PCSK_SKI1_1	103	107	PF00082	0.409
CLV_PCSK_SKI1_1	183	187	PF00082	0.481
CLV_PCSK_SKI1_1	250	254	PF00082	0.455
CLV_PCSK_SKI1_1	312	316	PF00082	0.417
CLV_PCSK_SKI1_1	357	361	PF00082	0.506
CLV_PCSK_SKI1_1	490	494	PF00082	0.510
CLV_PCSK_SKI1_1	602	606	PF00082	0.689
DEG_APCC_DBOX_1	780	788	PF00400	0.571
DEG_MDM2_SWIB_1	261	268	PF02201	0.309
DEG_Nend_Nbox_1	1	3	PF02207	0.380
DEG_SCF_TRCP1_1	61	67	PF00400	0.559
DEG_SPOP_SBC_1	54	58	PF00917	0.607
DEG_SPOP_SBC_1	631	635	PF00917	0.612
DOC_CKS1_1	648	653	PF01111	0.753
DOC_CKS1_1	77	82	PF01111	0.536
DOC_CYCLIN_RxL_1	177	188	PF00134	0.468
DOC_CYCLIN_RxL_1	380	389	PF00134	0.498
DOC_CYCLIN_yClb1_LxF_4	248	253	PF00134	0.413
DOC_MAPK_gen_1	102	113	PF00069	0.423
DOC_MAPK_gen_1	357	367	PF00069	0.388
DOC_MAPK_gen_1	489	495	PF00069	0.577
DOC_MAPK_gen_1	600	608	PF00069	0.559
DOC_PP1_RVXF_1	18	25	PF00149	0.462
DOC_PP1_RVXF_1	248	254	PF00149	0.472
DOC_PP4_FxxP_1	423	426	PF00568	0.462
DOC_USP7_MATH_1	121	125	PF00917	0.540
DOC_USP7_MATH_1	207	211	PF00917	0.568
DOC_USP7_MATH_1	629	633	PF00917	0.680
DOC_USP7_MATH_1	741	745	PF00917	0.703
DOC_USP7_MATH_1	78	82	PF00917	0.713
DOC_USP7_UBL2_3	357	361	PF12436	0.425
DOC_WW_Pin1_4	144	149	PF00397	0.613
DOC_WW_Pin1_4	229	234	PF00397	0.539
DOC_WW_Pin1_4	350	355	PF00397	0.442
DOC_WW_Pin1_4	437	442	PF00397	0.514
DOC_WW_Pin1_4	627	632	PF00397	0.793
DOC_WW_Pin1_4	647	652	PF00397	0.793
DOC_WW_Pin1_4	754	759	PF00397	0.592
DOC_WW_Pin1_4	76	81	PF00397	0.727
LIG_14-3-3_CanoR_1	704	711	PF00244	0.647
LIG_AP2alpha_2	178	180	PF02296	0.408
LIG_BRCT_BRCA1_1	346	350	PF00533	0.505
LIG_BRCT_BRCA1_1	83	87	PF00533	0.522
LIG_EVH1_2	95	99	PF00568	0.427
LIG_FHA_1	106	112	PF00498	0.365
LIG_FHA_1	17	23	PF00498	0.375
LIG_FHA_1	351	357	PF00498	0.642
LIG_FHA_1	376	382	PF00498	0.584
LIG_FHA_1	402	408	PF00498	0.374
LIG_FHA_1	431	437	PF00498	0.547
LIG_FHA_1	438	444	PF00498	0.475
LIG_FHA_1	460	466	PF00498	0.519
LIG_FHA_1	603	609	PF00498	0.670
LIG_FHA_1	632	638	PF00498	0.722
LIG_FHA_1	642	648	PF00498	0.725
LIG_FHA_2	113	119	PF00498	0.517
LIG_FHA_2	2	8	PF00498	0.442
LIG_FHA_2	323	329	PF00498	0.640
LIG_FHA_2	481	487	PF00498	0.524
LIG_FHA_2	56	62	PF00498	0.753
LIG_FHA_2	763	769	PF00498	0.626
LIG_FHA_2	86	92	PF00498	0.581
LIG_LIR_Apic_2	421	426	PF02991	0.460
LIG_LIR_Apic_2	696	701	PF02991	0.721
LIG_LIR_Gen_1	184	193	PF02991	0.430
LIG_LIR_Gen_1	302	310	PF02991	0.453
LIG_LIR_Gen_1	392	403	PF02991	0.402
LIG_LIR_Gen_1	454	465	PF02991	0.532
LIG_LIR_Gen_1	514	524	PF02991	0.573
LIG_LIR_Nem_3	127	133	PF02991	0.420
LIG_LIR_Nem_3	184	189	PF02991	0.406
LIG_LIR_Nem_3	191	196	PF02991	0.429
LIG_LIR_Nem_3	258	264	PF02991	0.376
LIG_LIR_Nem_3	302	307	PF02991	0.455
LIG_LIR_Nem_3	392	398	PF02991	0.378
LIG_LIR_Nem_3	421	427	PF02991	0.471
LIG_LIR_Nem_3	454	460	PF02991	0.512
LIG_LIR_Nem_3	514	519	PF02991	0.563
LIG_LIR_Nem_3	693	698	PF02991	0.684
LIG_MYND_1	152	156	PF01753	0.546
LIG_Pex14_2	13	17	PF04695	0.582
LIG_Pex14_2	261	265	PF04695	0.311
LIG_Rb_pABgroove_1	180	188	PF01858	0.474
LIG_REV1ctd_RIR_1	178	187	PF16727	0.470
LIG_SH2_CRK	274	278	PF00017	0.453
LIG_SH2_CRK	282	286	PF00017	0.415
LIG_SH2_CRK	439	443	PF00017	0.395
LIG_SH2_NCK_1	716	720	PF00017	0.622
LIG_SH2_STAP1	274	278	PF00017	0.519
LIG_SH2_STAP1	33	37	PF00017	0.477
LIG_SH2_STAP1	538	542	PF00017	0.573
LIG_SH2_STAP1	695	699	PF00017	0.604
LIG_SH2_STAT3	266	269	PF00017	0.387
LIG_SH2_STAT3	705	708	PF00017	0.563
LIG_SH2_STAT5	175	178	PF00017	0.472
LIG_SH2_STAT5	266	269	PF00017	0.387
LIG_SH2_STAT5	3	6	PF00017	0.429
LIG_SH2_STAT5	30	33	PF00017	0.443
LIG_SH2_STAT5	316	319	PF00017	0.354
LIG_SH2_STAT5	324	327	PF00017	0.436
LIG_SH2_STAT5	364	367	PF00017	0.361
LIG_SH2_STAT5	439	442	PF00017	0.388
LIG_SH2_STAT5	479	482	PF00017	0.422
LIG_SH2_STAT5	698	701	PF00017	0.685
LIG_SH2_STAT5	705	708	PF00017	0.661
LIG_SH3_3	146	152	PF00018	0.500
LIG_SH3_3	230	236	PF00018	0.549
LIG_SH3_3	284	290	PF00018	0.421
LIG_SH3_3	423	429	PF00018	0.372
LIG_SH3_3	567	573	PF00018	0.603
LIG_SH3_3	726	732	PF00018	0.596
LIG_SH3_3	89	95	PF00018	0.616
LIG_TRAF2_1	325	328	PF00917	0.423
LIG_TRAF2_1	483	486	PF00917	0.450
LIG_TRAF2_1	707	710	PF00917	0.629
LIG_TRAF2_1	776	779	PF00917	0.582
LIG_TYR_ITIM	272	277	PF00017	0.455
LIG_WRC_WIRS_1	315	320	PF05994	0.415
MOD_CDK_SPK_2	229	234	PF00069	0.539
MOD_CDK_SPK_2	350	355	PF00069	0.442
MOD_CDK_SPxxK_3	350	357	PF00069	0.421
MOD_CK1_1	16	22	PF00069	0.571
MOD_CK1_1	331	337	PF00069	0.575
MOD_CK1_1	344	350	PF00069	0.456
MOD_CK1_1	459	465	PF00069	0.504
MOD_CK1_1	46	52	PF00069	0.657
MOD_CK1_1	475	481	PF00069	0.455
MOD_CK1_1	501	507	PF00069	0.626
MOD_CK1_1	62	68	PF00069	0.684
MOD_CK1_1	627	633	PF00069	0.784
MOD_CK1_1	679	685	PF00069	0.735
MOD_CK1_1	686	692	PF00069	0.695
MOD_CK1_1	693	699	PF00069	0.675
MOD_CK1_1	721	727	PF00069	0.706
MOD_CK1_1	744	750	PF00069	0.752
MOD_CK1_1	81	87	PF00069	0.798
MOD_CK2_1	1	7	PF00069	0.403
MOD_CK2_1	112	118	PF00069	0.489
MOD_CK2_1	121	127	PF00069	0.485
MOD_CK2_1	158	164	PF00069	0.590
MOD_CK2_1	252	258	PF00069	0.483
MOD_CK2_1	322	328	PF00069	0.610
MOD_CK2_1	480	486	PF00069	0.573
MOD_CK2_1	550	556	PF00069	0.566
MOD_CK2_1	681	687	PF00069	0.758
MOD_CK2_1	704	710	PF00069	0.640
MOD_CK2_1	762	768	PF00069	0.678
MOD_CK2_1	85	91	PF00069	0.494
MOD_GlcNHglycan	118	122	PF01048	0.520
MOD_GlcNHglycan	209	212	PF01048	0.567
MOD_GlcNHglycan	330	333	PF01048	0.566
MOD_GlcNHglycan	346	349	PF01048	0.436
MOD_GlcNHglycan	552	555	PF01048	0.539
MOD_GlcNHglycan	61	64	PF01048	0.810
MOD_GlcNHglycan	617	620	PF01048	0.738
MOD_GlcNHglycan	626	629	PF01048	0.743
MOD_GlcNHglycan	662	665	PF01048	0.645
MOD_GlcNHglycan	678	681	PF01048	0.739
MOD_GlcNHglycan	712	715	PF01048	0.760
MOD_GlcNHglycan	720	723	PF01048	0.715
MOD_GlcNHglycan	742	746	PF01048	0.661
MOD_GlcNHglycan	750	753	PF01048	0.733
MOD_GlcNHglycan	81	84	PF01048	0.533
MOD_GSK3_1	117	124	PF00069	0.534
MOD_GSK3_1	299	306	PF00069	0.535
MOD_GSK3_1	327	334	PF00069	0.632
MOD_GSK3_1	342	349	PF00069	0.680
MOD_GSK3_1	452	459	PF00069	0.451
MOD_GSK3_1	52	59	PF00069	0.709
MOD_GSK3_1	623	630	PF00069	0.714
MOD_GSK3_1	675	682	PF00069	0.749
MOD_GSK3_1	686	693	PF00069	0.710
MOD_GSK3_1	72	79	PF00069	0.748
MOD_GSK3_1	741	748	PF00069	0.746
MOD_GSK3_1	81	88	PF00069	0.666
MOD_N-GLC_1	499	504	PF02516	0.649
MOD_N-GLC_1	748	753	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.456
MOD_NEK2_1	13	18	PF00069	0.570
MOD_NEK2_1	185	190	PF00069	0.484
MOD_NEK2_1	341	346	PF00069	0.713
MOD_NEK2_1	375	380	PF00069	0.484
MOD_NEK2_1	777	782	PF00069	0.706
MOD_NEK2_1	85	90	PF00069	0.497
MOD_NEK2_2	23	28	PF00069	0.511
MOD_OFUCOSY	450	456	PF10250	0.461
MOD_PIKK_1	158	164	PF00454	0.613
MOD_PIKK_1	667	673	PF00454	0.745
MOD_PIKK_1	704	710	PF00454	0.580
MOD_PKA_2	375	381	PF00069	0.513
MOD_PKA_2	592	598	PF00069	0.669
MOD_PKB_1	600	608	PF00069	0.710
MOD_Plk_1	121	127	PF00069	0.656
MOD_Plk_1	342	348	PF00069	0.695
MOD_Plk_1	472	478	PF00069	0.510
MOD_Plk_1	499	505	PF00069	0.526
MOD_Plk_1	602	608	PF00069	0.706
MOD_Plk_1	686	692	PF00069	0.687
MOD_Plk_1	693	699	PF00069	0.590
MOD_Plk_1	748	754	PF00069	0.774
MOD_Plk_1	762	768	PF00069	0.654
MOD_Plk_1	85	91	PF00069	0.538
MOD_Plk_2-3	762	768	PF00069	0.678
MOD_Plk_4	1	7	PF00069	0.420
MOD_Plk_4	218	224	PF00069	0.659
MOD_Plk_4	226	232	PF00069	0.595
MOD_Plk_4	267	273	PF00069	0.414
MOD_Plk_4	299	305	PF00069	0.436
MOD_Plk_4	314	320	PF00069	0.340
MOD_Plk_4	368	374	PF00069	0.460
MOD_Plk_4	475	481	PF00069	0.430
MOD_Plk_4	511	517	PF00069	0.476
MOD_Plk_4	633	639	PF00069	0.614
MOD_Plk_4	686	692	PF00069	0.598
MOD_ProDKin_1	144	150	PF00069	0.619
MOD_ProDKin_1	229	235	PF00069	0.536
MOD_ProDKin_1	350	356	PF00069	0.427
MOD_ProDKin_1	437	443	PF00069	0.508
MOD_ProDKin_1	627	633	PF00069	0.795
MOD_ProDKin_1	647	653	PF00069	0.751
MOD_ProDKin_1	754	760	PF00069	0.592
MOD_ProDKin_1	76	82	PF00069	0.725
MOD_SUMO_for_1	236	239	PF00179	0.587
MOD_SUMO_for_1	37	40	PF00179	0.408
TRG_AP2beta_CARGO_1	191	200	PF09066	0.528
TRG_AP2beta_CARGO_1	454	464	PF09066	0.535
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.535
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.428
TRG_ENDOCYTIC_2	274	277	PF00928	0.445
TRG_ENDOCYTIC_2	282	285	PF00928	0.431
TRG_ENDOCYTIC_2	3	6	PF00928	0.313
TRG_ENDOCYTIC_2	316	319	PF00928	0.365
TRG_ENDOCYTIC_2	364	367	PF00928	0.361
TRG_ENDOCYTIC_2	439	442	PF00928	0.399
TRG_ER_diArg_1	101	103	PF00400	0.598
TRG_ER_diArg_1	253	256	PF00400	0.434
TRG_ER_diArg_1	261	263	PF00400	0.376
TRG_ER_diArg_1	27	29	PF00400	0.479
TRG_ER_diArg_1	445	447	PF00400	0.442
TRG_ER_diArg_1	463	465	PF00400	0.358
TRG_ER_diArg_1	466	469	PF00400	0.415
TRG_ER_diArg_1	489	491	PF00400	0.546
TRG_ER_diArg_1	597	600	PF00400	0.709
TRG_NLS_MonoExtN_4	102	107	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	578	583	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	704	708	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	764	768	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW18	Leptomonas seymouri	43%	88%
A0A0N1PBA0	Leptomonas seymouri	56%	96%
A0A1X0NIQ9	Trypanosomatidae	35%	100%
A0A3Q8ICR1	Leishmania donovani	43%	89%
A0A3Q8ISU5	Leishmania donovani	91%	100%
A0A3R7KGN9	Trypanosoma rangeli	34%	100%
A4HJP3	Leishmania braziliensis	74%	100%
A4HJP4	Leishmania braziliensis	44%	89%
A4I760	Leishmania infantum	91%	100%
A4I761	Leishmania infantum	43%	89%
E9B254	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B255	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	77%
Q4Q605	Leishmania major	42%	78%
V5BC23	Trypanosoma cruzi	34%	100%