Putative dynein-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-associated protein, putative

Species:

Leishmania major

UniProt:

Q4Q5U1_LEIMA

TriTrypDb:

LmjF.31.3145 , LMJLV39_310042700 , LMJSD75_310042800

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q5U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5U1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.615
DOC_PP1_RVXF_1	41	48	PF00149	0.376
DOC_PP1_RVXF_1	74	81	PF00149	0.263
DOC_PP2B_LxvP_1	97	100	PF13499	0.244
DOC_USP7_MATH_1	4	8	PF00917	0.545
LIG_14-3-3_CanoR_1	88	96	PF00244	0.288
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.263
LIG_FHA_1	105	111	PF00498	0.252
LIG_FHA_1	70	76	PF00498	0.364
LIG_LIR_Gen_1	105	114	PF02991	0.294
LIG_LIR_Gen_1	83	94	PF02991	0.246
LIG_LIR_Nem_3	105	109	PF02991	0.294
LIG_LIR_Nem_3	46	50	PF02991	0.428
LIG_LIR_Nem_3	83	89	PF02991	0.298
LIG_SH2_CRK	106	110	PF00017	0.323
LIG_SH2_STAP1	106	110	PF00017	0.312
LIG_SH2_STAP1	60	64	PF00017	0.263
LIG_SH2_STAT5	106	109	PF00017	0.234
LIG_SH2_STAT5	34	37	PF00017	0.244
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.429
LIG_SUMO_SIM_par_1	107	113	PF11976	0.240
LIG_WRC_WIRS_1	44	49	PF05994	0.320
MOD_CK2_1	4	10	PF00069	0.511
MOD_CK2_1	50	56	PF00069	0.331
MOD_GlcNHglycan	6	9	PF01048	0.569
MOD_GSK3_1	70	77	PF00069	0.262
MOD_NEK2_1	50	55	PF00069	0.288
MOD_NEK2_1	70	75	PF00069	0.169
MOD_NEK2_2	60	65	PF00069	0.331
MOD_PKA_2	50	56	PF00069	0.346
MOD_PKA_2	87	93	PF00069	0.288
MOD_Plk_1	104	110	PF00069	0.373
MOD_Plk_1	18	24	PF00069	0.384
MOD_Plk_1	82	88	PF00069	0.282
MOD_Plk_4	104	110	PF00069	0.336
MOD_Plk_4	82	88	PF00069	0.259
TRG_ENDOCYTIC_2	106	109	PF00928	0.244
TRG_ENDOCYTIC_2	34	37	PF00928	0.244

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K9	Leptomonas seymouri	75%	100%
A0A1X0NII5	Trypanosomatidae	47%	100%
A0A3Q8IFL9	Leishmania donovani	98%	97%
A0A422NF11	Trypanosoma rangeli	51%	100%
A4HJW0	Leishmania braziliensis	88%	100%
A4I7C2	Leishmania infantum	97%	97%
C9ZMI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZWI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B2B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P62627	Mus musculus	35%	100%
P62628	Rattus norvegicus	35%	100%
Q32P85	Bos taurus	35%	100%
Q3T140	Bos taurus	35%	100%
Q8TF09	Homo sapiens	35%	100%
Q9DAJ5	Mus musculus	35%	100%
Q9NP97	Homo sapiens	35%	100%