Putative nucleoporin (NUP54/57)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP62

Species:

Leishmania major

UniProt:

Q4Q5W9_LEIMA

TriTrypDb:

LmjF.31.2900 , LMJLV39_310039700 , LMJSD75_310039700

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	8
GO:0032991	protein-containing complex	1	8
GO:0044613	nuclear pore central transport channel	3	2
GO:0140513	nuclear protein-containing complex	2	8

Expansion

Sequence features

Q4Q5W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5W9

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	2
GO:0006607	NLS-bearing protein import into nucleus	6	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0006996	organelle organization	4	2
GO:0006997	nucleus organization	5	2
GO:0006999	nuclear pore organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0036228	protein localization to nuclear inner membrane	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090435	protein localization to nuclear envelope	7	2

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	2
GO:0017056	structural constituent of nuclear pore	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.414
CLV_NRD_NRD_1	314	316	PF00675	0.382
CLV_NRD_NRD_1	341	343	PF00675	0.370
CLV_NRD_NRD_1	360	362	PF00675	0.148
CLV_PCSK_KEX2_1	279	281	PF00082	0.367
CLV_PCSK_KEX2_1	314	316	PF00082	0.382
CLV_PCSK_KEX2_1	341	343	PF00082	0.370
CLV_PCSK_SKI1_1	293	297	PF00082	0.316
CLV_PCSK_SKI1_1	361	365	PF00082	0.354
CLV_PCSK_SKI1_1	378	382	PF00082	0.298
CLV_Separin_Metazoa	276	280	PF03568	0.310
CLV_Separin_Metazoa	338	342	PF03568	0.361
DEG_Nend_Nbox_1	1	3	PF02207	0.662
DEG_SPOP_SBC_1	61	65	PF00917	0.498
DOC_MAPK_DCC_7	265	273	PF00069	0.329
DOC_MAPK_gen_1	279	290	PF00069	0.380
DOC_PP2B_LxvP_1	364	367	PF13499	0.340
DOC_PP4_FxxP_1	142	145	PF00568	0.753
DOC_PP4_FxxP_1	18	21	PF00568	0.500
DOC_PP4_FxxP_1	59	62	PF00568	0.632
DOC_USP7_MATH_1	192	196	PF00917	0.502
DOC_USP7_MATH_1	466	470	PF00917	0.491
DOC_USP7_MATH_1	60	64	PF00917	0.566
DOC_USP7_UBL2_3	289	293	PF12436	0.310
DOC_USP7_UBL2_3	458	462	PF12436	0.468
DOC_WW_Pin1_4	266	271	PF00397	0.330
DOC_WW_Pin1_4	49	54	PF00397	0.616
LIG_14-3-3_CanoR_1	193	201	PF00244	0.472
LIG_14-3-3_CanoR_1	329	334	PF00244	0.360
LIG_14-3-3_CanoR_1	342	352	PF00244	0.419
LIG_14-3-3_CanoR_1	369	377	PF00244	0.349
LIG_14-3-3_CanoR_1	378	388	PF00244	0.398
LIG_Clathr_ClatBox_1	201	205	PF01394	0.396
LIG_deltaCOP1_diTrp_1	438	442	PF00928	0.415
LIG_EVH1_2	21	25	PF00568	0.483
LIG_FHA_1	183	189	PF00498	0.605
LIG_FHA_1	238	244	PF00498	0.501
LIG_FHA_1	25	31	PF00498	0.650
LIG_FHA_1	294	300	PF00498	0.384
LIG_FHA_2	185	191	PF00498	0.594
LIG_FHA_2	427	433	PF00498	0.394
LIG_FHA_2	450	456	PF00498	0.429
LIG_LIR_Apic_2	139	145	PF02991	0.632
LIG_LIR_Gen_1	205	213	PF02991	0.388
LIG_LIR_Gen_1	438	446	PF02991	0.395
LIG_LIR_Nem_3	205	211	PF02991	0.389
LIG_LIR_Nem_3	438	442	PF02991	0.415
LIG_NRBOX	359	365	PF00104	0.460
LIG_NRBOX	452	458	PF00104	0.457
LIG_PCNA_PIPBox_1	194	203	PF02747	0.400
LIG_PCNA_yPIPBox_3	193	201	PF02747	0.472
LIG_PCNA_yPIPBox_3	285	299	PF02747	0.310
LIG_Pex14_2	55	59	PF04695	0.632
LIG_SH2_CRK	208	212	PF00017	0.393
LIG_SH2_CRK	331	335	PF00017	0.340
LIG_SH2_STAP1	239	243	PF00017	0.507
LIG_SH2_STAT5	200	203	PF00017	0.397
LIG_SH2_STAT5	239	242	PF00017	0.504
LIG_SH2_STAT5	434	437	PF00017	0.356
LIG_SH3_3	173	179	PF00018	0.803
LIG_SUMO_SIM_par_1	184	190	PF11976	0.656
MOD_CK1_1	112	118	PF00069	0.428
MOD_CK1_1	137	143	PF00069	0.604
MOD_CK1_1	28	34	PF00069	0.574
MOD_CK1_1	63	69	PF00069	0.587
MOD_CK1_1	78	84	PF00069	0.667
MOD_CK1_1	95	101	PF00069	0.591
MOD_CK2_1	343	349	PF00069	0.361
MOD_CK2_1	352	358	PF00069	0.265
MOD_CK2_1	449	455	PF00069	0.433
MOD_CK2_1	466	472	PF00069	0.356
MOD_GlcNHglycan	111	114	PF01048	0.438
MOD_GlcNHglycan	131	134	PF01048	0.537
MOD_GlcNHglycan	136	139	PF01048	0.606
MOD_GlcNHglycan	194	197	PF01048	0.500
MOD_GlcNHglycan	27	30	PF01048	0.507
MOD_GlcNHglycan	394	397	PF01048	0.498
MOD_GlcNHglycan	412	415	PF01048	0.525
MOD_GlcNHglycan	49	52	PF01048	0.522
MOD_GlcNHglycan	72	75	PF01048	0.538
MOD_GlcNHglycan	77	80	PF01048	0.484
MOD_GlcNHglycan	94	97	PF01048	0.457
MOD_GSK3_1	108	115	PF00069	0.642
MOD_GSK3_1	192	199	PF00069	0.489
MOD_GSK3_1	21	28	PF00069	0.601
MOD_GSK3_1	368	375	PF00069	0.427
MOD_GSK3_1	379	386	PF00069	0.400
MOD_GSK3_1	392	399	PF00069	0.414
MOD_GSK3_1	70	77	PF00069	0.637
MOD_GSK3_1	91	98	PF00069	0.684
MOD_N-GLC_1	33	38	PF02516	0.639
MOD_N-GLC_1	396	401	PF02516	0.562
MOD_N-GLC_2	223	225	PF02516	0.362
MOD_NEK2_1	109	114	PF00069	0.436
MOD_NEK2_1	134	139	PF00069	0.587
MOD_NEK2_1	204	209	PF00069	0.466
MOD_NEK2_1	25	30	PF00069	0.649
MOD_NEK2_1	352	357	PF00069	0.382
MOD_NEK2_1	410	415	PF00069	0.746
MOD_NEK2_1	75	80	PF00069	0.593
MOD_NEK2_1	92	97	PF00069	0.455
MOD_PIKK_1	271	277	PF00454	0.361
MOD_PIKK_1	368	374	PF00454	0.468
MOD_PIKK_1	389	395	PF00454	0.494
MOD_PIKK_1	420	426	PF00454	0.465
MOD_PKA_1	293	299	PF00069	0.323
MOD_PKA_2	192	198	PF00069	0.482
MOD_PKA_2	237	243	PF00069	0.499
MOD_PKA_2	278	284	PF00069	0.361
MOD_PKA_2	368	374	PF00069	0.335
MOD_Plk_1	204	210	PF00069	0.467
MOD_Plk_1	383	389	PF00069	0.466
MOD_Plk_4	196	202	PF00069	0.467
MOD_Plk_4	329	335	PF00069	0.299
MOD_ProDKin_1	266	272	PF00069	0.330
MOD_ProDKin_1	49	55	PF00069	0.619
MOD_SUMO_rev_2	455	464	PF00179	0.467
TRG_DiLeu_BaEn_2	375	381	PF01217	0.340
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.589
TRG_ENDOCYTIC_2	208	211	PF00928	0.398
TRG_ENDOCYTIC_2	331	334	PF00928	0.320
TRG_ER_diArg_1	278	280	PF00400	0.400
TRG_ER_diArg_1	313	315	PF00400	0.396
TRG_ER_diArg_1	340	342	PF00400	0.392
TRG_ER_diArg_1	467	470	PF00400	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JWT3	Bodo saltans	34%	100%
A0A3Q8ICT1	Leishmania donovani	86%	100%
A0A3R7KYW1	Trypanosoma rangeli	42%	100%
A4HJS8	Leishmania braziliensis	74%	100%
A4I794	Leishmania infantum	94%	100%
E9B289	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P48837	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	88%