J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5U7_LEIMA

TriTrypDb:

LmjF.31.3100 , LMJLV39_310042100 , LMJSD75_310042200

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0031207	Sec62/Sec63 complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	13
GO:0140534	endoplasmic reticulum protein-containing complex	2	2

Expansion

Sequence features

Q4Q5U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U7

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006613	cotranslational protein targeting to membrane	6	2
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	2
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045047	protein targeting to ER	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070972	protein localization to endoplasmic reticulum	6	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0008320	protein transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022884	macromolecule transmembrane transporter activity	3	2
GO:0140318	protein transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.628
CLV_MEL_PAP_1	131	137	PF00089	0.407
CLV_NRD_NRD_1	6	8	PF00675	0.436
CLV_PCSK_KEX2_1	6	8	PF00082	0.436
CLV_PCSK_SKI1_1	40	44	PF00082	0.265
CLV_PCSK_SKI1_1	6	10	PF00082	0.448
DEG_APCC_DBOX_1	133	141	PF00400	0.302
DEG_Nend_Nbox_1	1	3	PF02207	0.690
DEG_SPOP_SBC_1	104	108	PF00917	0.621
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.476
DOC_MAPK_gen_1	156	165	PF00069	0.490
DOC_MAPK_gen_1	35	43	PF00069	0.454
DOC_MAPK_gen_1	92	100	PF00069	0.604
DOC_MAPK_MEF2A_6	36	45	PF00069	0.497
DOC_PP4_FxxP_1	139	142	PF00568	0.590
DOC_USP7_MATH_1	27	31	PF00917	0.465
DOC_USP7_UBL2_3	31	35	PF12436	0.470
LIG_14-3-3_CanoR_1	134	138	PF00244	0.407
LIG_BIR_III_4	166	170	PF00653	0.390
LIG_BRCT_BRCA1_1	135	139	PF00533	0.407
LIG_BRCT_BRCA1_1	4	8	PF00533	0.548
LIG_DCNL_PONY_1	1	4	PF03556	0.602
LIG_FHA_2	150	156	PF00498	0.470
LIG_FHA_2	171	177	PF00498	0.534
LIG_LIR_Apic_2	136	142	PF02991	0.413
LIG_LIR_Gen_1	116	125	PF02991	0.629
LIG_LIR_Gen_1	63	70	PF02991	0.489
LIG_LIR_Nem_3	116	122	PF02991	0.560
LIG_LIR_Nem_3	136	141	PF02991	0.348
LIG_LIR_Nem_3	18	23	PF02991	0.479
LIG_LIR_Nem_3	196	202	PF02991	0.459
LIG_LIR_Nem_3	63	68	PF02991	0.481
LIG_MLH1_MIPbox_1	135	139	PF16413	0.301
LIG_Pex14_2	128	132	PF04695	0.406
LIG_SH2_CRK	20	24	PF00017	0.470
LIG_SH2_CRK	38	42	PF00017	0.470
LIG_SH2_NCK_1	101	105	PF00017	0.625
LIG_SH2_STAT3	75	78	PF00017	0.559
LIG_SH2_STAT5	111	114	PF00017	0.624
LIG_SH2_STAT5	99	102	PF00017	0.651
LIG_SH3_2	16	21	PF14604	0.454
LIG_SH3_3	13	19	PF00018	0.569
LIG_TRAF2_1	193	196	PF00917	0.437
LIG_TRFH_1	138	142	PF08558	0.403
LIG_TYR_ITIM	197	202	PF00017	0.464
MOD_CK1_1	113	119	PF00069	0.573
MOD_CK1_1	187	193	PF00069	0.627
MOD_CK2_1	170	176	PF00069	0.495
MOD_CK2_1	27	33	PF00069	0.323
MOD_CK2_1	46	52	PF00069	0.425
MOD_GlcNHglycan	112	115	PF01048	0.616
MOD_GlcNHglycan	206	209	PF01048	0.666
MOD_GlcNHglycan	48	51	PF01048	0.407
MOD_GlcNHglycan	75	78	PF01048	0.553
MOD_N-GLC_1	187	192	PF02516	0.725
MOD_N-GLC_2	184	186	PF02516	0.507
MOD_NEK2_1	159	164	PF00069	0.446
MOD_NEK2_1	2	7	PF00069	0.548
MOD_PKA_2	133	139	PF00069	0.400
MOD_PKA_2	2	8	PF00069	0.541
MOD_Plk_1	175	181	PF00069	0.662
MOD_Plk_4	133	139	PF00069	0.301
MOD_Plk_4	149	155	PF00069	0.553
MOD_Plk_4	170	176	PF00069	0.633
MOD_SUMO_rev_2	194	202	PF00179	0.547
MOD_SUMO_rev_2	28	37	PF00179	0.342
MOD_SUMO_rev_2	87	96	PF00179	0.594
TRG_ENDOCYTIC_2	119	122	PF00928	0.537
TRG_ENDOCYTIC_2	199	202	PF00928	0.512
TRG_ENDOCYTIC_2	20	23	PF00928	0.328
TRG_ENDOCYTIC_2	38	41	PF00928	0.323
TRG_ENDOCYTIC_2	65	68	PF00928	0.314
TRG_ER_diArg_1	6	8	PF00400	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ1	Leptomonas seymouri	61%	100%
A0A0N1PA62	Leptomonas seymouri	28%	89%
A0A1X0NIB0	Trypanosomatidae	44%	100%
A0A3Q8IAY4	Leishmania donovani	29%	89%
A0A3S7X515	Leishmania donovani	92%	100%
A0A422NEY3	Trypanosoma rangeli	44%	100%
A4HJV4	Leishmania braziliensis	76%	100%
A4HXQ8	Leishmania infantum	29%	89%
A4I7B6	Leishmania infantum	92%	100%
C9ZWJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	94%
D0A039	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	90%
E9ARH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	89%
E9B2A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QE09	Leishmania major	29%	89%