Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5V6_LEIMA

TriTrypDb:

LmjF.31.3020 , LMJLV39_310041100 , LMJSD75_310041100

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.492
CLV_NRD_NRD_1	364	366	PF00675	0.664
CLV_NRD_NRD_1	581	583	PF00675	0.816
CLV_NRD_NRD_1	75	77	PF00675	0.482
CLV_NRD_NRD_1	81	83	PF00675	0.448
CLV_PCSK_KEX2_1	135	137	PF00082	0.492
CLV_PCSK_KEX2_1	217	219	PF00082	0.666
CLV_PCSK_KEX2_1	67	69	PF00082	0.501
CLV_PCSK_KEX2_1	75	77	PF00082	0.545
CLV_PCSK_KEX2_1	81	83	PF00082	0.533
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.666
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.479
CLV_PCSK_SKI1_1	405	409	PF00082	0.607
CLV_PCSK_SKI1_1	566	570	PF00082	0.658
DEG_APCC_DBOX_1	153	161	PF00400	0.602
DEG_APCC_DBOX_1	402	410	PF00400	0.442
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SCF_FBW7_1	104	111	PF00400	0.474
DEG_SCF_FBW7_1	333	339	PF00400	0.607
DEG_SPOP_SBC_1	428	432	PF00917	0.443
DOC_CDC14_PxL_1	54	62	PF14671	0.452
DOC_CKS1_1	105	110	PF01111	0.474
DOC_CKS1_1	333	338	PF01111	0.625
DOC_CKS1_1	357	362	PF01111	0.624
DOC_CKS1_1	544	549	PF01111	0.634
DOC_CKS1_1	63	68	PF01111	0.456
DOC_MAPK_gen_1	403	411	PF00069	0.440
DOC_MAPK_gen_1	564	573	PF00069	0.657
DOC_MAPK_MEF2A_6	403	411	PF00069	0.440
DOC_PP1_RVXF_1	567	574	PF00149	0.706
DOC_PP2B_LxvP_1	55	58	PF13499	0.449
DOC_PP4_FxxP_1	573	576	PF00568	0.666
DOC_PP4_FxxP_1	6	9	PF00568	0.511
DOC_PP4_FxxP_1	69	72	PF00568	0.485
DOC_USP7_MATH_1	108	112	PF00917	0.469
DOC_USP7_MATH_1	169	173	PF00917	0.547
DOC_USP7_MATH_1	211	215	PF00917	0.722
DOC_USP7_MATH_1	245	249	PF00917	0.684
DOC_USP7_MATH_1	261	265	PF00917	0.626
DOC_USP7_MATH_1	297	301	PF00917	0.676
DOC_USP7_MATH_1	347	351	PF00917	0.635
DOC_USP7_MATH_1	467	471	PF00917	0.591
DOC_USP7_MATH_1	493	497	PF00917	0.772
DOC_USP7_MATH_1	597	601	PF00917	0.631
DOC_USP7_MATH_1	95	99	PF00917	0.439
DOC_WW_Pin1_4	104	109	PF00397	0.546
DOC_WW_Pin1_4	110	115	PF00397	0.588
DOC_WW_Pin1_4	292	297	PF00397	0.712
DOC_WW_Pin1_4	332	337	PF00397	0.669
DOC_WW_Pin1_4	351	356	PF00397	0.496
DOC_WW_Pin1_4	47	52	PF00397	0.450
DOC_WW_Pin1_4	474	479	PF00397	0.681
DOC_WW_Pin1_4	494	499	PF00397	0.637
DOC_WW_Pin1_4	5	10	PF00397	0.468
DOC_WW_Pin1_4	501	506	PF00397	0.741
DOC_WW_Pin1_4	517	522	PF00397	0.690
DOC_WW_Pin1_4	531	536	PF00397	0.703
DOC_WW_Pin1_4	543	548	PF00397	0.716
DOC_WW_Pin1_4	587	592	PF00397	0.715
DOC_WW_Pin1_4	598	603	PF00397	0.589
DOC_WW_Pin1_4	62	67	PF00397	0.445
DOC_WW_Pin1_4	93	98	PF00397	0.453
LIG_14-3-3_CanoR_1	189	194	PF00244	0.555
LIG_14-3-3_CanoR_1	227	232	PF00244	0.563
LIG_14-3-3_CanoR_1	291	296	PF00244	0.693
LIG_14-3-3_CanoR_1	337	341	PF00244	0.620
LIG_14-3-3_CanoR_1	426	436	PF00244	0.527
LIG_14-3-3_CanoR_1	451	456	PF00244	0.683
LIG_14-3-3_CanoR_1	469	474	PF00244	0.503
LIG_14-3-3_CanoR_1	582	586	PF00244	0.702
LIG_Actin_WH2_2	479	497	PF00022	0.588
LIG_BIR_III_2	490	494	PF00653	0.654
LIG_BRCT_BRCA1_1	180	184	PF00533	0.761
LIG_BRCT_BRCA1_1	2	6	PF00533	0.481
LIG_BRCT_BRCA1_1	20	24	PF00533	0.450
LIG_BRCT_BRCA1_1	299	303	PF00533	0.660
LIG_CaM_IQ_9	409	424	PF13499	0.434
LIG_Clathr_ClatBox_1	373	377	PF01394	0.500
LIG_CSL_BTD_1	518	521	PF09270	0.688
LIG_deltaCOP1_diTrp_1	421	425	PF00928	0.524
LIG_FHA_1	111	117	PF00498	0.487
LIG_FHA_1	244	250	PF00498	0.539
LIG_FHA_1	357	363	PF00498	0.698
LIG_FHA_1	429	435	PF00498	0.548
LIG_FHA_1	438	444	PF00498	0.632
LIG_FHA_1	546	552	PF00498	0.675
LIG_FHA_1	582	588	PF00498	0.691
LIG_FHA_1	97	103	PF00498	0.458
LIG_FHA_2	84	90	PF00498	0.434
LIG_LIR_Apic_2	111	115	PF02991	0.490
LIG_LIR_Apic_2	3	9	PF02991	0.471
LIG_LIR_Apic_2	542	547	PF02991	0.652
LIG_LIR_Apic_2	572	576	PF02991	0.664
LIG_LIR_Gen_1	172	182	PF02991	0.641
LIG_LIR_Gen_1	203	213	PF02991	0.616
LIG_LIR_Gen_1	21	32	PF02991	0.450
LIG_LIR_Gen_1	328	336	PF02991	0.673
LIG_LIR_Gen_1	457	467	PF02991	0.667
LIG_LIR_Gen_1	546	557	PF02991	0.539
LIG_LIR_Gen_1	98	109	PF02991	0.466
LIG_LIR_Nem_3	172	178	PF02991	0.636
LIG_LIR_Nem_3	203	209	PF02991	0.612
LIG_LIR_Nem_3	21	27	PF02991	0.449
LIG_LIR_Nem_3	281	287	PF02991	0.642
LIG_LIR_Nem_3	328	333	PF02991	0.674
LIG_LIR_Nem_3	457	462	PF02991	0.667
LIG_LIR_Nem_3	546	552	PF02991	0.550
LIG_LIR_Nem_3	98	104	PF02991	0.460
LIG_MLH1_MIPbox_1	299	303	PF16413	0.660
LIG_MYND_1	114	118	PF01753	0.499
LIG_NRBOX	25	31	PF00104	0.451
LIG_PAM2_1	103	115	PF00658	0.480
LIG_PDZ_Class_2	603	608	PF00595	0.621
LIG_PTAP_UEV_1	444	449	PF05743	0.540
LIG_RPA_C_Fungi	260	272	PF08784	0.560
LIG_SH2_CRK	112	116	PF00017	0.498
LIG_SH2_CRK	404	408	PF00017	0.516
LIG_SH2_CRK	544	548	PF00017	0.635
LIG_SH2_CRK	77	81	PF00017	0.444
LIG_SH2_NCK_1	175	179	PF00017	0.615
LIG_SH2_STAT5	103	106	PF00017	0.476
LIG_SH2_STAT5	112	115	PF00017	0.488
LIG_SH2_STAT5	285	288	PF00017	0.661
LIG_SH2_STAT5	302	305	PF00017	0.626
LIG_SH3_1	112	118	PF00018	0.497
LIG_SH3_1	34	40	PF00018	0.471
LIG_SH3_1	495	501	PF00018	0.651
LIG_SH3_2	538	543	PF14604	0.654
LIG_SH3_2	553	558	PF14604	0.497
LIG_SH3_2	63	68	PF14604	0.456
LIG_SH3_3	112	118	PF00018	0.525
LIG_SH3_3	190	196	PF00018	0.623
LIG_SH3_3	231	237	PF00018	0.644
LIG_SH3_3	306	312	PF00018	0.711
LIG_SH3_3	34	40	PF00018	0.471
LIG_SH3_3	352	358	PF00018	0.673
LIG_SH3_3	442	448	PF00018	0.537
LIG_SH3_3	481	487	PF00018	0.649
LIG_SH3_3	495	501	PF00018	0.645
LIG_SH3_3	532	538	PF00018	0.701
LIG_SH3_3	550	556	PF00018	0.704
LIG_SH3_3	58	64	PF00018	0.449
LIG_SH3_3	590	596	PF00018	0.799
LIG_SH3_CIN85_PxpxPR_1	501	506	PF14604	0.642
LIG_SH3_CIN85_PxpxPR_1	553	558	PF14604	0.527
LIG_SUMO_SIM_anti_2	318	326	PF11976	0.572
LIG_SUMO_SIM_anti_2	377	382	PF11976	0.562
LIG_SUMO_SIM_anti_2	86	94	PF11976	0.435
LIG_SUMO_SIM_par_1	25	31	PF11976	0.451
LIG_TRAF2_1	264	267	PF00917	0.550
LIG_WRC_WIRS_1	327	332	PF05994	0.627
LIG_WRC_WIRS_1	462	467	PF05994	0.670
LIG_WRC_WIRS_1	527	532	PF05994	0.709
LIG_WW_3	35	39	PF00397	0.471
LIG_WW_3	486	490	PF00397	0.635
LIG_WW_3	555	559	PF00397	0.527
MOD_CDC14_SPxK_1	601	604	PF00782	0.615
MOD_CDK_SPK_2	332	337	PF00069	0.627
MOD_CDK_SPK_2	501	506	PF00069	0.676
MOD_CDK_SPK_2	62	67	PF00069	0.454
MOD_CDK_SPxK_1	598	604	PF00069	0.620
MOD_CDK_SPxK_1	62	68	PF00069	0.457
MOD_CDK_SPxxK_3	499	506	PF00069	0.645
MOD_CK1_1	150	156	PF00069	0.603
MOD_CK1_1	177	183	PF00069	0.743
MOD_CK1_1	18	24	PF00069	0.451
MOD_CK1_1	185	191	PF00069	0.701
MOD_CK1_1	248	254	PF00069	0.722
MOD_CK1_1	260	266	PF00069	0.559
MOD_CK1_1	322	328	PF00069	0.655
MOD_CK1_1	329	335	PF00069	0.636
MOD_CK1_1	356	362	PF00069	0.632
MOD_CK1_1	42	48	PF00069	0.465
MOD_CK1_1	454	460	PF00069	0.628
MOD_CK1_1	474	480	PF00069	0.483
MOD_CK1_1	539	545	PF00069	0.663
MOD_CK1_1	93	99	PF00069	0.438
MOD_CK2_1	150	156	PF00069	0.516
MOD_CK2_1	261	267	PF00069	0.754
MOD_CK2_1	322	328	PF00069	0.649
MOD_CK2_1	597	603	PF00069	0.593
MOD_Cter_Amidation	73	76	PF01082	0.487
MOD_GlcNHglycan	122	125	PF01048	0.522
MOD_GlcNHglycan	140	143	PF01048	0.592
MOD_GlcNHglycan	223	226	PF01048	0.711
MOD_GlcNHglycan	259	262	PF01048	0.731
MOD_GlcNHglycan	267	270	PF01048	0.670
MOD_GlcNHglycan	274	277	PF01048	0.594
MOD_GlcNHglycan	341	344	PF01048	0.654
MOD_GlcNHglycan	396	399	PF01048	0.602
MOD_GlcNHglycan	431	434	PF01048	0.567
MOD_GlcNHglycan	445	448	PF01048	0.545
MOD_GlcNHglycan	451	454	PF01048	0.575
MOD_GlcNHglycan	473	476	PF01048	0.649
MOD_GlcNHglycan	531	534	PF01048	0.735
MOD_GlcNHglycan	93	96	PF01048	0.431
MOD_GSK3_1	104	111	PF00069	0.522
MOD_GSK3_1	165	172	PF00069	0.713
MOD_GSK3_1	174	181	PF00069	0.622
MOD_GSK3_1	184	191	PF00069	0.680
MOD_GSK3_1	223	230	PF00069	0.798
MOD_GSK3_1	257	264	PF00069	0.690
MOD_GSK3_1	272	279	PF00069	0.630
MOD_GSK3_1	286	293	PF00069	0.679
MOD_GSK3_1	322	329	PF00069	0.729
MOD_GSK3_1	332	339	PF00069	0.621
MOD_GSK3_1	347	354	PF00069	0.590
MOD_GSK3_1	461	468	PF00069	0.643
MOD_GSK3_1	539	546	PF00069	0.771
MOD_GSK3_1	581	588	PF00069	0.591
MOD_GSK3_1	91	98	PF00069	0.451
MOD_NEK2_1	182	187	PF00069	0.687
MOD_NEK2_1	20	25	PF00069	0.451
MOD_NEK2_1	286	291	PF00069	0.648
MOD_NEK2_1	30	35	PF00069	0.446
MOD_NEK2_1	361	366	PF00069	0.578
MOD_NEK2_1	392	397	PF00069	0.560
MOD_NEK2_1	437	442	PF00069	0.664
MOD_NEK2_1	465	470	PF00069	0.653
MOD_NEK2_1	585	590	PF00069	0.557
MOD_NEK2_1	83	88	PF00069	0.432
MOD_NEK2_1	90	95	PF00069	0.429
MOD_OFUCOSY	15	22	PF10250	0.450
MOD_PIKK_1	248	254	PF00454	0.721
MOD_PIKK_1	536	542	PF00454	0.576
MOD_PK_1	174	180	PF00069	0.616
MOD_PK_1	451	457	PF00069	0.606
MOD_PKA_2	188	194	PF00069	0.567
MOD_PKA_2	290	296	PF00069	0.659
MOD_PKA_2	336	342	PF00069	0.617
MOD_PKA_2	581	587	PF00069	0.639
MOD_Plk_1	165	171	PF00069	0.604
MOD_Plk_1	178	184	PF00069	0.680
MOD_Plk_1	83	89	PF00069	0.433
MOD_Plk_2-3	326	332	PF00069	0.626
MOD_Plk_4	15	21	PF00069	0.451
MOD_Plk_4	189	195	PF00069	0.736
MOD_Plk_4	205	211	PF00069	0.541
MOD_Plk_4	235	241	PF00069	0.720
MOD_Plk_4	298	304	PF00069	0.708
MOD_Plk_4	336	342	PF00069	0.602
MOD_Plk_4	83	89	PF00069	0.433
MOD_ProDKin_1	104	110	PF00069	0.546
MOD_ProDKin_1	114	120	PF00069	0.584
MOD_ProDKin_1	292	298	PF00069	0.714
MOD_ProDKin_1	332	338	PF00069	0.668
MOD_ProDKin_1	351	357	PF00069	0.496
MOD_ProDKin_1	47	53	PF00069	0.451
MOD_ProDKin_1	474	480	PF00069	0.683
MOD_ProDKin_1	494	500	PF00069	0.635
MOD_ProDKin_1	5	11	PF00069	0.464
MOD_ProDKin_1	501	507	PF00069	0.742
MOD_ProDKin_1	517	523	PF00069	0.688
MOD_ProDKin_1	531	537	PF00069	0.702
MOD_ProDKin_1	543	549	PF00069	0.716
MOD_ProDKin_1	587	593	PF00069	0.711
MOD_ProDKin_1	598	604	PF00069	0.589
MOD_ProDKin_1	62	68	PF00069	0.447
MOD_ProDKin_1	93	99	PF00069	0.455
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.549
TRG_ENDOCYTIC_2	175	178	PF00928	0.638
TRG_ENDOCYTIC_2	284	287	PF00928	0.647
TRG_ENDOCYTIC_2	404	407	PF00928	0.517
TRG_ENDOCYTIC_2	77	80	PF00928	0.444
TRG_ER_diArg_1	134	136	PF00400	0.489
TRG_ER_diArg_1	158	161	PF00400	0.535
TRG_ER_diArg_1	75	77	PF00400	0.549
TRG_ER_diArg_1	80	82	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGM6	Leishmania donovani	87%	100%
A4HJU1	Leishmania braziliensis	51%	100%
A4I7A7	Leishmania infantum	87%	100%
E9B2A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%