LeishMANIAdb
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GOLD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GOLD domain-containing protein
Gene product:
emp24/gp25L/p24 family/GOLD, putative
Species:
Leishmania major
UniProt:
Q4Q5Y7_LEIMA
TriTrypDb:
LmjF.31.2730 , LMJLV39_310037700 * , LMJSD75_310037700
Length:
263

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic GOLD domain proteins, involved in sorting of GPI-achored proteins. Kinetoplastids contain several paralogous GOLD domain protein families, not all closely related to each others.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 3
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 2
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 2
GO:0005794 Golgi apparatus 5 2
GO:0016020 membrane 2 13
GO:0030134 COPII-coated ER to Golgi transport vesicle 8 2
GO:0030135 coated vesicle 7 2
GO:0031410 cytoplasmic vesicle 6 2
GO:0031982 vesicle 4 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0097708 intracellular vesicle 5 2
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

Q4Q5Y7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Y7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006886 intracellular protein transport 4 2
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 2
GO:0006996 organelle organization 4 2
GO:0007030 Golgi organization 5 2
GO:0008104 protein localization 4 2
GO:0009987 cellular process 1 2
GO:0015031 protein transport 4 2
GO:0016043 cellular component organization 3 2
GO:0016192 vesicle-mediated transport 4 2
GO:0033036 macromolecule localization 2 2
GO:0045184 establishment of protein localization 3 2
GO:0046907 intracellular transport 3 2
GO:0048193 Golgi vesicle transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0070727 cellular macromolecule localization 3 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:0071840 cellular component organization or biogenesis 2 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 254 256 PF00675 0.421
CLV_PCSK_KEX2_1 166 168 PF00082 0.499
CLV_PCSK_KEX2_1 254 256 PF00082 0.404
CLV_PCSK_PC1ET2_1 166 168 PF00082 0.504
CLV_PCSK_SKI1_1 167 171 PF00082 0.507
DEG_APCC_DBOX_1 212 220 PF00400 0.362
DEG_Nend_Nbox_1 1 3 PF02207 0.663
DEG_ODPH_VHL_1 13 26 PF01847 0.643
DOC_MAPK_gen_1 166 172 PF00069 0.342
DOC_PP1_RVXF_1 156 163 PF00149 0.304
DOC_PP1_RVXF_1 79 85 PF00149 0.369
DOC_PP4_FxxP_1 84 87 PF00568 0.322
DOC_SPAK_OSR1_1 161 165 PF12202 0.377
DOC_WW_Pin1_4 153 158 PF00397 0.271
DOC_WW_Pin1_4 82 87 PF00397 0.339
LIG_14-3-3_CanoR_1 120 128 PF00244 0.310
LIG_14-3-3_CanoR_1 67 74 PF00244 0.291
LIG_BRCT_BRCA1_1 144 148 PF00533 0.385
LIG_FHA_1 51 57 PF00498 0.328
LIG_FHA_1 63 69 PF00498 0.261
LIG_FHA_1 83 89 PF00498 0.141
LIG_LIR_Apic_2 125 131 PF02991 0.273
LIG_LIR_Gen_1 149 160 PF02991 0.295
LIG_LIR_Gen_1 49 58 PF02991 0.360
LIG_LIR_Nem_3 149 155 PF02991 0.285
LIG_LIR_Nem_3 156 162 PF02991 0.254
LIG_LIR_Nem_3 49 55 PF02991 0.351
LIG_NRBOX 23 29 PF00104 0.607
LIG_Pex14_2 148 152 PF04695 0.291
LIG_SH2_CRK 128 132 PF00017 0.280
LIG_SH2_CRK 191 195 PF00017 0.339
LIG_SH2_CRK 240 244 PF00017 0.365
LIG_SH2_NCK_1 128 132 PF00017 0.280
LIG_SH2_PTP2 242 245 PF00017 0.433
LIG_SH2_SRC 240 243 PF00017 0.472
LIG_SH2_STAP1 126 130 PF00017 0.362
LIG_SH2_STAP1 52 56 PF00017 0.336
LIG_SH2_STAT5 128 131 PF00017 0.279
LIG_SH2_STAT5 242 245 PF00017 0.363
LIG_SH2_STAT5 52 55 PF00017 0.362
LIG_SH3_3 16 22 PF00018 0.624
LIG_SH3_3 9 15 PF00018 0.648
LIG_SUMO_SIM_par_1 168 173 PF11976 0.354
LIG_SUMO_SIM_par_1 231 236 PF11976 0.445
LIG_SUMO_SIM_par_1 24 32 PF11976 0.583
LIG_TRAF2_1 183 186 PF00917 0.356
MOD_CDK_SPK_2 153 158 PF00069 0.271
MOD_CK1_1 151 157 PF00069 0.302
MOD_CK2_1 179 185 PF00069 0.280
MOD_CK2_1 39 45 PF00069 0.326
MOD_GlcNHglycan 181 184 PF01048 0.530
MOD_GSK3_1 110 117 PF00069 0.313
MOD_GSK3_1 122 129 PF00069 0.245
MOD_GSK3_1 256 263 PF00069 0.715
MOD_GSK3_1 29 36 PF00069 0.588
MOD_GSK3_1 46 53 PF00069 0.311
MOD_GSK3_1 58 65 PF00069 0.240
MOD_GSK3_1 88 95 PF00069 0.317
MOD_NEK2_1 148 153 PF00069 0.291
MOD_NEK2_1 258 263 PF00069 0.721
MOD_NEK2_1 27 32 PF00069 0.577
MOD_NEK2_1 62 67 PF00069 0.313
MOD_NEK2_1 92 97 PF00069 0.313
MOD_PKA_2 110 116 PF00069 0.327
MOD_PKA_2 119 125 PF00069 0.289
MOD_PKA_2 66 72 PF00069 0.291
MOD_Plk_1 142 148 PF00069 0.291
MOD_Plk_1 88 94 PF00069 0.310
MOD_Plk_4 110 116 PF00069 0.285
MOD_Plk_4 190 196 PF00069 0.299
MOD_Plk_4 29 35 PF00069 0.573
MOD_ProDKin_1 153 159 PF00069 0.271
MOD_ProDKin_1 82 88 PF00069 0.339
TRG_DiLeu_BaLyEn_6 19 24 PF01217 0.551
TRG_ENDOCYTIC_2 191 194 PF00928 0.339
TRG_ENDOCYTIC_2 240 243 PF00928 0.334
TRG_ENDOCYTIC_2 52 55 PF00928 0.358
TRG_ER_diArg_1 253 255 PF00400 0.635
TRG_Pf-PMV_PEXEL_1 247 252 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4P8 Leptomonas seymouri 75% 100%
A0A0S4JHN1 Bodo saltans 28% 100%
A0A0S4JHW2 Bodo saltans 30% 100%
A0A1X0NIF0 Trypanosomatidae 51% 100%
A0A3Q8IGK5 Leishmania donovani 96% 100%
A0A3R7MK91 Trypanosoma rangeli 48% 100%
A4HJR1 Leishmania braziliensis 84% 100%
A4I778 Leishmania infantum 96% 100%
C9ZWM6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9B272 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5B7K8 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS