Myosin heavy chain

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Myosin heavy chain

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5V7_LEIMA

TriTrypDb:

LmjF.31.3010 , LMJLV39_310041000 , LMJSD75_310041000

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.523
CLV_NRD_NRD_1	207	209	PF00675	0.496
CLV_NRD_NRD_1	229	231	PF00675	0.449
CLV_NRD_NRD_1	262	264	PF00675	0.550
CLV_NRD_NRD_1	392	394	PF00675	0.530
CLV_NRD_NRD_1	500	502	PF00675	0.658
CLV_NRD_NRD_1	519	521	PF00675	0.673
CLV_NRD_NRD_1	81	83	PF00675	0.669
CLV_PCSK_FUR_1	169	173	PF00082	0.475
CLV_PCSK_KEX2_1	109	111	PF00082	0.523
CLV_PCSK_KEX2_1	171	173	PF00082	0.483
CLV_PCSK_KEX2_1	207	209	PF00082	0.506
CLV_PCSK_KEX2_1	228	230	PF00082	0.519
CLV_PCSK_KEX2_1	264	266	PF00082	0.544
CLV_PCSK_KEX2_1	276	278	PF00082	0.436
CLV_PCSK_KEX2_1	389	391	PF00082	0.611
CLV_PCSK_KEX2_1	500	502	PF00082	0.625
CLV_PCSK_KEX2_1	81	83	PF00082	0.749
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.483
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.519
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.544
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.436
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.611
CLV_PCSK_PC7_1	224	230	PF00082	0.492
CLV_PCSK_SKI1_1	239	243	PF00082	0.392
CLV_PCSK_SKI1_1	416	420	PF00082	0.488
CLV_Separin_Metazoa	221	225	PF03568	0.505
DEG_APCC_DBOX_1	150	158	PF00400	0.368
DEG_APCC_DBOX_1	48	56	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.511
DEG_SCF_FBW7_1	474	481	PF00400	0.577
DEG_SPOP_SBC_1	479	483	PF00917	0.584
DOC_ANK_TNKS_1	359	366	PF00023	0.518
DOC_CKS1_1	516	521	PF01111	0.668
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.540
DOC_MAPK_gen_1	403	413	PF00069	0.483
DOC_MAPK_MEF2A_6	406	415	PF00069	0.567
DOC_PP1_RVXF_1	242	248	PF00149	0.451
DOC_PP2B_LxvP_1	48	51	PF13499	0.507
DOC_PP2B_LxvP_1	8	11	PF13499	0.511
DOC_USP7_MATH_1	137	141	PF00917	0.555
DOC_USP7_MATH_1	252	256	PF00917	0.583
DOC_USP7_MATH_1	285	289	PF00917	0.629
DOC_USP7_MATH_1	376	380	PF00917	0.601
DOC_USP7_MATH_1	399	403	PF00917	0.599
DOC_USP7_MATH_1	425	429	PF00917	0.660
DOC_USP7_MATH_1	441	445	PF00917	0.586
DOC_USP7_MATH_1	457	461	PF00917	0.705
DOC_USP7_MATH_1	485	489	PF00917	0.683
DOC_USP7_MATH_1	66	70	PF00917	0.695
DOC_USP7_MATH_1	9	13	PF00917	0.506
DOC_WW_Pin1_4	34	39	PF00397	0.486
DOC_WW_Pin1_4	429	434	PF00397	0.759
DOC_WW_Pin1_4	472	477	PF00397	0.707
DOC_WW_Pin1_4	481	486	PF00397	0.703
DOC_WW_Pin1_4	515	520	PF00397	0.720
DOC_WW_Pin1_4	73	78	PF00397	0.664
DOC_WW_Pin1_4	91	96	PF00397	0.415
LIG_14-3-3_CanoR_1	393	401	PF00244	0.631
LIG_14-3-3_CanoR_1	490	498	PF00244	0.680
LIG_14-3-3_CanoR_1	81	88	PF00244	0.605
LIG_BRCT_BRCA1_1	25	29	PF00533	0.535
LIG_BRCT_BRCA1_1	36	40	PF00533	0.560
LIG_BRCT_BRCA1_1	493	497	PF00533	0.652
LIG_FHA_1	240	246	PF00498	0.507
LIG_FHA_1	403	409	PF00498	0.683
LIG_FHA_1	91	97	PF00498	0.538
LIG_FHA_2	100	106	PF00498	0.542
LIG_FHA_2	181	187	PF00498	0.504
LIG_FHA_2	257	263	PF00498	0.461
LIG_FHA_2	373	379	PF00498	0.499
LIG_Integrin_isoDGR_2	70	72	PF01839	0.584
LIG_LIR_Gen_1	19	29	PF02991	0.506
LIG_LIR_Gen_1	288	297	PF02991	0.698
LIG_LIR_Gen_1	510	519	PF02991	0.661
LIG_LIR_Nem_3	101	106	PF02991	0.535
LIG_LIR_Nem_3	19	25	PF02991	0.528
LIG_LIR_Nem_3	288	293	PF02991	0.737
LIG_LIR_Nem_3	37	43	PF02991	0.501
LIG_LIR_Nem_3	510	516	PF02991	0.660
LIG_Pex14_2	513	517	PF04695	0.665
LIG_SH2_NCK_1	231	235	PF00017	0.507
LIG_SH2_STAT5	156	159	PF00017	0.528
LIG_SH2_STAT5	237	240	PF00017	0.473
LIG_SH2_STAT5	24	27	PF00017	0.470
LIG_SH2_STAT5	46	49	PF00017	0.475
LIG_SH3_3	35	41	PF00018	0.512
LIG_SH3_3	435	441	PF00018	0.680
LIG_SH3_3	47	53	PF00018	0.531
LIG_SH3_3	492	498	PF00018	0.603
LIG_SH3_3	89	95	PF00018	0.584
LIG_SH3_4	308	315	PF00018	0.628
LIG_Sin3_3	290	297	PF02671	0.487
LIG_SUMO_SIM_par_1	409	414	PF11976	0.537
LIG_TRAF2_1	202	205	PF00917	0.510
LIG_TRAF2_1	213	216	PF00917	0.453
LIG_TRAF2_1	259	262	PF00917	0.531
LIG_TRFH_1	46	50	PF08558	0.475
LIG_WRC_WIRS_1	100	105	PF05994	0.497
LIG_WRC_WIRS_1	31	36	PF05994	0.484
LIG_WW_2	50	53	PF00397	0.482
LIG_WW_3	357	361	PF00397	0.533
MOD_CDK_SPK_2	515	520	PF00069	0.665
MOD_CDK_SPxK_1	474	480	PF00069	0.575
MOD_CDK_SPxK_1	515	521	PF00069	0.789
MOD_CDK_SPxxK_3	429	436	PF00069	0.634
MOD_CK1_1	12	18	PF00069	0.600
MOD_CK1_1	288	294	PF00069	0.655
MOD_CK1_1	402	408	PF00069	0.617
MOD_CK1_1	428	434	PF00069	0.699
MOD_CK1_1	460	466	PF00069	0.697
MOD_CK1_1	484	490	PF00069	0.589
MOD_CK1_1	507	513	PF00069	0.614
MOD_CK1_1	90	96	PF00069	0.516
MOD_CK1_1	99	105	PF00069	0.449
MOD_CK2_1	180	186	PF00069	0.594
MOD_CK2_1	256	262	PF00069	0.505
MOD_CK2_1	345	351	PF00069	0.555
MOD_CK2_1	372	378	PF00069	0.584
MOD_CK2_1	99	105	PF00069	0.549
MOD_GlcNHglycan	139	142	PF01048	0.522
MOD_GlcNHglycan	19	22	PF01048	0.475
MOD_GlcNHglycan	289	293	PF01048	0.623
MOD_GlcNHglycan	347	350	PF01048	0.635
MOD_GlcNHglycan	427	430	PF01048	0.670
MOD_GlcNHglycan	463	466	PF01048	0.736
MOD_GlcNHglycan	57	60	PF01048	0.587
MOD_GlcNHglycan	83	86	PF01048	0.685
MOD_GSK3_1	252	259	PF00069	0.494
MOD_GSK3_1	30	37	PF00069	0.532
MOD_GSK3_1	372	379	PF00069	0.564
MOD_GSK3_1	407	414	PF00069	0.585
MOD_GSK3_1	425	432	PF00069	0.734
MOD_GSK3_1	457	464	PF00069	0.736
MOD_GSK3_1	474	481	PF00069	0.772
MOD_GSK3_1	485	492	PF00069	0.661
MOD_GSK3_1	87	94	PF00069	0.629
MOD_GSK3_1	9	16	PF00069	0.508
MOD_N-GLC_1	457	462	PF02516	0.660
MOD_N-GLC_1	90	95	PF02516	0.630
MOD_NEK2_1	17	22	PF00069	0.485
MOD_NEK2_1	23	28	PF00069	0.525
MOD_NEK2_1	256	261	PF00069	0.503
MOD_NEK2_1	332	337	PF00069	0.555
MOD_NEK2_1	372	377	PF00069	0.610
MOD_NEK2_1	411	416	PF00069	0.610
MOD_NEK2_1	55	60	PF00069	0.581
MOD_NEK2_2	365	370	PF00069	0.524
MOD_NEK2_2	512	517	PF00069	0.663
MOD_PKA_1	81	87	PF00069	0.617
MOD_PKA_2	295	301	PF00069	0.700
MOD_PKA_2	359	365	PF00069	0.631
MOD_PKA_2	392	398	PF00069	0.620
MOD_PKA_2	402	408	PF00069	0.510
MOD_PKA_2	489	495	PF00069	0.699
MOD_PKA_2	81	87	PF00069	0.608
MOD_Plk_1	288	294	PF00069	0.592
MOD_Plk_1	377	383	PF00069	0.512
MOD_Plk_1	411	417	PF00069	0.547
MOD_Plk_1	457	463	PF00069	0.588
MOD_Plk_4	512	518	PF00069	0.662
MOD_ProDKin_1	34	40	PF00069	0.485
MOD_ProDKin_1	429	435	PF00069	0.764
MOD_ProDKin_1	472	478	PF00069	0.704
MOD_ProDKin_1	481	487	PF00069	0.706
MOD_ProDKin_1	515	521	PF00069	0.722
MOD_ProDKin_1	73	79	PF00069	0.663
MOD_ProDKin_1	91	97	PF00069	0.412
MOD_SUMO_for_1	170	173	PF00179	0.477
MOD_SUMO_for_1	243	246	PF00179	0.493
MOD_SUMO_rev_2	173	181	PF00179	0.482
MOD_SUMO_rev_2	268	278	PF00179	0.401
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.672
TRG_ENDOCYTIC_2	220	223	PF00928	0.652
TRG_ENDOCYTIC_2	231	234	PF00928	0.450
TRG_ENDOCYTIC_2	31	34	PF00928	0.617
TRG_ER_diArg_1	229	231	PF00400	0.449
TRG_ER_diArg_1	263	266	PF00400	0.548
TRG_ER_diArg_1	500	502	PF00400	0.666
TRG_ER_diArg_1	80	82	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X505	Leishmania donovani	84%	100%
A4HJU0	Leishmania braziliensis	63%	100%
A4I7A6	Leishmania infantum	86%	100%
E9B2A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	94%