Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5T5_LEIMA

TriTrypDb:

LmjF.32.0010 , LMJLV39_320005100 , LMJSD75_320005100

Length:

134

Annotations

LeishMANIAdb annotations

A protein with unclear topology, conserved but entirely restricted to Kinetoplastida.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q5T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5T5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.607
CLV_NRD_NRD_1	36	38	PF00675	0.439
CLV_NRD_NRD_1	8	10	PF00675	0.481
CLV_PCSK_KEX2_1	107	109	PF00082	0.601
CLV_PCSK_KEX2_1	121	123	PF00082	0.526
CLV_PCSK_KEX2_1	36	38	PF00082	0.439
CLV_PCSK_KEX2_1	8	10	PF00082	0.481
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.587
CLV_PCSK_PC7_1	103	109	PF00082	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DOC_MAPK_gen_1	121	132	PF00069	0.303
DOC_SPAK_OSR1_1	3	7	PF12202	0.570
DOC_USP7_MATH_1	126	130	PF00917	0.383
DOC_USP7_MATH_1	19	23	PF00917	0.693
DOC_USP7_UBL2_3	121	125	PF12436	0.435
DOC_USP7_UBL2_3	23	27	PF12436	0.558
DOC_WW_Pin1_4	9	14	PF00397	0.688
LIG_14-3-3_CanoR_1	71	76	PF00244	0.420
LIG_BRCT_BRCA1_1	128	132	PF00533	0.368
LIG_FHA_2	110	116	PF00498	0.386
LIG_LIR_Apic_2	17	21	PF02991	0.674
LIG_LIR_Gen_1	44	55	PF02991	0.455
LIG_LIR_Gen_1	93	104	PF02991	0.414
LIG_LIR_Nem_3	29	34	PF02991	0.641
LIG_LIR_Nem_3	44	50	PF02991	0.455
LIG_LIR_Nem_3	52	56	PF02991	0.431
LIG_LIR_Nem_3	62	67	PF02991	0.446
LIG_Pex14_2	53	57	PF04695	0.362
LIG_SH2_CRK	47	51	PF00017	0.419
LIG_SH2_STAT5	67	70	PF00017	0.362
LIG_SH3_3	80	86	PF00018	0.474
MOD_CK1_1	74	80	PF00069	0.519
MOD_CK2_1	109	115	PF00069	0.524
MOD_CK2_1	32	38	PF00069	0.478
MOD_GlcNHglycan	122	125	PF01048	0.551
MOD_GlcNHglycan	98	102	PF01048	0.610
MOD_GSK3_1	116	123	PF00069	0.534
MOD_GSK3_1	32	39	PF00069	0.496
MOD_N-GLC_1	69	74	PF02516	0.561
MOD_NEK2_1	2	7	PF00069	0.531
MOD_NEK2_1	59	64	PF00069	0.416
MOD_NEK2_1	69	74	PF00069	0.548
MOD_PK_1	36	42	PF00069	0.491
MOD_PKA_1	36	42	PF00069	0.551
MOD_PKA_2	2	8	PF00069	0.597
MOD_PKA_2	32	38	PF00069	0.539
MOD_Plk_2-3	109	115	PF00069	0.504
MOD_Plk_4	126	132	PF00069	0.464
MOD_ProDKin_1	9	15	PF00069	0.621
TRG_ENDOCYTIC_2	31	34	PF00928	0.537
TRG_ENDOCYTIC_2	47	50	PF00928	0.217
TRG_ER_diArg_1	7	9	PF00400	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P8	Leptomonas seymouri	77%	100%
A0A0S4J967	Bodo saltans	45%	100%
A0A1X0PA05	Trypanosomatidae	62%	99%
A0A3S7X509	Leishmania donovani	96%	100%
A4HJY0	Leishmania braziliensis	78%	100%
A4I7G4	Leishmania infantum	94%	100%
D0A202	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9B2C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%