Endoplasmic reticulum transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5Y9_LEIMA

TriTrypDb:

LmjF.31.2715 , LMJLV39_310037300 , LMJSD75_310037300

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q5Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.477
CLV_PCSK_KEX2_1	126	128	PF00082	0.504
CLV_PCSK_KEX2_1	92	94	PF00082	0.625
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.645
DOC_CDC14_PxL_1	11	19	PF14671	0.419
DOC_MAPK_gen_1	77	85	PF00069	0.394
DOC_MAPK_gen_1	92	102	PF00069	0.349
DOC_MAPK_MEF2A_6	79	87	PF00069	0.391
DOC_MAPK_MEF2A_6	95	104	PF00069	0.423
DOC_MAPK_RevD_3	100	115	PF00069	0.362
DOC_USP7_UBL2_3	73	77	PF12436	0.451
LIG_14-3-3_CanoR_1	28	37	PF00244	0.649
LIG_14-3-3_CanoR_1	79	87	PF00244	0.463
LIG_BRCT_BRCA1_1	59	63	PF00533	0.447
LIG_FHA_1	115	121	PF00498	0.452
LIG_FHA_1	16	22	PF00498	0.416
LIG_FHA_1	36	42	PF00498	0.636
LIG_LIR_Gen_1	3	12	PF02991	0.474
LIG_LIR_Gen_1	59	68	PF02991	0.356
LIG_LIR_Nem_3	18	23	PF02991	0.314
LIG_LIR_Nem_3	3	7	PF02991	0.442
LIG_LIR_Nem_3	59	64	PF02991	0.321
LIG_PCNA_PIPBox_1	13	22	PF02747	0.402
LIG_Pex14_1	70	74	PF04695	0.366
LIG_Pex14_2	61	65	PF04695	0.384
LIG_SH2_CRK	23	27	PF00017	0.480
LIG_SH2_PTP2	101	104	PF00017	0.447
LIG_SH2_STAT5	101	104	PF00017	0.335
LIG_SH2_STAT5	23	26	PF00017	0.438
LIG_SH3_3	9	15	PF00018	0.447
LIG_TRAF2_1	121	124	PF00917	0.630
LIG_UBA3_1	64	73	PF00899	0.544
LIG_WRC_WIRS_1	1	6	PF05994	0.507
LIG_WRC_WIRS_1	58	63	PF05994	0.381
MOD_CK1_1	134	140	PF00069	0.644
MOD_CK1_1	47	53	PF00069	0.374
MOD_CK1_1	59	65	PF00069	0.435
MOD_CK2_1	118	124	PF00069	0.555
MOD_GlcNHglycan	128	132	PF01048	0.520
MOD_GlcNHglycan	30	33	PF01048	0.481
MOD_GlcNHglycan	46	49	PF01048	0.404
MOD_GlcNHglycan	52	55	PF01048	0.456
MOD_GSK3_1	114	121	PF00069	0.368
MOD_GSK3_1	127	134	PF00069	0.668
MOD_N-GLC_1	44	49	PF02516	0.247
MOD_NEK2_2	15	20	PF00069	0.480
MOD_PKA_1	114	120	PF00069	0.246
MOD_PKA_2	134	140	PF00069	0.728
MOD_PKA_2	35	41	PF00069	0.627
MOD_PKA_2	78	84	PF00069	0.466
MOD_Plk_1	81	87	PF00069	0.388
MOD_Plk_4	15	21	PF00069	0.426
MOD_Plk_4	47	53	PF00069	0.334
MOD_SUMO_rev_2	84	94	PF00179	0.443
TRG_ENDOCYTIC_2	101	104	PF00928	0.447
TRG_ER_diArg_1	125	127	PF00400	0.711
TRG_ER_diArg_1	93	96	PF00400	0.416
TRG_NLS_MonoExtC_3	91	97	PF00514	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A6	Leptomonas seymouri	67%	99%
A0A0S4IVS1	Bodo saltans	24%	90%
A0A1X0NIN7	Trypanosomatidae	37%	100%
A0A3R7L4C4	Trypanosoma rangeli	35%	87%
A0A3S7X4X5	Leishmania donovani	95%	100%
A4HJQ9	Leishmania braziliensis	78%	100%
A4I776	Leishmania infantum	95%	100%
C9ZMF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B270	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%