RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4Q5Y3_LEIMA

TriTrypDb:

LmjF.31.2770 , LMJLV39_310038100 , LMJSD75_310038100

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q5Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Y3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.492
CLV_NRD_NRD_1	128	130	PF00675	0.582
CLV_NRD_NRD_1	61	63	PF00675	0.292
CLV_PCSK_KEX2_1	128	130	PF00082	0.582
CLV_PCSK_KEX2_1	61	63	PF00082	0.292
CLV_Separin_Metazoa	125	129	PF03568	0.558
DEG_APCC_DBOX_1	224	232	PF00400	0.734
DEG_SCF_FBW7_2	55	60	PF00400	0.492
DOC_PP4_FxxP_1	89	92	PF00568	0.492
DOC_USP7_MATH_1	175	179	PF00917	0.748
DOC_USP7_MATH_1	234	238	PF00917	0.661
DOC_USP7_MATH_1	249	253	PF00917	0.606
DOC_USP7_MATH_2	249	255	PF00917	0.707
DOC_WW_Pin1_4	107	112	PF00397	0.613
DOC_WW_Pin1_4	53	58	PF00397	0.492
DOC_WW_Pin1_4	88	93	PF00397	0.494
LIG_14-3-3_CanoR_1	118	127	PF00244	0.639
LIG_14-3-3_CanoR_1	177	185	PF00244	0.638
LIG_14-3-3_CanoR_1	196	202	PF00244	0.647
LIG_14-3-3_CanoR_1	260	269	PF00244	0.719
LIG_14-3-3_CanoR_1	283	293	PF00244	0.634
LIG_14-3-3_CanoR_1	50	56	PF00244	0.492
LIG_14-3-3_CanoR_1	9	19	PF00244	0.460
LIG_APCC_ABBA_1	201	206	PF00400	0.677
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_FHA_1	303	309	PF00498	0.565
LIG_FHA_1	63	69	PF00498	0.492
LIG_FHA_2	120	126	PF00498	0.531
LIG_FHA_2	27	33	PF00498	0.493
LIG_FHA_2	289	295	PF00498	0.570
LIG_FHA_2	54	60	PF00498	0.503
LIG_FHA_2	70	76	PF00498	0.513
LIG_LIR_Apic_2	287	293	PF02991	0.618
LIG_LIR_Apic_2	88	92	PF02991	0.483
LIG_LIR_Gen_1	214	222	PF02991	0.700
LIG_LIR_Nem_3	214	219	PF02991	0.703
LIG_LIR_Nem_3	32	37	PF02991	0.492
LIG_LIR_Nem_3	38	43	PF02991	0.492
LIG_LIR_Nem_3	65	70	PF02991	0.492
LIG_LYPXL_S_1	33	37	PF13949	0.292
LIG_SH2_CRK	216	220	PF00017	0.702
LIG_SH2_CRK	40	44	PF00017	0.492
LIG_SH2_GRB2like	216	219	PF00017	0.703
LIG_SH2_NCK_1	145	149	PF00017	0.745
LIG_SH2_NCK_1	290	294	PF00017	0.602
LIG_SH2_PTP2	101	104	PF00017	0.442
LIG_SH2_STAP1	156	160	PF00017	0.586
LIG_SH2_STAP1	216	220	PF00017	0.702
LIG_SH2_STAT5	101	104	PF00017	0.442
LIG_SH2_STAT5	241	244	PF00017	0.696
LIG_SH2_STAT5	27	30	PF00017	0.505
LIG_SH2_STAT5	290	293	PF00017	0.607
LIG_SH3_2	191	196	PF14604	0.595
LIG_SH3_3	188	194	PF00018	0.597
LIG_TRAF2_1	57	60	PF00917	0.495
LIG_TRAF2_1	92	95	PF00917	0.695
LIG_TYR_ITIM	99	104	PF00017	0.458
LIG_WRC_WIRS_1	86	91	PF05994	0.467
MOD_CDK_SPxxK_3	111	118	PF00069	0.590
MOD_CK1_1	146	152	PF00069	0.702
MOD_CK1_1	154	160	PF00069	0.582
MOD_CK1_1	178	184	PF00069	0.654
MOD_CK1_1	252	258	PF00069	0.736
MOD_CK1_1	262	268	PF00069	0.593
MOD_CK2_1	119	125	PF00069	0.514
MOD_CK2_1	288	294	PF00069	0.781
MOD_CK2_1	53	59	PF00069	0.496
MOD_CK2_1	69	75	PF00069	0.536
MOD_CK2_1	88	94	PF00069	0.685
MOD_CMANNOS	116	119	PF00535	0.501
MOD_GlcNHglycan	132	135	PF01048	0.621
MOD_GlcNHglycan	158	161	PF01048	0.612
MOD_GlcNHglycan	169	172	PF01048	0.734
MOD_GlcNHglycan	181	184	PF01048	0.682
MOD_GlcNHglycan	254	257	PF01048	0.650
MOD_GlcNHglycan	309	312	PF01048	0.580
MOD_GSK3_1	107	114	PF00069	0.495
MOD_GSK3_1	130	137	PF00069	0.616
MOD_GSK3_1	151	158	PF00069	0.616
MOD_GSK3_1	165	172	PF00069	0.630
MOD_GSK3_1	175	182	PF00069	0.694
MOD_GSK3_1	284	291	PF00069	0.630
MOD_GSK3_1	302	309	PF00069	0.591
MOD_GSK3_1	49	56	PF00069	0.492
MOD_N-GLC_1	267	272	PF02516	0.734
MOD_NEK2_1	127	132	PF00069	0.594
MOD_NEK2_1	167	172	PF00069	0.630
MOD_NEK2_1	239	244	PF00069	0.597
MOD_NEK2_1	284	289	PF00069	0.752
MOD_NEK2_1	306	311	PF00069	0.572
MOD_NEK2_1	87	92	PF00069	0.479
MOD_NEK2_2	35	40	PF00069	0.492
MOD_PIKK_1	10	16	PF00454	0.491
MOD_PIKK_1	119	125	PF00454	0.510
MOD_PIKK_1	176	182	PF00454	0.721
MOD_PKA_1	274	280	PF00069	0.688
MOD_PKA_2	127	133	PF00069	0.594
MOD_PKA_2	176	182	PF00069	0.635
MOD_PKA_2	259	265	PF00069	0.744
MOD_PKA_2	284	290	PF00069	0.634
MOD_PKA_2	49	55	PF00069	0.492
MOD_PKA_2	5	11	PF00069	0.518
MOD_Plk_1	183	189	PF00069	0.697
MOD_Plk_2-3	71	77	PF00069	0.492
MOD_Plk_4	234	240	PF00069	0.551
MOD_Plk_4	262	268	PF00069	0.746
MOD_ProDKin_1	107	113	PF00069	0.613
MOD_ProDKin_1	53	59	PF00069	0.492
MOD_ProDKin_1	88	94	PF00069	0.505
MOD_SUMO_rev_2	90	99	PF00179	0.531
TRG_ENDOCYTIC_2	101	104	PF00928	0.442
TRG_ENDOCYTIC_2	145	148	PF00928	0.764
TRG_ENDOCYTIC_2	216	219	PF00928	0.674
TRG_ENDOCYTIC_2	34	37	PF00928	0.492
TRG_ENDOCYTIC_2	40	43	PF00928	0.492
TRG_ER_diArg_1	127	129	PF00400	0.577
TRG_ER_diArg_1	61	63	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M2	Leptomonas seymouri	68%	99%
A0A3S5H7Q7	Leishmania donovani	96%	100%
A4HJR5	Leishmania braziliensis	84%	100%
A4I782	Leishmania infantum	96%	100%
E9B276	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%