Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5X6_LEIMA

TriTrypDb:

LmjF.31.2830 , LMJLV39_310039000 , LMJSD75_310039000

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.757
CLV_C14_Caspase3-7	545	549	PF00656	0.590
CLV_C14_Caspase3-7	56	60	PF00656	0.736
CLV_C14_Caspase3-7	65	69	PF00656	0.608
CLV_NRD_NRD_1	12	14	PF00675	0.733
CLV_NRD_NRD_1	123	125	PF00675	0.767
CLV_NRD_NRD_1	133	135	PF00675	0.787
CLV_NRD_NRD_1	140	142	PF00675	0.674
CLV_NRD_NRD_1	243	245	PF00675	0.693
CLV_NRD_NRD_1	251	253	PF00675	0.592
CLV_NRD_NRD_1	332	334	PF00675	0.660
CLV_NRD_NRD_1	424	426	PF00675	0.861
CLV_NRD_NRD_1	483	485	PF00675	0.819
CLV_NRD_NRD_1	488	490	PF00675	0.728
CLV_NRD_NRD_1	521	523	PF00675	0.862
CLV_NRD_NRD_1	539	541	PF00675	0.573
CLV_NRD_NRD_1	562	564	PF00675	0.799
CLV_NRD_NRD_1	613	615	PF00675	0.820
CLV_NRD_NRD_1	84	86	PF00675	0.730
CLV_PCSK_FUR_1	121	125	PF00082	0.664
CLV_PCSK_FUR_1	486	490	PF00082	0.614
CLV_PCSK_KEX2_1	123	125	PF00082	0.767
CLV_PCSK_KEX2_1	133	135	PF00082	0.787
CLV_PCSK_KEX2_1	140	142	PF00082	0.674
CLV_PCSK_KEX2_1	243	245	PF00082	0.693
CLV_PCSK_KEX2_1	251	253	PF00082	0.592
CLV_PCSK_KEX2_1	334	336	PF00082	0.667
CLV_PCSK_KEX2_1	485	487	PF00082	0.808
CLV_PCSK_KEX2_1	488	490	PF00082	0.753
CLV_PCSK_KEX2_1	520	522	PF00082	0.789
CLV_PCSK_KEX2_1	539	541	PF00082	0.553
CLV_PCSK_KEX2_1	562	564	PF00082	0.729
CLV_PCSK_KEX2_1	588	590	PF00082	0.810
CLV_PCSK_KEX2_1	608	610	PF00082	0.534
CLV_PCSK_KEX2_1	84	86	PF00082	0.860
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.667
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.773
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.789
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.810
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.534
CLV_PCSK_PC7_1	119	125	PF00082	0.665
CLV_PCSK_PC7_1	484	490	PF00082	0.616
CLV_PCSK_PC7_1	517	523	PF00082	0.779
CLV_PCSK_SKI1_1	127	131	PF00082	0.772
CLV_PCSK_SKI1_1	134	138	PF00082	0.813
CLV_PCSK_SKI1_1	228	232	PF00082	0.660
CLV_PCSK_SKI1_1	264	268	PF00082	0.679
CLV_PCSK_SKI1_1	352	356	PF00082	0.688
CLV_PCSK_SKI1_1	585	589	PF00082	0.799
CLV_PCSK_SKI1_1	603	607	PF00082	0.563
DEG_APCC_DBOX_1	227	235	PF00400	0.657
DEG_APCC_DBOX_1	347	355	PF00400	0.667
DEG_SPOP_SBC_1	164	168	PF00917	0.814
DOC_CYCLIN_RxL_1	222	235	PF00134	0.667
DOC_CYCLIN_RxL_1	258	271	PF00134	0.686
DOC_MAPK_FxFP_2	75	78	PF00069	0.589
DOC_MAPK_RevD_3	236	252	PF00069	0.677
DOC_PP4_FxxP_1	75	78	PF00568	0.706
DOC_USP7_MATH_1	164	168	PF00917	0.666
DOC_USP7_MATH_1	193	197	PF00917	0.633
DOC_USP7_MATH_1	221	225	PF00917	0.697
DOC_USP7_MATH_1	31	35	PF00917	0.780
DOC_USP7_MATH_1	399	403	PF00917	0.583
DOC_USP7_MATH_1	41	45	PF00917	0.692
DOC_USP7_MATH_1	564	568	PF00917	0.760
DOC_USP7_MATH_1	594	598	PF00917	0.821
DOC_USP7_MATH_1	610	614	PF00917	0.617
DOC_USP7_MATH_1	71	75	PF00917	0.751
DOC_USP7_MATH_1	96	100	PF00917	0.730
DOC_USP7_UBL2_3	602	606	PF12436	0.861
DOC_WW_Pin1_4	127	132	PF00397	0.842
DOC_WW_Pin1_4	142	147	PF00397	0.590
DOC_WW_Pin1_4	165	170	PF00397	0.814
DOC_WW_Pin1_4	189	194	PF00397	0.682
DOC_WW_Pin1_4	406	411	PF00397	0.828
DOC_WW_Pin1_4	590	595	PF00397	0.818
DOC_WW_Pin1_4	608	613	PF00397	0.552
LIG_14-3-3_CanoR_1	133	139	PF00244	0.772
LIG_14-3-3_CanoR_1	140	146	PF00244	0.686
LIG_14-3-3_CanoR_1	22	31	PF00244	0.810
LIG_14-3-3_CanoR_1	243	249	PF00244	0.633
LIG_14-3-3_CanoR_1	251	256	PF00244	0.582
LIG_14-3-3_CanoR_1	258	266	PF00244	0.446
LIG_14-3-3_CanoR_1	423	433	PF00244	0.860
LIG_14-3-3_CanoR_1	524	533	PF00244	0.654
LIG_14-3-3_CanoR_1	557	562	PF00244	0.818
LIG_14-3-3_CanoR_1	589	594	PF00244	0.738
LIG_14-3-3_CanoR_1	95	101	PF00244	0.844
LIG_BIR_III_2	534	538	PF00653	0.738
LIG_BIR_III_4	202	206	PF00653	0.682
LIG_BRCT_BRCA1_1	73	77	PF00533	0.587
LIG_FHA_1	130	136	PF00498	0.653
LIG_FHA_1	258	264	PF00498	0.551
LIG_FHA_1	50	56	PF00498	0.742
LIG_FHA_2	204	210	PF00498	0.677
LIG_FHA_2	286	292	PF00498	0.635
LIG_FHA_2	366	372	PF00498	0.658
LIG_FHA_2	453	459	PF00498	0.842
LIG_FHA_2	463	469	PF00498	0.698
LIG_FHA_2	499	505	PF00498	0.619
LIG_LIR_Apic_2	73	78	PF02991	0.704
LIG_LIR_Gen_1	265	273	PF02991	0.553
LIG_LIR_Gen_1	360	369	PF02991	0.671
LIG_LIR_Nem_3	224	230	PF02991	0.614
LIG_LIR_Nem_3	271	277	PF02991	0.623
LIG_LIR_Nem_3	360	365	PF02991	0.682
LIG_NRBOX	350	356	PF00104	0.683
LIG_NRP_CendR_1	622	625	PF00754	0.777
LIG_PTB_Apo_2	69	76	PF02174	0.617
LIG_RPA_C_Fungi	247	259	PF08784	0.626
LIG_SH2_CRK	227	231	PF00017	0.664
LIG_SH2_NCK_1	337	341	PF00017	0.639
LIG_SH2_SRC	337	340	PF00017	0.648
LIG_SH2_STAP1	337	341	PF00017	0.639
LIG_SH2_STAT5	293	296	PF00017	0.637
LIG_SH2_STAT5	318	321	PF00017	0.647
LIG_SH2_STAT5	353	356	PF00017	0.618
LIG_SH3_3	280	286	PF00018	0.714
LIG_SH3_3	380	386	PF00018	0.792
LIG_SH3_3	86	92	PF00018	0.802
LIG_TRAF2_1	438	441	PF00917	0.840
MOD_CDC14_SPxK_1	611	614	PF00782	0.731
MOD_CDK_SPK_2	165	170	PF00069	0.853
MOD_CDK_SPK_2	406	411	PF00069	0.766
MOD_CDK_SPxK_1	127	133	PF00069	0.855
MOD_CDK_SPxK_1	608	614	PF00069	0.738
MOD_CDK_SPxxK_3	127	134	PF00069	0.855
MOD_CDK_SPxxK_3	608	615	PF00069	0.808
MOD_CK1_1	101	107	PF00069	0.797
MOD_CK1_1	213	219	PF00069	0.751
MOD_CK1_1	247	253	PF00069	0.675
MOD_CK1_1	254	260	PF00069	0.535
MOD_CK1_1	424	430	PF00069	0.768
MOD_CK1_1	44	50	PF00069	0.803
MOD_CK1_1	525	531	PF00069	0.777
MOD_CK2_1	142	148	PF00069	0.659
MOD_CK2_1	165	171	PF00069	0.855
MOD_CK2_1	203	209	PF00069	0.673
MOD_CK2_1	357	363	PF00069	0.686
MOD_CK2_1	365	371	PF00069	0.526
MOD_CK2_1	466	472	PF00069	0.698
MOD_CK2_1	498	504	PF00069	0.616
MOD_CK2_1	512	518	PF00069	0.555
MOD_Cter_Amidation	331	334	PF01082	0.663
MOD_Cter_Amidation	482	485	PF01082	0.777
MOD_Cter_Amidation	486	489	PF01082	0.722
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.776
MOD_GlcNHglycan	103	106	PF01048	0.833
MOD_GlcNHglycan	107	110	PF01048	0.739
MOD_GlcNHglycan	112	115	PF01048	0.676
MOD_GlcNHglycan	125	130	PF01048	0.554
MOD_GlcNHglycan	179	182	PF01048	0.617
MOD_GlcNHglycan	200	206	PF01048	0.742
MOD_GlcNHglycan	212	215	PF01048	0.594
MOD_GlcNHglycan	35	38	PF01048	0.803
MOD_GlcNHglycan	43	46	PF01048	0.658
MOD_GlcNHglycan	441	445	PF01048	0.800
MOD_GlcNHglycan	495	498	PF01048	0.766
MOD_GlcNHglycan	514	517	PF01048	0.608
MOD_GlcNHglycan	527	530	PF01048	0.666
MOD_GlcNHglycan	594	597	PF01048	0.829
MOD_GlcNHglycan	79	82	PF01048	0.730
MOD_GSK3_1	125	132	PF00069	0.660
MOD_GSK3_1	189	196	PF00069	0.744
MOD_GSK3_1	203	210	PF00069	0.700
MOD_GSK3_1	216	223	PF00069	0.516
MOD_GSK3_1	247	254	PF00069	0.576
MOD_GSK3_1	272	279	PF00069	0.709
MOD_GSK3_1	29	36	PF00069	0.833
MOD_GSK3_1	353	360	PF00069	0.691
MOD_GSK3_1	41	48	PF00069	0.629
MOD_GSK3_1	462	469	PF00069	0.739
MOD_GSK3_1	564	571	PF00069	0.651
MOD_GSK3_1	590	597	PF00069	0.782
MOD_GSK3_1	96	103	PF00069	0.750
MOD_N-GLC_1	141	146	PF02516	0.618
MOD_N-GLC_1	194	199	PF02516	0.636
MOD_N-GLC_1	71	76	PF02516	0.620
MOD_NEK2_1	365	370	PF00069	0.654
MOD_NEK2_2	24	29	PF00069	0.753
MOD_NEK2_2	45	50	PF00069	0.709
MOD_PIKK_1	257	263	PF00454	0.699
MOD_PIKK_1	488	494	PF00454	0.766
MOD_PIKK_1	522	528	PF00454	0.775
MOD_PK_1	244	250	PF00069	0.688
MOD_PK_1	251	257	PF00069	0.597
MOD_PK_1	29	35	PF00069	0.754
MOD_PK_1	478	484	PF00069	0.779
MOD_PKA_1	251	257	PF00069	0.682
MOD_PKA_1	488	494	PF00069	0.727
MOD_PKA_2	24	30	PF00069	0.729
MOD_PKA_2	251	257	PF00069	0.682
MOD_PKA_2	3	9	PF00069	0.730
MOD_PKA_2	424	430	PF00069	0.861
MOD_PKA_2	488	494	PF00069	0.610
MOD_PKA_2	565	571	PF00069	0.805
MOD_PKB_1	486	494	PF00069	0.729
MOD_PKB_1	522	530	PF00069	0.625
MOD_Plk_1	370	376	PF00069	0.674
MOD_Plk_1	71	77	PF00069	0.622
MOD_Plk_4	3	9	PF00069	0.613
MOD_Plk_4	45	51	PF00069	0.826
MOD_ProDKin_1	127	133	PF00069	0.843
MOD_ProDKin_1	142	148	PF00069	0.594
MOD_ProDKin_1	165	171	PF00069	0.816
MOD_ProDKin_1	189	195	PF00069	0.681
MOD_ProDKin_1	406	412	PF00069	0.830
MOD_ProDKin_1	590	596	PF00069	0.822
MOD_ProDKin_1	608	614	PF00069	0.553
MOD_SUMO_rev_2	349	354	PF00179	0.676
TRG_DiLeu_BaEn_1	350	355	PF01217	0.679
TRG_ENDOCYTIC_2	227	230	PF00928	0.666
TRG_ENDOCYTIC_2	326	329	PF00928	0.633
TRG_ER_diArg_1	121	124	PF00400	0.788
TRG_ER_diArg_1	133	135	PF00400	0.726
TRG_ER_diArg_1	333	336	PF00400	0.671
TRG_ER_diArg_1	486	489	PF00400	0.671
TRG_ER_diArg_1	521	524	PF00400	0.636
TRG_ER_diArg_1	538	540	PF00400	0.590
TRG_ER_diArg_1	561	563	PF00400	0.665
TRG_ER_diArg_1	83	85	PF00400	0.857
TRG_ER_diArg_1	92	95	PF00400	0.703
TRG_ER_diLys_1	622	625	PF00400	0.851
TRG_NLS_MonoExtC_3	332	338	PF00514	0.660
TRG_NLS_MonoExtC_3	483	488	PF00514	0.746
TRG_NLS_MonoExtC_3	519	524	PF00514	0.621
TRG_NLS_MonoExtC_3	584	589	PF00514	0.797
TRG_NLS_MonoExtN_4	330	337	PF00514	0.663
TRG_NLS_MonoExtN_4	484	489	PF00514	0.735
TRG_NLS_MonoExtN_4	517	524	PF00514	0.781
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.797
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIU7	Leishmania donovani	91%	100%
A4HJS1	Leishmania braziliensis	70%	100%
A4I787	Leishmania infantum	91%	100%
E9B282	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%