Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5X5_LEIMA

TriTrypDb:

LmjF.31.2840 , LMJLV39_310039100 , LMJSD75_310039100

Length:

379

Annotations

LeishMANIAdb annotations

Appears to be unique to Kinetoplastids, with very unclear topology, localization and function.. Despite the topology, no signal peptides are present, although a mitochondrial transit signal cannot be excluded

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q5X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.592
CLV_NRD_NRD_1	39	41	PF00675	0.608
CLV_PCSK_KEX2_1	12	14	PF00082	0.595
CLV_PCSK_KEX2_1	365	367	PF00082	0.539
CLV_PCSK_KEX2_1	39	41	PF00082	0.608
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.539
CLV_PCSK_SKI1_1	66	70	PF00082	0.563
DOC_ANK_TNKS_1	354	361	PF00023	0.682
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.469
DOC_SPAK_OSR1_1	21	25	PF12202	0.358
DOC_SPAK_OSR1_1	248	252	PF12202	0.430
DOC_USP7_MATH_1	106	110	PF00917	0.379
DOC_USP7_MATH_1	271	275	PF00917	0.468
DOC_WW_Pin1_4	12	17	PF00397	0.387
DOC_WW_Pin1_4	150	155	PF00397	0.659
DOC_WW_Pin1_4	185	190	PF00397	0.705
DOC_WW_Pin1_4	32	37	PF00397	0.367
DOC_WW_Pin1_4	80	85	PF00397	0.544
DOC_WW_Pin1_4	88	93	PF00397	0.535
LIG_14-3-3_CanoR_1	76	84	PF00244	0.368
LIG_BRCT_BRCA1_1	64	68	PF00533	0.502
LIG_Clathr_ClatBox_1	330	334	PF01394	0.650
LIG_DCNL_PONY_1	1	4	PF03556	0.345
LIG_deltaCOP1_diTrp_1	287	293	PF00928	0.525
LIG_eIF4E_1	325	331	PF01652	0.526
LIG_EVH1_2	84	88	PF00568	0.346
LIG_FHA_1	156	162	PF00498	0.684
LIG_FHA_1	219	225	PF00498	0.539
LIG_FHA_1	232	238	PF00498	0.418
LIG_FHA_1	284	290	PF00498	0.599
LIG_FHA_1	342	348	PF00498	0.612
LIG_FHA_1	352	358	PF00498	0.634
LIG_FHA_2	150	156	PF00498	0.729
LIG_FHA_2	166	172	PF00498	0.499
LIG_FHA_2	282	288	PF00498	0.639
LIG_LIR_Gen_1	191	200	PF02991	0.745
LIG_LIR_Gen_1	20	30	PF02991	0.354
LIG_LIR_Gen_1	286	296	PF02991	0.500
LIG_LIR_Nem_3	191	195	PF02991	0.741
LIG_LIR_Nem_3	20	25	PF02991	0.357
LIG_LIR_Nem_3	372	377	PF02991	0.700
LIG_Pex14_2	125	129	PF04695	0.366
LIG_REV1ctd_RIR_1	127	138	PF16727	0.507
LIG_SH2_CRK	192	196	PF00017	0.778
LIG_SH2_NCK_1	192	196	PF00017	0.783
LIG_SH2_STAP1	131	135	PF00017	0.591
LIG_SH2_STAT5	257	260	PF00017	0.359
LIG_SH2_STAT5	325	328	PF00017	0.392
LIG_SH3_3	180	186	PF00018	0.721
LIG_SH3_3	27	33	PF00018	0.406
LIG_SH3_3	35	41	PF00018	0.409
LIG_SH3_3	353	359	PF00018	0.645
LIG_SH3_CIN85_PxpxPR_1	34	39	PF14604	0.370
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.631
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.444
LIG_SUMO_SIM_par_1	157	164	PF11976	0.618
LIG_SUMO_SIM_par_1	221	227	PF11976	0.472
LIG_SUMO_SIM_par_1	59	65	PF11976	0.362
LIG_UBA3_1	330	335	PF00899	0.655
MOD_CDK_SPxxK_3	32	39	PF00069	0.364
MOD_CK1_1	17	23	PF00069	0.415
MOD_CK1_1	62	68	PF00069	0.415
MOD_CK2_1	185	191	PF00069	0.703
MOD_CK2_1	281	287	PF00069	0.606
MOD_GlcNHglycan	302	305	PF01048	0.445
MOD_GlcNHglycan	367	370	PF01048	0.495
MOD_GlcNHglycan	374	377	PF01048	0.513
MOD_GlcNHglycan	93	96	PF01048	0.576
MOD_GSK3_1	161	168	PF00069	0.627
MOD_GSK3_1	214	221	PF00069	0.673
MOD_GSK3_1	271	278	PF00069	0.506
MOD_GSK3_1	361	368	PF00069	0.727
MOD_GSK3_1	372	379	PF00069	0.588
MOD_GSK3_1	80	87	PF00069	0.469
MOD_N-GLC_1	80	85	PF02516	0.667
MOD_NEK2_1	108	113	PF00069	0.411
MOD_NEK2_1	165	170	PF00069	0.620
MOD_NEK2_1	244	249	PF00069	0.393
MOD_NEK2_1	264	269	PF00069	0.141
MOD_NEK2_1	281	286	PF00069	0.567
MOD_NEK2_1	300	305	PF00069	0.205
MOD_NEK2_1	319	324	PF00069	0.220
MOD_NEK2_1	61	66	PF00069	0.449
MOD_PIKK_1	14	20	PF00454	0.356
MOD_PIKK_1	275	281	PF00454	0.652
MOD_PIKK_1	341	347	PF00454	0.614
MOD_PKA_1	365	371	PF00069	0.739
MOD_PKA_2	178	184	PF00069	0.679
MOD_PKA_2	341	347	PF00069	0.644
MOD_PKA_2	365	371	PF00069	0.739
MOD_PKA_2	75	81	PF00069	0.369
MOD_PKA_2	96	102	PF00069	0.463
MOD_PKB_1	12	20	PF00069	0.386
MOD_Plk_1	275	281	PF00069	0.644
MOD_Plk_1	351	357	PF00069	0.738
MOD_Plk_4	214	220	PF00069	0.646
MOD_Plk_4	231	237	PF00069	0.377
MOD_Plk_4	239	245	PF00069	0.537
MOD_ProDKin_1	12	18	PF00069	0.388
MOD_ProDKin_1	150	156	PF00069	0.652
MOD_ProDKin_1	185	191	PF00069	0.705
MOD_ProDKin_1	32	38	PF00069	0.369
MOD_ProDKin_1	80	86	PF00069	0.541
MOD_ProDKin_1	88	94	PF00069	0.536
MOD_SUMO_rev_2	362	367	PF00179	0.707
TRG_ENDOCYTIC_2	192	195	PF00928	0.737
TRG_ENDOCYTIC_2	374	377	PF00928	0.631
TRG_ER_diArg_1	12	14	PF00400	0.395
TRG_ER_diArg_1	177	180	PF00400	0.652
TRG_ER_diArg_1	38	40	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U5	Leptomonas seymouri	69%	100%
A0A0S4JIB3	Bodo saltans	33%	100%
A0A1X0NIE1	Trypanosomatidae	43%	100%
A0A3R7NC34	Trypanosoma rangeli	43%	100%
A0A3S7X4W5	Leishmania donovani	95%	100%
A4HJS2	Leishmania braziliensis	71%	100%
A4I788	Leishmania infantum	95%	100%
C9ZMG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZWL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B283	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
V5BC20	Trypanosoma cruzi	43%	100%