Nuclear segregation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear segregation protein, putative

Species:

Leishmania major

UniProt:

Q4Q5T4_LEIMA

TriTrypDb:

LmjF.32.0020 , LMJLV39_320005200 , LMJSD75_320005200

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	2
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q5T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5T4

Function

Biological processes
Term	Name	Level	Count
GO:0006403	RNA localization	3	2
GO:0008298	intracellular mRNA localization	4	2
GO:0009987	cellular process	1	2
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	237	243	PF00089	0.592
CLV_NRD_NRD_1	103	105	PF00675	0.507
CLV_NRD_NRD_1	11	13	PF00675	0.588
CLV_NRD_NRD_1	138	140	PF00675	0.509
CLV_NRD_NRD_1	152	154	PF00675	0.519
CLV_NRD_NRD_1	269	271	PF00675	0.519
CLV_NRD_NRD_1	284	286	PF00675	0.413
CLV_NRD_NRD_1	291	293	PF00675	0.532
CLV_NRD_NRD_1	338	340	PF00675	0.544
CLV_NRD_NRD_1	341	343	PF00675	0.556
CLV_NRD_NRD_1	379	381	PF00675	0.535
CLV_NRD_NRD_1	45	47	PF00675	0.528
CLV_NRD_NRD_1	85	87	PF00675	0.464
CLV_NRD_NRD_1	92	94	PF00675	0.463
CLV_PCSK_FUR_1	281	285	PF00082	0.494
CLV_PCSK_FUR_1	339	343	PF00082	0.596
CLV_PCSK_FUR_1	90	94	PF00082	0.585
CLV_PCSK_KEX2_1	11	13	PF00082	0.553
CLV_PCSK_KEX2_1	152	154	PF00082	0.519
CLV_PCSK_KEX2_1	213	215	PF00082	0.596
CLV_PCSK_KEX2_1	283	285	PF00082	0.516
CLV_PCSK_KEX2_1	291	293	PF00082	0.495
CLV_PCSK_KEX2_1	306	308	PF00082	0.510
CLV_PCSK_KEX2_1	340	342	PF00082	0.580
CLV_PCSK_KEX2_1	45	47	PF00082	0.477
CLV_PCSK_KEX2_1	85	87	PF00082	0.487
CLV_PCSK_KEX2_1	92	94	PF00082	0.524
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.596
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.635
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.519
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.574
CLV_PCSK_SKI1_1	12	16	PF00082	0.642
CLV_PCSK_SKI1_1	179	183	PF00082	0.526
CLV_PCSK_SKI1_1	213	217	PF00082	0.551
CLV_PCSK_SKI1_1	303	307	PF00082	0.567
CLV_PCSK_SKI1_1	374	378	PF00082	0.714
CLV_PCSK_SKI1_1	45	49	PF00082	0.373
CLV_PCSK_SKI1_1	72	76	PF00082	0.594
DEG_APCC_KENBOX_2	386	390	PF00400	0.649
DOC_MAPK_gen_1	326	334	PF00069	0.578
DOC_MAPK_gen_1	413	422	PF00069	0.543
DOC_MAPK_MEF2A_6	326	334	PF00069	0.519
DOC_USP7_MATH_1	18	22	PF00917	0.627
DOC_USP7_MATH_1	355	359	PF00917	0.692
DOC_USP7_UBL2_3	209	213	PF12436	0.596
DOC_USP7_UBL2_3	267	271	PF12436	0.466
DOC_USP7_UBL2_3	296	300	PF12436	0.520
DOC_USP7_UBL2_3	370	374	PF12436	0.704
DOC_USP7_UBL2_3	377	381	PF12436	0.686
DOC_WW_Pin1_4	387	392	PF00397	0.602
DOC_WW_Pin1_4	471	476	PF00397	0.686
LIG_14-3-3_CanoR_1	238	248	PF00244	0.579
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_deltaCOP1_diTrp_1	261	265	PF00928	0.469
LIG_FHA_1	164	170	PF00498	0.486
LIG_FHA_1	388	394	PF00498	0.606
LIG_FHA_1	449	455	PF00498	0.592
LIG_FHA_2	180	186	PF00498	0.518
LIG_FHA_2	428	434	PF00498	0.560
LIG_IBAR_NPY_1	309	311	PF08397	0.511
LIG_LIR_Gen_1	191	199	PF02991	0.452
LIG_LIR_Nem_3	191	195	PF02991	0.432
LIG_PTB_Apo_2	200	207	PF02174	0.550
LIG_PTB_Phospho_1	200	206	PF10480	0.545
LIG_SH2_CRK	192	196	PF00017	0.559
LIG_SH2_STAP1	206	210	PF00017	0.530
LIG_SH2_STAP1	311	315	PF00017	0.467
LIG_SH2_STAP1	445	449	PF00017	0.490
LIG_SH2_STAT3	324	327	PF00017	0.556
LIG_SH2_STAT5	273	276	PF00017	0.515
LIG_SH2_STAT5	324	327	PF00017	0.458
LIG_SH3_2	23	28	PF14604	0.595
LIG_SH3_3	20	26	PF00018	0.479
LIG_SH3_4	370	377	PF00018	0.692
LIG_SUMO_SIM_par_1	418	423	PF11976	0.535
LIG_TRAF2_1	182	185	PF00917	0.543
LIG_TRAF2_1	3	6	PF00917	0.749
LIG_UBA3_1	321	329	PF00899	0.489
LIG_UBA3_1	48	53	PF00899	0.515
MOD_CDK_SPxxK_3	387	394	PF00069	0.604
MOD_CDK_SPxxK_3	471	478	PF00069	0.687
MOD_CK1_1	242	248	PF00069	0.491
MOD_CK1_1	316	322	PF00069	0.464
MOD_CK1_1	364	370	PF00069	0.750
MOD_CK1_1	427	433	PF00069	0.583
MOD_CK2_1	179	185	PF00069	0.550
MOD_CK2_1	393	399	PF00069	0.742
MOD_CK2_1	440	446	PF00069	0.561
MOD_CMANNOS	262	265	PF00535	0.456
MOD_GlcNHglycan	1	4	PF01048	0.656
MOD_GlcNHglycan	142	146	PF01048	0.512
MOD_GlcNHglycan	314	318	PF01048	0.471
MOD_GlcNHglycan	457	460	PF01048	0.750
MOD_GSK3_1	355	362	PF00069	0.645
MOD_GSK3_1	440	447	PF00069	0.499
MOD_NEK2_1	141	146	PF00069	0.511
MOD_NEK2_1	372	377	PF00069	0.767
MOD_NEK2_1	454	459	PF00069	0.706
MOD_NEK2_1	55	60	PF00069	0.501
MOD_PIKK_1	242	248	PF00454	0.491
MOD_PIKK_1	348	354	PF00454	0.679
MOD_PIKK_1	440	446	PF00454	0.517
MOD_PIKK_1	62	68	PF00454	0.654
MOD_PKA_2	239	245	PF00069	0.574
MOD_Plk_4	316	322	PF00069	0.438
MOD_Plk_4	355	361	PF00069	0.572
MOD_ProDKin_1	387	393	PF00069	0.604
MOD_ProDKin_1	471	477	PF00069	0.686
MOD_SUMO_rev_2	162	166	PF00179	0.529
MOD_SUMO_rev_2	205	210	PF00179	0.576
MOD_SUMO_rev_2	358	367	PF00179	0.718
MOD_SUMO_rev_2	427	435	PF00179	0.593
MOD_SUMO_rev_2	50	55	PF00179	0.521
TRG_ENDOCYTIC_2	192	195	PF00928	0.496
TRG_ER_diArg_1	237	240	PF00400	0.591
TRG_ER_diArg_1	339	342	PF00400	0.624
TRG_ER_diArg_1	45	47	PF00400	0.382
TRG_NLS_Bipartite_1	86	108	PF00514	0.578
TRG_NLS_MonoExtC_3	103	109	PF00514	0.565
TRG_NLS_MonoExtC_3	211	216	PF00514	0.584
TRG_NLS_MonoExtC_3	376	381	PF00514	0.717
TRG_NLS_MonoExtN_4	102	108	PF00514	0.570
TRG_NLS_MonoExtN_4	209	216	PF00514	0.515
TRG_NLS_MonoExtN_4	374	381	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD36	Leptomonas seymouri	55%	95%
A0A0S4J925	Bodo saltans	38%	100%
A0A1X0P6U5	Trypanosomatidae	41%	99%
A0A3R7KQ83	Trypanosoma rangeli	41%	95%
A0A3S7X525	Leishmania donovani	91%	97%
A4HJX8	Leishmania braziliensis	76%	99%
A4HJY1	Leishmania braziliensis	76%	99%
A4I7G5	Leishmania infantum	91%	97%
C9ZZZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
V5BS50	Trypanosoma cruzi	42%	95%