Phosphatidylethanolaminen-methyltransferase-lik e protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolaminen-methyltransferase-lik e protein

Species:

Leishmania major

UniProt:

Q4Q5U4_LEIMA

TriTrypDb:

LmjF.31.3120 , LMJLV39_310042400 , LMJSD75_310042500

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q5U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	9
GO:0006644	phospholipid metabolic process	4	9
GO:0006650	glycerophospholipid metabolic process	5	9
GO:0006656	phosphatidylcholine biosynthetic process	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	9
GO:0008654	phospholipid biosynthetic process	5	9
GO:0009058	biosynthetic process	2	9
GO:0009987	cellular process	1	9
GO:0019637	organophosphate metabolic process	3	9
GO:0032259	methylation	2	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044255	cellular lipid metabolic process	3	9
GO:0045017	glycerolipid biosynthetic process	4	9
GO:0046470	phosphatidylcholine metabolic process	4	9
GO:0046474	glycerophospholipid biosynthetic process	5	9
GO:0046486	glycerolipid metabolic process	4	9
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901566	organonitrogen compound biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004608	phosphatidylethanolamine N-methyltransferase activity	6	6
GO:0008168	methyltransferase activity	4	9
GO:0008170	N-methyltransferase activity	5	6
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	6
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.638
CLV_NRD_NRD_1	115	117	PF00675	0.359
CLV_NRD_NRD_1	125	127	PF00675	0.361
CLV_NRD_NRD_1	536	538	PF00675	0.276
CLV_NRD_NRD_1	556	558	PF00675	0.376
CLV_NRD_NRD_1	578	580	PF00675	0.450
CLV_PCSK_KEX2_1	115	117	PF00082	0.359
CLV_PCSK_KEX2_1	125	127	PF00082	0.361
CLV_PCSK_KEX2_1	378	380	PF00082	0.408
CLV_PCSK_KEX2_1	401	403	PF00082	0.333
CLV_PCSK_KEX2_1	538	540	PF00082	0.264
CLV_PCSK_KEX2_1	556	558	PF00082	0.376
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.408
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.333
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.313
CLV_PCSK_SKI1_1	125	129	PF00082	0.343
CLV_PCSK_SKI1_1	229	233	PF00082	0.530
CLV_PCSK_SKI1_1	421	425	PF00082	0.401
CLV_PCSK_SKI1_1	556	560	PF00082	0.413
CLV_PCSK_SKI1_1	570	574	PF00082	0.418
DOC_CKS1_1	44	49	PF01111	0.639
DOC_CYCLIN_RxL_1	122	131	PF00134	0.567
DOC_CYCLIN_yClb5_NLxxxL_5	408	417	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.366
DOC_MAPK_gen_1	31	40	PF00069	0.582
DOC_MAPK_MEF2A_6	332	340	PF00069	0.495
DOC_PIKK_1	159	167	PF02985	0.555
DOC_PP1_RVXF_1	227	234	PF00149	0.272
DOC_PP2B_LxvP_1	349	352	PF13499	0.366
DOC_PP4_FxxP_1	240	243	PF00568	0.272
DOC_PP4_FxxP_1	32	35	PF00568	0.527
DOC_SPAK_OSR1_1	31	35	PF12202	0.544
DOC_USP7_MATH_1	451	455	PF00917	0.392
DOC_USP7_MATH_1	492	496	PF00917	0.496
DOC_USP7_MATH_1	517	521	PF00917	0.440
DOC_WW_Pin1_4	182	187	PF00397	0.560
DOC_WW_Pin1_4	293	298	PF00397	0.645
DOC_WW_Pin1_4	389	394	PF00397	0.588
DOC_WW_Pin1_4	43	48	PF00397	0.596
DOC_WW_Pin1_4	49	54	PF00397	0.465
DOC_WW_Pin1_4	507	512	PF00397	0.361
LIG_14-3-3_CanoR_1	115	123	PF00244	0.544
LIG_14-3-3_CanoR_1	332	340	PF00244	0.495
LIG_14-3-3_CanoR_1	51	57	PF00244	0.552
LIG_AP2alpha_1	145	149	PF02296	0.500
LIG_APCC_ABBA_1	324	329	PF00400	0.523
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	130	134	PF00533	0.533
LIG_BRCT_BRCA1_1	197	201	PF00533	0.409
LIG_Clathr_ClatBox_1	325	329	PF01394	0.539
LIG_deltaCOP1_diTrp_1	215	225	PF00928	0.272
LIG_eIF4E_1	344	350	PF01652	0.406
LIG_eIF4E_1	501	507	PF01652	0.328
LIG_FHA_1	122	128	PF00498	0.591
LIG_FHA_1	288	294	PF00498	0.472
LIG_FHA_1	346	352	PF00498	0.409
LIG_FHA_1	35	41	PF00498	0.555
LIG_FHA_1	442	448	PF00498	0.436
LIG_FHA_1	66	72	PF00498	0.336
LIG_FHA_2	13	19	PF00498	0.739
LIG_FHA_2	296	302	PF00498	0.592
LIG_GBD_Chelix_1	338	346	PF00786	0.409
LIG_LIR_Apic_2	30	35	PF02991	0.538
LIG_LIR_Apic_2	387	393	PF02991	0.589
LIG_LIR_Apic_2	424	428	PF02991	0.506
LIG_LIR_Apic_2	49	53	PF02991	0.519
LIG_LIR_Gen_1	109	118	PF02991	0.540
LIG_LIR_Gen_1	188	197	PF02991	0.444
LIG_LIR_Gen_1	234	245	PF02991	0.270
LIG_LIR_Gen_1	246	257	PF02991	0.272
LIG_LIR_Gen_1	261	270	PF02991	0.328
LIG_LIR_Gen_1	288	299	PF02991	0.600
LIG_LIR_Gen_1	456	466	PF02991	0.488
LIG_LIR_LC3C_4	321	324	PF02991	0.522
LIG_LIR_Nem_3	105	110	PF02991	0.523
LIG_LIR_Nem_3	169	173	PF02991	0.486
LIG_LIR_Nem_3	188	193	PF02991	0.328
LIG_LIR_Nem_3	21	26	PF02991	0.591
LIG_LIR_Nem_3	215	219	PF02991	0.272
LIG_LIR_Nem_3	222	227	PF02991	0.272
LIG_LIR_Nem_3	232	236	PF02991	0.272
LIG_LIR_Nem_3	261	265	PF02991	0.327
LIG_LIR_Nem_3	268	273	PF02991	0.323
LIG_LIR_Nem_3	288	294	PF02991	0.457
LIG_LIR_Nem_3	454	458	PF02991	0.366
LIG_LIR_Nem_3	463	467	PF02991	0.462
LIG_LIR_Nem_3	483	489	PF02991	0.333
LIG_LIR_Nem_3	499	504	PF02991	0.361
LIG_LIR_Nem_3	61	65	PF02991	0.388
LIG_NRBOX	345	351	PF00104	0.376
LIG_NRBOX	372	378	PF00104	0.463
LIG_Pex14_1	220	224	PF04695	0.272
LIG_Pex14_1	400	404	PF04695	0.498
LIG_Pex14_1	89	93	PF04695	0.328
LIG_Pex14_2	145	149	PF04695	0.500
LIG_Pex14_2	190	194	PF04695	0.284
LIG_Pex14_2	216	220	PF04695	0.330
LIG_Pex14_2	233	237	PF04695	0.272
LIG_Pex14_2	368	372	PF04695	0.370
LIG_Pex14_2	467	471	PF04695	0.475
LIG_Pex14_2	82	86	PF04695	0.343
LIG_PTB_Apo_2	409	416	PF02174	0.328
LIG_PTB_Phospho_1	409	415	PF10480	0.328
LIG_SH2_CRK	114	118	PF00017	0.601
LIG_SH2_CRK	170	174	PF00017	0.540
LIG_SH2_CRK	23	27	PF00017	0.560
LIG_SH2_CRK	253	257	PF00017	0.272
LIG_SH2_CRK	266	270	PF00017	0.328
LIG_SH2_CRK	291	295	PF00017	0.652
LIG_SH2_CRK	390	394	PF00017	0.511
LIG_SH2_CRK	482	486	PF00017	0.472
LIG_SH2_GRB2like	488	491	PF00017	0.496
LIG_SH2_NCK_1	390	394	PF00017	0.574
LIG_SH2_NCK_1	458	462	PF00017	0.480
LIG_SH2_SRC	316	319	PF00017	0.590
LIG_SH2_STAP1	249	253	PF00017	0.272
LIG_SH2_STAP1	262	266	PF00017	0.328
LIG_SH2_STAP1	358	362	PF00017	0.377
LIG_SH2_STAP1	565	569	PF00017	0.550
LIG_SH2_STAT3	540	543	PF00017	0.530
LIG_SH2_STAT5	245	248	PF00017	0.272
LIG_SH2_STAT5	262	265	PF00017	0.328
LIG_SH2_STAT5	316	319	PF00017	0.546
LIG_SH2_STAT5	344	347	PF00017	0.361
LIG_SH2_STAT5	375	378	PF00017	0.416
LIG_SH2_STAT5	415	418	PF00017	0.361
LIG_SH2_STAT5	422	425	PF00017	0.361
LIG_SH2_STAT5	452	455	PF00017	0.328
LIG_SH2_STAT5	466	469	PF00017	0.472
LIG_SH2_STAT5	488	491	PF00017	0.496
LIG_SH2_STAT5	72	75	PF00017	0.346
LIG_SH3_3	279	285	PF00018	0.472
LIG_SH3_3	528	534	PF00018	0.472
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.534
LIG_SUMO_SIM_anti_2	510	516	PF11976	0.335
LIG_SUMO_SIM_par_1	334	341	PF11976	0.372
LIG_TRAF2_1	298	301	PF00917	0.584
LIG_TYR_ITIM	168	173	PF00017	0.511
LIG_TYR_ITIM	264	269	PF00017	0.328
LIG_TYR_ITIM	480	485	PF00017	0.472
LIG_WRC_WIRS_1	107	112	PF05994	0.539
MOD_CDK_SPK_2	43	48	PF00069	0.643
MOD_CK1_1	13	19	PF00069	0.691
MOD_CK1_1	182	188	PF00069	0.530
MOD_CK1_1	2	8	PF00069	0.700
MOD_CK1_1	295	301	PF00069	0.636
MOD_CK1_1	49	55	PF00069	0.534
MOD_CK2_1	12	18	PF00069	0.744
MOD_CK2_1	295	301	PF00069	0.632
MOD_CK2_1	428	434	PF00069	0.401
MOD_CK2_1	453	459	PF00069	0.383
MOD_CK2_1	558	564	PF00069	0.602
MOD_GlcNHglycan	195	198	PF01048	0.230
MOD_GlcNHglycan	4	7	PF01048	0.484
MOD_GlcNHglycan	431	434	PF01048	0.643
MOD_GlcNHglycan	482	485	PF01048	0.296
MOD_GlcNHglycan	498	501	PF01048	0.321
MOD_GlcNHglycan	507	510	PF01048	0.297
MOD_GSK3_1	10	17	PF00069	0.686
MOD_GSK3_1	102	109	PF00069	0.537
MOD_GSK3_1	404	411	PF00069	0.318
MOD_GSK3_1	492	499	PF00069	0.472
MOD_LATS_1	104	110	PF00433	0.606
MOD_N-GLC_1	229	234	PF02516	0.569
MOD_N-GLC_1	404	409	PF02516	0.334
MOD_N-GLC_1	411	416	PF02516	0.313
MOD_N-GLC_1	480	485	PF02516	0.288
MOD_NEK2_1	12	17	PF00069	0.688
MOD_NEK2_1	128	133	PF00069	0.510
MOD_NEK2_1	258	263	PF00069	0.328
MOD_NEK2_1	265	270	PF00069	0.328
MOD_NEK2_1	338	343	PF00069	0.409
MOD_NEK2_1	345	350	PF00069	0.381
MOD_NEK2_1	480	485	PF00069	0.474
MOD_NEK2_1	496	501	PF00069	0.239
MOD_NEK2_1	558	563	PF00069	0.646
MOD_NEK2_1	71	76	PF00069	0.366
MOD_PKA_1	378	384	PF00069	0.582
MOD_PKA_2	331	337	PF00069	0.496
MOD_PKA_2	378	384	PF00069	0.607
MOD_Plk_1	128	134	PF00069	0.507
MOD_Plk_1	229	235	PF00069	0.337
MOD_Plk_1	287	293	PF00069	0.472
MOD_Plk_1	404	410	PF00069	0.334
MOD_Plk_1	411	417	PF00069	0.283
MOD_Plk_1	492	498	PF00069	0.459
MOD_Plk_2-3	36	42	PF00069	0.633
MOD_Plk_4	106	112	PF00069	0.534
MOD_Plk_4	128	134	PF00069	0.542
MOD_Plk_4	171	177	PF00069	0.503
MOD_Plk_4	260	266	PF00069	0.328
MOD_Plk_4	338	344	PF00069	0.385
MOD_Plk_4	345	351	PF00069	0.332
MOD_Plk_4	36	42	PF00069	0.561
MOD_Plk_4	441	447	PF00069	0.403
MOD_Plk_4	52	58	PF00069	0.486
MOD_ProDKin_1	182	188	PF00069	0.496
MOD_ProDKin_1	293	299	PF00069	0.641
MOD_ProDKin_1	389	395	PF00069	0.585
MOD_ProDKin_1	43	49	PF00069	0.590
MOD_ProDKin_1	507	513	PF00069	0.361
MOD_SUMO_for_1	377	380	PF00179	0.556
MOD_SUMO_for_1	574	577	PF00179	0.627
MOD_SUMO_rev_2	136	143	PF00179	0.630
MOD_SUMO_rev_2	561	569	PF00179	0.610
TRG_DiLeu_BaEn_1	21	26	PF01217	0.574
TRG_DiLeu_BaEn_1	318	323	PF01217	0.576
TRG_DiLeu_BaEn_2	433	439	PF01217	0.296
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.574
TRG_ENDOCYTIC_2	107	110	PF00928	0.540
TRG_ENDOCYTIC_2	114	117	PF00928	0.555
TRG_ENDOCYTIC_2	170	173	PF00928	0.488
TRG_ENDOCYTIC_2	23	26	PF00928	0.548
TRG_ENDOCYTIC_2	249	252	PF00928	0.272
TRG_ENDOCYTIC_2	262	265	PF00928	0.328
TRG_ENDOCYTIC_2	266	269	PF00928	0.328
TRG_ENDOCYTIC_2	291	294	PF00928	0.593
TRG_ENDOCYTIC_2	458	461	PF00928	0.486
TRG_ENDOCYTIC_2	464	467	PF00928	0.492
TRG_ENDOCYTIC_2	468	471	PF00928	0.502
TRG_ENDOCYTIC_2	482	485	PF00928	0.386
TRG_ENDOCYTIC_2	486	489	PF00928	0.401
TRG_ENDOCYTIC_2	501	504	PF00928	0.328
TRG_ER_diArg_1	114	116	PF00400	0.543
TRG_ER_diArg_1	125	127	PF00400	0.561
TRG_ER_diArg_1	536	539	PF00400	0.466
TRG_ER_diArg_1	555	557	PF00400	0.588
TRG_NLS_MonoExtN_4	534	541	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S1	Leptomonas seymouri	79%	100%
A0A0S4ITN2	Bodo saltans	53%	100%
A0A1X0NK27	Trypanosomatidae	59%	97%
A0A3Q8IF60	Leishmania donovani	97%	100%
A3LQW6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	30%	68%
A4HJV7	Leishmania braziliensis	86%	100%
A4I7B9	Leishmania infantum	97%	100%
A5DL79	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	31%	67%
A6ZUG8	Saccharomyces cerevisiae (strain YJM789)	30%	67%
A7TLA7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	33%	69%
A7TNI7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	33%	69%
B3LI73	Saccharomyces cerevisiae (strain RM11-1a)	30%	67%
B5VJA0	Saccharomyces cerevisiae (strain AWRI1631)	30%	67%
C4Y206	Clavispora lusitaniae (strain ATCC 42720)	30%	68%
C5DGB6	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	34%	69%
C5DZU3	Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)	31%	70%
C5M4D4	Candida tropicalis (strain ATCC MYA-3404 / T1)	30%	67%
C7GQ65	Saccharomyces cerevisiae (strain JAY291)	30%	67%
C8Z951	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	30%	67%
E9B2B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P05374	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	67%
Q6BY28	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	67%
Q6CJI9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	69%
Q6FVB6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	68%
Q754G0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	69%