Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5V3_LEIMA

TriTrypDb:

LmjF.31.3040 , LMJLV39_310041500 , LMJSD75_310041400

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q5V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.502
CLV_C14_Caspase3-7	78	82	PF00656	0.400
CLV_NRD_NRD_1	128	130	PF00675	0.410
CLV_NRD_NRD_1	132	134	PF00675	0.436
CLV_NRD_NRD_1	6	8	PF00675	0.662
CLV_PCSK_KEX2_1	128	130	PF00082	0.409
CLV_PCSK_KEX2_1	132	134	PF00082	0.437
CLV_PCSK_KEX2_1	215	217	PF00082	0.484
CLV_PCSK_KEX2_1	6	8	PF00082	0.703
CLV_PCSK_KEX2_1	85	87	PF00082	0.681
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.490
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.683
CLV_PCSK_PC7_1	128	134	PF00082	0.467
CLV_PCSK_SKI1_1	154	158	PF00082	0.451
CLV_PCSK_SKI1_1	237	241	PF00082	0.396
CLV_Separin_Metazoa	151	155	PF03568	0.624
CLV_Separin_Metazoa	41	45	PF03568	0.391
DEG_APCC_DBOX_1	236	244	PF00400	0.596
DEG_MDM2_SWIB_1	117	124	PF02201	0.362
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DOC_USP7_MATH_1	191	195	PF00917	0.645
DOC_USP7_MATH_1	209	213	PF00917	0.670
DOC_USP7_MATH_1	233	237	PF00917	0.691
DOC_USP7_MATH_1	66	70	PF00917	0.514
DOC_USP7_UBL2_3	139	143	PF12436	0.658
DOC_WW_Pin1_4	62	67	PF00397	0.484
LIG_14-3-3_CanoR_1	154	162	PF00244	0.731
LIG_14-3-3_CanoR_1	6	15	PF00244	0.450
LIG_Clathr_ClatBox_1	240	244	PF01394	0.596
LIG_FHA_1	180	186	PF00498	0.583
LIG_FHA_1	187	193	PF00498	0.591
LIG_FHA_1	208	214	PF00498	0.676
LIG_FHA_1	94	100	PF00498	0.511
LIG_LIR_Apic_2	105	110	PF02991	0.454
LIG_LIR_Apic_2	69	75	PF02991	0.470
LIG_LIR_Gen_1	87	95	PF02991	0.437
LIG_LIR_LC3C_4	238	242	PF02991	0.595
LIG_Pex14_1	103	107	PF04695	0.479
LIG_Pex14_2	117	121	PF04695	0.362
LIG_SH2_CRK	107	111	PF00017	0.301
LIG_SH2_CRK	72	76	PF00017	0.435
LIG_SH2_NCK_1	107	111	PF00017	0.331
LIG_SH3_3	48	54	PF00018	0.533
LIG_SUMO_SIM_anti_2	146	154	PF11976	0.619
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.651
LIG_SUMO_SIM_anti_2	238	246	PF11976	0.589
LIG_SUMO_SIM_par_1	238	246	PF11976	0.589
LIG_TRAF2_1	219	222	PF00917	0.612
MOD_CDC14_SPxK_1	65	68	PF00782	0.401
MOD_CDK_SPxK_1	62	68	PF00069	0.396
MOD_CK1_1	179	185	PF00069	0.625
MOD_CK1_1	62	68	PF00069	0.434
MOD_CMANNOS	123	126	PF00535	0.353
MOD_GlcNHglycan	202	205	PF01048	0.446
MOD_GlcNHglycan	23	26	PF01048	0.724
MOD_GlcNHglycan	46	50	PF01048	0.697
MOD_GlcNHglycan	61	64	PF01048	0.624
MOD_GSK3_1	1	8	PF00069	0.548
MOD_GSK3_1	187	194	PF00069	0.634
MOD_GSK3_1	58	65	PF00069	0.475
MOD_N-GLC_1	154	159	PF02516	0.411
MOD_N-GLC_1	36	41	PF02516	0.691
MOD_NEK2_1	1	6	PF00069	0.471
MOD_NEK2_1	98	103	PF00069	0.494
MOD_PIKK_1	98	104	PF00454	0.501
MOD_PK_1	193	199	PF00069	0.661
MOD_PKA_1	6	12	PF00069	0.457
MOD_PKA_2	127	133	PF00069	0.632
MOD_PKA_2	186	192	PF00069	0.589
MOD_PKA_2	197	203	PF00069	0.624
MOD_PKA_2	5	11	PF00069	0.480
MOD_Plk_4	209	215	PF00069	0.648
MOD_ProDKin_1	62	68	PF00069	0.485
TRG_ER_diArg_1	131	133	PF00400	0.640
TRG_ER_diArg_1	5	7	PF00400	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR85	Leptomonas seymouri	62%	100%
A0A3S7X4Y5	Leishmania donovani	93%	100%
A4HJU4	Leishmania braziliensis	79%	100%
A4I7A9	Leishmania infantum	93%	100%
C9ZWJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E8NHP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%