Iron/zinc transporter protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferrous iron transport protein, putative

Species:

Leishmania major

UniProt:

Q4Q5V1_LEIMA

TriTrypDb:

LmjF.31.3060 , LMJLV39_310041800 , LMJSD75_310041600

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	5
GO:0016020	membrane	2	31
GO:0110165	cellular anatomical entity	1	31
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4Q5V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5V1

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	5
GO:0006810	transport	3	5
GO:0006811	monoatomic ion transport	4	5
GO:0006812	monoatomic cation transport	5	5
GO:0006829	zinc ion transport	8	5
GO:0009987	cellular process	1	5
GO:0030001	metal ion transport	6	5
GO:0034220	monoatomic ion transmembrane transport	3	5
GO:0051179	localization	1	5
GO:0051234	establishment of localization	2	5
GO:0055085	transmembrane transport	2	5
GO:0071577	zinc ion transmembrane transport	6	5
GO:0098655	monoatomic cation transmembrane transport	4	5
GO:0098660	inorganic ion transmembrane transport	4	5
GO:0098662	inorganic cation transmembrane transport	5	5
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	31
GO:0005381	iron ion transmembrane transporter activity	7	2
GO:0005385	zinc ion transmembrane transporter activity	7	5
GO:0008324	monoatomic cation transmembrane transporter activity	4	31
GO:0015075	monoatomic ion transmembrane transporter activity	3	31
GO:0015093	ferrous iron transmembrane transporter activity	8	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	31
GO:0022857	transmembrane transporter activity	2	31
GO:0022890	inorganic cation transmembrane transporter activity	4	31
GO:0046873	metal ion transmembrane transporter activity	5	31
GO:0046915	transition metal ion transmembrane transporter activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.432
CLV_NRD_NRD_1	205	207	PF00675	0.338
CLV_PCSK_KEX2_1	164	166	PF00082	0.291
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.308
CLV_PCSK_SKI1_1	157	161	PF00082	0.336
CLV_PCSK_SKI1_1	300	304	PF00082	0.412
CLV_PCSK_SKI1_1	407	411	PF00082	0.288
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.311
DOC_MAPK_DCC_7	294	304	PF00069	0.221
DOC_MAPK_gen_1	405	414	PF00069	0.463
DOC_MAPK_HePTP_8	322	334	PF00069	0.546
DOC_MAPK_MEF2A_6	300	308	PF00069	0.243
DOC_MAPK_MEF2A_6	325	334	PF00069	0.541
DOC_MAPK_MEF2A_6	407	416	PF00069	0.480
DOC_MAPK_RevD_3	280	295	PF00069	0.222
DOC_PP1_RVXF_1	128	135	PF00149	0.177
DOC_PP1_RVXF_1	409	416	PF00149	0.516
DOC_PP2B_LxvP_1	340	343	PF13499	0.384
DOC_USP7_MATH_1	28	32	PF00917	0.394
DOC_USP7_MATH_1	316	320	PF00917	0.334
DOC_USP7_MATH_1	39	43	PF00917	0.447
DOC_USP7_UBL2_3	160	164	PF12436	0.549
DOC_USP7_UBL2_3	171	175	PF12436	0.405
DOC_WW_Pin1_4	181	186	PF00397	0.564
DOC_WW_Pin1_4	232	237	PF00397	0.553
DOC_WW_Pin1_4	353	358	PF00397	0.249
LIG_14-3-3_CanoR_1	206	215	PF00244	0.421
LIG_14-3-3_CanoR_1	268	278	PF00244	0.451
LIG_eIF4E_1	133	139	PF01652	0.323
LIG_eIF4E_1	382	388	PF01652	0.303
LIG_FHA_1	1	7	PF00498	0.380
LIG_FHA_1	10	16	PF00498	0.408
LIG_FHA_1	104	110	PF00498	0.358
LIG_FHA_1	165	171	PF00498	0.411
LIG_FHA_1	327	333	PF00498	0.559
LIG_FHA_1	384	390	PF00498	0.336
LIG_FHA_1	96	102	PF00498	0.350
LIG_GBD_Chelix_1	139	147	PF00786	0.304
LIG_GBD_Chelix_1	332	340	PF00786	0.300
LIG_LIR_Gen_1	363	372	PF02991	0.308
LIG_LIR_Nem_3	128	132	PF02991	0.238
LIG_LIR_Nem_3	263	269	PF02991	0.423
LIG_LIR_Nem_3	284	289	PF02991	0.332
LIG_LIR_Nem_3	363	368	PF02991	0.338
LIG_LYPXL_yS_3	86	89	PF13949	0.421
LIG_PDZ_Wminus1_1	430	432	PF00595	0.461
LIG_Pex14_2	308	312	PF04695	0.368
LIG_Pex14_2	415	419	PF04695	0.268
LIG_Pex14_2	61	65	PF04695	0.361
LIG_SH2_CRK	129	133	PF00017	0.254
LIG_SH2_SRC	269	272	PF00017	0.369
LIG_SH2_STAT5	133	136	PF00017	0.444
LIG_SH2_STAT5	14	17	PF00017	0.438
LIG_SH2_STAT5	266	269	PF00017	0.549
LIG_SH2_STAT5	382	385	PF00017	0.282
LIG_SH2_STAT5	399	402	PF00017	0.454
LIG_SH2_STAT5	88	91	PF00017	0.469
LIG_SH3_3	19	25	PF00018	0.481
LIG_SH3_3	233	239	PF00018	0.451
LIG_SUMO_SIM_anti_2	329	334	PF11976	0.538
LIG_SUMO_SIM_anti_2	367	374	PF11976	0.249
LIG_SUMO_SIM_par_1	100	106	PF11976	0.280
LIG_SUMO_SIM_par_1	230	235	PF11976	0.419
LIG_SUMO_SIM_par_1	367	374	PF11976	0.361
LIG_SUMO_SIM_par_1	385	391	PF11976	0.183
LIG_SxIP_EBH_1	66	78	PF03271	0.327
MOD_CDK_SPK_2	232	237	PF00069	0.362
MOD_CK1_1	103	109	PF00069	0.284
MOD_CK1_1	208	214	PF00069	0.555
MOD_CK1_1	32	38	PF00069	0.521
MOD_CK1_1	358	364	PF00069	0.290
MOD_CK1_1	95	101	PF00069	0.375
MOD_CK2_1	32	38	PF00069	0.502
MOD_GlcNHglycan	22	25	PF01048	0.697
MOD_GlcNHglycan	246	251	PF01048	0.309
MOD_GlcNHglycan	271	274	PF01048	0.307
MOD_GlcNHglycan	31	34	PF01048	0.712
MOD_GlcNHglycan	340	343	PF01048	0.347
MOD_GlcNHglycan	348	351	PF01048	0.368
MOD_GlcNHglycan	357	360	PF01048	0.477
MOD_GlcNHglycan	94	97	PF01048	0.409
MOD_GSK3_1	206	213	PF00069	0.581
MOD_GSK3_1	28	35	PF00069	0.464
MOD_GSK3_1	351	358	PF00069	0.307
MOD_GSK3_1	360	367	PF00069	0.237
MOD_GSK3_1	4	11	PF00069	0.463
MOD_GSK3_1	64	71	PF00069	0.279
MOD_GSK3_1	88	95	PF00069	0.523
MOD_NEK2_1	102	107	PF00069	0.269
MOD_NEK2_1	278	283	PF00069	0.323
MOD_NEK2_1	336	341	PF00069	0.310
MOD_NEK2_1	346	351	PF00069	0.316
MOD_NEK2_1	360	365	PF00069	0.264
MOD_NEK2_1	383	388	PF00069	0.353
MOD_NEK2_1	414	419	PF00069	0.240
MOD_NEK2_1	64	69	PF00069	0.295
MOD_PKA_1	164	170	PF00069	0.365
MOD_PKA_1	206	212	PF00069	0.421
MOD_PKA_1	294	300	PF00069	0.197
MOD_PKA_2	164	170	PF00069	0.497
MOD_PKA_2	205	211	PF00069	0.421
MOD_Plk_2-3	115	121	PF00069	0.229
MOD_Plk_4	281	287	PF00069	0.308
MOD_Plk_4	360	366	PF00069	0.283
MOD_Plk_4	414	420	PF00069	0.407
MOD_Plk_4	64	70	PF00069	0.302
MOD_Plk_4	79	85	PF00069	0.462
MOD_ProDKin_1	181	187	PF00069	0.564
MOD_ProDKin_1	232	238	PF00069	0.553
MOD_ProDKin_1	353	359	PF00069	0.249
MOD_SUMO_for_1	163	166	PF00179	0.435
MOD_SUMO_for_1	170	173	PF00179	0.413
MOD_SUMO_rev_2	199	209	PF00179	0.421
MOD_SUMO_rev_2	225	230	PF00179	0.369
MOD_SUMO_rev_2	296	302	PF00179	0.270
MOD_SUMO_rev_2	319	327	PF00179	0.295
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.369
TRG_DiLeu_LyEn_5	298	303	PF01217	0.249
TRG_ENDOCYTIC_2	129	132	PF00928	0.226
TRG_ENDOCYTIC_2	133	136	PF00928	0.246
TRG_ENDOCYTIC_2	382	385	PF00928	0.287
TRG_ENDOCYTIC_2	86	89	PF00928	0.530
TRG_ER_diArg_1	405	408	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	55%	100%
A0A1X0NSB9	Trypanosomatidae	34%	100%
A0A1X0NSI7	Trypanosomatidae	35%	100%
A0A3R7LZX6	Trypanosoma rangeli	33%	100%
A0A3S7X1N7	Leishmania donovani	39%	93%
A0A3S7X501	Leishmania donovani	90%	100%
A0A422MUI2	Trypanosoma rangeli	34%	100%
A4HGP7	Leishmania braziliensis	42%	100%
A4HJU9	Leishmania braziliensis	72%	100%
A4HJV0	Leishmania braziliensis	72%	100%
A4HJV1	Leishmania braziliensis	57%	100%
A4HM27	Leishmania braziliensis	31%	100%
A4I3R9	Leishmania infantum	39%	94%
A4I7B1	Leishmania infantum	90%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	96%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O04089	Arabidopsis thaliana	27%	100%
O82643	Arabidopsis thaliana	26%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q12436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q4Q3L6	Leishmania major	34%	88%
Q4Q5V0	Leishmania major	99%	100%
Q4Q873	Leishmania major	40%	100%
Q6L8F7	Oryza sativa subsp. japonica	27%	100%
Q6L8F9	Oryza sativa subsp. japonica	24%	100%
Q6L8G1	Oryza sativa subsp. japonica	23%	100%
Q8LE59	Arabidopsis thaliana	27%	100%
Q8W246	Arabidopsis thaliana	24%	100%
V5AWN3	Trypanosoma cruzi	34%	100%
V5BC34	Trypanosoma cruzi	35%	100%
V5DCU2	Trypanosoma cruzi	40%	100%