CABIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q604_LEIMA

TriTrypDb:

LmjF.31.2570 , LMJLV39_310035200 , LMJSD75_310035200

Length:

1111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q604

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q604

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1039	1043	PF00656	0.781
CLV_C14_Caspase3-7	162	166	PF00656	0.716
CLV_C14_Caspase3-7	252	256	PF00656	0.597
CLV_NRD_NRD_1	1077	1079	PF00675	0.725
CLV_NRD_NRD_1	284	286	PF00675	0.653
CLV_NRD_NRD_1	360	362	PF00675	0.466
CLV_NRD_NRD_1	470	472	PF00675	0.405
CLV_NRD_NRD_1	579	581	PF00675	0.635
CLV_NRD_NRD_1	67	69	PF00675	0.555
CLV_NRD_NRD_1	685	687	PF00675	0.702
CLV_NRD_NRD_1	695	697	PF00675	0.622
CLV_PCSK_FUR_1	683	687	PF00082	0.709
CLV_PCSK_KEX2_1	1077	1079	PF00082	0.725
CLV_PCSK_KEX2_1	284	286	PF00082	0.644
CLV_PCSK_KEX2_1	360	362	PF00082	0.466
CLV_PCSK_KEX2_1	470	472	PF00082	0.405
CLV_PCSK_KEX2_1	551	553	PF00082	0.567
CLV_PCSK_KEX2_1	579	581	PF00082	0.635
CLV_PCSK_KEX2_1	685	687	PF00082	0.702
CLV_PCSK_KEX2_1	695	697	PF00082	0.622
CLV_PCSK_PC1ET2_1	551	553	PF00082	0.567
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.719
CLV_PCSK_PC7_1	356	362	PF00082	0.455
CLV_PCSK_SKI1_1	100	104	PF00082	0.583
CLV_PCSK_SKI1_1	321	325	PF00082	0.420
CLV_PCSK_SKI1_1	356	360	PF00082	0.456
CLV_PCSK_SKI1_1	470	474	PF00082	0.400
CLV_PCSK_SKI1_1	649	653	PF00082	0.800
CLV_PCSK_SKI1_1	68	72	PF00082	0.506
CLV_PCSK_SKI1_1	686	690	PF00082	0.795
CLV_PCSK_SKI1_1	705	709	PF00082	0.539
CLV_PCSK_SKI1_1	966	970	PF00082	0.728
DEG_APCC_DBOX_1	99	107	PF00400	0.571
DEG_SCF_FBW7_1	267	274	PF00400	0.793
DEG_SPOP_SBC_1	1012	1016	PF00917	0.745
DEG_SPOP_SBC_1	748	752	PF00917	0.623
DOC_ANK_TNKS_1	770	777	PF00023	0.783
DOC_CKS1_1	268	273	PF01111	0.794
DOC_CYCLIN_RxL_1	406	415	PF00134	0.420
DOC_CYCLIN_RxL_1	683	693	PF00134	0.786
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.494
DOC_MAPK_gen_1	294	303	PF00069	0.524
DOC_MAPK_gen_1	360	367	PF00069	0.452
DOC_MAPK_gen_1	476	485	PF00069	0.460
DOC_MAPK_gen_1	68	78	PF00069	0.455
DOC_MAPK_gen_1	683	690	PF00069	0.648
DOC_MAPK_MEF2A_6	100	107	PF00069	0.562
DOC_MAPK_MEF2A_6	296	305	PF00069	0.476
DOC_MAPK_NFAT4_5	100	108	PF00069	0.557
DOC_PP1_RVXF_1	17	24	PF00149	0.392
DOC_PP1_RVXF_1	66	73	PF00149	0.518
DOC_PP2B_LxvP_1	199	202	PF13499	0.802
DOC_PP2B_LxvP_1	672	675	PF13499	0.783
DOC_PP2B_LxvP_1	782	785	PF13499	0.596
DOC_PP4_FxxP_1	1103	1106	PF00568	0.614
DOC_PP4_FxxP_1	264	267	PF00568	0.743
DOC_PP4_MxPP_1	673	676	PF00568	0.782
DOC_USP7_MATH_1	1022	1026	PF00917	0.676
DOC_USP7_MATH_1	1090	1094	PF00917	0.621
DOC_USP7_MATH_1	22	26	PF00917	0.476
DOC_USP7_MATH_1	271	275	PF00917	0.662
DOC_USP7_MATH_1	487	491	PF00917	0.546
DOC_USP7_MATH_1	586	590	PF00917	0.702
DOC_USP7_MATH_1	620	624	PF00917	0.718
DOC_USP7_MATH_1	631	635	PF00917	0.559
DOC_USP7_MATH_1	647	651	PF00917	0.638
DOC_USP7_MATH_1	733	737	PF00917	0.602
DOC_USP7_MATH_1	748	752	PF00917	0.788
DOC_USP7_MATH_1	757	761	PF00917	0.723
DOC_USP7_MATH_1	764	768	PF00917	0.613
DOC_USP7_MATH_1	778	782	PF00917	0.631
DOC_USP7_MATH_1	802	806	PF00917	0.692
DOC_USP7_MATH_1	92	96	PF00917	0.685
DOC_USP7_MATH_1	939	943	PF00917	0.626
DOC_USP7_MATH_1	958	962	PF00917	0.511
DOC_USP7_UBL2_3	290	294	PF12436	0.696
DOC_USP7_UBL2_3	71	75	PF12436	0.448
DOC_WW_Pin1_4	1013	1018	PF00397	0.699
DOC_WW_Pin1_4	1086	1091	PF00397	0.675
DOC_WW_Pin1_4	1102	1107	PF00397	0.599
DOC_WW_Pin1_4	191	196	PF00397	0.726
DOC_WW_Pin1_4	263	268	PF00397	0.670
DOC_WW_Pin1_4	541	546	PF00397	0.648
DOC_WW_Pin1_4	7	12	PF00397	0.497
DOC_WW_Pin1_4	749	754	PF00397	0.674
DOC_WW_Pin1_4	793	798	PF00397	0.694
DOC_WW_Pin1_4	916	921	PF00397	0.666
DOC_WW_Pin1_4	946	951	PF00397	0.752
DOC_WW_Pin1_4	961	966	PF00397	0.555
LIG_14-3-3_CanoR_1	100	106	PF00244	0.567
LIG_14-3-3_CanoR_1	147	157	PF00244	0.646
LIG_14-3-3_CanoR_1	276	282	PF00244	0.790
LIG_14-3-3_CanoR_1	314	319	PF00244	0.432
LIG_14-3-3_CanoR_1	424	430	PF00244	0.412
LIG_14-3-3_CanoR_1	633	637	PF00244	0.551
LIG_14-3-3_CanoR_1	792	797	PF00244	0.761
LIG_14-3-3_CanoR_1	801	810	PF00244	0.661
LIG_14-3-3_CanoR_1	889	898	PF00244	0.647
LIG_Actin_WH2_2	462	480	PF00022	0.415
LIG_BRCT_BRCA1_1	93	97	PF00533	0.535
LIG_Clathr_ClatBox_1	400	404	PF01394	0.430
LIG_EH1_1	591	599	PF00400	0.776
LIG_FHA_1	102	108	PF00498	0.402
LIG_FHA_1	1060	1066	PF00498	0.751
LIG_FHA_1	149	155	PF00498	0.721
LIG_FHA_1	172	178	PF00498	0.792
LIG_FHA_1	31	37	PF00498	0.552
LIG_FHA_1	348	354	PF00498	0.449
LIG_FHA_1	528	534	PF00498	0.679
LIG_FHA_1	744	750	PF00498	0.782
LIG_FHA_1	807	813	PF00498	0.672
LIG_FHA_1	916	922	PF00498	0.789
LIG_FHA_2	495	501	PF00498	0.496
LIG_FHA_2	514	520	PF00498	0.435
LIG_FHA_2	689	695	PF00498	0.655
LIG_FHA_2	750	756	PF00498	0.732
LIG_LIR_Apic_2	261	267	PF02991	0.740
LIG_LIR_Gen_1	140	149	PF02991	0.625
LIG_LIR_Gen_1	196	206	PF02991	0.663
LIG_LIR_Gen_1	428	437	PF02991	0.418
LIG_LIR_Gen_1	440	448	PF02991	0.441
LIG_LIR_Gen_1	502	510	PF02991	0.434
LIG_LIR_Gen_1	514	525	PF02991	0.460
LIG_LIR_Gen_1	553	562	PF02991	0.570
LIG_LIR_Nem_3	140	145	PF02991	0.689
LIG_LIR_Nem_3	219	225	PF02991	0.645
LIG_LIR_Nem_3	24	30	PF02991	0.401
LIG_LIR_Nem_3	277	282	PF02991	0.653
LIG_LIR_Nem_3	311	316	PF02991	0.431
LIG_LIR_Nem_3	364	370	PF02991	0.413
LIG_LIR_Nem_3	428	432	PF02991	0.380
LIG_LIR_Nem_3	436	441	PF02991	0.459
LIG_LIR_Nem_3	502	507	PF02991	0.444
LIG_LIR_Nem_3	514	520	PF02991	0.446
LIG_LIR_Nem_3	553	558	PF02991	0.550
LIG_LIR_Nem_3	809	813	PF02991	0.682
LIG_PTB_Apo_2	658	665	PF02174	0.708
LIG_REV1ctd_RIR_1	2	10	PF16727	0.404
LIG_REV1ctd_RIR_1	279	289	PF16727	0.641
LIG_SH2_CRK	27	31	PF00017	0.393
LIG_SH2_CRK	504	508	PF00017	0.426
LIG_SH2_CRK	810	814	PF00017	0.675
LIG_SH2_GRB2like	659	662	PF00017	0.710
LIG_SH2_NCK_1	517	521	PF00017	0.447
LIG_SH2_NCK_1	659	663	PF00017	0.708
LIG_SH2_STAP1	32	36	PF00017	0.551
LIG_SH2_STAP1	368	372	PF00017	0.396
LIG_SH2_STAP1	517	521	PF00017	0.447
LIG_SH2_STAT3	368	371	PF00017	0.394
LIG_SH2_STAT3	377	380	PF00017	0.481
LIG_SH2_STAT3	523	526	PF00017	0.595
LIG_SH2_STAT5	29	32	PF00017	0.382
LIG_SH2_STAT5	3	6	PF00017	0.406
LIG_SH2_STAT5	377	380	PF00017	0.484
LIG_SH2_STAT5	390	393	PF00017	0.402
LIG_SH2_STAT5	421	424	PF00017	0.391
LIG_SH2_STAT5	517	520	PF00017	0.434
LIG_SH2_STAT5	523	526	PF00017	0.458
LIG_SH2_STAT5	88	91	PF00017	0.542
LIG_SH3_3	1104	1110	PF00018	0.677
LIG_SH3_3	174	180	PF00018	0.724
LIG_SH3_3	189	195	PF00018	0.559
LIG_SH3_3	199	205	PF00018	0.668
LIG_SH3_3	265	271	PF00018	0.663
LIG_SH3_3	336	342	PF00018	0.492
LIG_SH3_3	439	445	PF00018	0.397
LIG_SH3_3	610	616	PF00018	0.726
LIG_SH3_3	715	721	PF00018	0.724
LIG_SH3_3	760	766	PF00018	0.760
LIG_SH3_3	831	837	PF00018	0.623
LIG_SH3_3	879	885	PF00018	0.672
LIG_SH3_3	892	898	PF00018	0.564
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.389
LIG_SUMO_SIM_anti_2	224	234	PF11976	0.654
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.391
LIG_TRAF2_1	479	482	PF00917	0.466
LIG_TRFH_1	810	814	PF08558	0.675
LIG_UBA3_1	398	406	PF00899	0.423
LIG_ULM_U2AF65_1	68	73	PF00076	0.499
LIG_WW_3	762	766	PF00397	0.768
MOD_CDK_SPK_2	961	966	PF00069	0.791
MOD_CK1_1	10	16	PF00069	0.464
MOD_CK1_1	1025	1031	PF00069	0.585
MOD_CK1_1	1088	1094	PF00069	0.654
MOD_CK1_1	135	141	PF00069	0.611
MOD_CK1_1	143	149	PF00069	0.611
MOD_CK1_1	152	158	PF00069	0.515
MOD_CK1_1	172	178	PF00069	0.495
MOD_CK1_1	251	257	PF00069	0.730
MOD_CK1_1	266	272	PF00069	0.650
MOD_CK1_1	274	280	PF00069	0.664
MOD_CK1_1	425	431	PF00069	0.427
MOD_CK1_1	494	500	PF00069	0.495
MOD_CK1_1	515	521	PF00069	0.546
MOD_CK1_1	546	552	PF00069	0.713
MOD_CK1_1	582	588	PF00069	0.710
MOD_CK1_1	62	68	PF00069	0.583
MOD_CK1_1	641	647	PF00069	0.645
MOD_CK1_1	660	666	PF00069	0.593
MOD_CK1_1	767	773	PF00069	0.807
MOD_CK1_1	912	918	PF00069	0.780
MOD_CK1_1	929	935	PF00069	0.509
MOD_CK1_1	961	967	PF00069	0.617
MOD_CK2_1	206	212	PF00069	0.560
MOD_CK2_1	240	246	PF00069	0.678
MOD_CK2_1	563	569	PF00069	0.604
MOD_CK2_1	749	755	PF00069	0.732
MOD_CK2_1	961	967	PF00069	0.655
MOD_Cter_Amidation	1075	1078	PF01082	0.727
MOD_DYRK1A_RPxSP_1	946	950	PF00069	0.756
MOD_GlcNHglycan	1024	1027	PF01048	0.622
MOD_GlcNHglycan	125	128	PF01048	0.629
MOD_GlcNHglycan	195	198	PF01048	0.768
MOD_GlcNHglycan	276	279	PF01048	0.630
MOD_GlcNHglycan	54	57	PF01048	0.606
MOD_GlcNHglycan	584	587	PF01048	0.775
MOD_GlcNHglycan	617	620	PF01048	0.751
MOD_GlcNHglycan	62	65	PF01048	0.635
MOD_GlcNHglycan	622	625	PF01048	0.640
MOD_GlcNHglycan	649	652	PF01048	0.756
MOD_GlcNHglycan	72	75	PF01048	0.584
MOD_GlcNHglycan	735	739	PF01048	0.729
MOD_GlcNHglycan	759	762	PF01048	0.790
MOD_GlcNHglycan	873	876	PF01048	0.747
MOD_GlcNHglycan	891	894	PF01048	0.695
MOD_GlcNHglycan	924	927	PF01048	0.699
MOD_GlcNHglycan	931	934	PF01048	0.586
MOD_GlcNHglycan	941	944	PF01048	0.565
MOD_GlcNHglycan	950	953	PF01048	0.667
MOD_GlcNHglycan	956	959	PF01048	0.613
MOD_GSK3_1	1081	1088	PF00069	0.671
MOD_GSK3_1	123	130	PF00069	0.639
MOD_GSK3_1	131	138	PF00069	0.636
MOD_GSK3_1	143	150	PF00069	0.451
MOD_GSK3_1	236	243	PF00069	0.681
MOD_GSK3_1	244	251	PF00069	0.676
MOD_GSK3_1	263	270	PF00069	0.548
MOD_GSK3_1	30	37	PF00069	0.409
MOD_GSK3_1	451	458	PF00069	0.495
MOD_GSK3_1	487	494	PF00069	0.538
MOD_GSK3_1	511	518	PF00069	0.430
MOD_GSK3_1	539	546	PF00069	0.672
MOD_GSK3_1	58	65	PF00069	0.640
MOD_GSK3_1	582	589	PF00069	0.718
MOD_GSK3_1	593	600	PF00069	0.613
MOD_GSK3_1	615	622	PF00069	0.754
MOD_GSK3_1	641	648	PF00069	0.636
MOD_GSK3_1	743	750	PF00069	0.665
MOD_GSK3_1	792	799	PF00069	0.671
MOD_GSK3_1	802	809	PF00069	0.623
MOD_GSK3_1	812	819	PF00069	0.569
MOD_GSK3_1	845	852	PF00069	0.658
MOD_GSK3_1	867	874	PF00069	0.769
MOD_GSK3_1	909	916	PF00069	0.621
MOD_GSK3_1	922	929	PF00069	0.661
MOD_GSK3_1	954	961	PF00069	0.658
MOD_GSK3_1	969	976	PF00069	0.641
MOD_N-GLC_1	127	132	PF02516	0.634
MOD_N-GLC_1	206	211	PF02516	0.652
MOD_N-GLC_1	425	430	PF02516	0.557
MOD_N-GLC_1	452	457	PF02516	0.509
MOD_N-GLC_1	59	64	PF02516	0.754
MOD_N-GLC_1	660	665	PF02516	0.640
MOD_N-GLC_1	705	710	PF02516	0.714
MOD_N-GLC_1	959	964	PF02516	0.661
MOD_N-GLC_1	973	978	PF02516	0.677
MOD_NEK2_1	141	146	PF00069	0.666
MOD_NEK2_1	30	35	PF00069	0.401
MOD_NEK2_1	513	518	PF00069	0.566
MOD_NEK2_1	574	579	PF00069	0.793
MOD_NEK2_1	593	598	PF00069	0.499
MOD_NEK2_1	657	662	PF00069	0.712
MOD_NEK2_1	688	693	PF00069	0.654
MOD_NEK2_1	826	831	PF00069	0.779
MOD_NEK2_1	909	914	PF00069	0.691
MOD_NEK2_2	487	492	PF00069	0.584
MOD_OFUCOSY	637	642	PF10250	0.678
MOD_PIKK_1	10	16	PF00454	0.601
MOD_PIKK_1	1059	1065	PF00454	0.737
MOD_PIKK_1	574	580	PF00454	0.657
MOD_PIKK_1	641	647	PF00454	0.627
MOD_PIKK_1	667	673	PF00454	0.633
MOD_PIKK_1	76	82	PF00454	0.416
MOD_PIKK_1	812	818	PF00454	0.776
MOD_PIKK_1	864	870	PF00454	0.701
MOD_PK_1	153	159	PF00069	0.705
MOD_PK_1	579	585	PF00069	0.676
MOD_PKA_1	579	585	PF00069	0.676
MOD_PKA_2	152	158	PF00069	0.750
MOD_PKA_2	491	497	PF00069	0.556
MOD_PKA_2	579	585	PF00069	0.711
MOD_PKA_2	632	638	PF00069	0.554
MOD_PKA_2	764	770	PF00069	0.664
MOD_PKA_2	791	797	PF00069	0.623
MOD_Plk_1	127	133	PF00069	0.761
MOD_Plk_1	135	141	PF00069	0.589
MOD_Plk_1	206	212	PF00069	0.650
MOD_Plk_1	235	241	PF00069	0.683
MOD_Plk_1	425	431	PF00069	0.550
MOD_Plk_1	452	458	PF00069	0.497
MOD_Plk_1	660	666	PF00069	0.637
MOD_Plk_1	740	746	PF00069	0.704
MOD_Plk_2-3	244	250	PF00069	0.813
MOD_Plk_2-3	820	826	PF00069	0.736
MOD_Plk_2-3	984	990	PF00069	0.667
MOD_Plk_4	101	107	PF00069	0.413
MOD_Plk_4	277	283	PF00069	0.659
MOD_Plk_4	296	302	PF00069	0.433
MOD_Plk_4	394	400	PF00069	0.389
MOD_Plk_4	425	431	PF00069	0.413
MOD_Plk_4	464	470	PF00069	0.396
MOD_Plk_4	593	599	PF00069	0.777
MOD_Plk_4	660	666	PF00069	0.637
MOD_Plk_4	995	1001	PF00069	0.668
MOD_ProDKin_1	1013	1019	PF00069	0.699
MOD_ProDKin_1	1086	1092	PF00069	0.670
MOD_ProDKin_1	1102	1108	PF00069	0.595
MOD_ProDKin_1	191	197	PF00069	0.729
MOD_ProDKin_1	263	269	PF00069	0.670
MOD_ProDKin_1	541	547	PF00069	0.652
MOD_ProDKin_1	7	13	PF00069	0.502
MOD_ProDKin_1	749	755	PF00069	0.679
MOD_ProDKin_1	793	799	PF00069	0.693
MOD_ProDKin_1	916	922	PF00069	0.667
MOD_ProDKin_1	946	952	PF00069	0.754
MOD_ProDKin_1	961	967	PF00069	0.556
TRG_DiLeu_BaEn_2	1098	1104	PF01217	0.768
TRG_DiLeu_BaEn_4	502	508	PF01217	0.502
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.649
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.394
TRG_ENDOCYTIC_2	27	30	PF00928	0.395
TRG_ENDOCYTIC_2	279	282	PF00928	0.651
TRG_ENDOCYTIC_2	3	6	PF00928	0.406
TRG_ENDOCYTIC_2	310	313	PF00928	0.429
TRG_ENDOCYTIC_2	390	393	PF00928	0.386
TRG_ENDOCYTIC_2	438	441	PF00928	0.416
TRG_ENDOCYTIC_2	504	507	PF00928	0.430
TRG_ENDOCYTIC_2	517	520	PF00928	0.434
TRG_ENDOCYTIC_2	555	558	PF00928	0.545
TRG_ENDOCYTIC_2	810	813	PF00928	0.688
TRG_ER_diArg_1	318	321	PF00400	0.412
TRG_ER_diArg_1	359	361	PF00400	0.463
TRG_ER_diArg_1	469	471	PF00400	0.402
TRG_ER_diArg_1	579	581	PF00400	0.747
TRG_NES_CRM1_1	463	475	PF08389	0.405
TRG_NLS_MonoExtN_4	683	689	PF00514	0.783
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P1	Leptomonas seymouri	57%	97%
A0A3S7X4T2	Leishmania donovani	94%	100%
A4HJP5	Leishmania braziliensis	78%	100%
A4I762	Leishmania infantum	94%	100%
E9B256	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%