LeishMANIAdb
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DUF1722 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1722 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5W8_LEIMA
TriTrypDb:
LmjF.31.2905 , LMJLV39_310039800 , LMJSD75_310039800
Length:
83

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q5W8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5W8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 12 16 PF00082 0.590
DOC_USP7_MATH_2 67 73 PF00917 0.393
DOC_WW_Pin1_4 46 51 PF00397 0.493
LIG_14-3-3_CanoR_1 10 15 PF00244 0.531
LIG_14-3-3_CanoR_1 76 83 PF00244 0.508
LIG_14-3-3_CterR_2 78 83 PF00244 0.527
LIG_BIR_II_1 1 5 PF00653 0.579
LIG_FHA_1 37 43 PF00498 0.487
LIG_FHA_1 47 53 PF00498 0.464
LIG_LIR_Nem_3 37 41 PF02991 0.459
LIG_PDZ_Class_1 78 83 PF00595 0.560
LIG_SH2_STAP1 38 42 PF00017 0.457
LIG_SH2_STAT5 38 41 PF00017 0.574
LIG_SH3_3 58 64 PF00018 0.441
LIG_UBA3_1 55 63 PF00899 0.393
MOD_GlcNHglycan 1 4 PF01048 0.591
MOD_GSK3_1 74 81 PF00069 0.433
MOD_NEK2_1 36 41 PF00069 0.473
MOD_NEK2_1 74 79 PF00069 0.442
MOD_PKA_2 77 83 PF00069 0.564
MOD_Plk_1 36 42 PF00069 0.488
MOD_ProDKin_1 46 52 PF00069 0.496
MOD_SUMO_for_1 14 17 PF00179 0.600
TRG_DiLeu_LyEn_5 47 52 PF01217 0.461
TRG_ER_diArg_1 75 78 PF00400 0.581
TRG_ER_diArg_1 9 12 PF00400 0.588
TRG_Pf-PMV_PEXEL_1 12 17 PF00026 0.554

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U1 Leptomonas seymouri 61% 100%
A0A3Q8IGL5 Leishmania donovani 92% 100%
A4HJS9 Leishmania braziliensis 73% 100%
A4I795 Leishmania infantum 92% 100%
C9ZMH2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 99%
E9B290 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS