Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q5Z0_LEIMA

TriTrypDb:

LmjF.31.2710 , LMJLV39_310037200 , LMJSD75_310037200

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Z0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.639
CLV_C14_Caspase3-7	62	66	PF00656	0.351
CLV_C14_Caspase3-7	763	767	PF00656	0.452
CLV_NRD_NRD_1	290	292	PF00675	0.448
CLV_NRD_NRD_1	335	337	PF00675	0.474
CLV_NRD_NRD_1	356	358	PF00675	0.503
CLV_NRD_NRD_1	379	381	PF00675	0.565
CLV_NRD_NRD_1	438	440	PF00675	0.511
CLV_NRD_NRD_1	480	482	PF00675	0.576
CLV_NRD_NRD_1	622	624	PF00675	0.692
CLV_NRD_NRD_1	635	637	PF00675	0.447
CLV_NRD_NRD_1	702	704	PF00675	0.517
CLV_NRD_NRD_1	915	917	PF00675	0.351
CLV_PCSK_KEX2_1	292	294	PF00082	0.419
CLV_PCSK_KEX2_1	38	40	PF00082	0.517
CLV_PCSK_KEX2_1	480	482	PF00082	0.576
CLV_PCSK_KEX2_1	673	675	PF00082	0.462
CLV_PCSK_KEX2_1	698	700	PF00082	0.512
CLV_PCSK_KEX2_1	702	704	PF00082	0.520
CLV_PCSK_KEX2_1	914	916	PF00082	0.351
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.419
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.517
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.462
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.421
CLV_PCSK_PC1ET2_1	914	916	PF00082	0.351
CLV_PCSK_SKI1_1	1073	1077	PF00082	0.532
CLV_PCSK_SKI1_1	211	215	PF00082	0.292
CLV_PCSK_SKI1_1	217	221	PF00082	0.387
CLV_PCSK_SKI1_1	38	42	PF00082	0.607
CLV_PCSK_SKI1_1	440	444	PF00082	0.525
CLV_PCSK_SKI1_1	450	454	PF00082	0.508
CLV_PCSK_SKI1_1	618	622	PF00082	0.656
CLV_PCSK_SKI1_1	695	699	PF00082	0.427
CLV_PCSK_SKI1_1	702	706	PF00082	0.459
CLV_PCSK_SKI1_1	722	726	PF00082	0.327
CLV_PCSK_SKI1_1	769	773	PF00082	0.374
CLV_PCSK_SKI1_1	830	834	PF00082	0.365
CLV_PCSK_SKI1_1	850	854	PF00082	0.171
DEG_APCC_DBOX_1	251	259	PF00400	0.440
DEG_APCC_DBOX_1	290	298	PF00400	0.551
DEG_SCF_FBW7_1	563	569	PF00400	0.455
DOC_AGCK_PIF_1	852	857	PF00069	0.357
DOC_CKS1_1	563	568	PF01111	0.460
DOC_CYCLIN_yClb1_LxF_4	848	853	PF00134	0.313
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.357
DOC_MAPK_gen_1	215	222	PF00069	0.373
DOC_MAPK_gen_1	291	300	PF00069	0.478
DOC_MAPK_gen_1	336	344	PF00069	0.462
DOC_MAPK_gen_1	38	46	PF00069	0.482
DOC_MAPK_gen_1	636	646	PF00069	0.503
DOC_PP1_RVXF_1	215	222	PF00149	0.375
DOC_PP1_RVXF_1	437	444	PF00149	0.431
DOC_PP1_RVXF_1	48	54	PF00149	0.357
DOC_PP1_RVXF_1	848	854	PF00149	0.313
DOC_PP1_RVXF_1	890	897	PF00149	0.384
DOC_PP1_SILK_1	287	292	PF00149	0.468
DOC_PP2B_LxvP_1	403	406	PF13499	0.541
DOC_PP4_FxxP_1	888	891	PF00568	0.378
DOC_USP7_MATH_1	1064	1068	PF00917	0.561
DOC_USP7_MATH_1	17	21	PF00917	0.556
DOC_USP7_MATH_1	264	268	PF00917	0.576
DOC_USP7_MATH_1	285	289	PF00917	0.439
DOC_USP7_MATH_1	3	7	PF00917	0.544
DOC_USP7_MATH_1	498	502	PF00917	0.668
DOC_USP7_MATH_1	554	558	PF00917	0.566
DOC_USP7_MATH_1	566	570	PF00917	0.595
DOC_USP7_MATH_1	764	768	PF00917	0.480
DOC_USP7_MATH_1	970	974	PF00917	0.335
DOC_USP7_UBL2_3	365	369	PF12436	0.490
DOC_USP7_UBL2_3	38	42	PF12436	0.608
DOC_USP7_UBL2_3	450	454	PF12436	0.567
DOC_USP7_UBL2_3	838	842	PF12436	0.357
DOC_USP7_UBL2_3	88	92	PF12436	0.351
DOC_WW_Pin1_4	13	18	PF00397	0.629
DOC_WW_Pin1_4	311	316	PF00397	0.577
DOC_WW_Pin1_4	507	512	PF00397	0.642
DOC_WW_Pin1_4	562	567	PF00397	0.572
LIG_14-3-3_CanoR_1	1017	1025	PF00244	0.351
LIG_14-3-3_CanoR_1	362	370	PF00244	0.394
LIG_14-3-3_CanoR_1	471	477	PF00244	0.562
LIG_14-3-3_CanoR_1	481	489	PF00244	0.567
LIG_14-3-3_CanoR_1	560	566	PF00244	0.569
LIG_14-3-3_CanoR_1	636	644	PF00244	0.592
LIG_14-3-3_CanoR_1	665	671	PF00244	0.566
LIG_14-3-3_CanoR_1	711	721	PF00244	0.432
LIG_14-3-3_CanoR_1	738	742	PF00244	0.403
LIG_14-3-3_CanoR_1	822	832	PF00244	0.226
LIG_14-3-3_CanoR_1	850	856	PF00244	0.383
LIG_14-3-3_CanoR_1	922	927	PF00244	0.357
LIG_14-3-3_CanoR_1	933	937	PF00244	0.412
LIG_14-3-3_CanoR_1	938	944	PF00244	0.460
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BRCT_BRCA1_1	884	888	PF00533	0.357
LIG_BRCT_BRCA1_1	965	969	PF00533	0.399
LIG_BRCT_BRCA1_1	999	1003	PF00533	0.357
LIG_CaM_IQ_9	697	713	PF13499	0.492
LIG_Clathr_ClatBox_1	220	224	PF01394	0.396
LIG_DLG_GKlike_1	674	682	PF00625	0.469
LIG_eIF4E_1	225	231	PF01652	0.451
LIG_eIF4E_1	719	725	PF01652	0.386
LIG_FHA_1	1010	1016	PF00498	0.398
LIG_FHA_1	1020	1026	PF00498	0.351
LIG_FHA_1	1029	1035	PF00498	0.321
LIG_FHA_1	315	321	PF00498	0.710
LIG_FHA_1	713	719	PF00498	0.460
LIG_FHA_1	766	772	PF00498	0.410
LIG_FHA_1	77	83	PF00498	0.431
LIG_FHA_1	824	830	PF00498	0.385
LIG_FHA_1	835	841	PF00498	0.422
LIG_FHA_1	854	860	PF00498	0.333
LIG_FHA_1	997	1003	PF00498	0.359
LIG_FHA_2	1050	1056	PF00498	0.564
LIG_FHA_2	237	243	PF00498	0.558
LIG_FHA_2	268	274	PF00498	0.514
LIG_FHA_2	346	352	PF00498	0.443
LIG_FHA_2	656	662	PF00498	0.458
LIG_FHA_2	945	951	PF00498	0.351
LIG_GBD_Chelix_1	581	589	PF00786	0.531
LIG_GBD_Chelix_1	980	988	PF00786	0.335
LIG_Integrin_isoDGR_2	920	922	PF01839	0.351
LIG_LIR_Apic_2	885	891	PF02991	0.357
LIG_LIR_Gen_1	1000	1011	PF02991	0.357
LIG_LIR_Gen_1	1055	1065	PF02991	0.430
LIG_LIR_Gen_1	459	469	PF02991	0.573
LIG_LIR_Gen_1	794	805	PF02991	0.365
LIG_LIR_Gen_1	923	932	PF02991	0.351
LIG_LIR_Nem_3	1000	1006	PF02991	0.392
LIG_LIR_Nem_3	1055	1061	PF02991	0.556
LIG_LIR_Nem_3	151	156	PF02991	0.351
LIG_LIR_Nem_3	459	465	PF02991	0.579
LIG_LIR_Nem_3	69	74	PF02991	0.351
LIG_LIR_Nem_3	794	800	PF02991	0.320
LIG_LIR_Nem_3	923	929	PF02991	0.351
LIG_NRBOX	1001	1007	PF00104	0.351
LIG_NRBOX	293	299	PF00104	0.458
LIG_NRBOX	650	656	PF00104	0.472
LIG_NRBOX	720	726	PF00104	0.385
LIG_PCNA_yPIPBox_3	573	582	PF02747	0.550
LIG_Pex14_1	247	251	PF04695	0.372
LIG_SH2_CRK	462	466	PF00017	0.578
LIG_SH2_GRB2like	156	159	PF00017	0.304
LIG_SH2_SRC	229	232	PF00017	0.454
LIG_SH2_STAP1	462	466	PF00017	0.554
LIG_SH2_STAP1	719	723	PF00017	0.430
LIG_SH2_STAP1	783	787	PF00017	0.465
LIG_SH2_STAP1	993	997	PF00017	0.351
LIG_SH2_STAT3	106	109	PF00017	0.351
LIG_SH2_STAT3	199	202	PF00017	0.357
LIG_SH2_STAT5	106	109	PF00017	0.270
LIG_SH2_STAT5	129	132	PF00017	0.311
LIG_SH2_STAT5	199	202	PF00017	0.292
LIG_SH2_STAT5	225	228	PF00017	0.432
LIG_SH2_STAT5	229	232	PF00017	0.466
LIG_SH2_STAT5	254	257	PF00017	0.461
LIG_SH2_STAT5	74	77	PF00017	0.308
LIG_SH2_STAT5	785	788	PF00017	0.328
LIG_SH2_STAT5	839	842	PF00017	0.428
LIG_SH2_STAT5	98	101	PF00017	0.332
LIG_SH3_3	403	409	PF00018	0.592
LIG_SH3_3	505	511	PF00018	0.624
LIG_SH3_3	8	14	PF00018	0.645
LIG_SUMO_SIM_anti_2	588	594	PF11976	0.503
LIG_SUMO_SIM_par_1	860	865	PF11976	0.340
LIG_SUMO_SIM_par_1	903	909	PF11976	0.291
LIG_SxIP_EBH_1	984	995	PF03271	0.247
LIG_TRAF2_1	457	460	PF00917	0.553
LIG_TRAF2_1	523	526	PF00917	0.511
LIG_UBA3_1	297	304	PF00899	0.529
LIG_UBA3_1	832	838	PF00899	0.313
LIG_WRC_WIRS_1	852	857	PF05994	0.357
MOD_CDK_SPxxK_3	511	518	PF00069	0.486
MOD_CK1_1	1028	1034	PF00069	0.254
MOD_CK1_1	2	8	PF00069	0.633
MOD_CK1_1	22	28	PF00069	0.559
MOD_CK1_1	267	273	PF00069	0.523
MOD_CK1_1	307	313	PF00069	0.668
MOD_CK1_1	314	320	PF00069	0.692
MOD_CK1_1	510	516	PF00069	0.529
MOD_CK1_1	55	61	PF00069	0.403
MOD_CK1_1	562	568	PF00069	0.525
MOD_CK1_1	580	586	PF00069	0.389
MOD_CK1_1	669	675	PF00069	0.567
MOD_CK1_1	677	683	PF00069	0.524
MOD_CK1_1	823	829	PF00069	0.355
MOD_CK1_1	973	979	PF00069	0.363
MOD_CK1_1	996	1002	PF00069	0.328
MOD_CK2_1	1017	1023	PF00069	0.390
MOD_CK2_1	1049	1055	PF00069	0.575
MOD_CK2_1	2	8	PF00069	0.524
MOD_CK2_1	236	242	PF00069	0.557
MOD_CK2_1	345	351	PF00069	0.441
MOD_CK2_1	561	567	PF00069	0.580
MOD_CK2_1	685	691	PF00069	0.404
MOD_CK2_1	710	716	PF00069	0.427
MOD_GlcNHglycan	1	4	PF01048	0.591
MOD_GlcNHglycan	181	184	PF01048	0.409
MOD_GlcNHglycan	23	27	PF01048	0.515
MOD_GlcNHglycan	308	312	PF01048	0.653
MOD_GlcNHglycan	390	393	PF01048	0.632
MOD_GlcNHglycan	403	406	PF01048	0.599
MOD_GlcNHglycan	5	8	PF01048	0.749
MOD_GlcNHglycan	54	57	PF01048	0.415
MOD_GlcNHglycan	567	571	PF01048	0.478
MOD_GlcNHglycan	593	596	PF01048	0.552
MOD_GlcNHglycan	637	640	PF01048	0.570
MOD_GlcNHglycan	691	694	PF01048	0.517
MOD_GlcNHglycan	750	753	PF01048	0.493
MOD_GlcNHglycan	808	811	PF01048	0.351
MOD_GlcNHglycan	822	825	PF01048	0.171
MOD_GlcNHglycan	863	867	PF01048	0.346
MOD_GlcNHglycan	873	876	PF01048	0.361
MOD_GlcNHglycan	900	903	PF01048	0.362
MOD_GlcNHglycan	953	956	PF01048	0.444
MOD_GlcNHglycan	965	968	PF01048	0.255
MOD_GSK3_1	13	20	PF00069	0.645
MOD_GSK3_1	22	29	PF00069	0.622
MOD_GSK3_1	236	243	PF00069	0.464
MOD_GSK3_1	264	271	PF00069	0.467
MOD_GSK3_1	307	314	PF00069	0.624
MOD_GSK3_1	384	391	PF00069	0.599
MOD_GSK3_1	395	402	PF00069	0.579
MOD_GSK3_1	506	513	PF00069	0.571
MOD_GSK3_1	514	521	PF00069	0.555
MOD_GSK3_1	55	62	PF00069	0.445
MOD_GSK3_1	562	569	PF00069	0.565
MOD_GSK3_1	577	584	PF00069	0.459
MOD_GSK3_1	674	681	PF00069	0.521
MOD_GSK3_1	685	692	PF00069	0.374
MOD_GSK3_1	72	79	PF00069	0.351
MOD_GSK3_1	737	744	PF00069	0.468
MOD_GSK3_1	820	827	PF00069	0.349
MOD_GSK3_1	834	841	PF00069	0.426
MOD_GSK3_1	96	103	PF00069	0.226
MOD_GSK3_1	993	1000	PF00069	0.357
MOD_N-GLC_1	1049	1054	PF02516	0.587
MOD_N-GLC_1	482	487	PF02516	0.732
MOD_N-GLC_1	876	881	PF02516	0.313
MOD_N-GLC_1	970	975	PF02516	0.351
MOD_NEK2_1	345	350	PF00069	0.460
MOD_NEK2_1	384	389	PF00069	0.525
MOD_NEK2_1	548	553	PF00069	0.594
MOD_NEK2_1	561	566	PF00069	0.678
MOD_NEK2_1	577	582	PF00069	0.486
MOD_NEK2_1	613	618	PF00069	0.526
MOD_NEK2_1	655	660	PF00069	0.409
MOD_NEK2_1	678	683	PF00069	0.662
MOD_NEK2_1	806	811	PF00069	0.336
MOD_NEK2_1	851	856	PF00069	0.404
MOD_NEK2_1	956	961	PF00069	0.348
MOD_NEK2_2	331	336	PF00069	0.494
MOD_NEK2_2	59	64	PF00069	0.292
MOD_NEK2_2	944	949	PF00069	0.351
MOD_PIKK_1	956	962	PF00454	0.478
MOD_PIKK_1	971	977	PF00454	0.219
MOD_PK_1	789	795	PF00069	0.313
MOD_PKA_1	357	363	PF00069	0.434
MOD_PKA_1	705	711	PF00069	0.503
MOD_PKA_2	1018	1024	PF00069	0.357
MOD_PKA_2	234	240	PF00069	0.552
MOD_PKA_2	384	390	PF00069	0.608
MOD_PKA_2	472	478	PF00069	0.572
MOD_PKA_2	559	565	PF00069	0.524
MOD_PKA_2	635	641	PF00069	0.474
MOD_PKA_2	710	716	PF00069	0.475
MOD_PKA_2	737	743	PF00069	0.369
MOD_PKA_2	932	938	PF00069	0.451
MOD_PKA_2	944	950	PF00069	0.334
MOD_PKB_1	1017	1025	PF00069	0.291
MOD_Plk_1	1025	1031	PF00069	0.351
MOD_Plk_1	285	291	PF00069	0.496
MOD_Plk_1	345	351	PF00069	0.487
MOD_Plk_1	518	524	PF00069	0.565
MOD_Plk_1	613	619	PF00069	0.561
MOD_Plk_1	678	684	PF00069	0.454
MOD_Plk_1	728	734	PF00069	0.490
MOD_Plk_1	776	782	PF00069	0.417
MOD_Plk_1	789	795	PF00069	0.269
MOD_Plk_1	997	1003	PF00069	0.357
MOD_Plk_2-3	411	417	PF00069	0.567
MOD_Plk_2-3	710	716	PF00069	0.475
MOD_Plk_4	1034	1040	PF00069	0.545
MOD_Plk_4	285	291	PF00069	0.471
MOD_Plk_4	577	583	PF00069	0.399
MOD_Plk_4	737	743	PF00069	0.411
MOD_Plk_4	824	830	PF00069	0.480
MOD_Plk_4	922	928	PF00069	0.464
MOD_Plk_4	944	950	PF00069	0.365
MOD_Plk_4	986	992	PF00069	0.297
MOD_Plk_4	997	1003	PF00069	0.314
MOD_ProDKin_1	13	19	PF00069	0.628
MOD_ProDKin_1	311	317	PF00069	0.575
MOD_ProDKin_1	507	513	PF00069	0.637
MOD_ProDKin_1	562	568	PF00069	0.564
MOD_SUMO_for_1	453	456	PF00179	0.580
MOD_SUMO_for_1	585	588	PF00179	0.538
MOD_SUMO_rev_2	1068	1078	PF00179	0.526
MOD_SUMO_rev_2	204	213	PF00179	0.364
MOD_SUMO_rev_2	267	276	PF00179	0.438
MOD_SUMO_rev_2	361	370	PF00179	0.498
MOD_SUMO_rev_2	632	639	PF00179	0.555
MOD_SUMO_rev_2	691	700	PF00179	0.550
MOD_SUMO_rev_2	81	89	PF00179	0.351
TRG_DiLeu_BaEn_1	650	655	PF01217	0.468
TRG_DiLeu_BaEn_1	720	725	PF01217	0.389
TRG_DiLeu_BaEn_3	614	620	PF01217	0.523
TRG_DiLeu_BaEn_4	467	473	PF01217	0.525
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.412
TRG_DiLeu_LyEn_5	650	655	PF01217	0.468
TRG_ENDOCYTIC_2	141	144	PF00928	0.322
TRG_ENDOCYTIC_2	462	465	PF00928	0.575
TRG_ER_diArg_1	290	293	PF00400	0.479
TRG_ER_diArg_1	471	474	PF00400	0.546
TRG_ER_diArg_1	480	482	PF00400	0.588
TRG_ER_diArg_1	541	544	PF00400	0.535
TRG_ER_diArg_1	702	704	PF00400	0.517
TRG_NES_CRM1_1	333	346	PF08389	0.508
TRG_NES_CRM1_1	463	477	PF08389	0.553
TRG_NES_CRM1_1	849	863	PF08389	0.313
TRG_NLS_MonoExtC_3	37	42	PF00514	0.600
TRG_NLS_MonoExtN_4	35	42	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY9	Leptomonas seymouri	51%	100%
A0A1X0NJ05	Trypanosomatidae	32%	100%
A0A3S7X4W4	Leishmania donovani	87%	100%
A4HJQ8	Leishmania braziliensis	71%	100%
A4I775	Leishmania infantum	88%	100%
E9B269	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%