Ubiquinol-cytochrome-c reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquinol-cytochrome-c reductase-like protein

Species:

Leishmania major

UniProt:

Q4Q603_LEIMA

TriTrypDb:

LmjF.31.2580 , LMJLV39_310035300 , LMJSD75_310035300

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005750	mitochondrial respiratory chain complex III	4	3
GO:0032991	protein-containing complex	1	3
GO:0045275	respiratory chain complex III	4	3
GO:0070069	cytochrome complex	3	3
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3
GO:0098800	inner mitochondrial membrane protein complex	3	3
GO:0098803	respiratory chain complex	3	3
GO:1902494	catalytic complex	2	3
GO:1902495	transmembrane transporter complex	3	3
GO:1990204	oxidoreductase complex	3	3
GO:1990351	transporter complex	2	3

Expansion

Sequence features

Q4Q603

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q603

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	3
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	3
GO:0008152	metabolic process	1	3
GO:0009060	aerobic respiration	6	3
GO:0009987	cellular process	1	3
GO:0015980	energy derivation by oxidation of organic compounds	4	3
GO:0019646	aerobic electron transport chain	6	3
GO:0022900	electron transport chain	4	3
GO:0022904	respiratory electron transport chain	5	3
GO:0044237	cellular metabolic process	2	3
GO:0045333	cellular respiration	5	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.613
DOC_PP2B_LxvP_1	38	41	PF13499	0.633
DOC_PP4_FxxP_1	14	17	PF00568	0.636
DOC_PP4_FxxP_1	55	58	PF00568	0.683
DOC_PP4_FxxP_1	67	70	PF00568	0.626
DOC_USP7_MATH_1	10	14	PF00917	0.705
DOC_USP7_MATH_1	71	75	PF00917	0.730
DOC_WW_Pin1_4	107	112	PF00397	0.549
DOC_WW_Pin1_4	54	59	PF00397	0.629
LIG_14-3-3_CanoR_1	105	110	PF00244	0.549
LIG_BRCT_BRCA1_1	10	14	PF00533	0.593
LIG_BRCT_BRCA1_1	56	60	PF00533	0.623
LIG_FHA_1	24	30	PF00498	0.642
LIG_FHA_1	35	41	PF00498	0.564
LIG_FHA_2	57	63	PF00498	0.620
LIG_LIR_Apic_2	11	17	PF02991	0.636
LIG_LIR_Apic_2	64	70	PF02991	0.744
LIG_MLH1_MIPbox_1	11	15	PF16413	0.637
LIG_MYND_1	134	138	PF01753	0.549
LIG_Pex14_2	15	19	PF04695	0.636
LIG_REV1ctd_RIR_1	12	16	PF16727	0.634
LIG_SH2_CRK	7	11	PF00017	0.791
LIG_SH2_GRB2like	7	10	PF00017	0.791
LIG_SH2_NCK_1	7	11	PF00017	0.791
LIG_SH2_STAT5	121	124	PF00017	0.549
LIG_TRAF2_1	59	62	PF00917	0.624
MOD_CDC14_SPxK_1	110	113	PF00782	0.549
MOD_CDK_SPxK_1	107	113	PF00069	0.549
MOD_CK1_1	8	14	PF00069	0.780
MOD_CK2_1	56	62	PF00069	0.623
MOD_GlcNHglycan	20	23	PF01048	0.656
MOD_GSK3_1	5	12	PF00069	0.696
MOD_GSK3_1	56	63	PF00069	0.595
MOD_N-GLC_1	34	39	PF02516	0.604
MOD_N-GLC_2	100	102	PF02516	0.549
MOD_N-GLC_2	28	30	PF02516	0.632
MOD_N-GLC_2	90	92	PF02516	0.549
MOD_NEK2_1	60	65	PF00069	0.709
MOD_NEK2_2	10	15	PF00069	0.567
MOD_Plk_2-3	56	62	PF00069	0.623
MOD_Plk_4	10	16	PF00069	0.631
MOD_ProDKin_1	107	113	PF00069	0.549
MOD_ProDKin_1	54	60	PF00069	0.628
MOD_SUMO_rev_2	129	136	PF00179	0.405
MOD_SUMO_rev_2	74	81	PF00179	0.676
TRG_ENDOCYTIC_2	121	124	PF00928	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9B257	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%