TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 14

Species:

Leishmania major

UniProt:

Q4Q5U5_LEIMA

TriTrypDb:

LmjF.31.3110 , LMJLV39_310042300 , LMJSD75_310042400

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.457
CLV_C14_Caspase3-7	336	340	PF00656	0.460
CLV_C14_Caspase3-7	417	421	PF00656	0.635
CLV_C14_Caspase3-7	667	671	PF00656	0.823
CLV_NRD_NRD_1	141	143	PF00675	0.598
CLV_NRD_NRD_1	159	161	PF00675	0.674
CLV_NRD_NRD_1	191	193	PF00675	0.692
CLV_NRD_NRD_1	243	245	PF00675	0.586
CLV_NRD_NRD_1	277	279	PF00675	0.669
CLV_NRD_NRD_1	302	304	PF00675	0.609
CLV_NRD_NRD_1	384	386	PF00675	0.683
CLV_NRD_NRD_1	394	396	PF00675	0.629
CLV_NRD_NRD_1	45	47	PF00675	0.727
CLV_NRD_NRD_1	456	458	PF00675	0.619
CLV_NRD_NRD_1	471	473	PF00675	0.562
CLV_NRD_NRD_1	527	529	PF00675	0.578
CLV_NRD_NRD_1	542	544	PF00675	0.609
CLV_NRD_NRD_1	60	62	PF00675	0.496
CLV_NRD_NRD_1	600	602	PF00675	0.703
CLV_NRD_NRD_1	647	649	PF00675	0.584
CLV_NRD_NRD_1	656	658	PF00675	0.613
CLV_NRD_NRD_1	800	802	PF00675	0.619
CLV_PCSK_FUR_1	189	193	PF00082	0.618
CLV_PCSK_KEX2_1	140	142	PF00082	0.591
CLV_PCSK_KEX2_1	159	161	PF00082	0.674
CLV_PCSK_KEX2_1	191	193	PF00082	0.692
CLV_PCSK_KEX2_1	230	232	PF00082	0.691
CLV_PCSK_KEX2_1	304	306	PF00082	0.672
CLV_PCSK_KEX2_1	45	47	PF00082	0.727
CLV_PCSK_KEX2_1	471	473	PF00082	0.642
CLV_PCSK_KEX2_1	485	487	PF00082	0.612
CLV_PCSK_KEX2_1	492	494	PF00082	0.555
CLV_PCSK_KEX2_1	542	544	PF00082	0.580
CLV_PCSK_KEX2_1	602	604	PF00082	0.792
CLV_PCSK_KEX2_1	647	649	PF00082	0.479
CLV_PCSK_KEX2_1	800	802	PF00082	0.594
CLV_PCSK_KEX2_1	821	823	PF00082	0.732
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.653
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.599
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.682
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.577
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.678
CLV_PCSK_PC1ET2_1	821	823	PF00082	0.732
CLV_PCSK_PC7_1	598	604	PF00082	0.728
CLV_PCSK_SKI1_1	102	106	PF00082	0.532
CLV_PCSK_SKI1_1	142	146	PF00082	0.619
CLV_PCSK_SKI1_1	259	263	PF00082	0.520
CLV_PCSK_SKI1_1	297	301	PF00082	0.477
CLV_PCSK_SKI1_1	326	330	PF00082	0.593
CLV_PCSK_SKI1_1	338	342	PF00082	0.550
CLV_PCSK_SKI1_1	385	389	PF00082	0.775
CLV_PCSK_SKI1_1	419	423	PF00082	0.700
CLV_PCSK_SKI1_1	481	485	PF00082	0.635
CLV_PCSK_SKI1_1	528	532	PF00082	0.579
CLV_PCSK_SKI1_1	586	590	PF00082	0.826
CLV_PCSK_SKI1_1	657	661	PF00082	0.665
DEG_SCF_TRCP1_1	670	675	PF00400	0.593
DOC_MAPK_gen_1	159	166	PF00069	0.692
DOC_MAPK_gen_1	710	717	PF00069	0.605
DOC_PP1_RVXF_1	7	13	PF00149	0.548
DOC_USP7_MATH_1	17	21	PF00917	0.650
DOC_USP7_MATH_1	218	222	PF00917	0.577
DOC_USP7_MATH_1	370	374	PF00917	0.699
DOC_USP7_MATH_1	407	411	PF00917	0.638
DOC_USP7_MATH_1	441	445	PF00917	0.682
DOC_USP7_MATH_1	676	680	PF00917	0.680
DOC_USP7_MATH_1	76	80	PF00917	0.555
DOC_USP7_MATH_1	770	774	PF00917	0.689
DOC_USP7_MATH_1	802	806	PF00917	0.470
DOC_USP7_MATH_1	825	829	PF00917	0.721
DOC_USP7_UBL2_3	481	485	PF12436	0.627
DOC_WW_Pin1_4	13	18	PF00397	0.777
DOC_WW_Pin1_4	581	586	PF00397	0.709
DOC_WW_Pin1_4	588	593	PF00397	0.719
DOC_WW_Pin1_4	672	677	PF00397	0.768
LIG_14-3-3_CanoR_1	326	331	PF00244	0.472
LIG_14-3-3_CanoR_1	45	50	PF00244	0.675
LIG_14-3-3_CanoR_1	595	601	PF00244	0.741
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	35	39	PF00533	0.667
LIG_deltaCOP1_diTrp_1	87	92	PF00928	0.531
LIG_FHA_1	143	149	PF00498	0.627
LIG_FHA_1	750	756	PF00498	0.768
LIG_FHA_1	758	764	PF00498	0.745
LIG_FHA_1	772	778	PF00498	0.589
LIG_FHA_2	103	109	PF00498	0.527
LIG_FHA_2	183	189	PF00498	0.616
LIG_FHA_2	211	217	PF00498	0.570
LIG_FHA_2	241	247	PF00498	0.653
LIG_FHA_2	270	276	PF00498	0.629
LIG_FHA_2	327	333	PF00498	0.464
LIG_FHA_2	334	340	PF00498	0.443
LIG_FHA_2	767	773	PF00498	0.750
LIG_IRF3_LxIS_1	527	534	PF10401	0.686
LIG_LIR_Gen_1	87	96	PF02991	0.515
LIG_LIR_LC3C_4	713	717	PF02991	0.675
LIG_LIR_Nem_3	87	92	PF02991	0.516
LIG_Pex14_2	88	92	PF04695	0.632
LIG_RPA_C_Fungi	214	226	PF08784	0.594
LIG_RPA_C_Plants	692	703	PF08784	0.606
LIG_SH2_STAP1	712	716	PF00017	0.578
LIG_SH2_STAP1	751	755	PF00017	0.693
LIG_SH2_STAT5	751	754	PF00017	0.695
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.571
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.529
LIG_SUMO_SIM_anti_2	555	560	PF11976	0.532
LIG_TRAF2_1	105	108	PF00917	0.559
LIG_TRAF2_1	329	332	PF00917	0.601
LIG_TRAF2_1	4	7	PF00917	0.560
LIG_TRAF2_1	579	582	PF00917	0.720
LIG_TRAF2_1	776	779	PF00917	0.640
LIG_TRAF2_2	377	382	PF00917	0.790
MOD_CDK_SPK_2	581	586	PF00069	0.709
MOD_CDK_SPK_2	593	598	PF00069	0.726
MOD_CDK_SPxxK_3	588	595	PF00069	0.723
MOD_CK1_1	33	39	PF00069	0.668
MOD_CK1_1	41	47	PF00069	0.666
MOD_CK1_1	443	449	PF00069	0.607
MOD_CK1_1	663	669	PF00069	0.721
MOD_CK1_1	750	756	PF00069	0.690
MOD_CK2_1	102	108	PF00069	0.555
MOD_CK2_1	182	188	PF00069	0.613
MOD_CK2_1	210	216	PF00069	0.568
MOD_CK2_1	240	246	PF00069	0.690
MOD_CK2_1	269	275	PF00069	0.665
MOD_CK2_1	326	332	PF00069	0.532
MOD_CK2_1	52	58	PF00069	0.586
MOD_CK2_1	576	582	PF00069	0.655
MOD_CK2_1	758	764	PF00069	0.762
MOD_CK2_1	766	772	PF00069	0.695
MOD_GlcNHglycan	220	223	PF01048	0.586
MOD_GlcNHglycan	372	375	PF01048	0.737
MOD_GlcNHglycan	409	412	PF01048	0.640
MOD_GlcNHglycan	498	502	PF01048	0.647
MOD_GlcNHglycan	513	516	PF01048	0.497
MOD_GlcNHglycan	670	673	PF01048	0.813
MOD_GlcNHglycan	752	755	PF01048	0.773
MOD_GlcNHglycan	766	769	PF01048	0.596
MOD_GlcNHglycan	774	777	PF01048	0.605
MOD_GlcNHglycan	817	820	PF01048	0.716
MOD_GlcNHglycan	829	832	PF01048	0.748
MOD_GlcNHglycan	842	845	PF01048	0.584
MOD_GSK3_1	13	20	PF00069	0.710
MOD_GSK3_1	26	33	PF00069	0.626
MOD_GSK3_1	34	41	PF00069	0.581
MOD_GSK3_1	507	514	PF00069	0.705
MOD_GSK3_1	584	591	PF00069	0.723
MOD_GSK3_1	660	667	PF00069	0.703
MOD_GSK3_1	668	675	PF00069	0.782
MOD_GSK3_1	766	773	PF00069	0.671
MOD_GSK3_1	811	818	PF00069	0.558
MOD_N-GLC_1	26	31	PF02516	0.684
MOD_N-GLC_1	825	830	PF02516	0.716
MOD_NEK2_1	26	31	PF00069	0.669
MOD_NEK2_1	34	39	PF00069	0.584
MOD_NEK2_1	440	445	PF00069	0.680
MOD_NEK2_1	660	665	PF00069	0.691
MOD_PIKK_1	312	318	PF00454	0.668
MOD_PIKK_1	507	513	PF00454	0.589
MOD_PIKK_1	531	537	PF00454	0.628
MOD_PIKK_1	802	808	PF00454	0.481
MOD_PK_1	175	181	PF00069	0.619
MOD_PK_1	45	51	PF00069	0.745
MOD_PKA_1	45	51	PF00069	0.716
MOD_PKA_1	542	548	PF00069	0.616
MOD_PKA_2	121	127	PF00069	0.580
MOD_PKA_2	174	180	PF00069	0.689
MOD_PKA_2	218	224	PF00069	0.592
MOD_PKA_2	37	43	PF00069	0.673
MOD_PKA_2	407	413	PF00069	0.639
MOD_PKA_2	44	50	PF00069	0.689
MOD_PKA_2	542	548	PF00069	0.616
MOD_PKA_2	719	725	PF00069	0.685
MOD_PKB_1	140	148	PF00069	0.620
MOD_PKB_1	28	36	PF00069	0.656
MOD_PKB_1	348	356	PF00069	0.640
MOD_Plk_1	152	158	PF00069	0.636
MOD_Plk_1	175	181	PF00069	0.642
MOD_Plk_1	297	303	PF00069	0.665
MOD_Plk_1	758	764	PF00069	0.739
MOD_Plk_2-3	333	339	PF00069	0.457
MOD_Plk_2-3	52	58	PF00069	0.586
MOD_Plk_4	152	158	PF00069	0.610
MOD_Plk_4	175	181	PF00069	0.642
MOD_Plk_4	443	449	PF00069	0.529
MOD_ProDKin_1	13	19	PF00069	0.778
MOD_ProDKin_1	581	587	PF00069	0.711
MOD_ProDKin_1	588	594	PF00069	0.721
MOD_ProDKin_1	672	678	PF00069	0.768
MOD_SUMO_for_1	484	487	PF00179	0.609
MOD_SUMO_rev_2	274	281	PF00179	0.681
MOD_SUMO_rev_2	332	336	PF00179	0.570
MOD_SUMO_rev_2	360	370	PF00179	0.684
MOD_SUMO_rev_2	373	380	PF00179	0.660
MOD_SUMO_rev_2	454	460	PF00179	0.642
MOD_SUMO_rev_2	462	467	PF00179	0.545
MOD_SUMO_rev_2	611	620	PF00179	0.555
TRG_DiLeu_BaEn_1	108	113	PF01217	0.542
TRG_DiLeu_BaEn_1	77	82	PF01217	0.652
TRG_DiLeu_BaEn_4	803	809	PF01217	0.609
TRG_ENDOCYTIC_2	712	715	PF00928	0.584
TRG_ER_diArg_1	139	142	PF00400	0.584
TRG_ER_diArg_1	189	192	PF00400	0.625
TRG_ER_diArg_1	302	305	PF00400	0.674
TRG_ER_diArg_1	470	472	PF00400	0.570
TRG_ER_diArg_1	600	603	PF00400	0.805
TRG_NES_CRM1_1	627	638	PF08389	0.440
TRG_NLS_Bipartite_1	45	65	PF00514	0.696
TRG_NLS_MonoExtC_3	600	605	PF00514	0.657
TRG_NLS_MonoExtN_4	598	605	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I335	Leptomonas seymouri	51%	97%
A0A3S7X4Z8	Leishmania donovani	91%	100%
A4HJV6	Leishmania braziliensis	66%	100%
A4I7B8	Leishmania infantum	92%	100%
E9B2B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%