Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5V8_LEIMA

TriTrypDb:

LmjF.31.3000 , LMJLV39_310040900 , LMJSD75_310040900

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.481
CLV_C14_Caspase3-7	821	825	PF00656	0.537
CLV_MEL_PAP_1	889	895	PF00089	0.452
CLV_NRD_NRD_1	269	271	PF00675	0.511
CLV_NRD_NRD_1	323	325	PF00675	0.749
CLV_NRD_NRD_1	429	431	PF00675	0.594
CLV_NRD_NRD_1	528	530	PF00675	0.499
CLV_NRD_NRD_1	544	546	PF00675	0.509
CLV_NRD_NRD_1	594	596	PF00675	0.508
CLV_NRD_NRD_1	658	660	PF00675	0.578
CLV_NRD_NRD_1	681	683	PF00675	0.525
CLV_NRD_NRD_1	751	753	PF00675	0.450
CLV_NRD_NRD_1	770	772	PF00675	0.534
CLV_NRD_NRD_1	780	782	PF00675	0.492
CLV_NRD_NRD_1	80	82	PF00675	0.524
CLV_NRD_NRD_1	843	845	PF00675	0.524
CLV_NRD_NRD_1	90	92	PF00675	0.385
CLV_NRD_NRD_1	926	928	PF00675	0.577
CLV_PCSK_FUR_1	321	325	PF00082	0.492
CLV_PCSK_KEX2_1	177	179	PF00082	0.534
CLV_PCSK_KEX2_1	269	271	PF00082	0.511
CLV_PCSK_KEX2_1	323	325	PF00082	0.748
CLV_PCSK_KEX2_1	429	431	PF00082	0.594
CLV_PCSK_KEX2_1	528	530	PF00082	0.654
CLV_PCSK_KEX2_1	546	548	PF00082	0.583
CLV_PCSK_KEX2_1	578	580	PF00082	0.605
CLV_PCSK_KEX2_1	594	596	PF00082	0.453
CLV_PCSK_KEX2_1	653	655	PF00082	0.523
CLV_PCSK_KEX2_1	658	660	PF00082	0.521
CLV_PCSK_KEX2_1	681	683	PF00082	0.540
CLV_PCSK_KEX2_1	729	731	PF00082	0.535
CLV_PCSK_KEX2_1	751	753	PF00082	0.464
CLV_PCSK_KEX2_1	770	772	PF00082	0.540
CLV_PCSK_KEX2_1	780	782	PF00082	0.603
CLV_PCSK_KEX2_1	80	82	PF00082	0.524
CLV_PCSK_KEX2_1	90	92	PF00082	0.385
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.528
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.655
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.605
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.523
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.500
CLV_PCSK_PC7_1	654	660	PF00082	0.491
CLV_PCSK_PC7_1	86	92	PF00082	0.465
CLV_PCSK_SKI1_1	189	193	PF00082	0.398
CLV_PCSK_SKI1_1	32	36	PF00082	0.405
CLV_PCSK_SKI1_1	654	658	PF00082	0.445
CLV_PCSK_SKI1_1	870	874	PF00082	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SCF_FBW7_2	565	571	PF00400	0.588
DOC_CKS1_1	399	404	PF01111	0.670
DOC_CKS1_1	565	570	PF01111	0.588
DOC_CYCLIN_RxL_1	184	195	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.595
DOC_MAPK_gen_1	177	183	PF00069	0.510
DOC_MAPK_gen_1	5	15	PF00069	0.465
DOC_MAPK_gen_1	575	583	PF00069	0.601
DOC_MAPK_gen_1	844	852	PF00069	0.466
DOC_MAPK_HePTP_8	874	886	PF00069	0.550
DOC_MAPK_MEF2A_6	877	886	PF00069	0.494
DOC_PP1_RVXF_1	422	428	PF00149	0.483
DOC_PP1_RVXF_1	69	75	PF00149	0.423
DOC_PP2B_LxvP_1	26	29	PF13499	0.382
DOC_PP2B_LxvP_1	331	334	PF13499	0.652
DOC_PP2B_LxvP_1	373	376	PF13499	0.770
DOC_PP4_FxxP_1	403	406	PF00568	0.565
DOC_USP7_MATH_1	124	128	PF00917	0.546
DOC_USP7_MATH_1	161	165	PF00917	0.607
DOC_USP7_MATH_1	226	230	PF00917	0.533
DOC_USP7_MATH_1	285	289	PF00917	0.543
DOC_USP7_MATH_1	327	331	PF00917	0.641
DOC_USP7_MATH_1	336	340	PF00917	0.565
DOC_USP7_MATH_1	39	43	PF00917	0.477
DOC_USP7_MATH_1	407	411	PF00917	0.578
DOC_USP7_MATH_1	606	610	PF00917	0.468
DOC_USP7_MATH_1	803	807	PF00917	0.771
DOC_USP7_MATH_1	904	908	PF00917	0.511
DOC_USP7_UBL2_3	193	197	PF12436	0.439
DOC_WW_Pin1_4	344	349	PF00397	0.654
DOC_WW_Pin1_4	395	400	PF00397	0.708
DOC_WW_Pin1_4	431	436	PF00397	0.578
DOC_WW_Pin1_4	447	452	PF00397	0.737
DOC_WW_Pin1_4	478	483	PF00397	0.641
DOC_WW_Pin1_4	564	569	PF00397	0.586
LIG_14-3-3_CanoR_1	125	135	PF00244	0.468
LIG_14-3-3_CanoR_1	158	168	PF00244	0.518
LIG_14-3-3_CanoR_1	178	182	PF00244	0.400
LIG_14-3-3_CanoR_1	184	192	PF00244	0.424
LIG_14-3-3_CanoR_1	32	37	PF00244	0.432
LIG_14-3-3_CanoR_1	357	366	PF00244	0.528
LIG_14-3-3_CanoR_1	382	387	PF00244	0.607
LIG_14-3-3_CanoR_1	408	414	PF00244	0.683
LIG_14-3-3_CanoR_1	456	466	PF00244	0.725
LIG_14-3-3_CanoR_1	594	600	PF00244	0.582
LIG_14-3-3_CanoR_1	695	701	PF00244	0.433
LIG_14-3-3_CanoR_1	892	897	PF00244	0.494
LIG_14-3-3_CanoR_1	906	911	PF00244	0.528
LIG_Actin_WH2_2	418	434	PF00022	0.584
LIG_Actin_WH2_2	704	720	PF00022	0.484
LIG_AP2alpha_2	413	415	PF02296	0.620
LIG_AP2alpha_2	45	47	PF02296	0.449
LIG_APCC_ABBA_1	558	563	PF00400	0.585
LIG_BRCT_BRCA1_1	362	366	PF00533	0.619
LIG_BRCT_BRCA1_1	411	415	PF00533	0.631
LIG_BRCT_BRCA1_1	43	47	PF00533	0.454
LIG_EVH1_2	399	403	PF00568	0.556
LIG_FHA_1	23	29	PF00498	0.459
LIG_FHA_1	368	374	PF00498	0.565
LIG_FHA_1	466	472	PF00498	0.684
LIG_FHA_1	588	594	PF00498	0.594
LIG_FHA_1	632	638	PF00498	0.588
LIG_FHA_1	655	661	PF00498	0.503
LIG_FHA_1	852	858	PF00498	0.476
LIG_FHA_1	90	96	PF00498	0.461
LIG_FHA_2	164	170	PF00498	0.584
LIG_FHA_2	228	234	PF00498	0.537
LIG_FHA_2	255	261	PF00498	0.410
LIG_FHA_2	719	725	PF00498	0.491
LIG_LIR_Apic_2	11	17	PF02991	0.391
LIG_LIR_Apic_2	401	406	PF02991	0.565
LIG_LIR_Gen_1	105	115	PF02991	0.395
LIG_LIR_Gen_1	132	142	PF02991	0.348
LIG_LIR_Gen_1	363	374	PF02991	0.565
LIG_LIR_Gen_1	412	422	PF02991	0.596
LIG_LIR_Gen_1	618	628	PF02991	0.480
LIG_LIR_Gen_1	883	893	PF02991	0.571
LIG_LIR_Gen_1	894	904	PF02991	0.446
LIG_LIR_Nem_3	105	111	PF02991	0.401
LIG_LIR_Nem_3	132	138	PF02991	0.337
LIG_LIR_Nem_3	412	418	PF02991	0.615
LIG_LIR_Nem_3	51	57	PF02991	0.477
LIG_LIR_Nem_3	625	630	PF02991	0.473
LIG_LIR_Nem_3	84	88	PF02991	0.567
LIG_LIR_Nem_3	883	889	PF02991	0.574
LIG_LIR_Nem_3	891	896	PF02991	0.473
LIG_LYPXL_S_1	15	19	PF13949	0.389
LIG_LYPXL_SIV_4	629	637	PF13949	0.469
LIG_LYPXL_yS_3	16	19	PF13949	0.402
LIG_MYND_1	281	285	PF01753	0.382
LIG_PCNA_PIPBox_1	649	658	PF02747	0.493
LIG_PTB_Apo_2	56	63	PF02174	0.391
LIG_PTB_Phospho_1	56	62	PF10480	0.390
LIG_RPA_C_Fungi	677	689	PF08784	0.389
LIG_SH2_CRK	108	112	PF00017	0.334
LIG_SH2_GRB2like	630	633	PF00017	0.464
LIG_SH2_NCK_1	131	135	PF00017	0.342
LIG_SH2_NCK_1	223	227	PF00017	0.371
LIG_SH2_PTP2	14	17	PF00017	0.399
LIG_SH2_SRC	14	17	PF00017	0.453
LIG_SH2_SRC	223	226	PF00017	0.447
LIG_SH2_SRC	630	633	PF00017	0.464
LIG_SH2_STAP1	131	135	PF00017	0.342
LIG_SH2_STAP1	62	66	PF00017	0.365
LIG_SH2_STAP1	627	631	PF00017	0.485
LIG_SH2_STAP1	638	642	PF00017	0.399
LIG_SH2_STAP1	679	683	PF00017	0.484
LIG_SH2_STAT3	638	641	PF00017	0.483
LIG_SH2_STAT5	102	105	PF00017	0.351
LIG_SH2_STAT5	14	17	PF00017	0.399
LIG_SH2_STAT5	620	623	PF00017	0.471
LIG_SH2_STAT5	630	633	PF00017	0.447
LIG_SH2_STAT5	638	641	PF00017	0.555
LIG_SH2_STAT5	655	658	PF00017	0.349
LIG_SH3_3	219	225	PF00018	0.413
LIG_SH3_3	275	281	PF00018	0.425
LIG_SH3_3	373	379	PF00018	0.779
LIG_SH3_3	396	402	PF00018	0.634
LIG_SH3_3	40	46	PF00018	0.514
LIG_SH3_3	50	56	PF00018	0.401
LIG_Sin3_3	508	515	PF02671	0.553
LIG_SUMO_SIM_anti_2	290	296	PF11976	0.347
LIG_TRAF2_1	739	742	PF00917	0.476
LIG_TRAF2_1	774	777	PF00917	0.491
LIG_TRAF2_1	853	856	PF00917	0.530
LIG_TRFH_1	242	246	PF08558	0.330
LIG_UBA3_1	646	653	PF00899	0.498
LIG_WRC_WIRS_1	893	898	PF05994	0.455
LIG_WW_3	405	409	PF00397	0.578
MOD_CDK_SPxxK_3	431	438	PF00069	0.621
MOD_CDK_SPxxK_3	478	485	PF00069	0.650
MOD_CK1_1	160	166	PF00069	0.610
MOD_CK1_1	254	260	PF00069	0.411
MOD_CK1_1	385	391	PF00069	0.652
MOD_CK1_1	395	401	PF00069	0.794
MOD_CK1_1	469	475	PF00069	0.665
MOD_CK1_1	490	496	PF00069	0.668
MOD_CK1_1	746	752	PF00069	0.497
MOD_CK1_1	828	834	PF00069	0.709
MOD_CK1_1	909	915	PF00069	0.560
MOD_CK2_1	126	132	PF00069	0.442
MOD_CK2_1	163	169	PF00069	0.609
MOD_CK2_1	254	260	PF00069	0.407
MOD_CK2_1	920	926	PF00069	0.560
MOD_Cter_Amidation	576	579	PF01082	0.501
MOD_GlcNHglycan	128	131	PF01048	0.472
MOD_GlcNHglycan	159	162	PF01048	0.612
MOD_GlcNHglycan	163	166	PF01048	0.572
MOD_GlcNHglycan	185	188	PF01048	0.492
MOD_GlcNHglycan	298	301	PF01048	0.445
MOD_GlcNHglycan	362	365	PF01048	0.632
MOD_GlcNHglycan	394	397	PF01048	0.726
MOD_GlcNHglycan	459	462	PF01048	0.737
MOD_GlcNHglycan	468	471	PF01048	0.605
MOD_GlcNHglycan	507	511	PF01048	0.613
MOD_GlcNHglycan	519	522	PF01048	0.607
MOD_GlcNHglycan	530	534	PF01048	0.563
MOD_GlcNHglycan	75	78	PF01048	0.435
MOD_GlcNHglycan	820	823	PF01048	0.740
MOD_GlcNHglycan	833	836	PF01048	0.453
MOD_GlcNHglycan	906	909	PF01048	0.575
MOD_GSK3_1	157	164	PF00069	0.607
MOD_GSK3_1	240	247	PF00069	0.333
MOD_GSK3_1	251	258	PF00069	0.397
MOD_GSK3_1	323	330	PF00069	0.709
MOD_GSK3_1	336	343	PF00069	0.565
MOD_GSK3_1	382	389	PF00069	0.619
MOD_GSK3_1	443	450	PF00069	0.710
MOD_GSK3_1	462	469	PF00069	0.535
MOD_GSK3_1	487	494	PF00069	0.657
MOD_GSK3_1	654	661	PF00069	0.605
MOD_GSK3_1	702	709	PF00069	0.433
MOD_GSK3_1	801	808	PF00069	0.600
MOD_GSK3_1	814	821	PF00069	0.726
MOD_GSK3_1	827	834	PF00069	0.580
MOD_GSK3_1	909	916	PF00069	0.612
MOD_N-GLC_1	340	345	PF02516	0.649
MOD_N-GLC_1	382	387	PF02516	0.653
MOD_N-GLC_1	487	492	PF02516	0.664
MOD_N-GLC_1	631	636	PF02516	0.466
MOD_NEK2_1	183	188	PF00069	0.483
MOD_NEK2_1	191	196	PF00069	0.359
MOD_NEK2_1	466	471	PF00069	0.635
MOD_NEK2_1	517	522	PF00069	0.498
MOD_NEK2_1	57	62	PF00069	0.383
MOD_NEK2_1	593	598	PF00069	0.588
MOD_NEK2_1	623	628	PF00069	0.472
MOD_NEK2_1	702	707	PF00069	0.599
MOD_NEK2_1	827	832	PF00069	0.597
MOD_NEK2_1	911	916	PF00069	0.603
MOD_NEK2_2	556	561	PF00069	0.576
MOD_NEK2_2	606	611	PF00069	0.466
MOD_NEK2_2	805	810	PF00069	0.553
MOD_NEK2_2	880	885	PF00069	0.491
MOD_OFUCOSY	291	297	PF10250	0.402
MOD_PIKK_1	124	130	PF00454	0.529
MOD_PIKK_1	386	392	PF00454	0.662
MOD_PIKK_1	913	919	PF00454	0.616
MOD_PK_1	658	664	PF00069	0.485
MOD_PKA_1	177	183	PF00069	0.457
MOD_PKA_1	323	329	PF00069	0.738
MOD_PKA_1	658	664	PF00069	0.485
MOD_PKA_1	90	96	PF00069	0.407
MOD_PKA_2	124	130	PF00069	0.498
MOD_PKA_2	157	163	PF00069	0.608
MOD_PKA_2	177	183	PF00069	0.320
MOD_PKA_2	323	329	PF00069	0.738
MOD_PKA_2	367	373	PF00069	0.618
MOD_PKA_2	407	413	PF00069	0.735
MOD_PKA_2	455	461	PF00069	0.734
MOD_PKA_2	593	599	PF00069	0.506
MOD_PKA_2	658	664	PF00069	0.480
MOD_PKA_2	717	723	PF00069	0.487
MOD_PKA_2	89	95	PF00069	0.419
MOD_PKA_2	891	897	PF00069	0.558
MOD_PKA_2	917	923	PF00069	0.623
MOD_PKB_1	321	329	PF00069	0.607
MOD_PKB_1	485	493	PF00069	0.570
MOD_Plk_1	22	28	PF00069	0.512
MOD_Plk_1	382	388	PF00069	0.653
MOD_Plk_1	418	424	PF00069	0.518
MOD_Plk_1	506	512	PF00069	0.553
MOD_Plk_1	615	621	PF00069	0.499
MOD_Plk_1	702	708	PF00069	0.432
MOD_Plk_1	743	749	PF00069	0.450
MOD_Plk_1	828	834	PF00069	0.633
MOD_Plk_1	880	886	PF00069	0.493
MOD_Plk_4	290	296	PF00069	0.347
MOD_Plk_4	437	443	PF00069	0.665
MOD_Plk_4	57	63	PF00069	0.385
MOD_Plk_4	616	622	PF00069	0.461
MOD_Plk_4	892	898	PF00069	0.492
MOD_Plk_4	90	96	PF00069	0.407
MOD_Plk_4	906	912	PF00069	0.530
MOD_Plk_4	98	104	PF00069	0.425
MOD_ProDKin_1	344	350	PF00069	0.654
MOD_ProDKin_1	395	401	PF00069	0.707
MOD_ProDKin_1	431	437	PF00069	0.582
MOD_ProDKin_1	447	453	PF00069	0.737
MOD_ProDKin_1	478	484	PF00069	0.642
MOD_ProDKin_1	564	570	PF00069	0.585
MOD_SUMO_rev_2	550	556	PF00179	0.660
MOD_SUMO_rev_2	722	731	PF00179	0.500
TRG_DiLeu_BaEn_1	507	512	PF01217	0.552
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.425
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.630
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.564
TRG_ENDOCYTIC_2	108	111	PF00928	0.335
TRG_ENDOCYTIC_2	16	19	PF00928	0.402
TRG_ENDOCYTIC_2	620	623	PF00928	0.627
TRG_ER_diArg_1	321	324	PF00400	0.581
TRG_ER_diArg_1	428	430	PF00400	0.592
TRG_ER_diArg_1	544	547	PF00400	0.578
TRG_ER_diArg_1	593	595	PF00400	0.559
TRG_ER_diArg_1	610	613	PF00400	0.477
TRG_ER_diArg_1	658	660	PF00400	0.570
TRG_ER_diArg_1	681	683	PF00400	0.492
TRG_ER_diArg_1	750	752	PF00400	0.450
TRG_ER_diArg_1	89	91	PF00400	0.460
TRG_NES_CRM1_1	855	869	PF08389	0.449
TRG_NLS_Bipartite_1	528	549	PF00514	0.475
TRG_NLS_MonoExtC_3	544	549	PF00514	0.573
TRG_NLS_MonoExtN_4	543	549	PF00514	0.571
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	536	541	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I347	Leptomonas seymouri	40%	99%
A0A3Q8ICU2	Leishmania donovani	86%	99%
A4I7A5	Leishmania infantum	86%	99%