Mutt/nudix family protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mutt/nudix family protein-like protein

Species:

Leishmania major

UniProt:

Q4Q5W3_LEIMA

TriTrypDb:

LmjF.31.2950 , LMJLV39_310040400 , LMJSD75_310040400

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5W3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006734	NADH metabolic process	2	2
GO:0006739	NADP metabolic process	7	2
GO:0006742	NADP catabolic process	7	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009987	cellular process	1	2
GO:0019362	pyridine nucleotide metabolic process	5	2
GO:0019364	pyridine nucleotide catabolic process	6	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019677	NAD catabolic process	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046496	nicotinamide nucleotide metabolic process	6	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072524	pyridine-containing compound metabolic process	4	2
GO:0072526	pyridine-containing compound catabolic process	5	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000210	NAD+ diphosphatase activity	7	7
GO:0003824	catalytic activity	1	7
GO:0004551	dinucleotide phosphatase activity	6	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0035529	NADH pyrophosphatase activity	7	7
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.564
CLV_NRD_NRD_1	103	105	PF00675	0.575
CLV_NRD_NRD_1	15	17	PF00675	0.569
CLV_NRD_NRD_1	167	169	PF00675	0.450
CLV_NRD_NRD_1	195	197	PF00675	0.387
CLV_NRD_NRD_1	220	222	PF00675	0.387
CLV_NRD_NRD_1	281	283	PF00675	0.333
CLV_PCSK_KEX2_1	103	105	PF00082	0.575
CLV_PCSK_KEX2_1	15	17	PF00082	0.569
CLV_PCSK_KEX2_1	195	197	PF00082	0.387
CLV_PCSK_KEX2_1	220	222	PF00082	0.387
CLV_PCSK_KEX2_1	281	283	PF00082	0.418
CLV_PCSK_SKI1_1	200	204	PF00082	0.365
CLV_PCSK_SKI1_1	281	285	PF00082	0.387
CLV_PCSK_SKI1_1	74	78	PF00082	0.580
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.411
DOC_MAPK_gen_1	195	204	PF00069	0.387
DOC_MAPK_gen_1	74	82	PF00069	0.557
DOC_PP1_RVXF_1	154	161	PF00149	0.417
DOC_PP1_RVXF_1	269	275	PF00149	0.386
DOC_USP7_MATH_1	229	233	PF00917	0.387
DOC_USP7_MATH_1	258	262	PF00917	0.312
DOC_WW_Pin1_4	256	261	PF00397	0.489
DOC_WW_Pin1_4	296	301	PF00397	0.423
LIG_14-3-3_CanoR_1	103	112	PF00244	0.616
LIG_APCC_ABBA_1	208	213	PF00400	0.489
LIG_BIR_III_2	257	261	PF00653	0.489
LIG_FHA_1	153	159	PF00498	0.520
LIG_FHA_2	148	154	PF00498	0.561
LIG_LIR_Apic_2	239	245	PF02991	0.387
LIG_LIR_Gen_1	157	165	PF02991	0.505
LIG_LIR_Gen_1	298	308	PF02991	0.400
LIG_LIR_Gen_1	90	101	PF02991	0.556
LIG_LIR_LC3C_4	259	264	PF02991	0.365
LIG_LIR_Nem_3	157	163	PF02991	0.504
LIG_LIR_Nem_3	298	304	PF02991	0.401
LIG_LYPXL_yS_3	244	247	PF13949	0.351
LIG_MYND_1	173	177	PF01753	0.503
LIG_PDZ_Class_1	320	325	PF00595	0.665
LIG_Pex14_1	242	246	PF04695	0.489
LIG_SH2_CRK	301	305	PF00017	0.465
LIG_SH2_NCK_1	253	257	PF00017	0.387
LIG_SH2_STAT5	236	239	PF00017	0.387
LIG_SH2_STAT5	246	249	PF00017	0.387
LIG_SH2_STAT5	81	84	PF00017	0.437
LIG_SH3_3	106	112	PF00018	0.513
LIG_SUMO_SIM_par_1	179	185	PF11976	0.489
LIG_SUMO_SIM_par_1	198	206	PF11976	0.158
LIG_SUMO_SIM_par_1	3	8	PF11976	0.469
LIG_TRAF2_1	214	217	PF00917	0.328
MOD_CK2_1	119	125	PF00069	0.404
MOD_CK2_1	211	217	PF00069	0.351
MOD_CK2_1	264	270	PF00069	0.411
MOD_CK2_1	286	292	PF00069	0.518
MOD_Cter_Amidation	101	104	PF01082	0.514
MOD_GlcNHglycan	205	208	PF01048	0.387
MOD_GlcNHglycan	213	216	PF01048	0.387
MOD_GlcNHglycan	224	229	PF01048	0.387
MOD_GlcNHglycan	9	12	PF01048	0.475
MOD_GSK3_1	196	203	PF00069	0.366
MOD_GSK3_1	211	218	PF00069	0.387
MOD_GSK3_1	316	323	PF00069	0.608
MOD_NEK2_1	119	124	PF00069	0.408
MOD_NEK2_1	131	136	PF00069	0.534
MOD_NEK2_1	273	278	PF00069	0.380
MOD_NEK2_1	5	10	PF00069	0.555
MOD_NEK2_2	215	220	PF00069	0.387
MOD_PIKK_1	103	109	PF00454	0.587
MOD_PIKK_1	190	196	PF00454	0.387
MOD_PIKK_1	236	242	PF00454	0.387
MOD_PK_1	43	49	PF00069	0.419
MOD_PKA_1	103	109	PF00069	0.538
MOD_PKA_1	196	202	PF00069	0.387
MOD_PKA_1	43	49	PF00069	0.419
MOD_PKA_2	103	109	PF00069	0.610
MOD_PKA_2	229	235	PF00069	0.400
MOD_PKA_2	316	322	PF00069	0.535
MOD_Plk_1	215	221	PF00069	0.328
MOD_Plk_1	5	11	PF00069	0.601
MOD_Plk_4	131	137	PF00069	0.479
MOD_Plk_4	200	206	PF00069	0.369
MOD_Plk_4	258	264	PF00069	0.438
MOD_ProDKin_1	256	262	PF00069	0.489
MOD_ProDKin_1	296	302	PF00069	0.421
MOD_SUMO_for_1	42	45	PF00179	0.560
MOD_SUMO_rev_2	193	202	PF00179	0.411
TRG_ENDOCYTIC_2	244	247	PF00928	0.384
TRG_ENDOCYTIC_2	252	255	PF00928	0.392
TRG_ENDOCYTIC_2	301	304	PF00928	0.458
TRG_ER_diArg_1	103	105	PF00400	0.595
TRG_ER_diArg_1	14	16	PF00400	0.569
TRG_ER_diArg_1	219	221	PF00400	0.387
TRG_ER_diArg_1	280	282	PF00400	0.412
TRG_ER_diArg_1	315	318	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP7	Leptomonas seymouri	64%	100%
A0A3Q8IKF6	Leishmania donovani	93%	100%
A4HJT4	Leishmania braziliensis	81%	100%
A4I7A0	Leishmania infantum	93%	100%
E9B295	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P53164	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	85%
Q4R7L8	Macaca fascicularis	29%	70%
Q5RD76	Pongo abelii	29%	70%
Q94A82	Arabidopsis thaliana	33%	74%
Q9BQG2	Homo sapiens	30%	70%
Q9Y7J0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	86%