Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5Z4_LEIMA

TriTrypDb:

LmjF.31.2670 , LMJLV39_310036500 , LMJSD75_310036500

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 3
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q5Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	604	606	PF00675	0.467
CLV_PCSK_KEX2_1	498	500	PF00082	0.530
CLV_PCSK_KEX2_1	604	606	PF00082	0.467
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.530
CLV_PCSK_SKI1_1	28	32	PF00082	0.355
CLV_PCSK_SKI1_1	442	446	PF00082	0.526
CLV_PCSK_SKI1_1	463	467	PF00082	0.511
CLV_PCSK_SKI1_1	607	611	PF00082	0.561
DEG_APCC_DBOX_1	102	110	PF00400	0.621
DEG_Nend_Nbox_1	1	3	PF02207	0.609
DEG_SPOP_SBC_1	254	258	PF00917	0.545
DEG_SPOP_SBC_1	277	281	PF00917	0.548
DEG_SPOP_SBC_1	284	288	PF00917	0.494
DEG_SPOP_SBC_1	294	298	PF00917	0.439
DEG_SPOP_SBC_1	304	308	PF00917	0.425
DEG_SPOP_SBC_1	314	318	PF00917	0.430
DEG_SPOP_SBC_1	324	328	PF00917	0.453
DEG_SPOP_SBC_1	334	338	PF00917	0.430
DEG_SPOP_SBC_1	344	348	PF00917	0.427
DEG_SPOP_SBC_1	354	358	PF00917	0.431
DEG_SPOP_SBC_1	367	371	PF00917	0.484
DOC_ANK_TNKS_1	779	786	PF00023	0.706
DOC_CKS1_1	566	571	PF01111	0.746
DOC_CKS1_1	707	712	PF01111	0.771
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.559
DOC_MAPK_DCC_7	555	565	PF00069	0.736
DOC_MAPK_gen_1	103	111	PF00069	0.633
DOC_MAPK_gen_1	555	565	PF00069	0.736
DOC_MAPK_gen_1	664	673	PF00069	0.731
DOC_MAPK_MEF2A_6	28	37	PF00069	0.557
DOC_MAPK_MEF2A_6	558	565	PF00069	0.735
DOC_MIT_MIM_1	34	44	PF04212	0.570
DOC_PP1_RVXF_1	211	217	PF00149	0.511
DOC_PP2B_LxvP_1	489	492	PF13499	0.773
DOC_PP2B_LxvP_1	575	578	PF13499	0.811
DOC_PP2B_LxvP_1	60	63	PF13499	0.612
DOC_PP2B_LxvP_1	690	693	PF13499	0.723
DOC_PP4_FxxP_1	226	229	PF00568	0.453
DOC_PP4_FxxP_1	566	569	PF00568	0.692
DOC_PP4_FxxP_1	802	805	PF00568	0.699
DOC_PP4_MxPP_1	752	755	PF00568	0.623
DOC_USP7_MATH_1	116	120	PF00917	0.638
DOC_USP7_MATH_1	140	144	PF00917	0.642
DOC_USP7_MATH_1	243	247	PF00917	0.576
DOC_USP7_MATH_1	252	256	PF00917	0.488
DOC_USP7_MATH_1	367	371	PF00917	0.503
DOC_USP7_MATH_1	377	381	PF00917	0.497
DOC_USP7_MATH_1	490	494	PF00917	0.724
DOC_USP7_MATH_1	677	681	PF00917	0.766
DOC_USP7_MATH_1	803	807	PF00917	0.733
DOC_USP7_MATH_1	95	99	PF00917	0.625
DOC_WW_Pin1_4	121	126	PF00397	0.636
DOC_WW_Pin1_4	17	22	PF00397	0.605
DOC_WW_Pin1_4	250	255	PF00397	0.597
DOC_WW_Pin1_4	379	384	PF00397	0.559
DOC_WW_Pin1_4	424	429	PF00397	0.648
DOC_WW_Pin1_4	493	498	PF00397	0.778
DOC_WW_Pin1_4	565	570	PF00397	0.746
DOC_WW_Pin1_4	641	646	PF00397	0.748
DOC_WW_Pin1_4	695	700	PF00397	0.731
DOC_WW_Pin1_4	706	711	PF00397	0.712
DOC_WW_Pin1_4	712	717	PF00397	0.671
DOC_WW_Pin1_4	778	783	PF00397	0.660
DOC_WW_Pin1_4	93	98	PF00397	0.661
LIG_14-3-3_CanoR_1	11	15	PF00244	0.617
LIG_14-3-3_CanoR_1	170	175	PF00244	0.379
LIG_14-3-3_CanoR_1	381	390	PF00244	0.476
LIG_14-3-3_CanoR_1	417	422	PF00244	0.582
LIG_14-3-3_CanoR_1	463	469	PF00244	0.709
LIG_14-3-3_CanoR_1	719	727	PF00244	0.676
LIG_14-3-3_CanoR_1	83	89	PF00244	0.616
LIG_Actin_WH2_2	142	158	PF00022	0.628
LIG_BIR_III_2	242	246	PF00653	0.473
LIG_BRCT_BRCA1_1	157	161	PF00533	0.701
LIG_BRCT_BRCA1_1	383	387	PF00533	0.483
LIG_BRCT_BRCA1_1	398	402	PF00533	0.349
LIG_BRCT_BRCA1_1	408	412	PF00533	0.274
LIG_BRCT_BRCA1_1	798	802	PF00533	0.707
LIG_BRCT_BRCA1_1	833	837	PF00533	0.626
LIG_EVH1_1	575	579	PF00568	0.706
LIG_FHA_1	173	179	PF00498	0.361
LIG_FHA_1	18	24	PF00498	0.619
LIG_FHA_1	203	209	PF00498	0.591
LIG_FHA_1	373	379	PF00498	0.524
LIG_FHA_1	416	422	PF00498	0.648
LIG_FHA_1	566	572	PF00498	0.811
LIG_FHA_1	696	702	PF00498	0.735
LIG_FHA_1	707	713	PF00498	0.714
LIG_FHA_2	268	274	PF00498	0.551
LIG_FHA_2	278	284	PF00498	0.481
LIG_FHA_2	288	294	PF00498	0.427
LIG_FHA_2	298	304	PF00498	0.447
LIG_FHA_2	308	314	PF00498	0.445
LIG_FHA_2	318	324	PF00498	0.475
LIG_FHA_2	328	334	PF00498	0.443
LIG_FHA_2	338	344	PF00498	0.452
LIG_FHA_2	348	354	PF00498	0.451
LIG_FHA_2	358	364	PF00498	0.455
LIG_IBAR_NPY_1	838	840	PF08397	0.657
LIG_LIR_Apic_2	224	229	PF02991	0.452
LIG_LIR_Apic_2	455	461	PF02991	0.706
LIG_LIR_Apic_2	799	805	PF02991	0.703
LIG_LIR_Gen_1	384	395	PF02991	0.253
LIG_LIR_Gen_1	409	416	PF02991	0.274
LIG_LIR_Nem_3	384	390	PF02991	0.410
LIG_LIR_Nem_3	399	405	PF02991	0.349
LIG_LIR_Nem_3	409	415	PF02991	0.274
LIG_LIR_Nem_3	834	840	PF02991	0.677
LIG_MAD2	191	199	PF02301	0.448
LIG_MYND_1	118	122	PF01753	0.636
LIG_MYND_1	579	583	PF01753	0.764
LIG_MYND_1	699	703	PF01753	0.756
LIG_NRBOX	177	183	PF00104	0.424
LIG_OCRL_FandH_1	33	45	PF00620	0.570
LIG_PALB2_WD40_1	627	635	PF16756	0.707
LIG_PCNA_yPIPBox_3	624	632	PF02747	0.606
LIG_Pex14_1	454	458	PF04695	0.715
LIG_PTB_Apo_2	513	520	PF02174	0.766
LIG_PTB_Phospho_1	513	519	PF10480	0.768
LIG_SH2_SRC	147	150	PF00017	0.631
LIG_SH2_STAP1	731	735	PF00017	0.715
LIG_SH2_STAT3	731	734	PF00017	0.768
LIG_SH2_STAT3	817	820	PF00017	0.700
LIG_SH2_STAT5	519	522	PF00017	0.764
LIG_SH2_STAT5	637	640	PF00017	0.753
LIG_SH2_STAT5	757	760	PF00017	0.692
LIG_SH3_2	122	127	PF14604	0.638
LIG_SH3_2	579	584	PF14604	0.662
LIG_SH3_3	110	116	PF00018	0.621
LIG_SH3_3	119	125	PF00018	0.622
LIG_SH3_3	193	199	PF00018	0.454
LIG_SH3_3	39	45	PF00018	0.578
LIG_SH3_3	566	572	PF00018	0.738
LIG_SH3_3	573	579	PF00018	0.695
LIG_SH3_3	668	674	PF00018	0.773
LIG_SH3_3	704	710	PF00018	0.727
LIG_SH3_3	756	762	PF00018	0.722
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.446
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.605
LIG_SUMO_SIM_par_1	179	185	PF11976	0.349
LIG_SUMO_SIM_par_1	475	482	PF11976	0.666
LIG_SUMO_SIM_par_1	487	493	PF11976	0.683
LIG_TRAF2_1	430	433	PF00917	0.777
LIG_TRAF2_1	611	614	PF00917	0.716
LIG_UBA3_1	542	551	PF00899	0.665
LIG_Vh1_VBS_1	168	186	PF01044	0.274
LIG_WRC_WIRS_1	465	470	PF05994	0.706
LIG_WW_1	754	757	PF00397	0.677
LIG_WW_3	114	118	PF00397	0.628
MOD_CDC14_SPxK_1	124	127	PF00782	0.639
MOD_CDC14_SPxK_1	496	499	PF00782	0.724
MOD_CDK_SPK_2	121	126	PF00069	0.636
MOD_CDK_SPK_2	493	498	PF00069	0.778
MOD_CDK_SPxK_1	121	127	PF00069	0.637
MOD_CDK_SPxK_1	493	499	PF00069	0.727
MOD_CDK_SPxxK_3	17	24	PF00069	0.602
MOD_CDK_SPxxK_3	712	719	PF00069	0.675
MOD_CK1_1	17	23	PF00069	0.585
MOD_CK1_1	209	215	PF00069	0.511
MOD_CK1_1	246	252	PF00069	0.550
MOD_CK1_1	253	259	PF00069	0.524
MOD_CK1_1	261	267	PF00069	0.475
MOD_CK1_1	370	376	PF00069	0.562
MOD_CK1_1	382	388	PF00069	0.499
MOD_CK1_1	448	454	PF00069	0.797
MOD_CK1_1	493	499	PF00069	0.772
MOD_CK1_1	680	686	PF00069	0.766
MOD_CK1_1	73	79	PF00069	0.600
MOD_CK1_1	738	744	PF00069	0.700
MOD_CK1_1	790	796	PF00069	0.709
MOD_CK1_1	798	804	PF00069	0.819
MOD_CK1_1	831	837	PF00069	0.732
MOD_CK2_1	244	250	PF00069	0.600
MOD_CK2_1	267	273	PF00069	0.551
MOD_CK2_1	277	283	PF00069	0.481
MOD_CK2_1	287	293	PF00069	0.428
MOD_CK2_1	297	303	PF00069	0.448
MOD_CK2_1	307	313	PF00069	0.443
MOD_CK2_1	317	323	PF00069	0.477
MOD_CK2_1	327	333	PF00069	0.444
MOD_CK2_1	337	343	PF00069	0.453
MOD_CK2_1	347	353	PF00069	0.451
MOD_CK2_1	357	363	PF00069	0.458
MOD_CK2_1	608	614	PF00069	0.758
MOD_CK2_1	646	652	PF00069	0.784
MOD_GlcNHglycan	184	187	PF01048	0.349
MOD_GlcNHglycan	208	211	PF01048	0.664
MOD_GlcNHglycan	250	253	PF01048	0.729
MOD_GlcNHglycan	387	390	PF01048	0.507
MOD_GlcNHglycan	408	411	PF01048	0.449
MOD_GlcNHglycan	492	495	PF01048	0.535
MOD_GlcNHglycan	610	613	PF01048	0.549
MOD_GlcNHglycan	679	682	PF01048	0.560
MOD_GlcNHglycan	737	740	PF01048	0.496
MOD_GlcNHglycan	747	750	PF01048	0.440
MOD_GSK3_1	10	17	PF00069	0.615
MOD_GSK3_1	150	157	PF00069	0.672
MOD_GSK3_1	202	209	PF00069	0.555
MOD_GSK3_1	244	251	PF00069	0.614
MOD_GSK3_1	252	259	PF00069	0.567
MOD_GSK3_1	260	267	PF00069	0.479
MOD_GSK3_1	275	282	PF00069	0.476
MOD_GSK3_1	283	290	PF00069	0.477
MOD_GSK3_1	293	300	PF00069	0.448
MOD_GSK3_1	303	310	PF00069	0.438
MOD_GSK3_1	313	320	PF00069	0.440
MOD_GSK3_1	323	330	PF00069	0.504
MOD_GSK3_1	333	340	PF00069	0.499
MOD_GSK3_1	343	350	PF00069	0.483
MOD_GSK3_1	353	360	PF00069	0.452
MOD_GSK3_1	363	370	PF00069	0.441
MOD_GSK3_1	373	380	PF00069	0.470
MOD_GSK3_1	381	388	PF00069	0.392
MOD_GSK3_1	445	452	PF00069	0.811
MOD_GSK3_1	641	648	PF00069	0.819
MOD_GSK3_1	71	78	PF00069	0.611
MOD_GSK3_1	741	748	PF00069	0.711
MOD_GSK3_1	82	89	PF00069	0.646
MOD_NEK2_1	10	15	PF00069	0.617
MOD_NEK2_1	155	160	PF00069	0.744
MOD_NEK2_1	36	41	PF00069	0.626
MOD_NEK2_1	406	411	PF00069	0.349
MOD_NEK2_1	415	420	PF00069	0.407
MOD_NEK2_1	50	55	PF00069	0.623
MOD_NEK2_1	597	602	PF00069	0.687
MOD_NEK2_1	71	76	PF00069	0.602
MOD_NEK2_1	77	82	PF00069	0.592
MOD_NEK2_2	221	226	PF00069	0.455
MOD_NEK2_2	476	481	PF00069	0.646
MOD_PIKK_1	449	455	PF00454	0.717
MOD_PIKK_1	50	56	PF00454	0.620
MOD_PIKK_1	714	720	PF00454	0.770
MOD_PIKK_1	738	744	PF00454	0.700
MOD_PIKK_1	803	809	PF00454	0.757
MOD_PIKK_1	828	834	PF00454	0.711
MOD_PKA_2	10	16	PF00069	0.615
MOD_PKA_2	116	122	PF00069	0.635
MOD_PKA_2	140	146	PF00069	0.631
MOD_PKA_2	155	161	PF00069	0.656
MOD_PKA_2	663	669	PF00069	0.736
MOD_PKA_2	82	88	PF00069	0.614
MOD_Plk_1	645	651	PF00069	0.724
MOD_Plk_1	669	675	PF00069	0.665
MOD_Plk_2-3	646	652	PF00069	0.762
MOD_Plk_4	221	227	PF00069	0.508
MOD_Plk_4	77	83	PF00069	0.623
MOD_Plk_4	819	825	PF00069	0.745
MOD_ProDKin_1	121	127	PF00069	0.637
MOD_ProDKin_1	17	23	PF00069	0.603
MOD_ProDKin_1	250	256	PF00069	0.598
MOD_ProDKin_1	379	385	PF00069	0.556
MOD_ProDKin_1	424	430	PF00069	0.649
MOD_ProDKin_1	493	499	PF00069	0.780
MOD_ProDKin_1	565	571	PF00069	0.746
MOD_ProDKin_1	641	647	PF00069	0.752
MOD_ProDKin_1	695	701	PF00069	0.733
MOD_ProDKin_1	706	712	PF00069	0.713
MOD_ProDKin_1	778	784	PF00069	0.654
MOD_ProDKin_1	93	99	PF00069	0.660
MOD_SUMO_for_1	125	128	PF00179	0.636
MOD_SUMO_for_1	444	447	PF00179	0.724
MOD_SUMO_rev_2	440	446	PF00179	0.726
TRG_DiLeu_BaEn_4	128	134	PF01217	0.651
TRG_DiLeu_BaEn_4	433	439	PF01217	0.732
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.666
TRG_ER_diArg_1	102	105	PF00400	0.612
TRG_ER_diArg_1	213	216	PF00400	0.510
TRG_ER_diArg_1	603	605	PF00400	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFJ2	Leishmania donovani	89%	100%
A4HJQ5	Leishmania braziliensis	57%	100%
A4I771	Leishmania infantum	88%	100%