Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania major

UniProt:

Q4Q5Y6_LEIMA

TriTrypDb:

LmjF.31.2740 , LMJLV39_310037800 , LMJSD75_310037800

Length:

467

Annotations

LeishMANIAdb annotations

A conserved ERGIC3 protein in all eukaryotes.. The N-terminal signal-anchor is very similar to a full signal peptide.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q5Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.356
CLV_NRD_NRD_1	231	233	PF00675	0.446
CLV_NRD_NRD_1	291	293	PF00675	0.519
CLV_NRD_NRD_1	301	303	PF00675	0.472
CLV_NRD_NRD_1	455	457	PF00675	0.343
CLV_NRD_NRD_1	458	460	PF00675	0.342
CLV_NRD_NRD_1	75	77	PF00675	0.327
CLV_PCSK_KEX2_1	231	233	PF00082	0.457
CLV_PCSK_KEX2_1	291	293	PF00082	0.530
CLV_PCSK_KEX2_1	66	68	PF00082	0.304
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.349
CLV_PCSK_SKI1_1	109	113	PF00082	0.459
CLV_PCSK_SKI1_1	189	193	PF00082	0.612
CLV_PCSK_SKI1_1	63	67	PF00082	0.329
DEG_APCC_KENBOX_2	201	205	PF00400	0.409
DEG_SPOP_SBC_1	6	10	PF00917	0.539
DOC_CYCLIN_RxL_1	299	309	PF00134	0.274
DOC_CYCLIN_RxL_1	38	50	PF00134	0.596
DOC_MAPK_DCC_7	396	406	PF00069	0.333
DOC_MAPK_gen_1	231	238	PF00069	0.333
DOC_MAPK_HePTP_8	122	134	PF00069	0.301
DOC_MAPK_MEF2A_6	125	134	PF00069	0.339
DOC_MAPK_MEF2A_6	397	406	PF00069	0.301
DOC_PP4_FxxP_1	315	318	PF00568	0.301
DOC_USP7_MATH_1	255	259	PF00917	0.281
DOC_USP7_MATH_1	274	278	PF00917	0.358
DOC_USP7_MATH_1	330	334	PF00917	0.329
DOC_USP7_MATH_1	422	426	PF00917	0.250
DOC_USP7_UBL2_3	189	193	PF12436	0.412
DOC_USP7_UBL2_3	73	77	PF12436	0.483
DOC_WW_Pin1_4	380	385	PF00397	0.270
DOC_WW_Pin1_4	408	413	PF00397	0.214
LIG_14-3-3_CanoR_1	109	115	PF00244	0.301
LIG_14-3-3_CanoR_1	17	26	PF00244	0.658
LIG_14-3-3_CanoR_1	346	350	PF00244	0.266
LIG_14-3-3_CanoR_1	360	364	PF00244	0.251
LIG_14-3-3_CanoR_1	83	88	PF00244	0.459
LIG_AP2alpha_1	315	319	PF02296	0.301
LIG_AP2alpha_2	317	319	PF02296	0.301
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BIR_III_4	196	200	PF00653	0.475
LIG_BRCT_BRCA1_1	1	5	PF00533	0.532
LIG_BRCT_BRCA1_1	276	280	PF00533	0.341
LIG_BRCT_BRCA1_1	448	452	PF00533	0.536
LIG_BRCT_BRCA1_1	49	53	PF00533	0.639
LIG_Clathr_ClatBox_1	145	149	PF01394	0.318
LIG_eIF4E_1	358	364	PF01652	0.318
LIG_FHA_1	131	137	PF00498	0.289
LIG_FHA_1	172	178	PF00498	0.435
LIG_FHA_1	190	196	PF00498	0.397
LIG_FHA_1	273	279	PF00498	0.259
LIG_FHA_1	299	305	PF00498	0.333
LIG_FHA_1	34	40	PF00498	0.666
LIG_FHA_1	405	411	PF00498	0.293
LIG_FHA_1	461	467	PF00498	0.622
LIG_FHA_1	54	60	PF00498	0.488
LIG_FHA_2	219	225	PF00498	0.250
LIG_FHA_2	381	387	PF00498	0.335
LIG_GBD_Chelix_1	95	103	PF00786	0.326
LIG_Integrin_isoDGR_2	344	346	PF01839	0.470
LIG_LIR_Apic_2	312	318	PF02991	0.301
LIG_LIR_Gen_1	137	146	PF02991	0.356
LIG_LIR_Gen_1	348	358	PF02991	0.259
LIG_LIR_Nem_3	137	141	PF02991	0.250
LIG_LIR_Nem_3	152	157	PF02991	0.240
LIG_LIR_Nem_3	348	353	PF02991	0.259
LIG_LIR_Nem_3	356	361	PF02991	0.259
LIG_LIR_Nem_3	69	74	PF02991	0.459
LIG_LYPXL_yS_3	423	426	PF13949	0.299
LIG_MAD2	414	422	PF02301	0.356
LIG_MLH1_MIPbox_1	1	5	PF16413	0.532
LIG_NRBOX	44	50	PF00104	0.521
LIG_Pex14_2	315	319	PF04695	0.259
LIG_Pex14_2	74	78	PF04695	0.459
LIG_SH2_CRK	361	365	PF00017	0.345
LIG_SH2_NCK_1	361	365	PF00017	0.345
LIG_SH2_STAP1	266	270	PF00017	0.356
LIG_SH2_STAT5	110	113	PF00017	0.242
LIG_SH2_STAT5	349	352	PF00017	0.250
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.321
LIG_SUMO_SIM_par_1	144	149	PF11976	0.341
LIG_TRAF2_1	113	116	PF00917	0.318
LIG_TRFH_1	408	412	PF08558	0.259
LIG_WRC_WIRS_1	266	271	PF05994	0.356
MOD_CDC14_SPxK_1	411	414	PF00782	0.250
MOD_CDK_SPxK_1	408	414	PF00069	0.228
MOD_CK1_1	10	16	PF00069	0.700
MOD_CK1_1	272	278	PF00069	0.326
MOD_CK1_1	333	339	PF00069	0.341
MOD_CK1_1	362	368	PF00069	0.341
MOD_CK1_1	52	58	PF00069	0.640
MOD_CK2_1	110	116	PF00069	0.250
MOD_CK2_1	255	261	PF00069	0.275
MOD_CK2_1	380	386	PF00069	0.309
MOD_Cter_Amidation	289	292	PF01082	0.541
MOD_GlcNHglycan	178	181	PF01048	0.654
MOD_GlcNHglycan	257	260	PF01048	0.472
MOD_GlcNHglycan	332	335	PF01048	0.541
MOD_GlcNHglycan	376	379	PF01048	0.534
MOD_GlcNHglycan	453	456	PF01048	0.265
MOD_GlcNHglycan	87	90	PF01048	0.450
MOD_GSK3_1	130	137	PF00069	0.302
MOD_GSK3_1	265	272	PF00069	0.345
MOD_GSK3_1	326	333	PF00069	0.356
MOD_GSK3_1	370	377	PF00069	0.270
MOD_GSK3_1	404	411	PF00069	0.259
MOD_GSK3_1	49	56	PF00069	0.638
MOD_GSK3_1	6	13	PF00069	0.614
MOD_N-GLC_1	10	15	PF02516	0.432
MOD_N-GLC_1	134	139	PF02516	0.450
MOD_NEK2_1	121	126	PF00069	0.321
MOD_NEK2_1	130	135	PF00069	0.276
MOD_NEK2_1	16	21	PF00069	0.671
MOD_NEK2_1	265	270	PF00069	0.302
MOD_NEK2_1	296	301	PF00069	0.275
MOD_NEK2_1	304	309	PF00069	0.222
MOD_NEK2_1	326	331	PF00069	0.315
MOD_NEK2_1	446	451	PF00069	0.410
MOD_NEK2_1	47	52	PF00069	0.694
MOD_NEK2_1	5	10	PF00069	0.601
MOD_NEK2_1	53	58	PF00069	0.676
MOD_PIKK_1	389	395	PF00454	0.359
MOD_PKA_2	16	22	PF00069	0.688
MOD_PKA_2	272	278	PF00069	0.259
MOD_PKA_2	345	351	PF00069	0.259
MOD_PKA_2	359	365	PF00069	0.251
MOD_PKB_1	83	91	PF00069	0.541
MOD_Plk_1	134	140	PF00069	0.253
MOD_Plk_1	239	245	PF00069	0.250
MOD_Plk_2-3	144	150	PF00069	0.318
MOD_Plk_2-3	239	245	PF00069	0.283
MOD_Plk_4	359	365	PF00069	0.274
MOD_Plk_4	49	55	PF00069	0.597
MOD_Plk_4	90	96	PF00069	0.311
MOD_ProDKin_1	380	386	PF00069	0.270
MOD_ProDKin_1	408	414	PF00069	0.214
MOD_SUMO_rev_2	119	126	PF00179	0.333
MOD_SUMO_rev_2	186	191	PF00179	0.411
MOD_SUMO_rev_2	333	342	PF00179	0.356
MOD_SUMO_rev_2	69	78	PF00179	0.470
TRG_DiLeu_BaEn_2	106	112	PF01217	0.318
TRG_ENDOCYTIC_2	266	269	PF00928	0.318
TRG_ENDOCYTIC_2	286	289	PF00928	0.120
TRG_ENDOCYTIC_2	361	364	PF00928	0.326
TRG_ENDOCYTIC_2	423	426	PF00928	0.250
TRG_ER_diArg_1	291	293	PF00400	0.329
TRG_NLS_MonoExtC_3	455	460	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	26%	100%
A0A0N0P4A5	Leptomonas seymouri	73%	100%
A0A0S4JE72	Bodo saltans	50%	100%
A0A0S4JXT2	Bodo saltans	25%	100%
A0A1X0NIB7	Trypanosomatidae	59%	100%
A0A1X0NVX1	Trypanosomatidae	25%	100%
A0A3Q8IGC2	Leishmania donovani	26%	100%
A0A3Q8IGE1	Leishmania donovani	96%	100%
A0A3R7KGP9	Trypanosoma rangeli	60%	98%
A0A3R7MPC0	Trypanosoma rangeli	27%	100%
A0A3S5H6H6	Leishmania donovani	24%	100%
A4H9V6	Leishmania braziliensis	26%	90%
A4HJR2	Leishmania braziliensis	87%	86%
A4HL28	Leishmania braziliensis	28%	100%
A4HUR4	Leishmania infantum	24%	100%
A4I779	Leishmania infantum	96%	100%
A4I8K9	Leishmania infantum	26%	100%
C9ZMG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D0A7P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ANE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B3G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
O94283	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P39727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q04651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
Q09895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q4Q4N1	Leishmania major	27%	100%
Q4QH78	Leishmania major	24%	100%
Q4R5C3	Macaca fascicularis	21%	100%
Q4R8X1	Macaca fascicularis	34%	100%
Q54DW2	Dictyostelium discoideum	34%	100%
Q5EAE0	Bos taurus	34%	100%
Q5R8G3	Pongo abelii	34%	100%
Q66KH2	Xenopus laevis	33%	100%
Q6NVS2	Xenopus tropicalis	33%	100%
Q803I2	Danio rerio	35%	100%
Q96RQ1	Homo sapiens	21%	100%
Q9CQE7	Mus musculus	34%	100%
Q9CR89	Mus musculus	21%	100%
Q9Y282	Homo sapiens	34%	100%
V5AS26	Trypanosoma cruzi	59%	100%
V5BGJ7	Trypanosoma cruzi	28%	100%