Smr domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5X8_LEIMA

TriTrypDb:

LmjF.31.2810 , LMJLV39_310038800 , LMJSD75_310038800

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5X8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.271
CLV_PCSK_KEX2_1	201	203	PF00082	0.569
CLV_PCSK_KEX2_1	91	93	PF00082	0.265
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.525
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.280
CLV_PCSK_SKI1_1	201	205	PF00082	0.425
DEG_APCC_DBOX_1	201	209	PF00400	0.345
DEG_SPOP_SBC_1	177	181	PF00917	0.411
DOC_CDC14_PxL_1	224	232	PF14671	0.374
DOC_MAPK_gen_1	128	136	PF00069	0.347
DOC_MAPK_gen_1	80	88	PF00069	0.178
DOC_USP7_MATH_1	176	180	PF00917	0.423
DOC_USP7_MATH_1	248	252	PF00917	0.661
DOC_USP7_MATH_1	259	263	PF00917	0.677
DOC_USP7_MATH_1	265	269	PF00917	0.698
DOC_USP7_UBL2_3	171	175	PF12436	0.388
DOC_USP7_UBL2_3	243	247	PF12436	0.763
LIG_14-3-3_CanoR_1	19	25	PF00244	0.438
LIG_14-3-3_CanoR_1	202	206	PF00244	0.550
LIG_14-3-3_CanoR_1	30	36	PF00244	0.370
LIG_Actin_WH2_2	9	27	PF00022	0.318
LIG_APCC_ABBAyCdc20_2	92	98	PF00400	0.330
LIG_BRCT_BRCA1_1	92	96	PF00533	0.330
LIG_FHA_1	195	201	PF00498	0.432
LIG_FHA_1	32	38	PF00498	0.525
LIG_FHA_1	8	14	PF00498	0.218
LIG_FHA_2	179	185	PF00498	0.445
LIG_FHA_2	45	51	PF00498	0.511
LIG_LIR_Apic_2	72	76	PF02991	0.480
LIG_LIR_Gen_1	180	189	PF02991	0.451
LIG_LIR_Nem_3	180	186	PF02991	0.491
LIG_MAD2	63	71	PF02301	0.498
LIG_PTB_Apo_2	67	74	PF02174	0.388
LIG_PTB_Phospho_1	67	73	PF10480	0.393
LIG_SH2_STAT5	150	153	PF00017	0.348
LIG_SH2_STAT5	207	210	PF00017	0.420
LIG_SH3_3	222	228	PF00018	0.399
LIG_SH3_3	242	248	PF00018	0.597
LIG_TRAF2_1	214	217	PF00917	0.440
MOD_CK2_1	167	173	PF00069	0.429
MOD_CK2_1	178	184	PF00069	0.442
MOD_CK2_1	233	239	PF00069	0.657
MOD_GlcNHglycan	192	195	PF01048	0.554
MOD_GlcNHglycan	250	253	PF01048	0.641
MOD_GlcNHglycan	261	264	PF01048	0.552
MOD_GSK3_1	190	197	PF00069	0.479
MOD_GSK3_1	261	268	PF00069	0.654
MOD_NEK2_2	20	25	PF00069	0.443
MOD_PIKK_1	194	200	PF00454	0.449
MOD_PIKK_1	64	70	PF00454	0.571
MOD_PKA_1	201	207	PF00069	0.346
MOD_PKA_2	167	173	PF00069	0.403
MOD_PKA_2	201	207	PF00069	0.515
MOD_Plk_1	97	103	PF00069	0.310
MOD_SUMO_rev_2	123	127	PF00179	0.287
MOD_SUMO_rev_2	170	177	PF00179	0.540
TRG_DiLeu_BaEn_3	159	165	PF01217	0.394
TRG_ENDOCYTIC_2	150	153	PF00928	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U4	Leptomonas seymouri	65%	100%
A0A0S4JKD1	Bodo saltans	29%	89%
A0A3Q8IKE2	Leishmania donovani	91%	100%
A0A422NF86	Trypanosoma rangeli	54%	100%
A4H981	Leishmania braziliensis	69%	100%
A4HJR9	Leishmania braziliensis	69%	100%
A4I785	Leishmania infantum	91%	100%
C9ZMG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B280	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9UTP4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5BGM8	Trypanosoma cruzi	55%	98%