Ribosomal protein l7/l12-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein l7/l12-like protein

Species:

Leishmania major

UniProt:

Q4Q5X4_LEIMA

TriTrypDb:

LmjF.31.2850 , LMJLV39_310039200 , LMJSD75_310039200

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q5X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5X4

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.479
CLV_PCSK_KEX2_1	12	14	PF00082	0.516
CLV_PCSK_SKI1_1	14	18	PF00082	0.627
CLV_PCSK_SKI1_1	142	146	PF00082	0.469
CLV_PCSK_SKI1_1	159	163	PF00082	0.195
CLV_PCSK_SKI1_1	38	42	PF00082	0.715
CLV_PCSK_SKI1_1	73	77	PF00082	0.555
CLV_Separin_Metazoa	77	81	PF03568	0.640
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DEG_SIAH_1	115	123	PF03145	0.530
DEG_SPOP_SBC_1	111	115	PF00917	0.746
DOC_MAPK_gen_1	162	172	PF00069	0.284
DOC_MAPK_gen_1	197	205	PF00069	0.417
DOC_MAPK_gen_1	35	45	PF00069	0.656
DOC_MAPK_MEF2A_6	142	151	PF00069	0.342
DOC_PP2B_LxvP_1	43	46	PF13499	0.517
DOC_USP7_MATH_1	128	132	PF00917	0.635
DOC_USP7_UBL2_3	138	142	PF12436	0.516
DOC_WW_Pin1_4	112	117	PF00397	0.655
DOC_WW_Pin1_4	38	43	PF00397	0.666
LIG_14-3-3_CanoR_1	13	21	PF00244	0.600
LIG_14-3-3_CanoR_1	2	6	PF00244	0.588
LIG_Actin_WH2_2	183	201	PF00022	0.369
LIG_BRCT_BRCA1_1	102	106	PF00533	0.421
LIG_FHA_1	15	21	PF00498	0.602
LIG_FHA_1	74	80	PF00498	0.497
LIG_FHA_2	141	147	PF00498	0.601
LIG_FHA_2	175	181	PF00498	0.397
LIG_LIR_Gen_1	57	67	PF02991	0.456
LIG_SH2_GRB2like	59	62	PF00017	0.437
LIG_SH2_SRC	95	98	PF00017	0.531
LIG_SH2_STAP1	95	99	PF00017	0.490
LIG_SH2_STAT5	59	62	PF00017	0.455
LIG_SH3_3	113	119	PF00018	0.666
LIG_TRAF2_1	171	174	PF00917	0.311
MOD_CK2_1	168	174	PF00069	0.365
MOD_CK2_1	190	196	PF00069	0.304
MOD_GlcNHglycan	102	105	PF01048	0.584
MOD_GlcNHglycan	106	109	PF01048	0.617
MOD_GlcNHglycan	130	133	PF01048	0.591
MOD_GSK3_1	100	107	PF00069	0.666
MOD_LATS_1	71	77	PF00433	0.379
MOD_NEK2_1	1	6	PF00069	0.686
MOD_NEK2_1	100	105	PF00069	0.593
MOD_NEK2_1	145	150	PF00069	0.335
MOD_NEK2_1	20	25	PF00069	0.620
MOD_PKA_2	1	7	PF00069	0.644
MOD_PKA_2	100	106	PF00069	0.655
MOD_PKB_1	12	20	PF00069	0.503
MOD_Plk_1	140	146	PF00069	0.499
MOD_Plk_4	1	7	PF00069	0.645
MOD_ProDKin_1	112	118	PF00069	0.655
MOD_ProDKin_1	38	44	PF00069	0.664
MOD_SUMO_rev_2	171	178	PF00179	0.349
TRG_ENDOCYTIC_2	59	62	PF00928	0.440
TRG_ER_diArg_1	11	14	PF00400	0.605
TRG_NES_CRM1_1	163	174	PF08389	0.230

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G0	Leptomonas seymouri	58%	100%
A0A0S4IRA5	Bodo saltans	41%	92%
A0A0S4JKH3	Bodo saltans	38%	88%
A0A1X0NIA7	Trypanosomatidae	45%	100%
A0A3Q8IFU2	Leishmania donovani	90%	100%
A0A422NF54	Trypanosoma rangeli	43%	100%
A4HJS3	Leishmania braziliensis	70%	100%
A4I789	Leishmania infantum	89%	100%
C9ZMG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B284	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BGN2	Trypanosoma cruzi	43%	72%