AP2 domain transcription factor AP2X-11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5Z5_LEIMA

TriTrypDb:

LmjF.31.2655 , LMJLV39_310036200 , LMJSD75_310036200

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.758
CLV_C14_Caspase3-7	470	474	PF00656	0.586
CLV_NRD_NRD_1	193	195	PF00675	0.623
CLV_NRD_NRD_1	427	429	PF00675	0.792
CLV_NRD_NRD_1	432	434	PF00675	0.521
CLV_NRD_NRD_1	444	446	PF00675	0.729
CLV_NRD_NRD_1	482	484	PF00675	0.719
CLV_PCSK_KEX2_1	193	195	PF00082	0.623
CLV_PCSK_KEX2_1	427	429	PF00082	0.792
CLV_PCSK_KEX2_1	431	433	PF00082	0.735
CLV_PCSK_KEX2_1	444	446	PF00082	0.729
CLV_PCSK_KEX2_1	482	484	PF00082	0.719
CLV_PCSK_PC7_1	427	433	PF00082	0.788
CLV_PCSK_SKI1_1	243	247	PF00082	0.677
CLV_PCSK_SKI1_1	391	395	PF00082	0.758
CLV_PCSK_SKI1_1	534	538	PF00082	0.704
DEG_SCF_TRCP1_1	553	559	PF00400	0.709
DEG_SPOP_SBC_1	271	275	PF00917	0.626
DEG_SPOP_SBC_1	8	12	PF00917	0.710
DOC_MAPK_gen_1	153	162	PF00069	0.743
DOC_MAPK_gen_1	444	452	PF00069	0.722
DOC_MAPK_gen_1	482	488	PF00069	0.719
DOC_MAPK_JIP1_4	156	162	PF00069	0.705
DOC_PP1_SILK_1	189	194	PF00149	0.744
DOC_PP2B_LxvP_1	407	410	PF13499	0.581
DOC_PP2B_LxvP_1	530	533	PF13499	0.663
DOC_PP4_FxxP_1	311	314	PF00568	0.700
DOC_USP7_MATH_1	113	117	PF00917	0.738
DOC_USP7_MATH_1	138	142	PF00917	0.783
DOC_USP7_MATH_1	271	275	PF00917	0.829
DOC_USP7_MATH_1	31	35	PF00917	0.778
DOC_USP7_MATH_1	319	323	PF00917	0.817
DOC_USP7_MATH_1	328	332	PF00917	0.689
DOC_USP7_MATH_1	399	403	PF00917	0.708
DOC_USP7_MATH_1	456	460	PF00917	0.807
DOC_USP7_MATH_1	573	577	PF00917	0.618
DOC_USP7_UBL2_3	306	310	PF12436	0.810
DOC_WW_Pin1_4	103	108	PF00397	0.765
DOC_WW_Pin1_4	142	147	PF00397	0.794
DOC_WW_Pin1_4	200	205	PF00397	0.726
DOC_WW_Pin1_4	274	279	PF00397	0.763
DOC_WW_Pin1_4	299	304	PF00397	0.742
DOC_WW_Pin1_4	310	315	PF00397	0.647
DOC_WW_Pin1_4	322	327	PF00397	0.695
DOC_WW_Pin1_4	335	340	PF00397	0.631
DOC_WW_Pin1_4	386	391	PF00397	0.690
DOC_WW_Pin1_4	498	503	PF00397	0.599
DOC_WW_Pin1_4	56	61	PF00397	0.801
DOC_WW_Pin1_4	81	86	PF00397	0.583
LIG_14-3-3_CanoR_1	286	292	PF00244	0.671
LIG_14-3-3_CanoR_1	385	393	PF00244	0.759
LIG_14-3-3_CanoR_1	439	448	PF00244	0.591
LIG_14-3-3_CanoR_1	482	486	PF00244	0.699
LIG_14-3-3_CanoR_1	487	497	PF00244	0.677
LIG_14-3-3_CanoR_1	508	514	PF00244	0.721
LIG_14-3-3_CanoR_1	517	525	PF00244	0.609
LIG_14-3-3_CanoR_1	69	74	PF00244	0.725
LIG_BRCT_BRCA1_1	129	133	PF00533	0.588
LIG_BRCT_BRCA1_1	233	237	PF00533	0.806
LIG_BRCT_BRCA1_1	360	364	PF00533	0.686
LIG_CtBP_PxDLS_1	146	150	PF00389	0.720
LIG_DLG_GKlike_1	444	452	PF00625	0.722
LIG_DLG_GKlike_1	69	77	PF00625	0.722
LIG_FHA_1	107	113	PF00498	0.732
LIG_FHA_1	142	148	PF00498	0.738
LIG_FHA_1	167	173	PF00498	0.689
LIG_FHA_1	174	180	PF00498	0.692
LIG_FHA_1	224	230	PF00498	0.741
LIG_FHA_1	399	405	PF00498	0.605
LIG_FHA_1	9	15	PF00498	0.755
LIG_FHA_2	75	81	PF00498	0.716
LIG_Integrin_isoDGR_2	67	69	PF01839	0.745
LIG_LIR_Apic_2	308	314	PF02991	0.702
LIG_LIR_Nem_3	327	332	PF02991	0.826
LIG_LIR_Nem_3	348	354	PF02991	0.716
LIG_Pex14_2	118	122	PF04695	0.722
LIG_SH2_GRB2like	365	368	PF00017	0.551
LIG_SH2_SRC	365	368	PF00017	0.551
LIG_SH2_STAT5	351	354	PF00017	0.673
LIG_SH3_3	329	335	PF00018	0.757
LIG_SH3_3	33	39	PF00018	0.793
LIG_SH3_3	372	378	PF00018	0.706
LIG_SH3_3	407	413	PF00018	0.725
LIG_SH3_3	447	453	PF00018	0.778
LIG_SH3_3	52	58	PF00018	0.538
LIG_SH3_3	567	573	PF00018	0.705
LIG_SUMO_SIM_par_1	38	43	PF11976	0.734
MOD_CDC14_SPxK_1	302	305	PF00782	0.731
MOD_CDC14_SPxK_1	501	504	PF00782	0.595
MOD_CDK_SPK_2	103	108	PF00069	0.751
MOD_CDK_SPK_2	299	304	PF00069	0.672
MOD_CDK_SPK_2	386	391	PF00069	0.690
MOD_CDK_SPxK_1	299	305	PF00069	0.742
MOD_CDK_SPxK_1	498	504	PF00069	0.599
MOD_CDK_SPxxK_3	299	306	PF00069	0.705
MOD_CK1_1	106	112	PF00069	0.761
MOD_CK1_1	141	147	PF00069	0.791
MOD_CK1_1	196	202	PF00069	0.761
MOD_CK1_1	218	224	PF00069	0.782
MOD_CK1_1	231	237	PF00069	0.740
MOD_CK1_1	274	280	PF00069	0.743
MOD_CK1_1	322	328	PF00069	0.805
MOD_CK1_1	337	343	PF00069	0.592
MOD_CK1_1	384	390	PF00069	0.752
MOD_CK1_1	398	404	PF00069	0.561
MOD_CK1_1	421	427	PF00069	0.704
MOD_CK1_1	496	502	PF00069	0.794
MOD_CK1_1	542	548	PF00069	0.778
MOD_CK1_1	549	555	PF00069	0.732
MOD_CK1_1	556	562	PF00069	0.550
MOD_CK1_1	71	77	PF00069	0.718
MOD_CK2_1	462	468	PF00069	0.694
MOD_CK2_1	74	80	PF00069	0.717
MOD_GlcNHglycan	136	139	PF01048	0.790
MOD_GlcNHglycan	195	198	PF01048	0.631
MOD_GlcNHglycan	221	224	PF01048	0.784
MOD_GlcNHglycan	31	34	PF01048	0.795
MOD_GlcNHglycan	359	363	PF01048	0.719
MOD_GlcNHglycan	369	372	PF01048	0.619
MOD_GlcNHglycan	397	400	PF01048	0.771
MOD_GlcNHglycan	401	404	PF01048	0.709
MOD_GlcNHglycan	423	426	PF01048	0.691
MOD_GlcNHglycan	458	461	PF01048	0.808
MOD_GlcNHglycan	467	472	PF01048	0.677
MOD_GlcNHglycan	510	513	PF01048	0.693
MOD_GlcNHglycan	548	551	PF01048	0.793
MOD_GlcNHglycan	553	556	PF01048	0.765
MOD_GlcNHglycan	98	102	PF01048	0.775
MOD_GSK3_1	123	130	PF00069	0.624
MOD_GSK3_1	134	141	PF00069	0.593
MOD_GSK3_1	145	152	PF00069	0.663
MOD_GSK3_1	156	163	PF00069	0.669
MOD_GSK3_1	192	199	PF00069	0.606
MOD_GSK3_1	214	221	PF00069	0.736
MOD_GSK3_1	224	231	PF00069	0.568
MOD_GSK3_1	249	256	PF00069	0.810
MOD_GSK3_1	270	277	PF00069	0.831
MOD_GSK3_1	310	317	PF00069	0.747
MOD_GSK3_1	324	331	PF00069	0.651
MOD_GSK3_1	380	387	PF00069	0.774
MOD_GSK3_1	395	402	PF00069	0.545
MOD_GSK3_1	477	484	PF00069	0.697
MOD_GSK3_1	496	503	PF00069	0.590
MOD_GSK3_1	542	549	PF00069	0.790
MOD_GSK3_1	69	76	PF00069	0.775
MOD_LATS_1	7	13	PF00433	0.714
MOD_N-GLC_1	133	138	PF02516	0.740
MOD_N-GLC_1	142	147	PF02516	0.733
MOD_N-GLC_1	399	404	PF02516	0.770
MOD_NEK2_1	118	123	PF00069	0.719
MOD_NEK2_1	133	138	PF00069	0.575
MOD_NEK2_1	149	154	PF00069	0.664
MOD_NEK2_1	192	197	PF00069	0.707
MOD_NEK2_1	380	385	PF00069	0.712
MOD_NEK2_1	461	466	PF00069	0.721
MOD_NEK2_1	546	551	PF00069	0.803
MOD_NEK2_1	73	78	PF00069	0.780
MOD_NEK2_2	113	118	PF00069	0.730
MOD_NMyristoyl	1	7	PF02799	0.576
MOD_PIKK_1	216	222	PF00454	0.648
MOD_PIKK_1	277	283	PF00454	0.635
MOD_PIKK_1	384	390	PF00454	0.752
MOD_PK_1	209	215	PF00069	0.589
MOD_PKA_1	193	199	PF00069	0.601
MOD_PKA_1	304	310	PF00069	0.636
MOD_PKA_1	427	433	PF00069	0.788
MOD_PKA_1	444	450	PF00069	0.725
MOD_PKA_2	149	155	PF00069	0.719
MOD_PKA_2	192	198	PF00069	0.744
MOD_PKA_2	231	237	PF00069	0.822
MOD_PKA_2	384	390	PF00069	0.752
MOD_PKA_2	395	401	PF00069	0.603
MOD_PKA_2	427	433	PF00069	0.788
MOD_PKA_2	444	450	PF00069	0.795
MOD_PKA_2	462	468	PF00069	0.562
MOD_PKA_2	481	487	PF00069	0.629
MOD_PKA_2	507	513	PF00069	0.715
MOD_PKA_2	523	529	PF00069	0.538
MOD_PKA_2	68	74	PF00069	0.726
MOD_Plk_1	118	124	PF00069	0.720
MOD_Plk_1	347	353	PF00069	0.529
MOD_Plk_4	113	119	PF00069	0.728
MOD_Plk_4	187	193	PF00069	0.740
MOD_Plk_4	224	230	PF00069	0.808
MOD_Plk_4	347	353	PF00069	0.550
MOD_Plk_4	389	395	PF00069	0.756
MOD_Plk_4	74	80	PF00069	0.717
MOD_ProDKin_1	103	109	PF00069	0.766
MOD_ProDKin_1	142	148	PF00069	0.798
MOD_ProDKin_1	200	206	PF00069	0.725
MOD_ProDKin_1	274	280	PF00069	0.762
MOD_ProDKin_1	299	305	PF00069	0.742
MOD_ProDKin_1	310	316	PF00069	0.645
MOD_ProDKin_1	322	328	PF00069	0.696
MOD_ProDKin_1	335	341	PF00069	0.629
MOD_ProDKin_1	386	392	PF00069	0.691
MOD_ProDKin_1	498	504	PF00069	0.599
MOD_ProDKin_1	56	62	PF00069	0.801
MOD_ProDKin_1	81	87	PF00069	0.585
MOD_SUMO_rev_2	240	245	PF00179	0.808
MOD_SUMO_rev_2	302	311	PF00179	0.701
MOD_SUMO_rev_2	43	50	PF00179	0.695
TRG_DiLeu_BaEn_1	436	441	PF01217	0.723
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.738
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.726
TRG_DiLeu_LyEn_5	436	441	PF01217	0.583
TRG_ENDOCYTIC_2	351	354	PF00928	0.655
TRG_ER_diArg_1	192	194	PF00400	0.625
TRG_ER_diArg_1	284	287	PF00400	0.729
TRG_ER_diArg_1	426	428	PF00400	0.792
TRG_ER_diArg_1	431	433	PF00400	0.721
TRG_ER_diArg_1	444	446	PF00400	0.733
TRG_ER_diArg_1	481	483	PF00400	0.714
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKC7	Leishmania donovani	89%	100%
A4HJQ4	Leishmania braziliensis	52%	98%
A4I770	Leishmania infantum	89%	100%
E9B265	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%