CrcB-like_protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CrcB-like_protein

Gene product:

CrcB-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q5Z9_LEIMA

TriTrypDb:

LmjF.31.2620 , LMJLV39_310035700 , LMJSD75_310035700

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	8
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q5Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Z9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0009987	cellular process	1	2
GO:0015698	inorganic anion transport	6	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098661	inorganic anion transmembrane transport	5	2
GO:1903424	fluoride transmembrane transport	6	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0008509	monoatomic anion transmembrane transporter activity	4	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015103	inorganic anion transmembrane transporter activity	4	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8
GO:1903425	fluoride transmembrane transporter activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.407
CLV_C14_Caspase3-7	52	56	PF00656	0.677
CLV_PCSK_SKI1_1	109	113	PF00082	0.590
CLV_PCSK_SKI1_1	20	24	PF00082	0.587
CLV_PCSK_SKI1_1	229	233	PF00082	0.426
CLV_PCSK_SKI1_1	284	288	PF00082	0.351
DEG_APCC_DBOX_1	228	236	PF00400	0.598
DEG_APCC_DBOX_1	9	17	PF00400	0.635
DEG_Nend_UBRbox_3	1	3	PF02207	0.732
DEG_ODPH_VHL_1	276	289	PF01847	0.432
DOC_AGCK_PIF_1	122	127	PF00069	0.240
DOC_CYCLIN_RxL_1	226	236	PF00134	0.576
DOC_MAPK_MEF2A_6	284	291	PF00069	0.417
DOC_PP1_RVXF_1	206	213	PF00149	0.605
DOC_USP7_MATH_1	368	372	PF00917	0.417
DOC_USP7_MATH_1	73	77	PF00917	0.766
DOC_USP7_UBL2_3	114	118	PF12436	0.343
DOC_WW_Pin1_4	217	222	PF00397	0.674
DOC_WW_Pin1_4	30	35	PF00397	0.768
DOC_WW_Pin1_4	66	71	PF00397	0.741
DOC_WW_Pin1_4	76	81	PF00397	0.667
LIG_14-3-3_CanoR_1	264	274	PF00244	0.426
LIG_14-3-3_CanoR_1	284	290	PF00244	0.465
LIG_14-3-3_CanoR_1	3	7	PF00244	0.720
LIG_14-3-3_CanoR_1	360	369	PF00244	0.258
LIG_14-3-3_CterR_2	388	392	PF00244	0.660
LIG_BRCT_BRCA1_1	370	374	PF00533	0.413
LIG_Clathr_ClatBox_2	220	225	PF01394	0.624
LIG_deltaCOP1_diTrp_1	219	225	PF00928	0.574
LIG_EH_1	118	122	PF12763	0.307
LIG_FHA_1	192	198	PF00498	0.414
LIG_FHA_1	222	228	PF00498	0.674
LIG_FHA_1	266	272	PF00498	0.361
LIG_FHA_2	179	185	PF00498	0.408
LIG_GBD_Chelix_1	305	313	PF00786	0.435
LIG_LIR_Apic_2	126	130	PF02991	0.240
LIG_LIR_Gen_1	165	174	PF02991	0.432
LIG_LIR_Gen_1	371	381	PF02991	0.413
LIG_LIR_Nem_3	165	169	PF02991	0.433
LIG_LIR_Nem_3	371	377	PF02991	0.443
LIG_LIR_Nem_3	82	88	PF02991	0.672
LIG_NRBOX	309	315	PF00104	0.413
LIG_Pex14_2	136	140	PF04695	0.365
LIG_Pex14_2	162	166	PF04695	0.409
LIG_Pex14_2	240	244	PF04695	0.334
LIG_PTB_Apo_2	116	123	PF02174	0.336
LIG_SH2_CRK	125	129	PF00017	0.390
LIG_SH2_CRK	367	371	PF00017	0.365
LIG_SH2_CRK	88	92	PF00017	0.540
LIG_SH2_GRB2like	290	293	PF00017	0.499
LIG_SH2_NCK_1	367	371	PF00017	0.417
LIG_SH2_PTP2	127	130	PF00017	0.402
LIG_SH2_SRC	365	368	PF00017	0.330
LIG_SH2_STAP1	88	92	PF00017	0.570
LIG_SH2_STAT3	65	68	PF00017	0.821
LIG_SH2_STAT5	125	128	PF00017	0.300
LIG_SH2_STAT5	257	260	PF00017	0.458
LIG_SH2_STAT5	290	293	PF00017	0.499
LIG_SH2_STAT5	365	368	PF00017	0.344
LIG_SH2_STAT5	81	84	PF00017	0.655
LIG_SH3_3	117	123	PF00018	0.340
LIG_SH3_3	141	147	PF00018	0.456
LIG_SH3_3	215	221	PF00018	0.651
LIG_SH3_3	272	278	PF00018	0.337
LIG_SH3_3	378	384	PF00018	0.413
LIG_SH3_3	67	73	PF00018	0.782
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.413
LIG_SUMO_SIM_par_1	89	94	PF11976	0.421
LIG_Vh1_VBS_1	231	249	PF01044	0.540
LIG_WRC_WIRS_1	133	138	PF05994	0.402
LIG_WRC_WIRS_1	166	171	PF05994	0.351
LIG_WRC_WIRS_1	352	357	PF05994	0.340
MOD_CK1_1	132	138	PF00069	0.308
MOD_CK1_1	165	171	PF00069	0.363
MOD_CK1_1	343	349	PF00069	0.284
MOD_CK1_1	64	70	PF00069	0.795
MOD_CK1_1	76	82	PF00069	0.569
MOD_CK2_1	217	223	PF00069	0.655
MOD_CMANNOS	222	225	PF00535	0.434
MOD_GlcNHglycan	105	108	PF01048	0.413
MOD_GlcNHglycan	357	360	PF01048	0.513
MOD_GlcNHglycan	362	365	PF01048	0.351
MOD_GlcNHglycan	55	58	PF01048	0.565
MOD_GlcNHglycan	75	78	PF01048	0.535
MOD_GSK3_1	164	171	PF00069	0.384
MOD_GSK3_1	217	224	PF00069	0.632
MOD_GSK3_1	340	347	PF00069	0.284
MOD_GSK3_1	351	358	PF00069	0.394
MOD_GSK3_1	368	375	PF00069	0.263
MOD_N-GLC_1	53	58	PF02516	0.624
MOD_N-GLC_2	2	4	PF02516	0.525
MOD_NEK2_1	103	108	PF00069	0.344
MOD_NEK2_1	138	143	PF00069	0.373
MOD_NEK2_1	162	167	PF00069	0.351
MOD_NEK2_1	227	232	PF00069	0.570
MOD_NEK2_1	244	249	PF00069	0.212
MOD_NEK2_1	285	290	PF00069	0.419
MOD_NEK2_1	355	360	PF00069	0.334
MOD_NEK2_1	91	96	PF00069	0.409
MOD_NEK2_2	40	45	PF00069	0.772
MOD_PIKK_1	64	70	PF00454	0.818
MOD_PKA_2	2	8	PF00069	0.721
MOD_PKB_1	10	18	PF00069	0.638
MOD_Plk_4	123	129	PF00069	0.323
MOD_Plk_4	132	138	PF00069	0.381
MOD_Plk_4	140	146	PF00069	0.369
MOD_Plk_4	168	174	PF00069	0.373
MOD_Plk_4	2	8	PF00069	0.621
MOD_Plk_4	244	250	PF00069	0.359
MOD_Plk_4	285	291	PF00069	0.418
MOD_Plk_4	351	357	PF00069	0.370
MOD_Plk_4	40	46	PF00069	0.793
MOD_ProDKin_1	217	223	PF00069	0.678
MOD_ProDKin_1	30	36	PF00069	0.768
MOD_ProDKin_1	66	72	PF00069	0.738
MOD_ProDKin_1	76	82	PF00069	0.655
TRG_ENDOCYTIC_2	125	128	PF00928	0.328
TRG_ENDOCYTIC_2	367	370	PF00928	0.365
TRG_ENDOCYTIC_2	88	91	PF00928	0.585
TRG_ER_diArg_1	10	13	PF00400	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P462	Leptomonas seymouri	61%	100%
A0A1X0NID7	Trypanosomatidae	35%	100%
A0A3Q8IGC8	Leishmania donovani	89%	100%
A0A422NPK8	Trypanosoma rangeli	35%	100%
A4HJQ0	Leishmania braziliensis	73%	100%
A4I767	Leishmania infantum	89%	100%