Autophagy protein 10 (ATG10)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 10

Species:

Leishmania major

UniProt:

Q4Q5U6_LEIMA

TriTrypDb:

LmjF.31.3105 , LMJLV39_310042200 , LMJSD75_310042300

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3
GO:0019787	ubiquitin-like protein transferase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.496
CLV_PCSK_FUR_1	213	217	PF00082	0.377
CLV_PCSK_FUR_1	98	102	PF00082	0.462
CLV_PCSK_KEX2_1	100	102	PF00082	0.518
CLV_PCSK_KEX2_1	215	217	PF00082	0.496
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.543
DEG_APCC_DBOX_1	40	48	PF00400	0.459
DEG_Nend_UBRbox_2	1	3	PF02207	0.431
DOC_CDC14_PxL_1	236	244	PF14671	0.462
DOC_CKS1_1	60	65	PF01111	0.479
DOC_MAPK_gen_1	98	108	PF00069	0.318
DOC_MAPK_RevD_3	200	216	PF00069	0.418
DOC_PP2B_LxvP_1	241	244	PF13499	0.467
DOC_PP4_FxxP_1	104	107	PF00568	0.324
DOC_PP4_FxxP_1	140	143	PF00568	0.403
DOC_USP7_MATH_1	186	190	PF00917	0.365
DOC_USP7_MATH_2	94	100	PF00917	0.452
DOC_WW_Pin1_4	19	24	PF00397	0.404
DOC_WW_Pin1_4	59	64	PF00397	0.468
DOC_WW_Pin1_4	90	95	PF00397	0.462
LIG_14-3-3_CanoR_1	185	191	PF00244	0.382
LIG_14-3-3_CanoR_1	41	49	PF00244	0.455
LIG_14-3-3_CanoR_1	79	83	PF00244	0.369
LIG_Actin_WH2_2	29	45	PF00022	0.443
LIG_AP2alpha_2	102	104	PF02296	0.421
LIG_BH_BH3_1	221	237	PF00452	0.399
LIG_eIF4E_1	115	121	PF01652	0.319
LIG_FHA_1	112	118	PF00498	0.405
LIG_FHA_1	129	135	PF00498	0.320
LIG_FHA_1	178	184	PF00498	0.560
LIG_FHA_1	206	212	PF00498	0.346
LIG_FHA_1	70	76	PF00498	0.553
LIG_FHA_2	151	157	PF00498	0.579
LIG_LIR_Apic_2	102	107	PF02991	0.469
LIG_LIR_Apic_2	139	143	PF02991	0.332
LIG_LIR_Gen_1	81	86	PF02991	0.331
LIG_LIR_Nem_3	234	238	PF02991	0.403
LIG_LIR_Nem_3	81	85	PF02991	0.449
LIG_MYND_1	240	244	PF01753	0.476
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.372
LIG_Pex14_2	136	140	PF04695	0.394
LIG_PTB_Apo_2	134	141	PF02174	0.409
LIG_PTB_Apo_2	161	168	PF02174	0.393
LIG_SH2_PTP2	20	23	PF00017	0.420
LIG_SH2_STAT5	17	20	PF00017	0.402
LIG_SH2_STAT5	235	238	PF00017	0.440
LIG_SH3_1	20	26	PF00018	0.417
LIG_SH3_3	165	171	PF00018	0.445
LIG_SH3_3	20	26	PF00018	0.417
LIG_SH3_3	234	240	PF00018	0.462
LIG_SH3_3	57	63	PF00018	0.457
LIG_Sin3_3	239	246	PF02671	0.452
LIG_WRC_WIRS_1	187	192	PF05994	0.428
MOD_CK1_1	150	156	PF00069	0.524
MOD_CK1_1	34	40	PF00069	0.504
MOD_CK2_1	116	122	PF00069	0.554
MOD_CK2_1	150	156	PF00069	0.467
MOD_CK2_1	169	175	PF00069	0.597
MOD_CK2_1	90	96	PF00069	0.522
MOD_GlcNHglycan	122	126	PF01048	0.616
MOD_GSK3_1	147	154	PF00069	0.487
MOD_GSK3_1	186	193	PF00069	0.360
MOD_GSK3_1	67	74	PF00069	0.622
MOD_N-GLC_1	148	153	PF02516	0.469
MOD_N-GLC_1	163	168	PF02516	0.268
MOD_N-GLC_2	116	118	PF02516	0.400
MOD_NEK2_1	111	116	PF00069	0.346
MOD_NEK2_1	121	126	PF00069	0.438
MOD_NEK2_1	147	152	PF00069	0.471
MOD_NEK2_2	64	69	PF00069	0.499
MOD_PIKK_1	190	196	PF00454	0.497
MOD_PKA_2	42	48	PF00069	0.439
MOD_PKA_2	78	84	PF00069	0.428
MOD_Plk_1	111	117	PF00069	0.405
MOD_Plk_1	148	154	PF00069	0.469
MOD_Plk_1	163	169	PF00069	0.282
MOD_Plk_4	116	122	PF00069	0.447
MOD_Plk_4	163	169	PF00069	0.453
MOD_Plk_4	223	229	PF00069	0.431
MOD_ProDKin_1	19	25	PF00069	0.403
MOD_ProDKin_1	59	65	PF00069	0.471
MOD_ProDKin_1	90	96	PF00069	0.462
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.431
TRG_ENDOCYTIC_2	199	202	PF00928	0.446
TRG_ENDOCYTIC_2	235	238	PF00928	0.440
TRG_ER_diArg_1	212	215	PF00400	0.470
TRG_ER_diArg_1	40	43	PF00400	0.504
TRG_ER_diArg_1	51	54	PF00400	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N4	Leptomonas seymouri	49%	100%
A0A1X0NI81	Trypanosomatidae	28%	100%
A0A3R7KLN3	Trypanosoma rangeli	26%	100%
A0A3S5H7Q9	Leishmania donovani	90%	100%
A4HJV5	Leishmania braziliensis	75%	100%
A4I7B7	Leishmania infantum	92%	100%
C9ZWJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B2B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%