C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5T2_LEIMA

TriTrypDb:

LmjF.32.0040 , LMJLV39_320005400 , LMJSD75_320005400

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5T2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.367
CLV_C14_Caspase3-7	216	220	PF00656	0.606
CLV_MEL_PAP_1	100	106	PF00089	0.356
CLV_NRD_NRD_1	121	123	PF00675	0.453
CLV_NRD_NRD_1	59	61	PF00675	0.450
CLV_NRD_NRD_1	68	70	PF00675	0.460
CLV_NRD_NRD_1	84	86	PF00675	0.515
CLV_PCSK_KEX2_1	121	123	PF00082	0.453
CLV_PCSK_KEX2_1	68	70	PF00082	0.460
CLV_PCSK_KEX2_1	84	86	PF00082	0.515
CLV_PCSK_SKI1_1	122	126	PF00082	0.421
CLV_PCSK_SKI1_1	21	25	PF00082	0.453
CLV_PCSK_SKI1_1	233	237	PF00082	0.627
CLV_PCSK_SKI1_1	68	72	PF00082	0.433
CLV_PCSK_SKI1_1	73	77	PF00082	0.388
CLV_PCSK_SKI1_1	84	88	PF00082	0.387
CLV_PCSK_SKI1_1	93	97	PF00082	0.283
DEG_COP1_1	190	198	PF00400	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DOC_CYCLIN_RxL_1	119	129	PF00134	0.434
DOC_MAPK_gen_1	18	28	PF00069	0.446
DOC_MAPK_MEF2A_6	18	26	PF00069	0.453
DOC_USP7_MATH_1	189	193	PF00917	0.580
DOC_USP7_MATH_1	201	205	PF00917	0.507
DOC_USP7_MATH_1	296	300	PF00917	0.591
DOC_USP7_MATH_1	309	313	PF00917	0.552
DOC_WW_Pin1_4	77	82	PF00397	0.386
LIG_14-3-3_CanoR_1	103	109	PF00244	0.465
LIG_APCC_ABBAyCdc20_2	121	127	PF00400	0.411
LIG_BRCT_BRCA1_1	104	108	PF00533	0.408
LIG_FHA_1	109	115	PF00498	0.362
LIG_FHA_1	134	140	PF00498	0.442
LIG_FHA_1	188	194	PF00498	0.621
LIG_FHA_1	274	280	PF00498	0.718
LIG_FHA_1	70	76	PF00498	0.426
LIG_FHA_2	127	133	PF00498	0.482
LIG_FHA_2	214	220	PF00498	0.604
LIG_LIR_Gen_1	211	221	PF02991	0.649
LIG_LIR_Gen_1	234	243	PF02991	0.639
LIG_LIR_Nem_3	211	217	PF02991	0.772
LIG_LIR_Nem_3	234	238	PF02991	0.611
LIG_MYND_1	196	200	PF01753	0.613
LIG_NRBOX	82	88	PF00104	0.431
LIG_Pex14_2	28	32	PF04695	0.434
LIG_REV1ctd_RIR_1	68	77	PF16727	0.411
LIG_SH2_CRK	214	218	PF00017	0.672
LIG_SH2_CRK	63	67	PF00017	0.475
LIG_SH2_GRB2like	63	66	PF00017	0.556
LIG_SH2_NCK_1	116	120	PF00017	0.415
LIG_SH2_NCK_1	63	67	PF00017	0.487
LIG_SH2_SRC	159	162	PF00017	0.408
LIG_SH2_STAP1	116	120	PF00017	0.375
LIG_SH2_STAT5	159	162	PF00017	0.408
LIG_SH2_STAT5	63	66	PF00017	0.504
LIG_SH2_STAT5	99	102	PF00017	0.377
LIG_SH3_2	228	233	PF14604	0.562
LIG_SH3_3	225	231	PF00018	0.571
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.387
LIG_UBA3_1	86	93	PF00899	0.461
LIG_WRC_WIRS_1	29	34	PF05994	0.450
MOD_CDK_SPxxK_3	77	84	PF00069	0.385
MOD_CK1_1	126	132	PF00069	0.480
MOD_CK1_1	150	156	PF00069	0.517
MOD_CK1_1	264	270	PF00069	0.831
MOD_CK1_1	292	298	PF00069	0.689
MOD_CK1_1	299	305	PF00069	0.628
MOD_CK1_1	312	318	PF00069	0.628
MOD_CK1_1	336	342	PF00069	0.693
MOD_CK2_1	126	132	PF00069	0.556
MOD_GlcNHglycan	224	227	PF01048	0.813
MOD_GlcNHglycan	249	252	PF01048	0.723
MOD_GlcNHglycan	267	270	PF01048	0.528
MOD_GlcNHglycan	302	305	PF01048	0.661
MOD_GlcNHglycan	311	314	PF01048	0.689
MOD_GlcNHglycan	316	319	PF01048	0.676
MOD_GlcNHglycan	338	341	PF01048	0.658
MOD_GSK3_1	143	150	PF00069	0.394
MOD_GSK3_1	222	229	PF00069	0.649
MOD_GSK3_1	261	268	PF00069	0.654
MOD_GSK3_1	273	280	PF00069	0.592
MOD_GSK3_1	292	299	PF00069	0.796
MOD_GSK3_1	38	45	PF00069	0.488
MOD_LATS_1	260	266	PF00433	0.657
MOD_N-GLC_1	273	278	PF02516	0.664
MOD_N-GLC_1	320	325	PF02516	0.685
MOD_N-GLC_1	331	336	PF02516	0.571
MOD_NEK2_1	143	148	PF00069	0.403
MOD_NEK2_1	28	33	PF00069	0.466
MOD_NEK2_1	71	76	PF00069	0.404
MOD_NEK2_2	189	194	PF00069	0.535
MOD_PIKK_1	296	302	PF00454	0.616
MOD_PKA_2	102	108	PF00069	0.455
MOD_PKA_2	261	267	PF00069	0.817
MOD_PKA_2	37	43	PF00069	0.480
MOD_Plk_1	210	216	PF00069	0.617
MOD_Plk_1	273	279	PF00069	0.677
MOD_ProDKin_1	77	83	PF00069	0.381
TRG_DiLeu_BaEn_1	82	87	PF01217	0.466
TRG_DiLeu_LyEn_5	19	24	PF01217	0.460
TRG_DiLeu_LyEn_5	82	87	PF01217	0.418
TRG_ENDOCYTIC_2	214	217	PF00928	0.795
TRG_ER_diArg_1	120	122	PF00400	0.449
TRG_ER_diArg_1	68	70	PF00400	0.499
TRG_ER_diArg_1	83	85	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I963	Leptomonas seymouri	57%	90%
A0A3S7X526	Leishmania donovani	90%	100%
A4HJY4	Leishmania braziliensis	70%	100%
A4I7G7	Leishmania infantum	91%	100%
E9B2C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%