TerD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TerD domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q602_LEIMA

TriTrypDb:

LmjF.31.2590 , LMJLV39_310035400 , LMJSD75_310035400

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q602

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q602

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.573
CLV_C14_Caspase3-7	486	490	PF00656	0.691
CLV_MEL_PAP_1	877	883	PF00089	0.547
CLV_NRD_NRD_1	105	107	PF00675	0.538
CLV_NRD_NRD_1	113	115	PF00675	0.605
CLV_NRD_NRD_1	179	181	PF00675	0.727
CLV_NRD_NRD_1	315	317	PF00675	0.635
CLV_NRD_NRD_1	521	523	PF00675	0.628
CLV_NRD_NRD_1	617	619	PF00675	0.725
CLV_NRD_NRD_1	626	628	PF00675	0.721
CLV_NRD_NRD_1	675	677	PF00675	0.775
CLV_NRD_NRD_1	687	689	PF00675	0.681
CLV_PCSK_FUR_1	110	114	PF00082	0.562
CLV_PCSK_KEX2_1	105	107	PF00082	0.535
CLV_PCSK_KEX2_1	112	114	PF00082	0.610
CLV_PCSK_KEX2_1	178	180	PF00082	0.740
CLV_PCSK_KEX2_1	315	317	PF00082	0.604
CLV_PCSK_KEX2_1	436	438	PF00082	0.685
CLV_PCSK_KEX2_1	521	523	PF00082	0.631
CLV_PCSK_KEX2_1	616	618	PF00082	0.726
CLV_PCSK_KEX2_1	626	628	PF00082	0.721
CLV_PCSK_KEX2_1	675	677	PF00082	0.770
CLV_PCSK_KEX2_1	891	893	PF00082	0.560
CLV_PCSK_KEX2_1	924	926	PF00082	0.693
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.685
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.572
CLV_PCSK_PC1ET2_1	924	926	PF00082	0.531
CLV_PCSK_PC7_1	175	181	PF00082	0.753
CLV_PCSK_SKI1_1	113	117	PF00082	0.663
CLV_PCSK_SKI1_1	316	320	PF00082	0.582
CLV_PCSK_SKI1_1	440	444	PF00082	0.539
CLV_PCSK_SKI1_1	654	658	PF00082	0.779
CLV_PCSK_SKI1_1	812	816	PF00082	0.489
DEG_APCC_DBOX_1	314	322	PF00400	0.655
DEG_APCC_DBOX_1	722	730	PF00400	0.583
DEG_COP1_1	438	448	PF00400	0.567
DEG_SPOP_SBC_1	793	797	PF00917	0.634
DOC_CDC14_PxL_1	442	450	PF14671	0.477
DOC_CYCLIN_RxL_1	313	320	PF00134	0.533
DOC_MAPK_DCC_7	440	450	PF00069	0.495
DOC_MAPK_gen_1	315	321	PF00069	0.578
DOC_MAPK_gen_1	44	54	PF00069	0.547
DOC_MAPK_gen_1	675	684	PF00069	0.563
DOC_MAPK_gen_1	746	755	PF00069	0.490
DOC_MAPK_gen_1	775	783	PF00069	0.624
DOC_MAPK_gen_1	807	816	PF00069	0.483
DOC_MAPK_gen_1	878	886	PF00069	0.531
DOC_MAPK_gen_1	9	19	PF00069	0.478
DOC_MAPK_MEF2A_6	12	21	PF00069	0.481
DOC_MAPK_MEF2A_6	44	53	PF00069	0.547
DOC_MAPK_MEF2A_6	807	815	PF00069	0.454
DOC_PP1_RVXF_1	785	791	PF00149	0.654
DOC_PP2B_LxvP_1	311	314	PF13499	0.576
DOC_PP4_FxxP_1	11	14	PF00568	0.475
DOC_PP4_FxxP_1	443	446	PF00568	0.514
DOC_USP7_MATH_1	314	318	PF00917	0.616
DOC_USP7_MATH_1	389	393	PF00917	0.466
DOC_USP7_MATH_1	539	543	PF00917	0.676
DOC_USP7_MATH_1	668	672	PF00917	0.767
DOC_USP7_MATH_1	791	795	PF00917	0.663
DOC_USP7_MATH_2	586	592	PF00917	0.594
DOC_USP7_UBL2_3	436	440	PF12436	0.588
DOC_WW_Pin1_4	776	781	PF00397	0.518
LIG_14-3-3_CanoR_1	315	319	PF00244	0.660
LIG_14-3-3_CanoR_1	532	537	PF00244	0.717
LIG_14-3-3_CanoR_1	543	548	PF00244	0.646
LIG_14-3-3_CanoR_1	627	633	PF00244	0.650
LIG_14-3-3_CanoR_1	925	929	PF00244	0.658
LIG_Actin_WH2_2	367	384	PF00022	0.507
LIG_APCC_ABBA_1	226	231	PF00400	0.486
LIG_APCC_ABBA_1	360	365	PF00400	0.480
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BRCT_BRCA1_1	23	27	PF00533	0.529
LIG_Clathr_ClatBox_1	361	365	PF01394	0.521
LIG_Clathr_ClatBox_1	828	832	PF01394	0.520
LIG_deltaCOP1_diTrp_1	752	756	PF00928	0.514
LIG_eIF4E_1	777	783	PF01652	0.588
LIG_FHA_1	248	254	PF00498	0.480
LIG_FHA_1	301	307	PF00498	0.569
LIG_FHA_1	410	416	PF00498	0.462
LIG_FHA_1	651	657	PF00498	0.747
LIG_FHA_1	701	707	PF00498	0.722
LIG_FHA_1	757	763	PF00498	0.642
LIG_FHA_1	816	822	PF00498	0.573
LIG_FHA_1	866	872	PF00498	0.693
LIG_FHA_2	212	218	PF00498	0.465
LIG_FHA_2	339	345	PF00498	0.574
LIG_FHA_2	425	431	PF00498	0.539
LIG_FHA_2	843	849	PF00498	0.735
LIG_HCF-1_HBM_1	372	375	PF13415	0.512
LIG_Integrin_isoDGR_2	519	521	PF01839	0.735
LIG_LIR_Apic_2	412	416	PF02991	0.446
LIG_LIR_Apic_2	441	446	PF02991	0.477
LIG_LIR_Gen_1	204	213	PF02991	0.452
LIG_LIR_Gen_1	217	226	PF02991	0.384
LIG_LIR_Gen_1	24	33	PF02991	0.550
LIG_LIR_Gen_1	295	306	PF02991	0.426
LIG_LIR_Gen_1	358	364	PF02991	0.401
LIG_LIR_Gen_1	404	415	PF02991	0.434
LIG_LIR_Gen_1	447	457	PF02991	0.571
LIG_LIR_Gen_1	45	54	PF02991	0.542
LIG_LIR_Gen_1	510	518	PF02991	0.559
LIG_LIR_Gen_1	711	720	PF02991	0.552
LIG_LIR_Nem_3	204	210	PF02991	0.436
LIG_LIR_Nem_3	217	221	PF02991	0.393
LIG_LIR_Nem_3	24	28	PF02991	0.540
LIG_LIR_Nem_3	295	301	PF02991	0.429
LIG_LIR_Nem_3	358	363	PF02991	0.443
LIG_LIR_Nem_3	404	410	PF02991	0.439
LIG_LIR_Nem_3	447	452	PF02991	0.542
LIG_LIR_Nem_3	45	51	PF02991	0.548
LIG_LIR_Nem_3	510	516	PF02991	0.585
LIG_LIR_Nem_3	631	636	PF02991	0.678
LIG_LIR_Nem_3	711	717	PF02991	0.492
LIG_LIR_Nem_3	799	805	PF02991	0.511
LIG_LIR_Nem_3	848	853	PF02991	0.562
LIG_MYND_1	75	79	PF01753	0.662
LIG_Pex14_1	428	432	PF04695	0.572
LIG_Pex14_2	296	300	PF04695	0.440
LIG_Pex14_2	513	517	PF04695	0.629
LIG_Pex14_2	54	58	PF04695	0.476
LIG_PTB_Apo_2	52	59	PF02174	0.459
LIG_PTB_Apo_2	771	778	PF02174	0.604
LIG_PTB_Apo_2	917	924	PF02174	0.690
LIG_PTB_Phospho_1	771	777	PF10480	0.603
LIG_PTB_Phospho_1	917	923	PF10480	0.685
LIG_SH2_CRK	777	781	PF00017	0.511
LIG_SH2_CRK	80	84	PF00017	0.497
LIG_SH2_CRK	808	812	PF00017	0.553
LIG_SH2_GRB2like	131	134	PF00017	0.752
LIG_SH2_GRB2like	720	723	PF00017	0.659
LIG_SH2_GRB2like	918	921	PF00017	0.679
LIG_SH2_NCK_1	131	135	PF00017	0.699
LIG_SH2_PTP2	581	584	PF00017	0.518
LIG_SH2_SRC	370	373	PF00017	0.442
LIG_SH2_SRC	581	584	PF00017	0.486
LIG_SH2_STAP1	131	135	PF00017	0.716
LIG_SH2_STAP1	161	165	PF00017	0.650
LIG_SH2_STAP1	603	607	PF00017	0.626
LIG_SH2_STAP1	710	714	PF00017	0.670
LIG_SH2_STAP1	873	877	PF00017	0.515
LIG_SH2_STAP1	914	918	PF00017	0.660
LIG_SH2_STAT3	213	216	PF00017	0.575
LIG_SH2_STAT3	919	922	PF00017	0.684
LIG_SH2_STAT5	131	134	PF00017	0.719
LIG_SH2_STAT5	213	216	PF00017	0.483
LIG_SH2_STAT5	370	373	PF00017	0.461
LIG_SH2_STAT5	449	452	PF00017	0.473
LIG_SH2_STAT5	581	584	PF00017	0.521
LIG_SH2_STAT5	596	599	PF00017	0.393
LIG_SH2_STAT5	802	805	PF00017	0.540
LIG_SH3_2	741	746	PF14604	0.587
LIG_SH3_3	454	460	PF00018	0.652
LIG_SH3_3	580	586	PF00018	0.591
LIG_SH3_3	738	744	PF00018	0.508
LIG_SUMO_SIM_anti_2	317	323	PF11976	0.656
LIG_SUMO_SIM_anti_2	404	412	PF11976	0.438
LIG_SUMO_SIM_anti_2	825	830	PF11976	0.460
LIG_SUMO_SIM_par_1	31	36	PF11976	0.439
LIG_SUMO_SIM_par_1	779	784	PF11976	0.623
LIG_TRAF2_1	262	265	PF00917	0.726
LIG_TRAF2_1	282	285	PF00917	0.644
LIG_TRFH_1	573	577	PF08558	0.635
LIG_TYR_ITIM	78	83	PF00017	0.498
LIG_TYR_ITSM	629	636	PF00017	0.556
LIG_WRC_WIRS_1	191	196	PF05994	0.542
LIG_WRC_WIRS_1	293	298	PF05994	0.451
LIG_WRC_WIRS_1	429	434	PF05994	0.534
MOD_CAAXbox	926	929	PF01239	0.599
MOD_CK1_1	211	217	PF00069	0.581
MOD_CK1_1	546	552	PF00069	0.754
MOD_CK1_1	794	800	PF00069	0.599
MOD_CK1_1	84	90	PF00069	0.511
MOD_CK2_1	229	235	PF00069	0.562
MOD_CK2_1	260	266	PF00069	0.724
MOD_CK2_1	424	430	PF00069	0.535
MOD_CK2_1	557	563	PF00069	0.730
MOD_CK2_1	631	637	PF00069	0.718
MOD_Cter_Amidation	519	522	PF01082	0.721
MOD_GlcNHglycan	351	354	PF01048	0.499
MOD_GlcNHglycan	36	40	PF01048	0.436
MOD_GlcNHglycan	391	394	PF01048	0.492
MOD_GlcNHglycan	400	403	PF01048	0.520
MOD_GlcNHglycan	536	539	PF01048	0.722
MOD_GlcNHglycan	543	546	PF01048	0.718
MOD_GlcNHglycan	633	636	PF01048	0.745
MOD_GlcNHglycan	670	673	PF01048	0.764
MOD_GlcNHglycan	83	86	PF01048	0.553
MOD_GlcNHglycan	873	876	PF01048	0.509
MOD_GSK3_1	125	132	PF00069	0.754
MOD_GSK3_1	13	20	PF00069	0.511
MOD_GSK3_1	190	197	PF00069	0.595
MOD_GSK3_1	243	250	PF00069	0.490
MOD_GSK3_1	269	276	PF00069	0.669
MOD_GSK3_1	292	299	PF00069	0.444
MOD_GSK3_1	336	343	PF00069	0.588
MOD_GSK3_1	424	431	PF00069	0.536
MOD_GSK3_1	530	537	PF00069	0.775
MOD_GSK3_1	539	546	PF00069	0.619
MOD_GSK3_1	62	69	PF00069	0.602
MOD_GSK3_1	631	638	PF00069	0.796
MOD_GSK3_1	643	650	PF00069	0.647
MOD_GSK3_1	697	704	PF00069	0.662
MOD_GSK3_1	791	798	PF00069	0.534
MOD_GSK3_1	81	88	PF00069	0.560
MOD_LATS_1	530	536	PF00433	0.693
MOD_N-GLC_1	229	234	PF02516	0.534
MOD_N-GLC_1	247	252	PF02516	0.342
MOD_N-GLC_1	453	458	PF02516	0.512
MOD_N-GLC_1	721	726	PF02516	0.652
MOD_NEK2_1	194	199	PF00069	0.515
MOD_NEK2_1	296	301	PF00069	0.442
MOD_NEK2_1	35	40	PF00069	0.417
MOD_NEK2_1	396	401	PF00069	0.675
MOD_NEK2_1	505	510	PF00069	0.583
MOD_NEK2_1	534	539	PF00069	0.743
MOD_NEK2_1	756	761	PF00069	0.636
MOD_NEK2_1	815	820	PF00069	0.577
MOD_NEK2_1	879	884	PF00069	0.483
MOD_NEK2_2	628	633	PF00069	0.549
MOD_NEK2_2	635	640	PF00069	0.528
MOD_NEK2_2	767	772	PF00069	0.633
MOD_PIKK_1	260	266	PF00454	0.631
MOD_PIKK_1	507	513	PF00454	0.600
MOD_PK_1	380	386	PF00069	0.555
MOD_PK_1	532	538	PF00069	0.824
MOD_PK_1	543	549	PF00069	0.676
MOD_PKA_2	242	248	PF00069	0.577
MOD_PKA_2	314	320	PF00069	0.590
MOD_PKA_2	389	395	PF00069	0.479
MOD_PKA_2	608	614	PF00069	0.645
MOD_PKA_2	879	885	PF00069	0.492
MOD_Plk_1	216	222	PF00069	0.474
MOD_Plk_1	326	332	PF00069	0.515
MOD_Plk_1	35	41	PF00069	0.399
MOD_Plk_1	453	459	PF00069	0.590
MOD_Plk_1	62	68	PF00069	0.676
MOD_Plk_1	680	686	PF00069	0.772
MOD_Plk_1	701	707	PF00069	0.699
MOD_Plk_1	85	91	PF00069	0.596
MOD_Plk_2-3	827	833	PF00069	0.546
MOD_Plk_4	13	19	PF00069	0.555
MOD_Plk_4	190	196	PF00069	0.434
MOD_Plk_4	296	302	PF00069	0.431
MOD_Plk_4	418	424	PF00069	0.432
MOD_Plk_4	438	444	PF00069	0.274
MOD_Plk_4	628	634	PF00069	0.617
MOD_Plk_4	701	707	PF00069	0.603
MOD_Plk_4	767	773	PF00069	0.524
MOD_ProDKin_1	776	782	PF00069	0.514
MOD_SUMO_for_1	333	336	PF00179	0.663
MOD_SUMO_rev_2	768	776	PF00179	0.616
TRG_AP2beta_CARGO_1	404	414	PF09066	0.441
TRG_DiLeu_BaEn_1	406	411	PF01217	0.438
TRG_DiLeu_BaEn_2	189	195	PF01217	0.435
TRG_ENDOCYTIC_2	298	301	PF00928	0.425
TRG_ENDOCYTIC_2	449	452	PF00928	0.422
TRG_ENDOCYTIC_2	581	584	PF00928	0.499
TRG_ENDOCYTIC_2	633	636	PF00928	0.741
TRG_ENDOCYTIC_2	710	713	PF00928	0.623
TRG_ENDOCYTIC_2	80	83	PF00928	0.480
TRG_ENDOCYTIC_2	802	805	PF00928	0.523
TRG_ENDOCYTIC_2	808	811	PF00928	0.479
TRG_ER_diArg_1	105	107	PF00400	0.573
TRG_ER_diArg_1	110	113	PF00400	0.655
TRG_ER_diArg_1	177	180	PF00400	0.802
TRG_ER_diArg_1	314	316	PF00400	0.634
TRG_ER_diArg_1	521	523	PF00400	0.671
TRG_ER_diArg_1	616	618	PF00400	0.726
TRG_ER_diArg_1	674	676	PF00400	0.770
TRG_ER_diArg_1	706	709	PF00400	0.701
TRG_ER_diArg_1	810	813	PF00400	0.433
TRG_ER_diArg_1	877	880	PF00400	0.450
TRG_NES_CRM1_1	574	588	PF08389	0.639
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P463	Leptomonas seymouri	66%	100%
A0A1X0NIL2	Trypanosomatidae	40%	100%
A0A3S7X4T6	Leishmania donovani	93%	100%
A4HJP7	Leishmania braziliensis	77%	100%
A4I764	Leishmania infantum	93%	100%
C9ZME9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZWN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B258	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B2Y1	Trypanosoma cruzi	47%	100%