Phosphatidylethanolaminen-methyltransferase-lik e protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolaminen-methyltransferase-lik e protein

Species:

Leishmania major

UniProt:

Q4Q5U4_LEIMA

TriTrypDb:

LmjF.31.3120 , LMJLV39_310042400 , LMJSD75_310042500

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

Q4Q5U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U4

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0006644	phospholipid metabolic process	4	9
GO:0006650	glycerophospholipid metabolic process	5	9
GO:0006656	phosphatidylcholine biosynthetic process	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	9
GO:0008654	phospholipid biosynthetic process	5	9

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004608	phosphatidylethanolamine N-methyltransferase activity	6	6
GO:0008168	methyltransferase activity	4	9
GO:0008170	N-methyltransferase activity	5	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.638
CLV_NRD_NRD_1	115	117	PF00675	0.359
CLV_NRD_NRD_1	125	127	PF00675	0.361
CLV_NRD_NRD_1	536	538	PF00675	0.276
CLV_NRD_NRD_1	556	558	PF00675	0.376
CLV_NRD_NRD_1	578	580	PF00675	0.450
CLV_PCSK_KEX2_1	115	117	PF00082	0.359
CLV_PCSK_KEX2_1	125	127	PF00082	0.361
CLV_PCSK_KEX2_1	378	380	PF00082	0.408
CLV_PCSK_KEX2_1	401	403	PF00082	0.333

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S1	Leptomonas seymouri	79%	100%
A0A0S4ITN2	Bodo saltans	53%	100%
A0A1X0NK27	Trypanosomatidae	59%	97%
A0A3Q8IF60	Leishmania donovani	97%	100%
A3LQW6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	30%	68%
A4HJV7	Leishmania braziliensis	86%	100%
A4I7B9	Leishmania infantum	97%	100%
A5DL79	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	31%	67%
A6ZUG8	Saccharomyces cerevisiae (strain YJM789)	30%	67%
A7TLA7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	33%	69%

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