BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5U9_LEIMA

TriTrypDb:

LmjF.31.3080 , LMJLV39_310041900 , LMJSD75_310042000

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0051259	protein complex oligomerization	6	2
GO:0051260	protein homooligomerization	7	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.649
CLV_C14_Caspase3-7	186	190	PF00656	0.484
CLV_NRD_NRD_1	142	144	PF00675	0.717
CLV_NRD_NRD_1	63	65	PF00675	0.683
CLV_NRD_NRD_1	78	80	PF00675	0.525
CLV_PCSK_KEX2_1	144	146	PF00082	0.726
CLV_PCSK_KEX2_1	63	65	PF00082	0.630
CLV_PCSK_KEX2_1	77	79	PF00082	0.526
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.726
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.545
CLV_PCSK_SKI1_1	107	111	PF00082	0.393
CLV_PCSK_SKI1_1	313	317	PF00082	0.462
CLV_PCSK_SKI1_1	53	57	PF00082	0.545
DOC_CKS1_1	271	276	PF01111	0.542
DOC_CYCLIN_RxL_1	101	113	PF00134	0.460
DOC_CYCLIN_RxL_1	50	58	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.440
DOC_MAPK_gen_1	164	173	PF00069	0.523
DOC_MAPK_MEF2A_6	167	175	PF00069	0.407
DOC_PP1_RVXF_1	121	127	PF00149	0.341
DOC_PP1_RVXF_1	287	293	PF00149	0.412
DOC_PP1_RVXF_1	311	317	PF00149	0.466
DOC_PP1_RVXF_1	319	326	PF00149	0.483
DOC_PP4_FxxP_1	217	220	PF00568	0.560
DOC_SPAK_OSR1_1	207	211	PF12202	0.576
DOC_USP7_MATH_1	136	140	PF00917	0.694
DOC_USP7_MATH_1	157	161	PF00917	0.405
DOC_USP7_MATH_1	345	349	PF00917	0.393
DOC_USP7_MATH_1	350	354	PF00917	0.410
DOC_WW_Pin1_4	270	275	PF00397	0.546
LIG_14-3-3_CanoR_1	207	217	PF00244	0.563
LIG_14-3-3_CanoR_1	352	360	PF00244	0.409
LIG_14-3-3_CanoR_1	44	54	PF00244	0.688
LIG_BRCT_BRCA1_1	115	119	PF00533	0.365
LIG_BRCT_BRCA1_1	235	239	PF00533	0.430
LIG_FHA_1	153	159	PF00498	0.617
LIG_FHA_2	151	157	PF00498	0.640
LIG_LIR_Nem_3	194	200	PF02991	0.346
LIG_MLH1_MIPbox_1	235	239	PF16413	0.430
LIG_NRBOX	171	177	PF00104	0.375
LIG_PCNA_yPIPBox_3	164	172	PF02747	0.407
LIG_Pex14_1	204	208	PF04695	0.405
LIG_PTB_Apo_2	202	209	PF02174	0.517
LIG_PTB_Apo_2	325	332	PF02174	0.516
LIG_PTB_Phospho_1	325	331	PF10480	0.515
LIG_SH2_GRB2like	284	287	PF00017	0.374
LIG_SH2_STAT5	216	219	PF00017	0.570
LIG_SH2_STAT5	293	296	PF00017	0.546
LIG_SH2_STAT5	331	334	PF00017	0.519
LIG_SH3_3	156	162	PF00018	0.540
LIG_SH3_3	268	274	PF00018	0.545
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.447
LIG_SUMO_SIM_anti_2	353	361	PF11976	0.531
LIG_SUMO_SIM_par_1	155	163	PF11976	0.551
LIG_TRAF2_1	26	29	PF00917	0.578
LIG_UBA3_1	171	180	PF00899	0.424
MOD_CK1_1	128	134	PF00069	0.609
MOD_CK1_1	150	156	PF00069	0.461
MOD_CK1_1	354	360	PF00069	0.536
MOD_CK1_1	49	55	PF00069	0.713
MOD_CK2_1	157	163	PF00069	0.588
MOD_CK2_1	187	193	PF00069	0.458
MOD_CK2_1	23	29	PF00069	0.538
MOD_CK2_1	65	71	PF00069	0.585
MOD_Cter_Amidation	141	144	PF01082	0.581
MOD_GlcNHglycan	130	133	PF01048	0.535
MOD_GlcNHglycan	138	141	PF01048	0.585
MOD_GlcNHglycan	200	203	PF01048	0.564
MOD_GlcNHglycan	266	269	PF01048	0.529
MOD_GlcNHglycan	57	60	PF01048	0.710
MOD_GSK3_1	113	120	PF00069	0.516
MOD_GSK3_1	143	150	PF00069	0.672
MOD_GSK3_1	221	228	PF00069	0.566
MOD_GSK3_1	233	240	PF00069	0.364
MOD_GSK3_1	260	267	PF00069	0.468
MOD_GSK3_1	34	41	PF00069	0.646
MOD_GSK3_1	350	357	PF00069	0.523
MOD_GSK3_1	45	52	PF00069	0.545
MOD_LATS_1	141	147	PF00433	0.728
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	103	108	PF00069	0.482
MOD_NEK2_1	117	122	PF00069	0.295
MOD_NEK2_1	126	131	PF00069	0.413
MOD_NEK2_1	203	208	PF00069	0.488
MOD_NEK2_1	221	226	PF00069	0.576
MOD_NEK2_1	238	243	PF00069	0.324
MOD_NEK2_1	248	253	PF00069	0.374
MOD_NEK2_1	260	265	PF00069	0.464
MOD_NEK2_1	38	43	PF00069	0.603
MOD_NEK2_1	55	60	PF00069	0.629
MOD_NEK2_2	187	192	PF00069	0.455
MOD_NEK2_2	288	293	PF00069	0.475
MOD_PIKK_1	210	216	PF00454	0.465
MOD_PIKK_1	248	254	PF00454	0.434
MOD_PIKK_1	351	357	PF00454	0.507
MOD_PIKK_1	85	91	PF00454	0.287
MOD_PKA_1	143	149	PF00069	0.712
MOD_PKA_1	63	69	PF00069	0.467
MOD_PKA_2	351	357	PF00069	0.429
MOD_PKA_2	63	69	PF00069	0.610
MOD_PKB_1	145	153	PF00069	0.528
MOD_Plk_1	150	156	PF00069	0.528
MOD_Plk_1	246	252	PF00069	0.504
MOD_Plk_2-3	65	71	PF00069	0.622
MOD_Plk_4	113	119	PF00069	0.369
MOD_Plk_4	288	294	PF00069	0.480
MOD_Plk_4	354	360	PF00069	0.512
MOD_Plk_4	46	52	PF00069	0.693
MOD_Plk_4	7	13	PF00069	0.469
MOD_ProDKin_1	270	276	PF00069	0.545
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.504
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.680
TRG_ENDOCYTIC_2	80	83	PF00928	0.564
TRG_ER_diArg_1	62	64	PF00400	0.538
TRG_ER_diArg_1	78	80	PF00400	0.432
TRG_NLS_MonoExtC_3	142	147	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N2	Leptomonas seymouri	61%	100%
A0A1X0NIJ4	Trypanosomatidae	39%	100%
A0A3R7K9T3	Trypanosoma rangeli	36%	100%
A0A3S7X510	Leishmania donovani	95%	100%
A0A422P2R6	Trypanosoma rangeli	24%	70%
A4HJU7	Leishmania braziliensis	79%	100%
A4HJV2	Leishmania braziliensis	80%	100%
A4I7B4	Leishmania infantum	96%	100%
C9ZWJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B2A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B9A8	Trypanosoma cruzi	37%	100%
V5DUU9	Trypanosoma cruzi	25%	71%