Kinetoplastid_kinetochore_protein_2_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 8, putative

Species:

Leishmania major

UniProt:

Q4Q5Y5_LEIMA

TriTrypDb:

LmjF.31.2750 , LMJLV39_310037900 , LMJSD75_310037900

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Y5

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	2
GO:0009987	cellular process	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.624
CLV_NRD_NRD_1	19	21	PF00675	0.618
CLV_NRD_NRD_1	191	193	PF00675	0.548
CLV_NRD_NRD_1	274	276	PF00675	0.512
CLV_NRD_NRD_1	287	289	PF00675	0.361
CLV_NRD_NRD_1	312	314	PF00675	0.543
CLV_NRD_NRD_1	342	344	PF00675	0.774
CLV_NRD_NRD_1	431	433	PF00675	0.659
CLV_PCSK_FUR_1	285	289	PF00082	0.532
CLV_PCSK_KEX2_1	19	21	PF00082	0.602
CLV_PCSK_KEX2_1	273	275	PF00082	0.504
CLV_PCSK_KEX2_1	285	287	PF00082	0.383
CLV_PCSK_KEX2_1	303	305	PF00082	0.413
CLV_PCSK_KEX2_1	342	344	PF00082	0.774
CLV_PCSK_KEX2_1	430	432	PF00082	0.561
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.433
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.561
CLV_PCSK_SKI1_1	320	324	PF00082	0.478
CLV_PCSK_SKI1_1	347	351	PF00082	0.575
DEG_APCC_DBOX_1	181	189	PF00400	0.504
DEG_APCC_DBOX_1	324	332	PF00400	0.627
DEG_COP1_1	76	86	PF00400	0.712
DEG_SCF_TRCP1_1	360	366	PF00400	0.485
DEG_SPOP_SBC_1	42	46	PF00917	0.705
DOC_MAPK_gen_1	182	190	PF00069	0.470
DOC_MAPK_gen_1	430	436	PF00069	0.587
DOC_MAPK_MEF2A_6	215	224	PF00069	0.491
DOC_PP1_RVXF_1	345	352	PF00149	0.556
DOC_PP2B_LxvP_1	39	42	PF13499	0.595
DOC_USP7_MATH_1	121	125	PF00917	0.558
DOC_USP7_MATH_1	353	357	PF00917	0.544
DOC_USP7_MATH_1	42	46	PF00917	0.668
DOC_USP7_MATH_1	65	69	PF00917	0.710
DOC_USP7_MATH_1	8	12	PF00917	0.710
DOC_USP7_UBL2_3	310	314	PF12436	0.529
DOC_WW_Pin1_4	10	15	PF00397	0.540
DOC_WW_Pin1_4	92	97	PF00397	0.713
LIG_14-3-3_CanoR_1	10	14	PF00244	0.541
LIG_14-3-3_CanoR_1	141	145	PF00244	0.577
LIG_14-3-3_CanoR_1	215	220	PF00244	0.491
LIG_14-3-3_CanoR_1	342	349	PF00244	0.677
LIG_14-3-3_CanoR_1	40	48	PF00244	0.715
LIG_14-3-3_CanoR_1	66	72	PF00244	0.710
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BRCT_BRCA1_1	415	419	PF00533	0.697
LIG_CaM_IQ_9	185	201	PF13499	0.551
LIG_FHA_1	11	17	PF00498	0.574
LIG_FHA_1	216	222	PF00498	0.479
LIG_FHA_1	257	263	PF00498	0.550
LIG_GSK3_LRP6_1	92	97	PF00069	0.584
LIG_IBAR_NPY_1	108	110	PF08397	0.670
LIG_LIR_Apic_2	143	147	PF02991	0.619
LIG_LIR_Apic_2	214	220	PF02991	0.466
LIG_LIR_Apic_2	27	32	PF02991	0.630
LIG_LIR_Apic_2	63	67	PF02991	0.775
LIG_LIR_Apic_2	99	104	PF02991	0.712
LIG_LIR_Gen_1	203	210	PF02991	0.423
LIG_LIR_Gen_1	278	284	PF02991	0.429
LIG_LIR_Nem_3	27	31	PF02991	0.633
LIG_LIR_Nem_3	278	283	PF02991	0.415
LIG_LIR_Nem_3	295	300	PF02991	0.541
LIG_LIR_Nem_3	401	407	PF02991	0.558
LIG_LYPXL_yS_3	154	157	PF13949	0.672
LIG_MYND_1	155	159	PF01753	0.585
LIG_SH2_CRK	144	148	PF00017	0.570
LIG_SH2_CRK	29	33	PF00017	0.700
LIG_SH2_CRK	6	10	PF00017	0.629
LIG_SH2_NCK_1	29	33	PF00017	0.700
LIG_SH2_PTP2	101	104	PF00017	0.582
LIG_SH2_STAT3	132	135	PF00017	0.654
LIG_SH2_STAT5	101	104	PF00017	0.725
LIG_SH2_STAT5	132	135	PF00017	0.586
LIG_SH2_STAT5	201	204	PF00017	0.500
LIG_SH2_STAT5	217	220	PF00017	0.360
LIG_SH2_STAT5	261	264	PF00017	0.554
LIG_SH2_STAT5	29	32	PF00017	0.594
LIG_SH2_STAT5	297	300	PF00017	0.524
LIG_SH2_STAT5	386	389	PF00017	0.671
LIG_SH3_3	103	109	PF00018	0.546
LIG_SH3_3	120	126	PF00018	0.645
LIG_SH3_3	149	155	PF00018	0.638
LIG_SH3_3	88	94	PF00018	0.692
LIG_SH3_CIN85_PxpxPR_1	92	97	PF14604	0.584
LIG_SUMO_SIM_par_1	371	376	PF11976	0.654
LIG_TRAF2_1	175	178	PF00917	0.502
LIG_TRAF2_1	279	282	PF00917	0.535
LIG_WW_1	14	17	PF00397	0.542
MOD_CDK_SPK_2	92	97	PF00069	0.682
MOD_CK1_1	27	33	PF00069	0.648
MOD_CK1_1	366	372	PF00069	0.717
MOD_CK1_1	385	391	PF00069	0.680
MOD_CK1_1	43	49	PF00069	0.725
MOD_CK2_1	358	364	PF00069	0.656
MOD_CK2_1	365	371	PF00069	0.660
MOD_Cter_Amidation	340	343	PF01082	0.648
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.541
MOD_GlcNHglycan	1	4	PF01048	0.742
MOD_GlcNHglycan	343	346	PF01048	0.651
MOD_GlcNHglycan	360	363	PF01048	0.656
MOD_GlcNHglycan	364	368	PF01048	0.657
MOD_GlcNHglycan	378	381	PF01048	0.695
MOD_GlcNHglycan	387	390	PF01048	0.752
MOD_GlcNHglycan	6	9	PF01048	0.644
MOD_GlcNHglycan	67	70	PF01048	0.690
MOD_GlcNHglycan	98	101	PF01048	0.644
MOD_GSK3_1	108	115	PF00069	0.511
MOD_GSK3_1	337	344	PF00069	0.651
MOD_GSK3_1	376	383	PF00069	0.764
MOD_GSK3_1	384	391	PF00069	0.637
MOD_GSK3_1	4	11	PF00069	0.726
MOD_GSK3_1	413	420	PF00069	0.596
MOD_GSK3_1	67	74	PF00069	0.585
MOD_GSK3_1	92	99	PF00069	0.664
MOD_N-GLC_1	376	381	PF02516	0.642
MOD_N-GLC_1	421	426	PF02516	0.656
MOD_NEK2_1	200	205	PF00069	0.467
MOD_NEK2_1	382	387	PF00069	0.667
MOD_NEK2_1	9	14	PF00069	0.564
MOD_NEK2_2	67	72	PF00069	0.594
MOD_PIKK_1	108	114	PF00454	0.612
MOD_PIKK_1	251	257	PF00454	0.517
MOD_PIKK_1	314	320	PF00454	0.516
MOD_PKA_2	140	146	PF00069	0.554
MOD_PKA_2	341	347	PF00069	0.637
MOD_PKA_2	424	430	PF00069	0.708
MOD_PKA_2	65	71	PF00069	0.727
MOD_PKA_2	9	15	PF00069	0.542
MOD_PKA_2	96	102	PF00069	0.696
MOD_Plk_1	177	183	PF00069	0.416
MOD_Plk_1	353	359	PF00069	0.657
MOD_Plk_1	75	81	PF00069	0.654
MOD_Plk_2-3	265	271	PF00069	0.494
MOD_Plk_2-3	371	377	PF00069	0.714
MOD_Plk_4	102	108	PF00069	0.594
MOD_Plk_4	128	134	PF00069	0.687
MOD_Plk_4	24	30	PF00069	0.710
MOD_Plk_4	353	359	PF00069	0.562
MOD_Plk_4	424	430	PF00069	0.644
MOD_ProDKin_1	10	16	PF00069	0.542
MOD_ProDKin_1	92	98	PF00069	0.715
MOD_SUMO_rev_2	295	305	PF00179	0.430
TRG_DiLeu_BaEn_4	197	203	PF01217	0.550
TRG_ENDOCYTIC_2	154	157	PF00928	0.672
TRG_ENDOCYTIC_2	28	31	PF00928	0.706
TRG_ENDOCYTIC_2	297	300	PF00928	0.507
TRG_ENDOCYTIC_2	6	9	PF00928	0.743
TRG_ER_diArg_1	18	20	PF00400	0.626
TRG_ER_diArg_1	273	275	PF00400	0.476
TRG_ER_diArg_1	285	288	PF00400	0.378
TRG_ER_FFAT_2	381	392	PF00635	0.630
TRG_NLS_MonoCore_2	429	434	PF00514	0.649
TRG_NLS_MonoExtC_3	429	435	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH8	Leptomonas seymouri	64%	100%
A0A0S4JLB3	Bodo saltans	23%	81%
A0A1X0NJ59	Trypanosomatidae	36%	100%
A0A3S7X4V3	Leishmania donovani	95%	100%
A0A422NPB6	Trypanosoma rangeli	39%	100%
A4HJR3	Leishmania braziliensis	85%	100%
A4I780	Leishmania infantum	95%	100%
C9ZMG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B274	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5D822	Trypanosoma cruzi	41%	100%