LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5W5_LEIMA
TriTrypDb:
LmjF.31.2930 * , LMJLV39_310040200 * , LMJSD75_310040200 *
Length:
294

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5W5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5W5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 227 231 PF00656 0.489
CLV_PCSK_SKI1_1 109 113 PF00082 0.452
CLV_Separin_Metazoa 122 126 PF03568 0.395
DOC_CDC14_PxL_1 240 248 PF14671 0.532
DOC_CYCLIN_yCln2_LP_2 134 140 PF00134 0.360
DOC_MAPK_gen_1 25 34 PF00069 0.486
DOC_MAPK_gen_1 52 60 PF00069 0.497
DOC_MAPK_MEF2A_6 52 60 PF00069 0.412
DOC_PP1_RVXF_1 278 285 PF00149 0.359
DOC_USP7_MATH_1 199 203 PF00917 0.698
DOC_USP7_MATH_1 213 217 PF00917 0.436
DOC_USP7_MATH_1 37 41 PF00917 0.452
DOC_WW_Pin1_4 133 138 PF00397 0.417
DOC_WW_Pin1_4 211 216 PF00397 0.494
DOC_WW_Pin1_4 64 69 PF00397 0.522
LIG_14-3-3_CanoR_1 125 134 PF00244 0.365
LIG_14-3-3_CanoR_1 152 157 PF00244 0.388
LIG_14-3-3_CanoR_1 25 34 PF00244 0.478
LIG_14-3-3_CanoR_1 52 57 PF00244 0.353
LIG_FHA_1 133 139 PF00498 0.375
LIG_FHA_1 142 148 PF00498 0.441
LIG_FHA_1 259 265 PF00498 0.502
LIG_FHA_1 64 70 PF00498 0.446
LIG_FHA_2 110 116 PF00498 0.447
LIG_FHA_2 127 133 PF00498 0.415
LIG_FHA_2 137 143 PF00498 0.365
LIG_GBD_Chelix_1 3 11 PF00786 0.455
LIG_LIR_Apic_2 207 213 PF02991 0.635
LIG_LIR_Apic_2 62 68 PF02991 0.466
LIG_LIR_Gen_1 176 187 PF02991 0.399
LIG_LIR_Gen_1 216 225 PF02991 0.541
LIG_LIR_Nem_3 107 111 PF02991 0.407
LIG_LIR_Nem_3 176 182 PF02991 0.424
LIG_LIR_Nem_3 216 221 PF02991 0.525
LIG_LIR_Nem_3 241 246 PF02991 0.538
LIG_LYPXL_yS_3 243 246 PF13949 0.482
LIG_NRBOX 274 280 PF00104 0.372
LIG_PDZ_Class_2 289 294 PF00595 0.461
LIG_SH2_CRK 108 112 PF00017 0.455
LIG_SH2_CRK 179 183 PF00017 0.374
LIG_SH2_CRK 65 69 PF00017 0.474
LIG_SH2_NCK_1 179 183 PF00017 0.350
LIG_SH2_STAP1 179 183 PF00017 0.338
LIG_SH2_STAP1 218 222 PF00017 0.454
LIG_SH2_STAT5 179 182 PF00017 0.377
LIG_SH2_STAT5 65 68 PF00017 0.478
LIG_SH3_1 189 195 PF00018 0.473
LIG_SH3_3 188 194 PF00018 0.458
LIG_SH3_3 230 236 PF00018 0.456
LIG_SH3_3 31 37 PF00018 0.474
LIG_SUMO_SIM_anti_2 135 142 PF11976 0.379
LIG_SUMO_SIM_anti_2 180 186 PF11976 0.366
LIG_SUMO_SIM_anti_2 55 62 PF11976 0.343
LIG_SUMO_SIM_par_1 109 115 PF11976 0.471
LIG_SUMO_SIM_par_1 135 142 PF11976 0.358
LIG_SUMO_SIM_par_1 180 186 PF11976 0.413
LIG_SUMO_SIM_par_1 55 62 PF11976 0.356
LIG_TRAF2_1 129 132 PF00917 0.412
LIG_TYR_ITIM 106 111 PF00017 0.444
LIG_UBA3_1 278 285 PF00899 0.359
MOD_CK1_1 136 142 PF00069 0.438
MOD_CK1_1 166 172 PF00069 0.586
MOD_CK1_1 216 222 PF00069 0.452
MOD_CK1_1 224 230 PF00069 0.485
MOD_CK2_1 109 115 PF00069 0.427
MOD_CK2_1 126 132 PF00069 0.327
MOD_CK2_1 170 176 PF00069 0.590
MOD_GlcNHglycan 126 129 PF01048 0.423
MOD_GlcNHglycan 165 168 PF01048 0.510
MOD_GlcNHglycan 171 175 PF01048 0.493
MOD_GlcNHglycan 201 204 PF01048 0.622
MOD_GlcNHglycan 227 230 PF01048 0.492
MOD_GlcNHglycan 275 278 PF01048 0.412
MOD_GSK3_1 111 118 PF00069 0.468
MOD_GSK3_1 132 139 PF00069 0.488
MOD_GSK3_1 166 173 PF00069 0.537
MOD_GSK3_1 195 202 PF00069 0.567
MOD_GSK3_1 221 228 PF00069 0.505
MOD_GSK3_1 59 66 PF00069 0.411
MOD_GSK3_1 7 14 PF00069 0.458
MOD_N-GLC_1 104 109 PF02516 0.411
MOD_N-GLC_2 271 273 PF02516 0.464
MOD_N-GLC_2 51 53 PF02516 0.402
MOD_NEK2_1 11 16 PF00069 0.582
MOD_NEK2_1 123 128 PF00069 0.558
MOD_NEK2_1 160 165 PF00069 0.382
MOD_NEK2_1 221 226 PF00069 0.486
MOD_NEK2_1 59 64 PF00069 0.394
MOD_PIKK_1 17 23 PF00454 0.488
MOD_PK_1 27 33 PF00069 0.497
MOD_PK_1 52 58 PF00069 0.350
MOD_PKA_2 124 130 PF00069 0.366
MOD_PKB_1 33 41 PF00069 0.461
MOD_Plk_1 104 110 PF00069 0.411
MOD_Plk_1 141 147 PF00069 0.298
MOD_Plk_1 7 13 PF00069 0.545
MOD_Plk_2-3 115 121 PF00069 0.376
MOD_Plk_4 136 142 PF00069 0.429
MOD_Plk_4 152 158 PF00069 0.370
MOD_Plk_4 177 183 PF00069 0.402
MOD_Plk_4 213 219 PF00069 0.474
MOD_Plk_4 27 33 PF00069 0.477
MOD_ProDKin_1 133 139 PF00069 0.412
MOD_ProDKin_1 211 217 PF00069 0.482
MOD_ProDKin_1 64 70 PF00069 0.515
TRG_DiLeu_BaLyEn_6 65 70 PF01217 0.425
TRG_ENDOCYTIC_2 108 111 PF00928 0.446
TRG_ENDOCYTIC_2 179 182 PF00928 0.377
TRG_ENDOCYTIC_2 218 221 PF00928 0.569
TRG_ENDOCYTIC_2 243 246 PF00928 0.482
TRG_ER_diArg_1 32 35 PF00400 0.479

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJH1 Leptomonas seymouri 47% 100%
A0A3Q8IF52 Leishmania donovani 94% 100%
A4HJT2 Leishmania braziliensis 72% 100%
A4I798 Leishmania infantum 94% 100%
E9B293 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS