Kynurenine formamidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative cyclase, putative

Species:

Leishmania major

UniProt:

Q4Q5V2_LEIMA

TriTrypDb:

LmjF.31.3050 , LMJLV39_310041600 , LMJSD75_310041500

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5V2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006568	tryptophan metabolic process	5	7
GO:0006569	tryptophan catabolic process	5	7
GO:0006576	biogenic amine metabolic process	5	7
GO:0006586	indolalkylamine metabolic process	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009063	amino acid catabolic process	4	7
GO:0009072	aromatic amino acid metabolic process	4	7
GO:0009074	aromatic amino acid family catabolic process	5	7
GO:0009308	amine metabolic process	4	7
GO:0009987	cellular process	1	7
GO:0016054	organic acid catabolic process	4	7
GO:0019439	aromatic compound catabolic process	4	7
GO:0019441	tryptophan catabolic process to kynurenine	5	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0042180	cellular ketone metabolic process	3	7
GO:0042430	indole-containing compound metabolic process	4	7
GO:0042436	indole-containing compound catabolic process	5	7
GO:0042537	benzene-containing compound metabolic process	4	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044270	cellular nitrogen compound catabolic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	7
GO:0046395	carboxylic acid catabolic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046700	heterocycle catabolic process	4	7
GO:0070189	kynurenine metabolic process	4	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901361	organic cyclic compound catabolic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:1901606	alpha-amino acid catabolic process	5	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004061	arylformamidase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.389
CLV_PCSK_SKI1_1	124	128	PF00082	0.445
CLV_PCSK_SKI1_1	90	94	PF00082	0.525
DEG_Nend_UBRbox_1	1	4	PF02207	0.577
DOC_CYCLIN_RxL_1	87	96	PF00134	0.549
DOC_MAPK_MEF2A_6	2	10	PF00069	0.402
DOC_MAPK_MEF2A_6	71	79	PF00069	0.427
DOC_PP1_RVXF_1	88	95	PF00149	0.546
DOC_PP2B_LxvP_1	6	9	PF13499	0.389
DOC_PP4_FxxP_1	72	75	PF00568	0.389
DOC_USP7_MATH_1	82	86	PF00917	0.416
DOC_WW_Pin1_4	160	165	PF00397	0.431
LIG_APCC_ABBAyCdc20_2	90	96	PF00400	0.537
LIG_BRCT_BRCA1_1	146	150	PF00533	0.434
LIG_Clathr_ClatBox_1	137	141	PF01394	0.436
LIG_FHA_1	133	139	PF00498	0.368
LIG_FHA_2	47	53	PF00498	0.330
LIG_LIR_Apic_2	149	154	PF02991	0.435
LIG_LIR_Apic_2	70	75	PF02991	0.389
LIG_LIR_Nem_3	133	137	PF02991	0.416
LIG_LIR_Nem_3	146	151	PF02991	0.438
LIG_SH2_CRK	134	138	PF00017	0.488
LIG_SH2_CRK	151	155	PF00017	0.417
LIG_SH2_NCK_1	95	99	PF00017	0.440
LIG_SH2_STAT5	134	137	PF00017	0.407
LIG_SH3_3	111	117	PF00018	0.427
LIG_SH3_3	48	54	PF00018	0.389
LIG_SUMO_SIM_par_1	2	7	PF11976	0.389
LIG_TRAF2_1	117	120	PF00917	0.579
LIG_TYR_ITIM	132	137	PF00017	0.414
LIG_TYR_ITIM	93	98	PF00017	0.431
MOD_CDC14_SPxK_1	163	166	PF00782	0.454
MOD_CDK_SPxK_1	160	166	PF00069	0.443
MOD_GSK3_1	23	30	PF00069	0.374
MOD_GSK3_1	42	49	PF00069	0.365
MOD_Plk_1	4	10	PF00069	0.456
MOD_Plk_1	82	88	PF00069	0.455
MOD_ProDKin_1	160	166	PF00069	0.443
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.353
TRG_ENDOCYTIC_2	11	14	PF00928	0.389
TRG_ENDOCYTIC_2	134	137	PF00928	0.407
TRG_ENDOCYTIC_2	95	98	PF00928	0.444
TRG_ER_diArg_1	155	158	PF00400	0.494
TRG_NES_CRM1_1	5	20	PF08389	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2A0	Leptomonas seymouri	73%	88%
A0A3Q8IGG1	Leishmania donovani	95%	100%
A0KA00	Burkholderia cenocepacia (strain HI2424)	29%	82%
A0REX1	Bacillus thuringiensis (strain Al Hakam)	28%	83%
A1TLB1	Acidovorax citrulli (strain AAC00-1)	29%	81%
A1V195	Burkholderia mallei (strain SAVP1)	28%	82%
A2S926	Burkholderia mallei (strain NCTC 10229)	28%	82%
A3MHE3	Burkholderia mallei (strain NCTC 10247)	28%	82%
A3N6H4	Burkholderia pseudomallei (strain 668)	28%	82%
A3NS57	Burkholderia pseudomallei (strain 1106a)	28%	82%
A4HJU5	Leishmania braziliensis	87%	100%
A4I7B0	Leishmania infantum	95%	100%
A4IT60	Geobacillus thermodenitrificans (strain NG80-2)	28%	83%
A6V681	Pseudomonas aeruginosa (strain PA7)	27%	82%
A7GPY2	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	28%	83%
A9AGH3	Burkholderia multivorans (strain ATCC 17616 / 249)	28%	82%
A9VHP8	Bacillus mycoides (strain KBAB4)	27%	83%
B1JXI7	Burkholderia cenocepacia (strain MC0-3)	29%	82%
B1YVH0	Burkholderia ambifaria (strain MC40-6)	29%	82%
B2SY84	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	25%	82%
B3R5Q1	Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)	27%	81%
B4E9I9	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	31%	82%
E9B2A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q0APM5	Maricaulis maris (strain MCS10)	22%	83%
Q0BCE2	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	29%	82%
Q0K7X9	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	28%	81%
Q126P9	Polaromonas sp. (strain JS666 / ATCC BAA-500)	26%	79%
Q13UP0	Paraburkholderia xenovorans (strain LB400)	25%	82%
Q1BU36	Burkholderia cenocepacia (strain AU 1054)	29%	82%
Q1GTB8	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	25%	83%
Q1IY56	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	27%	82%
Q2N5X0	Erythrobacter litoralis (strain HTCC2594)	26%	81%
Q2S2F5	Salinibacter ruber (strain DSM 13855 / M31)	32%	82%
Q2T0N2	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	28%	82%
Q39DG4	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	28%	82%
Q3JVD6	Burkholderia pseudomallei (strain 1710b)	28%	82%
Q474J5	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	27%	79%
Q58193	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	30%	94%
Q62M97	Burkholderia mallei (strain ATCC 23344)	28%	82%
Q63AJ1	Bacillus cereus (strain ZK / E33L)	28%	83%
Q63WP3	Burkholderia pseudomallei (strain K96243)	28%	82%
Q6HHX8	Bacillus thuringiensis subsp. konkukian (strain 97-27)	27%	83%
Q736W4	Bacillus cereus (strain ATCC 10987 / NRS 248)	27%	83%
Q81CK1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	28%	83%
Q81PP9	Bacillus anthracis	27%	83%
Q8Y1D0	Ralstonia solanacearum (strain GMI1000)	29%	83%