Putative inositol polyphosphate 1-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol polyphosphate 1-phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q5W6_LEIMA

TriTrypDb:

LmjF.31.2920 , LMJLV39_310040000 , LMJSD75_310040000

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5W6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006066	alcohol metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0043647	inositol phosphate metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	11
GO:0046164	alcohol catabolic process	4	11
GO:0046174	polyol catabolic process	5	11
GO:0046434	organophosphate catabolic process	4	11
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	11
GO:0046855	obsolete inositol phosphate dephosphorylation	5	11
GO:0071545	inositol phosphate catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901575	organic substance catabolic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901616	organic hydroxy compound catabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	8	6
GO:0016312	inositol bisphosphate phosphatase activity	7	6
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0052745	inositol phosphate phosphatase activity	6	6
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	285	287	PF00675	0.334
CLV_NRD_NRD_1	46	48	PF00675	0.508
CLV_PCSK_KEX2_1	285	287	PF00082	0.334
CLV_PCSK_KEX2_1	46	48	PF00082	0.506
CLV_PCSK_SKI1_1	163	167	PF00082	0.566
CLV_PCSK_SKI1_1	169	173	PF00082	0.519
CLV_PCSK_SKI1_1	194	198	PF00082	0.389
CLV_PCSK_SKI1_1	6	10	PF00082	0.489
DEG_SPOP_SBC_1	257	261	PF00917	0.525
DOC_CKS1_1	119	124	PF01111	0.620
DOC_MAPK_DCC_7	109	117	PF00069	0.541
DOC_MAPK_FxFP_2	91	94	PF00069	0.535
DOC_MAPK_gen_1	285	293	PF00069	0.516
DOC_MAPK_gen_1	46	53	PF00069	0.403
DOC_MAPK_MEF2A_6	109	117	PF00069	0.541
DOC_MAPK_MEF2A_6	46	53	PF00069	0.397
DOC_PP1_RVXF_1	283	290	PF00149	0.396
DOC_PP4_FxxP_1	213	216	PF00568	0.300
DOC_PP4_FxxP_1	91	94	PF00568	0.535
DOC_USP7_MATH_1	258	262	PF00917	0.569
DOC_WW_Pin1_4	118	123	PF00397	0.551
DOC_WW_Pin1_4	149	154	PF00397	0.450
DOC_WW_Pin1_4	205	210	PF00397	0.423
DOC_WW_Pin1_4	273	278	PF00397	0.421
LIG_14-3-3_CanoR_1	158	167	PF00244	0.449
LIG_14-3-3_CanoR_1	169	176	PF00244	0.401
LIG_14-3-3_CanoR_1	286	292	PF00244	0.440
LIG_APCC_ABBA_1	35	40	PF00400	0.541
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	23	27	PF00533	0.388
LIG_eIF4E_1	187	193	PF01652	0.428
LIG_FHA_1	160	166	PF00498	0.497
LIG_FHA_1	257	263	PF00498	0.566
LIG_FHA_1	267	273	PF00498	0.496
LIG_FHA_1	288	294	PF00498	0.534
LIG_FHA_2	159	165	PF00498	0.474
LIG_FHA_2	170	176	PF00498	0.413
LIG_FHA_2	206	212	PF00498	0.471
LIG_GBD_Chelix_1	283	291	PF00786	0.393
LIG_LIR_Apic_2	211	216	PF02991	0.301
LIG_LIR_Gen_1	126	136	PF02991	0.513
LIG_LIR_Gen_1	16	23	PF02991	0.589
LIG_LIR_Nem_3	126	131	PF02991	0.507
LIG_LIR_Nem_3	16	21	PF02991	0.529
LIG_LYPXL_yS_3	249	252	PF13949	0.563
LIG_NRBOX	166	172	PF00104	0.432
LIG_PTB_Apo_2	85	92	PF02174	0.347
LIG_SH2_CRK	190	194	PF00017	0.433
LIG_SH2_CRK	5	9	PF00017	0.617
LIG_SH2_STAP1	13	17	PF00017	0.548
LIG_SH3_3	121	127	PF00018	0.509
LIG_SH3_3	133	139	PF00018	0.476
LIG_SH3_3	211	217	PF00018	0.423
LIG_SUMO_SIM_par_1	269	276	PF11976	0.441
LIG_TYR_ITIM	247	252	PF00017	0.445
MOD_CK1_1	159	165	PF00069	0.405
MOD_CK2_1	158	164	PF00069	0.511
MOD_CK2_1	169	175	PF00069	0.467
MOD_CK2_1	258	264	PF00069	0.552
MOD_GSK3_1	256	263	PF00069	0.567
MOD_N-GLC_1	56	61	PF02516	0.269
MOD_N-GLC_2	60	62	PF02516	0.272
MOD_NEK2_1	21	26	PF00069	0.591
MOD_NEK2_1	251	256	PF00069	0.454
MOD_NEK2_1	287	292	PF00069	0.409
MOD_NEK2_1	95	100	PF00069	0.484
MOD_PIKK_1	169	175	PF00454	0.446
MOD_PIKK_1	21	27	PF00454	0.438
MOD_PKA_2	157	163	PF00069	0.430
MOD_Plk_4	69	75	PF00069	0.327
MOD_ProDKin_1	118	124	PF00069	0.552
MOD_ProDKin_1	149	155	PF00069	0.444
MOD_ProDKin_1	205	211	PF00069	0.415
MOD_ProDKin_1	273	279	PF00069	0.420
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.460
TRG_ENDOCYTIC_2	18	21	PF00928	0.444
TRG_ENDOCYTIC_2	190	193	PF00928	0.431
TRG_ENDOCYTIC_2	249	252	PF00928	0.476
TRG_ENDOCYTIC_2	5	8	PF00928	0.571
TRG_ER_diArg_1	285	287	PF00400	0.330
TRG_ER_diArg_1	45	47	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U3	Leptomonas seymouri	56%	68%
A0A1X0NIY3	Trypanosomatidae	37%	75%
A0A3R7KA15	Trypanosoma rangeli	34%	69%
A0A3S5H7Q8	Leishmania donovani	90%	100%
A4HJT1	Leishmania braziliensis	72%	68%
A4I797	Leishmania infantum	89%	100%
C9ZWL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	76%
E9B292	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q869K3	Dictyostelium discoideum	27%	95%
V5AS37	Trypanosoma cruzi	35%	76%